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Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy

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World Journal of Gastroenterology 2017年第2期23卷 328-335页

作者： Yoriaki Komeda Hiroshi Kashida Toshiharu Sakurai George Tribonias Kazuki Okamoto Masashi Kono Mitsunari Yamada Teppei Adachi Hiromasa Mine Tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui Tomohiro Watanabe Masayuki Kitano takaaki Chikugo Yasutaka Chiba Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Department of Pathology Kindai University Faculty of Medicine Clinical Research Center Kindai University Hospital

AIMTo compare the efficacy and safety of cold snare polypectomy (CSP) and hot forceps biopsy (HFB) for diminutive colorectal *** prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. The primary outcome measures were en-bloc resection (endoscopic evaluation) and complete resection rates (pathological evaluation). The secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn’t routinely *** hundred eight patients were randomized into the CSP (102), HFB (106) and 283 polyps were evaluated (CSP: 148, HFB: 135). The en-bloc resection rate was significantly higher with CSP than with HFB [99.3% (147/148) vs 80.0% (108/135), P < 0.0001]. The complete resection rate was significantly higher with CSP than with HFB [80.4% (119/148) vs 47.4% (64/135), P < 0.0001]. The immediate bleeding rate was similar between the groups [8.6% (13/148) vs 8.1% (11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. The rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6% (71/135) vs 1.3% (2/148), P < 0.0001]. Polyp retrieval failure was encountered CSP (7), HFB (2).CONCLUSIONCSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required.

关键词： Cold snare polypectomy Colonoscopy Polypectomy Colorectal diminutive polyps Hot forceps biopsy

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A Fundamental Study on Multi-agent Pedestrian Model Based on Risk Avoidance Behavior during Road Blockage and Evacuation Simulation of Regional Urban Disaster

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Journal of Civil Engineering and Architecture 2019年第4期13卷 219-237页

作者： Hideaki Takayanagi Tatsuto Kihara Yosuke Kurita Kazuhide Kawaguchi Hidetoshi Kawaguchi takaaki Furukawa Takuhi Ono Shogo Yamada Department of Urban Life Studies Tokyo City UniversityTokyo 158-8586Japan General Design Planning KIHARA Tokyo157-0067Japan Chuo Fukken Consultants co. LTD.Osaka533-0033Japan The Graduate of Environmental and Information Tokyo202-0006Japan

Regional cities in Japan are at the risk of experiencing big fire accidents or earthquakes every ***,neither the number nor the capacity of shelters has increased because local governments might not consider them owing to budget *** contrast,wide-area evacuation simulations can easily provide an antagonizing image of regional urban *** a disaster,the city collapses and the evacuation routes are closed;consequently,evacuees feel anxious and they cannot move as *** anxiety behavior has not been considered in previous related studies and *** this study,a wide-area evacuation simulation is developed;this model can not only calculate the possibility of blocking escape routes when the city is broken but also provide safe and more realistic evacuation plans before a disaster occurs by incorporating into the simulation the risk avoidance behaviors of evacuees from road blockage,such as“the route re-seeking behavior”and“the shelter re-selecting behavior”.

关键词： Wide-area evacuation simulation multi-agent model risk avoidance behavior regional disaster prevention plan

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土壤平衡或非平衡吸附特性评价方法的研究

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2017年

主讲人： takaaki Inamo

近年来，环境污染和生态破坏严重影响到人类的健康和生存，其中重金属元素对环境污染的作用是不可忽视的。了解重金属在土壤中的迁移转化规律及其在土壤中的浓度、活性、生物有效性和毒性，是环境科学研究的一个活跃领域，为确定土壤环...

近年来，环境污染和生态破坏严重影响到人类的健康和生存，其中重金属元素对环境污染的作用是不可忽视的。了解重金属在土壤中的迁移转化规律及其在土壤中的浓度、活性、生物有效性和毒性，是环境科学研究的一个活跃领域，为确定土壤环境容量和治理土壤重金属污染提供了理论依据。

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海滨房屋日本神奈川

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世界建筑导报 2019年第5期34卷 10-13页

作者： Toshiyuki Yano takaaki Murakami Shinichi Ogawa & Associates

这套两层房屋坐落于一个美丽的地方,在这里,您可以俯瞰从Shichirigahama海岸奔而出的壮丽的太平洋海浪。该地位于江之岛电铁线和134国道上方的住宅区。房屋北面的正面是一面简约的白墙,没有与周围环境相通的开放型设计,仅种植了一颗棕... 详细信息

这套两层房屋坐落于一个美丽的地方,在这里,您可以俯瞰从Shichirigahama海岸奔而出的壮丽的太平洋海浪。该地位于江之岛电铁线和134国道上方的住宅区。房屋北面的正面是一面简约的白墙,没有与周围环境相通的开放型设计,仅种植了一颗棕榈树。南面露台采用外悬的白色装饰,通过露台,可俯瞰美丽的太平洋。

关键词：房屋海滨周围环境太平洋住宅区开放型棕榈树露台

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Difference in incidence of developing hepatocellular carcinoma between hepatitis B virus-and hepatitis C virus-infected patients

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World Journal of Meta-Analysis 2022年第3期10卷 186-194页

作者： Kazuo Tarao Akito Nozaki Hirokazu Komatsu Naomi Ideno Tatsuji Komatsu takaaki Ikeda Masataka Taguri Shin Maeda Department of Gastroenterology Tarao's Gastroenterological ClinicYokohama City 241-0821Japan Gastroenterological Center Yokohama City University Medical CenterYokohama City 232-0024Japan Department of Gastroenterology Yokohama Municipal Citizen’s HospitalYokohama City 2211-0855Japan Department of Clinical Research National Hospital OrganizationYokohama Medical CenterYokohama City 2458575Japan Department of Gastroenterology Yokosuka General Hospital UwamachiYokosuka City 238-8567Japan Department of Data Science Yokohama City UniversityYokohamaYokohama City 236-0004Japan Department of Gastroenterology Yokohama City University Graduate School of MedicineYokohama City 236-0004Japan

BACKGROUND It is generally accepted that the incidence of hepatocellular carcinoma(HCC)in hepatitis C virus(HCV)-associated patients is higher than that in hepatitis B virus(HBV)-associated *** reason why this difference in the incidence of HCC occurs in patients with HBV and HCV infections remains *** report the possibility that the contributing power of inflammation,which is the main risk factor for developing HCC,may be different with HBV and HCV *** To investigate this,we surveyed the hazard ratio of inflammation for HCC development which was identified by serum alanine aminotransferase(ALT)levels between patients with HBV and HCV *** The PubMed database was searched(2001-2021)for studies published in English regarding the incidence of HCC identifying 8924 HBV-and 7376 HCV-infected *** these studies,interferon-treated patients with both HBV and HCV infections were ***,in HBV patients,those administered nucleos(t)ide analogues were excluded,and in HCV patients,those administered direct acting antivirals were also *** citing hazard ratios of HCC regarding inflammation(serum elevated alanine aminotransferase levels)were ***,there were 14 studies of HBV-infected patients and 8 studies of HCV-infected *** calculated the hazard ratio in patients in an inflammatory state(serum ALT levels were above the normal range).RESULTS In the 14 studies of HBV patients,the average hazard ratio(HR)of elevated ALT for developing HCC was 2.74[1.98-3.77]and that in the 8 studies of HCV-infected patients was 5.51[3.08-9.83].The HR of inflammation for HCC development in HCV-associated liver diseases is about twice that in HBV-associated liver *** in HCV-infected patients was significantly(P=0.0391)higher than that in HBV-infected *** hepatitis B patients,the abnormal range adopted was 28-45 IU/L,and in hepatitis C patients,it was 20-50 IU/*** was demonstrated that the

关键词： Hazard ratio of alanine aminotransferase Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Elevated alanine aminotransferase

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Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

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Open Journal of Ophthalmology 2014年第3期4卷 79-85页

作者： Yuji Kumano Yumi Soejima Shinichiro Numa Hiroyasu Matsui Ikuko Zushi Masahito Shigematsu takaaki Matsui Teruo Nishida Department of Oral and Maxillofacial Surgery Saga University Saga Japan Ohshima Hospital of Ophthalmology Fukuoka Japan Zushi Eye Clinic Fukuoka Japan

Purpose: Additional analyses of outcomes of laser-assisted subepithelial keratectomy (LASEK) are still necessary to improve the safety of LASEK. Therefore, in our study, outcomes were assessed retrospectively in 561 eyes that underwent LASEK treatment. Methods: Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA) and residual spherical equivalent were analyzed at 3 and 6 months postoperatively. We assessed four subgroups based on the degree of preoperative myopia considering mean BSCVA and loss of two or more lines. Results: Mean UCVAs and BSCVAs were obtained at 3 and 6 months postoperatively (1.23/1.35 and 1.23/1.37, respectively). The mean predictability was within ±0.125 diopters. Conversely, the safety indexes were 0.94 and 0.96 respectively, and the efficacy indexes were 0.86 and 0.86 at 3 and 6 months postoperatively, respectively. 8.4% eyes and 5.2% eyes lost two or more lines of BSCVA at 3 and 6 months postoperatively, respectively. The mean BSCVAs of the high or ultra-high groups were significantly lower than those of the low or mild groups both 3 months and 6 months postoperatively. The incidence rates of losing two or more lines of BSCVA in the high or ultra-high myopia groups were significantly greater than in the low or mild groups at 3 months and 6 months postoperatively. Conclusion: LASEK predictably corrected myopia achieving >1.2 in UCVA and BSCVA. However, the safety and efficacy indexes were <1.0, which were related to the loss of two or more lines of BSCVA. Since the incidence rates of losing two or more lines of BSCVA were greater in the high or ultra-high myopia groups, we consider LASEK as more safely performed in patients with low to mild preoperative myopia.

关键词： BSCVA LASEK Loss of Two or More Lines Preoperative Myopia Re-Evaluation

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Effect of Dai-Saiko-To (Da-Chai-Hu-Tang) on LDL-Receptor Gene Expression in Human Hepatoma Cell Line (HepG2)

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American Journal of Plant Sciences 2013年第2期4卷 454-459页

作者： Akira Iizuka Fumihiko Yoshie Sakae Amagaya takaaki Yasuda Maki Iizuka Haruyo Yamaguchi Seiji Nagumo Kazuo Kondo Clinical Pharmacy Education Center for Integrative Medicine Department of Kampo Pharmacological Sciences Department of Medicinal Chemistry Nihon Pharmaceutical University Saitama Japan Department of Medicinal Plant Science Hoshi University Ebara Tokyo Japan Institute of Environmental Science for Human Life Ochanomizu University Tokyo Japan

We previously reported that Dai-saiko-to (Da-Chai-Hu-Tang), a traditional Japanese kampo medicine, increased LDL receptor mRNA expression in the liver of the hypercholesterolemic rabbits. In this study, we focused on LDL receptor gene expression in a human hepatoma cell line (HepG2) treated with Dai-saiko-to extract and the extracts of eight herbs presented in Dai-saiko-to. Dai-saiko-to extract significantly increased LDL receptor gene and SREBP2 gene expression compared with the control. The extracts of four herbs, Bupleurum root, Pinellia tuber, Scutellaria root and Peony root significantly increased the LDL receptor gene expression. Whereas, Jujube, Immature orange, Ginger and Rhubarb extracts did not change the gene expression. These results suggest that Dai-saiko-to increased the expression of the cholesterol transport gene (LDL receptor) regulated by SREBP2 gene in the human hepatoma cell line. The pharmacological activity of Dai-saiko-to against hypercholesterolemia and atheromatous lesions related for these four herbal components.

关键词： Kampo Dai-Saiko-To LDL Receptor Gene Expression HepG2

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Sarcomatoid malignant pleural mesothelioma confirmed by full-thickness biopsy specimen using insulated-tip diathermic knife while only atypical cells by thoracoscopic conventional biopsy:brief report and literature review

Sarcomatoid malignant pleural mesothelioma confirmed by full...

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Chaosheng Deng Shinji Sasada Takehiro Izumo Yukiko Nakamura Koji Tsuta takaaki Tsuchida First Affiliated Hospital of Fujian Medical University National Cancer Center

Introduction:Diffuse malignant pleural mesothelioma (DMPM) is a rare thoracic malignancy,but its incidence is dramatically increasing worldwide as a result of widespread use of *** remains suffering poor prognosis and the diagnosis should always be based on adequate,representative tissue samples. There still remains a considerable number of patients with DMPM who are misdiagnosed after a complete investigation including thoracoscopic ***

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Determination of Asymmetric Dimethylarginine and Symmetric Dimethylarginine in Biological Samples of Mice Using LC/MS/MS

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American Journal of Analytical Chemistry 2011年第3期2卷 303-313页

作者： Daisuke Saigusa Mai Takahashi Yoshitomi Kanemitsu Ayako Ishida takaaki Abe Tohru Yamakuni Naoto Suzuki Yoshihisa Tomioka Laboratory of Oncology Pharmacy Practice and Sciences Graduate School of Pharmaceutical Sciences Tohoku University Sendai Japan

Herein, we present a novel method of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) determination within biological samples using protein precipitation and LC/MS/MS. Chromatographic separation of ADMA and SDMA was successfully performed using a silica column with optimized elution, or mobile phase, of 10 mM ammonium acetate buffer H2O/methanol/acetonitrile (20/30/45, v/v) at pH 4. The calibration ranges were 0.50 – 50.0 μg●mL-1, and good linearities were obtained for all compounds ( γ > 0.99). The intra- and inter-assay accuracies with recoveries and precisions at three concentration levels (i.e. 1.00, 5.00 and 25.0 μg●mL-1) were better than 86.9% and 7.36%, respectively. The analytical performance of the method was evaluated by determination of compounds in plasma, urine and tissues from male BALBc/J mice. For the first time, we were able to characterize the distribution of ADMA, SDMA and ADMA/SDMA in plasma, urine, brain, heart, kidneys, liver, lungs, pancreas and spleen. Additionally, we demonstrated that the ADMA/SDMA ratio in the brain was approximately 10-fold lower than all the other biological samples. Only 10 μL of plasma, 1 μL of urine and about 25 mg of tissues were required. These results suggest that the developed methodology was useful in ADMA and SDMA determination within biological samples.

关键词： Asymmetric Dimethylarginine Symmetric Dimethylarginine Creatinine Arginine Tissue Liquid Chromatography/Tandem Mass Spectrometry.

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Milnacipran for Attention-Deficit Hyperactivity Disorder Symptoms in Adult Asperger’s Disorder

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Open Journal of Psychiatry 2014年第3期4卷 195-201页

作者： Hirobumi Mashiko Hiromichi Ishikawa Shuntaro Itagaki Yasuko Takanashi Norihiro Miyashita takaaki Okano Shin-Ichi Niwa Hirooki Yabe Department of Neuropsychiatry School of Medicine Fukushima Medical University Fukushima City Japan

The efficacy of milnacipran for the treatment of ADHD symptoms in adult Asperger’s disorder patients was examined. Fifteen consecutive adult Asperger’s disorder patients with ADHD symptoms were treated with milnacipran for 8 weeks. Global Assessment of Functioning (GAF) and Conners’ Adult ADHD Rating Scales Objective Screening Version (CAARS-O-SV) were used for the assessment. The mean GAF scores in the 15 patients improved significantly. Inattention, inattention + hyperactivity/impulsivity and ADHD index in CAARS-O-SV were also significantly improved. Milnacipran might be useful for ADHD symptoms, exerting its effects by increasing serotonin and noradrenaline activities in Asperger’s disorder.

关键词： Milnacipran ADHD Asperger’s Disorder

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