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Journal of Energy and Power Engineering 2013年第4期7卷 705-710页

作者： takahiro yoshida Tetsuya Sano Takashi Nomura Hideki Gensai Hiroki Watada Seiji Ohara Forestry and Forest Products Research Institute Tsukuba 305-8687 Japan Fukui Prefectural Green Center Sakai 910-0336 Japan

In order to upgrade the conventional wood pellet, Japanese softwood and hardwood chips were torrefied at around 200-350℃, and pelletized. The characteristics of the torrefied material/pellets such as their calorific value, grinding energy, pelletizing energy and elemental composition, were also evaluated in this study. The calorific value rose with increasing torrefaction temperature and exceeded 25 MJ/kg （an increase of nearly 40% compared to the untreated state） for torrefaction at around 350℃. The grinding energy greatly decreased with increasing torrefaction temperature, and the reduction was larger for Japanese oak hardwood chips. The pelletization energy for the torrefied material tended to be slightly smaller than in the untreated case. People named such torrefied pellet as ＂hyper wood pellet＂.

关键词： Wood pellets torrefaction calorific value.

Upgraded Pellet Making by Torrefaction—Torrefaction of Japanese Wood Pellets

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Journal of Sustainable Bioenergy Systems 2015年第3期5卷 82-88页

作者： takahiro yoshida Takashi Nomura Hideki Gensai Hiroki Watada Tetsuya Sano Seiji Ohara Forestry and Forest Products Research Institute Tsukuba Japan Fukui Prefectural Green Center Sakai Japan Present Address: Tohoku Institute of Technology Sendai Japan

Upgraded wood pellets were produced and evaluated by torrefaction of wood pellets. In this study, conventional wood pellets were initially prepared and subsequently torrefied on a laboratory and then larger scale. During the laboratory scale production, pellets from wooden parts of Japanese cedar (sugi, Cryptomeria japonica) and Japanese oak (konara, Quercus serrata) trees were heat- treated in an inert gas oven under nitrogen atmosphere around 170°C - 320°C. For the Japanese cedar, the calorific values were improved by heat treatment up to 260°C. By heat treatment at 240°C, the upgrade ratio of higher heating value (HHV) was nearly 30% and the energy yield was 97%. For the Japanese oak, the calorific values were improved by heat treatment up to 320°C. By heat treatment at 280°C, the upgrade ratio of HHV exceeded 30% and the energy yield was 84%. On a larger scale, a conventional charcoal oven was modified for torrefied wood pellet production, meaning that torrefied wood pellet with 25 MJ/kg of calorific value was produced during heat treatment at 350°C. A mixture of conventional and torrefied pellets was applied to a commercial pellet stove, and torrefied wood pellets produced in this study might be usable as fuel for conventional pellet stoves.

关键词： Component Wood Pellet Torrefaction Calorific Value

Early Results of Omitting Completion Axillary Lymph Node Dissection in Sentinel Lymph Node Metastasis-Positive Breast Cancer Patients

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Advances in Breast Cancer Research 2013年第4期2卷 126-132页

作者： Junko Honda Hisashi Matsuoka Chieko Hirose Taeko Nagao takahiro yoshida Masako Takahashi Issei Imoto Mitsunori Sasa Department of Human Genetics Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan Department of Oncological and Regenerative Surgery Institute of Health Biosciences The University of Tokushima Graduate Scholl Tokushima Japan Department of Surgery National Hospital Organization Higashitokushima Medical Center Tokushima Japan Department of Surgery Tokushima Breast Care Clinic Tokushima Japan

Background: We investigated the early results of omitting completion axillary lymph node dissection (ALND) for axillary node metastasis-negative (N0), sentinel node (SN) metastasis-positive breast cancer patients. Patients and Methods: 489 patients had invasive N0 breast cancer treated without completion ALND, regardless of their SN metastasis status. Analyses included the associations between the SN metastasis status, clinicopathological findings and recurrence, between recurrence and clinicopathological findings, and recurrence-free survival. Results: 430 patients were SN biopsy (SNB)-negative, and 59 were SNB-positive. The SNB-positive patients received significantly more potent adjuvant therapy than the SNB-negative patients. Median follow-up was 3.7 years, and the axillary node recurrence was seen in 6 patients (1.2%) and recurrence in 21 patients. The SN status showed no associations with the clinicopathological findings or recurrence. Univariate analysis showed recurrence was associated with absence of hormonal therapy, ER-negative, PgR-negative, HER2-positive or triple-negative (TNBC) disease, a tumor ≥2.1 cm and higher nuclear grade. Multivariate analysis showed recurrence was associated with absence of hormonal therapy and a tumor ≥2.1 cm. Cox proportional hazards model showed recurrence was extremely early in ER-negative and TNBC patients. Conclusion: Completion ALND can be skipped in N0 breast cancer patients even if they are SNB-positive, but adjuvant therapy is essential.

关键词： Axillary Lymph Node Dissection Breast Cancer Sentinel Node Biopsy

Squamous Cell Carcinoma Arising from Aparaurethral Region

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Case Reports in Clinical Medicine 2016年第4期5卷 154-157页

作者： Kyosuke Matsuzaki takahiro yoshida Yasuyuki Kobayashi Ken Takeda Yasuyuki Arai Masashi Nakayama Ken-ichi Kakimoto Yasuhiko Tomita Kazuo Nishimura Department of Urology Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Japan Department of Pathology Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Japan

A 69-year-old man was referred to our hospital with dysuria and gross hematuria associated with a rapidly growing perineal mass. Serum squamous cell carcinoma (SCC) antigen level was high (2.4 ng/mL). Magnetic resonance imaging examination revealed a tumor posterior and inferior to the pendular urethra with a cystic lesion inside. Tumor resection together with total penectomy was performed. Pathohistological findings revealed well-differentiated SCC arising from the paraurethral region. The patient remained free of disease without adjuvant therapy at 70 months after surgery. To our knowledge, this is the second reported case of paraurethral SCC.

关键词： Paraurethral Squamous Cell Carcinoma Perineal Mass

城市内部结构和人口密度对地表温度空间变化的影响——以东京新宿区为例

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红外 2022年第7期43卷 34-40页

作者：陈曦陈超民哈斯巴干吉田崇紘上海师范大学环境与地理科学学院上海200234

随着城市化进程的加快和人口的快速增长,城市空间内部格局正发生变化,城市热岛效应不断加剧。本研究旨在根据建筑、人口与地表热环境的关系来寻求可持续发展。与其他研究相比,本文采用了东京新宿区的机载热红外图像、机载激光雷达数据... 详细信息

随着城市化进程的加快和人口的快速增长,城市空间内部格局正发生变化,城市热岛效应不断加剧。本研究旨在根据建筑、人口与地表热环境的关系来寻求可持续发展。与其他研究相比,本文采用了东京新宿区的机载热红外图像、机载激光雷达数据、建筑物矢量数据和人口普查数据等新颖数据,且最大创新点在于对建筑密度、平均高度、平均地表温度(Land Surface Temperature,LST)和人口密度之间进行的定量分析。结果显示,平均LST与建筑密度的相关性最大(r=0.6718),其次是平均LST与人口密度的相关性(r=0.6050);建筑密度与人口密度呈正相关(r=0.4949),平均LST与建筑物平均高度呈负相关(r=-0.3814)。经研究可知,通过合理规划城市内部结构有望为减弱城市热岛效应和实现环境可持续发展提供参考。

关键词：城市建筑热环境机载热红外图像机载激光雷达相关分析

Usefulness and limitations of taste sensors in the evaluation of palatability and taste-masking in oral dosage forms

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Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 479-485页

作者： Tamami Haraguchi Miyako yoshida Honami Kojima takahiro Uchida School of Pharmaceutical Science Mukogawa Women’s University

The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations.

关键词： Palatability Taste sensor Orally disintegrating tablet (ODT) Disintegration time Drug formulation

Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation

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Neural Regeneration Research 2023年第11期18卷 2466-2473页

作者： Kanae Murata Kenya Nozawa Mayumi Matsushita Aozora Yamashita Rintaro Fujii Yuji Awaga Aldric Hama takahiro Natsume Go yoshida Yukihiro Matsuyama Hiroyuki Takamatsu Hamamatsu Pharma Research Inc.HamamatsuShizuokaJapan Department of Orthopedic Surgery Hamamatsu University School of MedicineHamamatsuShizuokaJapan

The lack of truly robust analgesics for chronic pain is owed,in part,to the lack of an animal model that reflects the clinical pain state and of a mechanismbased,objective neurological indicator of *** present study examined stimulus-evo ked brain activation with functional magnetic resonance imaging in male and female cynomolgus macaques following unilateral L7 spinal nerve ligation and the effects of clinical analgesics pregabalin,duloxetine,and morphine on brain activation in these macaques.A modified straight leg raise test was used to assess pain severity in awake animals and to evo ke regional brain activation in anesthetized *** potential effects of clinical analgesics on both awake pain behavior and regional brain activation were *** spinal nerve ligation,both male and female macaques showed significantly decreased ipsilateral straight leg raise thresholds,suggesting the presence of radicula rlike *** treatment increased straight leg raise thresholds in both males and females whereas duloxetine and pregabalin did *** male macaques,the ipsilateral straight leg raise activated contralateral insular and somatosensory cortex(Ins/SII),and *** female macaques,the ipsilateral leg raise activated cingulate cortex and contralateral insular and somatosensory *** leg raises of the contralateral,unligated leg did not evoke brain *** reduced activation in all brain regions in both male and female *** males,neither pregabalin nor duloxetine decreased brain activation compared with vehicle *** females,however,pregabalin and duloxetine decreased the activation of cingulate cortex compared with vehicle *** current findings suggest a diffe rential activation of brain areas depending on sex following a peripheral nerve *** rential brain activation observed in this study could underlie qualitative sexual dimorphism in clinical chronic pain perception and responses to

关键词： biomarkers functional magnetic resonance imaging lumbar radicular pain Macaca fascicularis neuroimaging neuropathic pain sciatica straight leg raise

Abdominal Aortic Aneurysm Repair in a Patient with Superior Mesenteric Artery Occlusion with Transient Intraoperative Infusion of the Inferior Mesenteric Artery: A Surgical Case Report

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World Journal of Cardiovascular Surgery 2018年第11期8卷 213-218页

作者： Yasuhiko Kobayashi takahiro Yamaguchi Junichi yoshida Department of Cardiovascular Surgery Amagasaki Central Hospital Amagasaki Japan Department of Cardiovascular Surgery Kawachi General Hospital Osaka Japan Department of Cardiology Amagasaki Central Hospital Amagasaki Japan

Abdominal aortic aneurysms (AAA) with mesenteric artery stenosis or obstructive lesions are occasionally recognized. While performing the graft replacement operation in such cases, if the collateral circulation supplying the gastrointestinal tract is well developed, it is necessary that this collateral circulation should be well perfused during aortic cross-clamping. A 72-year-old woman was admitted because of expansion of AAA. Computed tomography (CT) scan examination revealed occlusion at the origin of the superior mesenteric artery (SMA) and the development of a collateral circulatory pathway via the inferior mesenteric artery (IMA). During this operation, a vein cannula was placed in the IMA, through which blood was supplied with an extension tube for the protection of the intra-abdominal organs. The IMA was reimplanted after the graft replacement. Previous reports indicate that intestinal ischemia may be successfully prevented by supplying blood to the collateral circulation using various techniques. We report the surgical approach for treatment of AAA using a simple and convenient method to maintain intra-operative blood supply to vital organs.

关键词： Abdominal Aortic Aneurysm Occlusion of the Superior Mesenteric Artery Transient Perfusion Simple Method

Evaluating the Effects of Crystallinity on Drug Release Behaviour in Itraconazole- or Miconazole-Loaded PLGA Microparticles Prepared Using a Co-Grinding Method

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Pharmacology & Pharmacy 2023年第9期14卷 348-362页

作者： Kazuhiro Matsuura Honami Kojima Miyako yoshida takahiro Uchida Formulation Technology Research Laboratories Daiichi Sankyo Co. Ltd. Hiratsuka Japan Faculty of Pharmaceutical Science Mukogawa Women’s University Nishinomiya Japan

This study aimed to prepare and characterize itraconazole (ITCZ)- or miconazole (MCZ)-loaded poly (lactide-co-glycolide) (PLGA) microparticles (MP) using a co-grinding method with ball milling, which is a solvent-free and convenient procedure. PLGA MP was prepared by grinding for 60 min, and the fixed theoretical drug loading was set at 9.1% and 16.7% for both drugs. The obtained loading efficiency for both drugs was estimated to be approximately 100%. The average diameters of the drug-loaded PLGA MP were approximately 20 - 35 μm. Powder X-ray diffraction (PXRD) or differential scanning calorimetry (DSC) confirmed amorphization of ITCZ and MCZ in ITCZ- or MCZ-loaded PLGA MP in all formulations. The drug release percentage from 9.1%-loaded ITCZ-PLGA7505 MP at 24 h was almost 50%, which was higher than that of ITCZ powder. The drug release percentage from MCZ-loaded PLGA7505 MP at 4 h was over 80%, which was higher than that of MCZ powder. This enhancement of release rate is caused by the amorphization of ITCZ or MCZ in the PLGA matrix. MCZ-loaded PLGA7510 MP showed a sustained release profile up to 24 h, suggesting that MCZ exists in an amorphous form in the PLGA matrix;however, the release rate declined owing to the large molecular weight of PLGA. Therefore, the release enhancement of antifungal drugs loaded on PLGA MP could be achieved by their amorphization using a co-grinding method with ball milling.

关键词： Co-Grinding Method Ball Milling Poly (Lactide-co-Glycolide) Itraconazole Miconazole Amorphization

Incidence and localization of lymphoid follicles in early colorectal neoplasms

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World Journal of Gastroenterology 2005年第43期11卷 6863-6866页

作者： Kuang-I Fu Yasushi Sano Shigeharu Kato takahiro Fujii Ikura Koba Takayuki Yoshino Atsushi Ochiai Shigeaki yoshida takahiro Fujimori Division of Gastrointestinal Oncology and Digestive Endoscopy Division of Pathology Department of Surgical and Molecular Pathology

AIM： TO investigate the incidence and Iocalizations of lymphoid follicles （LFs） in early colorectal neoplasms in human beings. METHODS： From July 1992 to September 1999, a total of 1 324 early colorectal neoplasms were removed endoscopically or surgically at our hospital; 1 031 （77.9%） were available for analysis in this study. Localization of LFs was defined histologically： as submucosal LFs, if located under the muscularis mucosa; and as intramucosal LFs, if located across or over the muscularis RESULTS： Histologically, the materials included 903 intramucosal neoplasms and 128 submucosal cancers. Overall incidence of LFs was 27.2% （280/1 031）. The incidence of LFs was significantly higher in females （33.6% vs 24.9%, P = 0.0064）, the right-sided colon （32.2% vs 25.6%, P = 0.0403） and in flat or depressed type lesions （34.6% vs 25.2%, P〈O.O001） as compared to males, left-sided colon and protruding type lesions, respectively. The incidences of intramucosal neoplasms and submucosal cancers were 24.3% and 43.8%, respectively （P〈O.O001）. Localizations of LFs （intramucosal LF/submucosal LF） in depressed, flat, and protruding types were 1/24, 14/36, and 131/74, respectively. CONCLUSION： The incidence of LFs in early human colorectal neoplasms significantly differs by gender, location, macroscopic type, and histology. Moreover,localization significantly differs by macroscopic type.

关键词： Lymphoid follicle Early colorectal neoplasm Carcinogenesis