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Basal Cell Carcinoma Arising from a Follicular Hybrid Cyst

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Case Reports in Clinical Medicine 2015年第9期4卷 317-320页

作者： Takayuki Aizu takahide kaneko Noriko Takiyoshi Satoko Minakawa Ayumi Korekawa Hajime Nakano Daisuke Sawamura Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan

Malignant tumors arising from follicular cysts are rare. Herein, we report of a 62-year-old Japanese woman with a slowly growing tumor, 22 × 20 mm in size, located on her nose for 2 years. Histopathological examination of the surgically excised tumor showed that the tumor cells were basaloid and formed peripheral palisading patterns. The tumor contained a cystic structure in its center, and the cyst wall was lined with stratified epithelium with or without keratohyalin granules. Based on these findings, a diagnosis of basal cell carcinoma arising from a follicular hybrid cyst was made. To our knowledge, this is the first case of basal cell carcinoma originating from a follicular hybrid cyst. A review of previous reports of basal cell carcinoma from a follicular cyst indicated that the majority of previous cysts were located on the face, and that the lesions had been present for a relatively long time. The present case showed typical clinical findings and followed a regular course. Malignant transformation may be a rare event, but it can occur in a follicular cyst, so cysts and suspected cysts, especially those found on the face and those persisting for relatively long time, should always be subjected to histological examination.

关键词： Epidermoid Cysts Trichilemmal Cyst Malignant Transformation

Spindle Cell Hemangioma and Decorin Expression

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第1期2卷 8-10页

作者： Daiki Rokunohe Hitoshi Takeda takahide kaneko Takayuki Aizu Eijiro Akasaka Yasushi Matsuzaki Hajime Nakano Daisuke Sawamura Department of Dermatology Graduate School of Medicine Hirosaki University Hirosaki Japan.

Spindle cell hemangioma (SCH) is a rare benign vascular tumor and we report 2 cases of SCH who are 50-year-old man and 16-year-old girl. A growing amount of evidence indicates that multifunctional ECM molecule decorin regulate endothelial cell-matrix interactions during angiogenesis. Furthermore, a current publication shows that no detectable decorin expression was found in the stromas of tumor nests in Kaposi’s sarcoma or angiosarcoma groups while the expression was clearly observed in the connective tissue stromas within benign vascular tumors. SCH exhibits spindle cell proliferation and resembles Kaposi’s sarcoma. Therefore, this study examined decorin expression in the tissues of our SCH cases by immunohistochemical analysis. The results demonstrated that immunoreactivity of decorin was clearly detectable in the connective tissue stroma within tumor nests. SCH was first perceived as sarcoma because of spindle cell proliferation, but this proliferation was subsequently found to be reactive. The presence of decorin expression in our cases also indicates that SCH have benign properties. Moreover, this study further increases the reliability of examination of decorin expression for differentiation between benign and malignant vascular tumors.

关键词： Proteoglycan Skin Endothelium Malignant Matrix

Effect of cytokines and ultraviolet B radiation on the promoter activity of the metallothionein gene in keratinocytes

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Advances in Bioscience and Biotechnology 2013年第9期4卷 896-899页

作者： Hiromi Narumi Hajime Nakano takahide kaneko Koji Nakajima Yasushi Matsuzaki Takayuki Aizu Daisuke Sawamura Katsumi Hanada Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan

Metallothionein (MT) has many functions that are modulated by several factors, including ultraviolet (UV) radiation and cytokines. We thought that these diverse functions of MT might reflect the specific regulatory mechanisms of its expression. To understand some of the molecular mechanisms underlying MT expression, we examined the effects of several cytokines and UVB on the promoter activity of the MT gene. First, we introduced the MT promoter construct into the HaCaT keratinocytes and treated them with various concentrations of interleukin-1α (IL-1α) and IL-6. The addition of IL-1α and IL-6 led to an increase in the promoter activity of the MT gene. UVB is known to induce MT expression in epidermal keratinocytes, and IL-6 is a possible mediator of MT induction by UV radiation. Therefore, we investigated whether UVB could induce MT promoter activity. Our results showed, interestingly, that UVB radiation has no or little effect on the promoter activity. This suggested a complex molecular regulation of the MT gene.

关键词： Sunburn Cytokine Epidermis Ultraviolet Light Promoter

A Case of Erythema Nodosum Associated with Subareolar Abscess

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第4期2卷 263-264页

作者： Satoko Minakawa Yasushi Matsuzaki Daiki Rokunoke Eijiro Akasaka Koji Nakajima Takayuki Aizu takahide kaneko Hajime Nakano Kazutoshi Takashima Daisuke Sawamura Departments of Dermatology Hirosaki University Graduate School of Medicine Departments of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan Departments of Surgery Hiro- saki University Graduate School of Medicine Hirosaki Japan

While erythema nodosum is a nodular, erythematous eruption predominantly affecting the extensor aspects of the legs, breast abscesses are the result of relatively common bacterial infections, and only 2 studies have reported an association between erythema nodosum and breast abscesses. Here, we report the case of a patient with repeated erythema nodosum associated with subareolar abscesses. The patient was a 34-year-old woman with painful erythematous nodules on her right shin, accompanied by an indurated lesion on her right breast 4 days before the onset of the nodules. Therefore, the patient underwent circumareolar incision, and consequently the painful erythematous nodules disappeared. However, after 39 days, the patient developed another tender, painful lesion in her right breast and painful erythematous nodules on her right shin. After another circumareolar incision, the painful erythematous nodules disappeared again. Therefore, we suggested a significant association between erythema nodosum and breast abscess in this patient. The most common underlying causative organism in breast abscess is Staphylococcus aureus;however, erythema nodosum has rarely been proven to be associated with staphylococcal infections. Therefore, the relationship between S. aureus and erythema nodosum is rather controversial. However, the resistance to the usual treatment methods and prolonged clinical course in our case suggest that the pathogenesis of erythema nodosum associated with breast abscesses might be different from that of the common form of erythema nodosum.

关键词： Erythema Nodosum Subareolar Abscess Breast Staphylococcal Infections

Amplification of Papillomavirus Oncogene Transcripts Assay for Bowenoid Papulosis

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International Journal of Clinical Medicine 2013年第10期4卷 428-431页

作者： takahide kaneko Gen Nakahishi Koji Nakajima Takayuki Aizu Kayo Jin Daiki Rokunohe Yasushi Matsuzaki Nakano Hajime Toshihiro Tanaka Daisuke Sawamura Department of Dermatology Shiga University of Medical Science Otsu Japan Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan Department of Dermatology Shiga University of Medical Science Otsu Japan.

Human papillomavirus (HPV) is an important causative agent of cervical carcinoma and some malignant cutaneous tumors. The integration of HPV DNA into the host genome is one of the most important risk factors for malignant transformation. Here, we report the case of a 53-year-old man with multiple, black-brown genital macules and nodules. Histological findings resembled those for Bowen’s disease, and we made a diagnosis of bowenoid papulosis. This condition is generally benign, but invasive squamous cell carcinoma (SCC) arising from bowenoid papulosis has been previously reported. Therefore, we took biopsy specimens from 10 lesions and tested them for the presence of HPV DNA. DNA sequencing identified HPV type 16 (HPV-16) DNA in all samples. Next, we excised 4 different relatively large lesions and performed an amplification of papillomavirus oncogene transcripts (APOT) assay. This assay showed that all samples had only episome-derived viral transcripts, indicating no integration of HPV DNA into the host genome. We have followed this case for 3 years, and no progression to Bowen’s disease or SCC has so far been observed. We conclude that the APOT assay is a feasible method for evaluating the malignant potential of bowenoid papulosis.

关键词： HPV 16 Integration Malignant Transformation

Assessment of a Case of Immediate-Type Allergy against Human Insulin in a Type 2 Diabetic Patient and Allergic Reactions to Human Insulin in Japan

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Case Reports in Clinical Medicine 2014年第8期3卷 496-499页

作者： Satoko Minakawa takahide kaneko Tomohisa Fukui Yusuke Sakuraba Takayuki Aizu Ayumi Korekawa Noriko Takiyoshi Akiko Rokunohe Takako Moriyama Daisuke Sawamura Department of Dermatology Graduate School of Medicine Hirosaki University Hirosaki Japan Endocrinology and Metabolism Graduate School of Medicine Hirosaki University Hirosaki Japan

We report a 64-year-old female patient with an insulin allergy. She was treated with a combination of oral antihistamines, topical hydrocortisone cream, and moisturizing agents, which resulted in the improvement of eczema and intense pruritus. To evaluate insulin allergy, intradermal skin tests were performed with several insulin agents for clinical use and 0.9% NaCl. Skin testing with semisynthetic human insulin resulted in local, immediate skin reactions such as itchy erythema and wheals. Furthermore, we analyzed our case and 25 Japanese cases of insulin allergy previously reported in the literature as far as we know. Interestingly, the number of male patients was approximately two times higher than that of female, and the insulin-specific IgE antibody test was positive in 21 patients. We should keep the possibility of human insulin allergy in mind and prepare for it when initiating human insulin therapy.

关键词： Immediate-Type Allergy IgE Intradermal Skin Tests Human Insulin Human Insulin Analog