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Skull metastasis from hepatocellular carcinoma with chronic hepatitis B

World Journal of Gastrointestinal Oncology 2010年第3期2卷 165-168页

作者： Takashi Goto takahiro dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi Department of Gastroenterology Akita University School of Medicine

A 56-year-old male visited our hospital for evaluation of an occipital *** computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the *** resonance imaging showed bone metastasis in the thoracic *** for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade *** diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis *** was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for *** he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and *** showed HCC with multiple bone *** liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular *** the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting *** necrosis was not *** fibrosis was *** 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial *** lesion was osteolytic and showed invasion into the dura *** the subdural cavity nor the brain showed involvement from the metastatic ***,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of ***,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC.

关键词： Hepatocellular carcinoma Skull metastasis Bone metastasis Osteolytic change Chronic hepatitis B

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