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Journal of Rare Earths 2006年第Z1期24卷 213-216页

作者： Sunao abe takahiro Terada Yasutada Nakagawa Kazuhiko Kashima Silicon Company Toshiba Ceramics Co.Ltd. 6-861-5 Higashikou Seirou-machi Niigata 957-0197 Japan Corporate Manufacturing Engineering Center Toshiba Corp. 33 Shin-isogo Isogo-ku Yokohama Kanagawa 235-0017 Japan Corporate Manufacturing Engineering Center Toshiba Corp. 33 Shin-isogo Isogo-ku Yokohama Kanagawa 235-0017 Japan New Business Creation Division Toshiba Ceramics Co.Ltd. 1-6-3 Osaki Shinagawa-ku Tokyo 141-0032 Japan

A numerical analysis technique that incorporates Voronkov's model were examined and used to estimate the distribution of defects during crystal growth. By comparisons of the distribution of the density of LSTD and the position of R-OSF in non-nitrogen-doped (non-N-doped) and nitrogen-doped (N-doped) silicon crystals, it is found that the results of the numerical analyses agree with practically evaluated data. The observations suggest that the R-OSF nucleus is a VO2 complex that is formed by bonds between oxygen atoms and residual vacancies consumed during the formation of void defects. This suggests that Voronkov's model can be used to accurately predict the generation and growth of defects in silicon crystals. This numerical analysis technique was also found to be an effective method of estimating the distribution of defects in silicon crystals during crystal growth.

关键词： computer simulation nucleation point defects volume defect semiconducting silicon

Secretory carcinoma——impact of translocation and gene fusions on salivary gland tumor

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Chinese Journal of Cancer Research 2017年第5期29卷 379-384页

作者： Ryoko Inaki Masanobu abe Liang Zong takahiro abe Aya Shinozaki-Ushiku Tetsuo Ushiku Kazuto Hoshi Department of Oral & Maxillofacial Surgery University of Tokyo Hospital Division for Health Service Promotion University of Tokyo Graduate School of Medicine University of Tokyo Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Department of Pathology Graduate School of Medicine University of Tokyo

Secretory carcinoma（SC）, previously described as mammary analogue secretory carcinoma（MASC）, is a recently described salivary gland tumor which morphologically resembles mammary secretory carcinoma. The first description of SC/MASC, reported by Skálová et al. in 2010, was as a rare salivary carcinoma imitating secretory carcinoma of the breast. SC/MASC is a unique salivary gland tumor with morphological overlap with acinic cell carcinoma（Aci CC）, mucoepidermoid carcinoma（MEC）, and adenocarcinoma not otherwise specified（ADCNOS）. SC/MASC shares similar clinicopathological features with Aci CC. As a critical difference between SC/MASC and Aci CC, SC/MASC characteristically has the chromosomal translocation t（12;15）（p13;q25） which leads to a fusion gene between the ETV6 gene on chromosome 12 and the NTRK3 gene on chromosome 15. This genetic background is an important differential diagnostic finding for excluding other salivary gland tumors and may be a critical factor determining the prognosis for patients with SC/MASC. Research in recent years has provided a large body of new data on SC/MASC and suggests the possibility that the ETV6-NTRK3 translocation could be a therapeutic target. Here, we review the morphological and clinicopathological features of SC/MASC and discuss new directions for therapy.

关键词： Secretory carcinoma mammary analogue secretory carcinoma MASC ETV6-NTRK3 fusion gene salivary gland tumor

BRAF inhibitor:a novel therapy for ameloblastoma in mandible

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Chinese Journal of Cancer Research 2018年第6期30卷 677-678页

作者： Masanobu abe Liang Zong takahiro abe Hideyuki Takeshima Jiafu Ji Toshikazu Ushijima Kazuto Hoshi Department of Oral & Maxillofacial Surgery University of Tokyo Hospital Division for Health Service Promotion University of Tokyo Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal SurgeryPeking University Cancer Hospital & Institute Graduate School of Medicine University of Tokyo Division of Epigenomics National Cancer Center Research Institute

Ameloblastoma is a benign but locally aggressive odontogenic neoplasm that accounts for 10% of all tumors arising in the mandible and maxilla (1). Eighty percent of ameloblastomas arise in the mandible, and they are u... 详细信息

关键词： BRAF inhibitor:a novel therapy for ameloblastoma in mandible

A Case of Pleomorphic Adenoma of the Parotid Gland with Multiple Local Recurrences through Facial to Cervical Regions

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Open Journal of Stomatology 2014年第9期4卷 441-445页

作者： Masanobu abe Yoshiyuki Mori Yuki Kanno Kazuto Hoshi Hideto Saijo takahiro abe Kazumi Ohkubo Tsuyoshi Takato Department of Oral & Maxillofacial Surgery University of Tokyo Hospital Tokyo Japan

Pleomorphic adenoma is the most common benign parotid gland tumor. Although its local recurrence rate is known to be high, the recurrence extending to the cervical region is rare. Here we report a case of a young female (25 years old) with pleomorphic adenoma of the parotid gland which showed multiple recurrences through facial to cervical regions over a span of eight years. We also discuss how this benign tumor with a high recurrence rate has been treated in other cases, and how it should be treated.

关键词： Pleomorphic Adenoma Parotid Gland Salivary Neoplasm

地方性知识的调查、保存与应用——以日本山形县农村文化研究所的实践为例

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艺术与民俗 2022年第2期 46-52,97页

作者：程亮 [日]阿部宇洋广东外语外贸大学日本山形大学

地方性知识的调查研究,不应以理论认知为终点,而应回到实践中。日本山形县的农村文化研究所作为一家由当地农民创办、大学学者参与的公益性研究机构,在当地居民与外来研究者之间建立对话平台,解决了当地居民缺乏专业研究能力以及研究者... 详细信息

地方性知识的调查研究,不应以理论认知为终点,而应回到实践中。日本山形县的农村文化研究所作为一家由当地农民创办、大学学者参与的公益性研究机构,在当地居民与外来研究者之间建立对话平台,解决了当地居民缺乏专业研究能力以及研究者缺乏本地视角的问题,有效地保证了地方性知识的调查、保存与应用,值得中国学者借鉴。

关键词：地方性知识日本山形县农村文化研究所当地居民主导型

Effects of reduction on the catalytic performance of limonite ore

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Journal of Energy Chemistry 2018年第5期27卷 1489-1495页

作者： Keisuke abe Ade Kurniawan takahiro Nomura Tomohiro Akiyama Graduate school of Engineering Hokkaido University Sapporo 060-8628 Japan Center for Advanced Research of Energy and Materials Hokkaido University Sapporo 060-8628 Japan

The catalytic performance of Ni-containing limonite ore in the dry reforming reaction of methane （CH_4＋CO_2→2H_2＋2CO） was determined before and after hydrogen reduction, and under a flow of hydrogen. After hydrogen reduction, the limonite ore exhibited higher catalytic performance, because of the formation of Fe-Ni. However, the Fe in Fe-Ni was readily oxidized by the input CO_2 gas. resulting in a rapid decrease in the catalytic performance of limonite ore. The performance de- crease was due to a decrease in the Ni surface area; Ni could not dissolve in iron oxides and this caused segregation in the iron oxides. When the reaction was conducted under a hydrogen flow, the Fe-Ni was formed and maintained. Ni was highly dispersed in the Fe-Ni phase, resulting in greater surface area of Ni and higher conversion rate of CH_4 and CO_2. The catalytic performance of the limonite ore was inferior to the Ni/Al_2O_3 catalyst because the effect of catalyst support was small, however, the limonite ore was more stable during catalytic use and much cheaper than the Ni/Al_2O_3.

关键词： Limonite Dry reforming Fe-Ni Catalyst

Glycogen synthase kinase 3b biology in bone and soft tissue sarcomas

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 660-674页

作者： Kensaku abe Shingo Shimozaki takahiro Domoto Norio Yamamoto Hiroyuki Tsuchiya Toshinari Minamoto Department of Orthopaedic Surgery Graduate School of Medical SciencesKanazawa UniversityKanazawa 920-8641Japan Division of Translational and Clinical Oncology Cancer Research InstituteKanazawa UniversityKanazawa 920-0934Japan Shimozaki Orthopaedic Hospital HakusanIshikawa 924-0802Japan

Bone and soft tissue sarcomas are malignant neoplasms probably originating from musculoskeletal and mesenchymal progenitor *** than 80 different histopathological subtypes are encountered in *** standard of care for sarcoma patients involves a multidisciplinary combination of surgery,anthracycline-based multiagent chemotherapy and ***,these are associated with adverse events and occasionally disappointing *** genomic-,biologically-,and immunologically-based therapies are still under evaluation in early-phase clinical ***,there are strong barriers to the development and clinical translation of new therapeutic *** is due to the rarity of these diseases,the broad spectrum of tumor subtypes with genetic and biological heterogeneity,and the wide variability in clinical manifestation,response to treatment and prognosis.A potential approach toward overcoming this barrier is to identify therapeutic targets that cover multiple sarcoma *** synthase kinase 3b(GSK3b)has emerged as a common therapeutic target in more than 25 different cancer *** we review the evidence for tumor-promoting roles of GSK3b in the major types of bone and soft tissue sarcomas including osteosarcoma,rhabdomyosarcoma,synovial sarcoma,and *** this review,we describe the therapeutic effects of inhibiting GSK3b in these sarcoma types,while also protecting healthy cells and tissues from detrimental effects associated with conventional therapies,such as doxorubicin-induced ***,we highlight GSK3b as a potential therapeutic target spanning multiple sarcoma types.

关键词： Osteosarcoma rhabdomyosarcoma synovial sarcoma fibrosarcoma glycogen synthase kinase 3b

Triple Range Imager and POLarimeter(TRIPOL)——a compact and economical optical imaging polarimeter for small telescopes

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Research in Astronomy and Astrophysics 2019年第9期19卷 149-158页

作者： Shuji Sato Po Chieh Huang Wen Ping Chen takahiro Zenno Chakali Eswaraiah Bo He Su Shinsuke abe Daisuke Kinoshita Jia Wei Wang Astrophysics Department Nagoya UniversityNagoya464–8602Japan Graduate Institute of Astronomy NCUTaoyuan32001 Department of Physics and Institute of Astronomy NTHUHsinchu30013

We report the design concept and performance of a compact, lightweight and economical imaging polarimeter, the Triple Range Imager and POLarimeter(TRIPOL), capable of simultaneous optical imagery and polarimetry. TRIPOL splits the beam in wavelengths from 400 to 830 nm into g′-, r′-and i′-bands with two dichroic mirrors, and measures polarization with an achromatic half-waveplate and a wire grid polarizer. The simultaneity makes TRIPOL a useful tool for small telescopes for the photometry and polarimetry of time variable and wavelength dependent phenomena. TRIPOL is designed for a Cassegrain telescope with an aperture of^1 m. This paper presents the engineering considerations of TRIPOL and compares the expected with observed performance. Using the Lulin 1-m telescope and 100 seconds of integration, the limiting magnitudes are g′~19.0 mag, r′~18.5 mag and i′~18.0 mag with a signal-to-noise ratio of 10, in agreement with design expectation. The instrumental polarization is measured to be^0.3% in the three bands. Two applications, one to the star-forming cloud IC 5146 and the other to the young variable GM Cep, are presented as demonstrations.

关键词： instrumentation:photometers instrumentation:polarimeters techniques:photometric techniques:polarimetric methods:observational ISM:magnetic fields

Gravity assistance enables liver stiffness measurements to detect liver fibrosis under congestive circumstances

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World Journal of Hepatology 2022年第4期14卷 778-790页

作者： Takeshi Suda Ai Sugimoto Tsutomu Kanefuji Atsushi abe Takeshi Yokoo takahiro Hoshi Satoshi abe Shinichi Morita Kazuyoshi Yagi Masashi Takahashi Shuji Terai Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami Uonuma 949-7302NiigataJapan Division of Thoracic and Cardiovascular Surgery Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan Department of Gastroenterology and Hepatology Tsubame Rosai HospitalTsubame 959-1228NiigataJapan Department of Administration Joetsu-Area General Health Care CenterJoetsu 943-0803NiigataJapan Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life Niigata University School of MedicineNiigata 951-8122Japan Division of Gastroenterology and Hepatology School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan

BACKGROUND As survival has been prolonged owing to surgical and medical improvements,liver failure has become a prognostic determinant in patients with congestive heart *** hepatopathy,an abnormal state of the liver as a result of congestion,insidiously proceed toward end-stage liver disease without effective biomarkers evaluating pathological *** measurements of shear wave elastography cannot qualify liver fibrosis,which is a prognosticator in any type of chronic liver disease,in cases of congestion because congestion makes the liver stiff without *** hypothesized that the effects of congestion and fibrosis on liver stiffness can be dissociated by inducing architectural deformation of the liver to expose structural *** establish a strategy measuring liver stiffness as a reflection of architectural rigidity under *** Two-dimensional shear wave elastography(2dSWE)was measured in the supine(Sp)and left decubitus(Ld)positions in 298 consecutive cases as they were subjected to an ultrasound study for various liver *** of interest were placed at twelve sites,and the median and robust coefficient of variation were *** data were compared using the Mann-Whitney U or Kruskal-Wallis test followed by Dunn's post-hoc multiple *** inferior vena cava(IVC)diameters at different body positions were compared using the Wilcoxon matched pairs signed rank *** number of cases with cardiothoracic ratios greater than or not greater than 50%was compared using Fisher’s exact test.A correlation of 2dSWE between different body positions was evaluated by calculating Spearman correlation *** The IVC diameter was significantly reduced in Ld in subjects with higher 2dSWE values in Ld(LdSWE)than in Sp(SpSWE)(P=0.007,(average±SD)13.9±3.6 vs 13.1±3.4 mm)but not in those with lower LdSWE values(P=0.32,13.3±3.5 vs 13.0±3.5 mm).In 81 subjects,SpSWE was increased or decreased in

关键词： Shear wave elastography Inferior vena cava diameter Congestive hepatopathy Liver fibrosis Body positions Fibrosis-4 index

Rational arrangement of measuring shear wave speed in the liver

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World Journal of Gastroenterology 2019年第20期25卷 2503-2513页

作者： Takeshi Yokoo Tsutomu Kanefuji Takeshi Suda Itsuo Nagayama takahiro Hoshi Satoshi abe Shinichi Morita Hiroteru Kamimura Kenya Kamimura Atsunori Tsuchiya Masaaki Takamura Kazuyoshi Yagi Shuji Terai Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life Niigata University School of MedicineNiigataNiigata 951-8122Japan Division of Gastroenterology and Hepatology Niigata Tokamachi HospitalTokamachiNiigata 948-0065Japan Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami UonumaNiigata 949-7302Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan

BACKGROUND Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM To provide procedural standardization of shear wave speed measurement. METHODS Point shear wave elastography (pSWE) was measured in 781 patients, and twodimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS The CVR showed a significantly broader distribution in the left lobe (P < 0.0001),and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes.

关键词： Liver stiffness Ultrasound Shear wave elastography Acoustic radiation force impulse Heterogeneity