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Isolation and characterization of Xenopus laevis homologs of the mouse inv gene and functional analysis of the conserved calmodulin binding sites

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Cell Research 2006年第4期16卷 337-346页

作者： YukutoYasuhiko KoichiroShiokawa Toshio Mochizuki Makoto Asashima takahiko yokoyama Department of Biological Sciences Graduate School of ScienceUniversity of Tokyo7-3-1 HongoBunkyo-kuToyo113-0033Japan Department of Medicine Kidney CenterTokyo Women's Medical UniversitySchool of MedicineJapan Department of Life Science University of Tokyo3-8-1 Komaba.Meguro-kuTokyo 158-8902.Japan Department of Anatomy and Developmental Biology Tokyo Women's Medical College8-1 Kawada-choShinjuku-kuTokyo 162-8666Japan

The homozygous inv(inversion of embryonic turning)mouse mutant shows situs inversus and polycystic kidney disease,both of which result from the lack of the inv ***,we suggested that inv may be important for the ieft-rightaxis formation,not only in mice but also in Xenopus,and that calmodulin regulates this inv protein ***,weisolated and characterized two Xenopus laevis homologs(Xinv-1 and Xinv-2)of the mouse inv gene,and performedfunctional analysis of the conserved IQ motifs that interact with ***-1 expresses early in development in thesame manner as mouse inv ***,a full-length Xenopus inv mRNA did not randomize cardiac orientationwhen injected into Xenopus embryos,which is different from mouse inv *** to mouse inv mRNA,Xenopusinv mRNA with mutated IQ randomized cardiac *** present study indicates that calmodulin binding sites(IQ motifs)are crucial in controlling the biological activity of both mouse and Xenopus inv *** mouseand Xenopus inv genes have a quite similar structure,the interaction with calmodulin and IQ motifs ofXenopus inv andmouse inv proteins may regulate their function in different ways.

关键词： Left-right asymmetry inv calmodulin ankyrin IQ motif Xenopus calcium

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发电不确定性条件下电动汽车对智能家居能量管理的贡献(英文)

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电力系统自动化 2011年第22期35卷 18-24页

作者： Ryuichi yokoyama Kouichirou YOSHIMI takahiko MASUDA Haruhiko KONDOU 早稻田大学日产自动车株式会社

光伏、风电等可再生能源的大规模接入给电力系统的运行带来了诸多问题,如由发电过剩引起的电网反向潮流、电网频率和节点电压调节容量的不足。作为解决可再生能源出力波动性引起的不确定性问题的方法之一,采用电动汽车作为储能装置,即... 详细信息

光伏、风电等可再生能源的大规模接入给电力系统的运行带来了诸多问题,如由发电过剩引起的电网反向潮流、电网频率和节点电压调节容量的不足。作为解决可再生能源出力波动性引起的不确定性问题的方法之一,采用电动汽车作为储能装置,即所谓的V2H(vehicle to house)或者V2G(vehicle to grid),将发挥重要作用,因此有必要建立电动汽车应用评估方法。以配有光伏发电装置和一辆电动汽车的某智能家居为例,定量评估了电动汽车电池充放电对光伏发电输出功率的家庭内部使用比例、家庭用电成本和CO2排放量的影响。分析结果表明,通过光伏发电装置和电功汽车电池的有效配合使用,可以减少反向潮流和CO2排放。最后,通过仿真分析论证了多辆电动汽车对含有多栋智能家居的智能化小区能量管理的贡献。

关键词：光伏发电电动汽车 V2H 可再生能源智能家居

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Skin Hydrating Effects of <i>Corchorus olitorius</i>Extract in a Mouse Model of Atopic Dermatitis

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第1期4卷 1-6页

作者： Satoshi yokoyama Keiichi Hiramoto takahiko Fujikawa Hiroya Kondo Nobuyuki Konishi Shu Sudo Makoto Iwashima Kazuya Ooi Faculty of Pharmaceutical Sciences Suzuka University of Medical Science Mie Japan Fundamental Research Division Research and Development Department Mikimoto Pharmaceutical & Co. Ltd. Mie Japan Mie Prefecture Agricultural Research Institute Mie Japan

Background: Corchorus olitorius leaf contains a significant amount of mucilaginous polysaccharide. It has been generally accepted that the polysaccharides derived from botanical extracts increase skin hydration. Since skin hydration improves skin barrier function, it is one of the most effective treatments for atopic dermatitis (AD). However, other components of botanical extracts other than polysaccharides may influence skin hydration and transepidermal water loss (TEWL). The aim of this study was to evaluate the hydration efficacy and skin barrier protection afforded to the skin after exposure to Corchorus olitorius extract without high-molecular-weight compounds (COEW), such as polysaccharides. Methods: NC/Nga mice possess disrupted skin barrier function, and were used as a model for AD. A stable base cream was supplemented with 0.2% COEW and applied to the dorsal skin of these mice. Skin hydration and TEWL were analyzed after a 14-d period of daily application. AD scores and plasma immunoglobulin E (IgE) concentrations were also investigated. Results: Compared to control mice, mice treated with the COEW cream showed significantly increased skin hydration and reduced TEWL. Plasma IgE concentrations were not affected by the COEW cream, whereas an increase in AD score in NC/Nga mice was prevented because of the application of the COEW cream. Conclusions: COEW has the ability to maintain hydration of the skin, and to prevent the disruption of skin barrier function, which leads to the aggravation of AD. COEW may be used as an adjunct treatment for AD.

关键词： Corchorus olitorius Atopic Dermatitis Skin Hydration Transepidermal Water Loss

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