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Putting the treatment of paediatric schistosomiasis into context

Infectious Diseases of Poverty 2017年第1期6卷 748-753页

作者： takafira mduluza Francisca Mutapi Biochemistry Department University of ZimbabweP.O.Box MP167Mount PleasantHarareZimbabwe School of Laboratory Medicine and Medical Sciences College of Health SciencesUniversity of KwaZulu NatalDurbanSouth Africa Institute of Immunology&Infection Research University of EdinburghAshworth LaboratoriesKing’s BuildingsCharlotte Auerbach RoadEdinburgh EH93FLUK

Despite increased international efforts to control schistosomiasis using preventive chemotherapy,several challenges still exist in reaching the target *** recently,preschool-aged children had been excluded from the recommended target population for mass drug administration,*** school children aged 6-15 *** studies and those of others provided the evidence base for the need to treat preschool-aged children that led to recommendations by the World Health Organization to include preschool-aged children in treatment programmes in *** major challenge now lies in the unavailability of a child-size formulation of the appropriate anthelmintic drug,*** currently available formulation of praziquantel presents several ***,it is a large tablet,making it difficult for young children and infants to swallow it and thus requires its breaking/crushing to allow for safe ***,it is bitter so it is often mixed with a sweetener to make it palatable for young ***,the current formulation of 600 mg does not allow for flexible dose adjustments for this age ***,there is a need to formulate a child-appropriate praziquantel *** paper discusses the target product profile for paediatric praziquantel,as well as knowledge gaps pertinent to the successful control of schistosome infection and disease in preschool-aged children.

关键词： Paediatric schistosomiasis Praziquantel Child-size medicine Target product profile Drug pipeline

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