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Br-radical-mediated [3+2] annulation: synthesis of 2-bromomethylsubstituted alkenylcyclopentanes by the reaction of alkenylcyclopropanes with allyl bromides under photo irradiation

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Science China Chemistry 2019年第11期62卷 1525-1528页

作者： takahide Fukuyama Takashi Kippo Kanako Hamaoka Ilhyong Ryu Department of Chemistry Graduate School of Science Osaka Prefecture University

A radical chain addition of allyl bromides 2 to alkenylcyclopropanes 1 resulted in[3+2]annulation to give 2-bromomethylalkenylcyclopentanes 3 in good yields(16 examples).In this reaction,two kinetically fast radical reactions,cyclopropylcarbinyl radical-ring-opening and 5-exo-radical cyclization,preceded theβ-fragmentation of a bromine radical to make the formal cycloaddition possible.

关键词： [3+2]annulation bromine radical alkenylcyclopropanes alkenylcyclopentanes photo irradiation

One-Stage Bilateral Total Hip Arthroplasty for Hemophilic Spontaneous Ankylotic Hip: A Case Report

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Case Reports in Clinical Medicine 2020年第9期9卷 269-274页

作者： Mariko Asahi Atsushi Kusaba Akihiko maeda Saiji Kondo takahide Tsuchiya Institute of Joint Replacement and Rheumatology Ebina General Hospital Kawaraguchi Ebina Kanagawa Japan Department of Orthopaedic Surgery Showa University Fujigaoka Hospital Fujigaoka Aoba-ku Yokohama Japan Department of Hematology Ebina General Hospital Kawaraguchi Ebina Kanagawa Japan

Total hip arthroplastys (THAs) for hemophilic spontaneous ankylotic hips are rare. We performed one-stage bilateral THA for hemophilic patient and I would like to report the results of the case. A 61-year-old male had been diagnosed with mild hemophilia A as a neonate. He had severe pain in both hips and moderate pain in both knees. His hips were ankylotic and had no mobility. Uncemented simultaneous bilateral THAs were performed under general anesthesia. This case suggests that one-stage THA can be a good option for hemophilic hips, provided that sufficient substitution therapy is used.

关键词： Hemophilic Arthropathy One-Stage Bilateral THA Complication

Coronary Artery Bypass Grafting with Complete Revascularization Can Provide Equivalent Long-Term Prevention of Ischemic Cardiac Events in Patients on and Not on Hemodialysis: A Graft-Matched and Baseline-Adjusted Analysis

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Surgical Science 2018年第10期9卷 367-380页

作者： Hajime Imura Makoto Shirakawa Motohiro maeda Kenichiro Takahashi takahide Yosio Yuji Maruyama Takashi Nitta Department of Cardiovascular Surgery Nippon Medical School Musashikosugi Hospital Kanagawa Japan Nippon Medical School Hospital Kawasaki Japan

Background: Patients on hemodialysis are at high risk of adverse cardiac events after coronary artery bypass grafting (CABG). The aim of this study is to know whether CABG with complete revascularization and similar graft selection can provide equivalent long-term benefits for patients on and not on hemodialysis. Methods: Between 2004 and 2018, 746 patients underwent isolated CABG, of which 106 were on hemodialysis. Propensity matching on baseline characteristics, graft types and on/off-pump CABG was performed to compare clinical outcomes between patients on (n = 102) and not on (n = 102) hemodialysis. Results: Complete revascularization was achieved in all patients. The mean follow-up was 112.5 ± 46.6 months. Off-pump rates (hemodialysis vs non-hemodialysis, 93/102 vs 94/102, p > 0.999) and graft selections (distal anastomoses: 3.7 ± 1.4 vs 3.8 ± 1.5, p = 0.377, ITA grafts: 1.4 ± 0.6 vs 1.5 ± 0.6, p = 0.560, arterial grafts: 1.9 ± 0.9 vs 2.0 ± 0.8, p = 0.658, vein grafts: 0.69 ± 0.63 vs 0.65 ± 0.70, p = 0.513) were well balanced between the groups. Hospital mortality was higher in patients on hemodialysis than in those not on hemodialysis (5/102 vs 1/102, p = 0.212). The Kaplan-Meier analysis revealed that cardiac death (without non-cardiac causes) was significantly more common in patients on hemodialysis than in those not on hemodialysis (p = 0.018). However, there were no significant differences in deaths due to ischemic heart disease (p = 0.327), repeated revascularization (p = 0.542), myocardial infarction (p = 0.783), and heart failure requiring admission (p = 0.371). Conclusion: CABG with complete revascularization and similar graft selection provides equivalent long-term benefits with regard to the prevention of adverse cardiac events due to ischemic heart disease in patients on and not on hemodialysis.

关键词： Coronary Artery Bypass Grafting Hemodialysis Complete Revasculariza-tion Gastroepiploic Artery

Evaluation of sorafenib for hepatocellular carcinoma by contrast-enhanced ultrasonography:A pilot study

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World Journal of Gastroenterology 2012年第40期18卷 5753-5758页

作者： Kazue Shiozawa Manabu Watanabe Yoshinori Kikuchi takahide Kudo Kenichi Maruyama Yasukiyo Sumino Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Medical CenterOmori HospitalTokyo 143-8541Japan Department of Clinical Functional Physiology Toho University Medical CenterOmori HospitalTokyo 143-8541Japan

AIM:To determine the usefulness of arrival time parametric imaging(AtPI) using contrast-enhanced ultrasonography(CEUS) with Sonazoid in evaluating early response to sorafenib for hepatocellular carcinoma(HCC).METHODS:Fourteen advanced HCC patients who received sorafenib 400/800 mg/d for at least 4 wk and were followed up by CEUS were enrolled in this *** was performed before treatment and 2 and 4 wk after treatment,and images of the target lesion in the arterial phase were recorded for each *** images were analyzed by *** mapping(CM) images obtained by AtPI were compared before and after the *** these CM images,the mean arrival time of the contrast agent in the region of interest from the starting point [mean time(MT)] was *** each patient,differences between MT before and MT 2 and 4 wk after the treatment were compared with responses evaluated 4-8 wk after the treatment by dynamic computed tomography(CT),and statistical analysis was *** response evaluation criteria in solid tumors was used for the response ***:In CM images both 2 and 4 wk after the treatment,delays in the arrival time of the contrast agent were noted in 8 of the 14 *** the other 6 patients,no color changes were observed in the tumor,or red and/or yellow increase,suggesting a decrease in blood flow velocity between images 2 and 4 wk after the treatment and those before the *** CT could be performed 4-8 wk after the treatment in 13 of the 14 *** differences in the MT were 1.13 s and 1.015 s,2 and 4 wk after the treatment,respectively,in the 8 patients who showed stable disease(SD)/partial response(PR) on dynamic *** differences in the MT were-0.39 s and-0.95 s,2 and 4 wk after the treatment,respectively,in the 5 patients who showed progressive disease(PD).Differences in the median MT between SD/PR and PD groups were significant 2 and 4 wk after the treatment with P = 0.019 and P = 0.028,resp

关键词： Sorafenib Sonazoid Contrast-enhanced ul-trasonography Hepatocellular carcinoma Therapeutic response

Recent Advances in Evaluation of Iron Ore for the Sintering Process

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Recent Advances in Evaluation of Iron Ore for the Sintering ...

Isolation of lymphocytes from the human gastric mucosa

第十届中国钢铁年会暨第六届宝钢学术年会

作者： Lu Liming Higuchi takahide CSIRO Mineral Resources Steel Research Laboratory JFE Steel Corporation 1 Kokan-cho

With the rapid change in iron ore supplies and composition, steel mills now have to adjust the composition of the ore mixture to the sinter plant more frequently than ever before. Hence, different scales of test methods have been developed to help sinter plants evaluate new ore types and ore blends in order to optimise their ore mixtures. The reactions in the combustion-melting zone of a sintering bed have a great effect not only on the structural formation of sinter cake but also the permeability of the sintering bed. Understanding of the sintering reactions occurring in this zone is therefore particularly important to improve coke combustion and control melting. Progress has been recently made to carry out in-situ studies of sintering reactions. This paper provides an overview of various techniques which have been developed recently in order to evaluate iron ore and improve the understanding of the iron ore sintering process.

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World Journal of Methodology 2021年第4期11卷 199-207页

作者： Masaya Iwamuro takahide Takahashi Natsuki Watanabe Hiroyuki Okada Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Division of Medical Support Okayama University HospitalOkayama 700-8558Japan

Flow cytometry is widely used for lymphocyte immunophenotyping in clinical ***,few studies have applied it for analyzing lymphocytes of the gastric *** review offers an overview of methodologies for isolating lymphocytes from the human *** reported articles were reviewed,focusing on procedures for isolating human gastric mucosal *** pylori-associated peptic diseases and gastric cancer are two major subjects of research in this *** dissociation,mechanical dissociation,or a combination of the two have been used to isolate lymphocytes from the ***-epithelial and lamina propria lymphocytes were separately isolated in several *** also summarize the history and present trends in analyzing lymphocytes in patients with gastric disease.

关键词： Gastrointestinal biopsies Gastrointestinal endoscopy Gastric cancers Helicobacter pylori Gastric ulcer Flow cytometry

Intralymphatic Histiocytosis with Rheumatoid Arthritis: Possible Association with the Joint Involvement

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Case Reports in Clinical Medicine 2014年第3期3卷 149-152页

作者： takahide Kaneko Sonoko Takeuchi Hajime Nakano Daisuke Sawamura Department of Dermatology Hirosaki Univer-sity Graduate School of Medicine Hirosaki Japan

Intralymphatic histiocytosis is characterized by dilated vessels containing aggregates of mononuclear histiocytes in their lumina, and the majority of cases have been associated with rheumatoid arthritis (RA). We report a case of a 61-year-old woman with RA who presented with livedo-like erythema and red papules around the right elbow and forearm. Histological examinations demonstrated numerous dilated vessels in the dermis partially filled with medium- to large-sized mononuclear cells. Immunohistochemically, most of the intraluminal cells were CD68-positive histiocytes. Endothelial cells were positive for D2-40, a marker for lymphatic endothelial cells. We diagnosed the patient with intralymphatic histiocytosis based on these clinical and histological findings. Interestingly, the skin manifestations exacerbated during the course of the disease when the swelling of the patient’s right elbow joint progressed. Then, the puncture of content fluid of the joint was performed, since then, the symptoms of the skin lesion immediately improved. These observations suggest a possible association between the eruptions of intralymphatic histiocytosis and the involved joint. The results suggest that such skin eruptions may be ameliorated by treating severe arthritis.

关键词： Lymphedema Synovitis Aspiration

Acetabular Reconstruction with Massive Allograft Shaped to the Cavity and Kerboull-Type Acetabular Reinforcement Device for Multiple Failures of Impaction Bone Graft: A Case Report

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Open Journal of Orthopedics 2017年第1期7卷 14-20页

作者： Takaya Taniguchi Mayumi Sonekatsu Wataru Taniguchi Erabu Miyamoto takahide Sasaki Munehito Yoshida Department of Orthopaedic Surgery Wakayama Medical University Wakayama Japan

Acetabular component revision in the presence of severe bone loss is difficult for reconstructing an acetabular component in the anatomical hip center. Various treatment options are available, although often the acetabular defect cannot be corrected with a single option alone. Precise assessment of the bone loss and a suitable combination of methods are needed. Here we report a case of multiple failures with impaction bone grafting reconstruction for an acetabular bone defect of American Academy of Orthopedic Surgeons classification type III. We finally reconstructed the acetabulum with three femoral head allografts and a Kerboull-type acetabular reinforcement device. The allograft was a casted, jet-type helmet-like shape. A year later the patient was able to walk without a cane and perform light agricultural work. Accurate evaluation of the acetabular bone loss and appropriate reconstruction is important.

关键词： Acetabular Reconstruction Bone Defect Allograft KT Plate Impaction Bone Graft

Application of Radiation Chemistry to the Construction of Functional Organic Materials

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Application of Radiation Chemistry to the Construction of Fu...