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Cell sheet technology for regeneration of esophageal mucosa

World Journal of Gastroenterology 2012年第37期18卷 5145-5150页

作者： Ryo Takagi Masayuki Yamato Nobuo Kanai Daisuke Murakami Makoto Kondo takaaki Ishii Takeshi Ohki Hideo Namiki Masakazu Yamamoto Teruo Okano Institute of Advanced Biomedical Engineering and Science Tokyo Women's Medical University Department of Surgery Institute of GastroenterologyTokyo Women's Medical University Graduate School of Science and Engineering Waseda University

The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative *** mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD.

关键词： Cell sheet Endoscopic resection Esophagealstenosis Oral mucosa Good manufacturing practice

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A theranostic agent for cancer therapy and imaging in the second nearinfrared window

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Nano Research 2019年第2期12卷 273-279页

作者： Zhuoran Ma Hao Wan Weizhi Wang Xiaodong Zhang takaaki Uno Qianglai Yang Jingying Yue Hongpeng Gao Yeteng Zhong Ye Tian Qinchao Sun Yongye Liang Hongjie Dai Department of Chemistry Stanford University Stanford CA 94305 USA CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology School of Sciences Tianjin University Tianjin 300350 China JSR Corporation Advanced Materials Research Laboratories 100 Kawajiri-Cho Yokkaichi Mie 5108552 Japan Department of Materials Science and Engineering South University of Science and Technology of China Shenzhen 518055 China

Thera no stic nano particles are integrated systems useful for simulta neous diag nosis and imaging guided delivery of therapeutic drugs, with wide ranging pote ntial applicati ons in the clinic. Here we developed a thera no stic nan oparticle (~24 nm size by dynamic light scatteri ng) p-FE-PTX-FA based on polymeric micelle encapsulating an organic dye (FE) fluorescing in the 1,000-1,700 nm second near-infrared (NIR-Ⅱ) window and an an ti-ca ncer drug paclitaxel. Folic acid (FA) was conjugated to the nan oparticles to afford specific binding to molecular folate receptors on muri ne breast can cer 4T1 tumor cells. In vivo, the nan oparticles accumulated in 4T1 tumor through both passive and active targeting effect. Under an 808 nm laser excitation, fluorescence detection above 1,300 nm afforded a large Stokes shift, allowing targeted molecular imaging tumor with high signal to background ratios, reaching a high tumor to normal tissue signal ratio (T/NT) of (20.0±2.3). Further, 4T1 tumors on mice were completed eradicated by paclitaxel released from p-FE-PTA-FA within 20 days of the first injection. Pharmacokinetics and histology studies indicated p-FE-PTX-FA had no obvious toxic side effects to major organs. This represented the first NIR-Ⅱ theranostic age nt developed.

关键词： theranostic nanoparticles second near-infrared window fluorescenee imaging cancer therapy

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Iron overload and cofactors with special reference to alcohol,hepatitis C virus infection and steatosis/insulin resistance

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World Journal of Gastroenterology 2007年第35期13卷 4699-4706页

作者： Yutaka Kohgo Katsuya Ikuta takaaki Ohtake Yoshihiro Torimoto Junji Kato Division of Gastroenterology and Hematology/Oncology Department of MedicineAsahikawa Medical CollegeMidorigaoka-higashi 2-1Asahikawa 078-8510Japan Fourth Department of Internal Medicine Sapporo Medical UniversitySouth-1West-14ChuokuSapporo 060-0030Japan

There are several cofactors which affect body iron metabolism and accelerate iron overload. Alcohol and hepatic viral infections are the most typical examples for clarifying the role of cofactors in iron overload. In these conditions, iron is deposited in hepatocytes and Kupffer cells and reactive oxygen species （ROS） produced through Fenton reaction have key role to facilitate cellular uptake of transferrin-bound iron. Furthermore, hepcidin, antimicrobial peptide produced mainly in the liver is also responsible for intestinal iron absorption and reticuloendothelial iron release. In patients with ceruloplasmin deficiency, anemia and secondary iron overload in liver and neurodegeneration are reported. Furthermore, there is accumulating evidence that fatty acid accumulation without alcohol and obesity itself modifies iron overload states. Ineffective erythropoiesis is also an important factor to accelerate iron overload, which is associated with diseases such as thalassemia and myelodysplastic syndrome. When this condition persists, the dietary iron absorption is increased due to the increment of bone marrow erythropoiesis and tissue iron overload will thereafter occurs. In porphyria cutanea tarda, iron is secondarily accumulated in the liver.

关键词： Iron overload Cofactors Alcohol Chronic hepatic C Non-alcoholic steatohepatitis Insulin resistance Hepatocellular carcinoma

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Fungal Isolate “KMI” Is a New Type of Orchid Mycorrhizal Fungus

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American Journal of Plant Sciences 2012年第8期3卷 1121-1126页

作者： Tomoko Matsubara Motohito Yoneda takaaki Ishii Graduate School of Life Environmental Sciences Kyoto Prefectural University Kyoto Japan.

We analyzed an isolate of fungus that seems to be a new type orchid mycorrhizal fungus, “KMI (refers to Kyoto-Ma- tsubara-Ishii)”, obtained from the roots of Paphiopedilum thailandense Fowl. KMI has hyphal branching into right angle similar to Rhizoctonia-like fungi, but its spore formation resembled Nectoria, which is known as a teleomorph of Fusarium rather than Rhizoctonia. Its ribosomal DNA sequences of 18S and ITS have no similarity with any known fungal species. Proteins in molecular weight of 53 and 24 kDa, which are common to mycorrhizal fungi, were detected in KMI. When KMI was inoculated onto orchids, however it didn’t form pelotons or coils, but the hyphae in the root tissues were observed and the tissues were not decayed. No significant symptoms of Rhizoctonia or Fusarium disease, however, were developed on tomato and cucumber plants. The evidences suggest that KMI is a new type of orchid mycorrhizal fungus.

关键词： KMI Orchid Mycorrhizal Fungus Paphiopedilum thailandense Protein Analysis Ribosomal DNA Sequence

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Diabetes Reflect Study: Redefining Fundamental Learning of SMBG through Educational Color Tools

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International Journal of Clinical Medicine 2015年第4期6卷 227-234页

作者： Katsunori Suzuki takaaki Sato Mariko Hatta Division of Endocrinology and Metabolism Saiseikai Niigata Daini Hospital Niigata Japan Department of Nutrition Saiseikai Niigata Daini Hospital Niigata Japan

Aims: To investigate the effects of a newly developed color-coded educational glucose control instruction (COLOR), combined with a color-displayed glucose meter on changes in type-2 diabetes patient’s behavior and their HbA1c levels. Material and Methods: Patients using a COLOR-self-monitoring of blood glucose (SMBG) method were instructed to record daily blood glucose levels with red (high glucose ≥ 180 mg/dL) or blue (low glucose ≤ 70 mg/dL) colored circles on their SMBG notebooks according to the colors displayed on the glucose meter. Results: COLOR-SMBG showed an improved the actual behavior modification scores by 14% compared to Conventional group at 1-month follow-up

关键词： Color-Coded Educational Glucose Control Instruction Education SMBG Type 2 Diabetes

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A New Type of a Magnetic Plane Motor Coupled Mechanical Vibration with Electromagnetic Force

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Engineering（科研） 2014年第9期6卷 491-499页

作者： Hiroyuki Yaguchi Kazuya Iino takaaki Eguchi Faculty of Engineering Tohoku Gakuin University Tagajo Japan

This paper proposes a new magnetic plane motor capable of rotation by the resonance energy of double-cantilever beam model excited by an electromagnetic force. This magnetic plane motor has two double-cantilever models, and the rotational direction is able to change by changing of the vibration mode. Basic characteristics of a prototype for the magnetic plane motor, such as rotational speed, output torque and efficiency were determined experimentally. Experimental results demonstrated that the rotational speed of 8.1 rpm was obtained with output torque of 0.07 Ncm for the magnetic plane motor having double-cantilever model. The output torque characteristics of the magnetic plane motor with two double-cantilever models improved 200 percent compared with double-cantilever model.

关键词： Magnetic Plane Motor Inertia Force High Torque Resonance-Drive Vibration Mode

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Discovery of unique African Helicobacter pylori CagAmultimerization motif in the Dominican Republic

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World Journal of Gastroenterology 2020年第45期26卷 7118-7130页

作者： takaaki Ono Modesto Cruz Hiroyuki Nagashima Phawinee Subsomwong Junko Akada Takashi Matsumoto Tomohisa Uchida Rumiko Suzuki Celso Hosking Jose A Jimenez Abreu Yoshio Yamaoka Department of Environmental and Preventive Medicine Oita University Faculty of MedicineYufu 879-5593Japan Criminal Investigation Laboratory Oita Prefectural Police HeadquartersOita 870-1117Japan Institute of Microbiology and Parasitology IMPAFaculty of ScienceAutonomous University of Santo DomingoSanto Domingo 10103Dominican Republic Department of Biomedical Research National Institute of Medicine and Diagnostic ImagingSanto Domingo 10107Dominican Republic Department of Gastroenterology Hokkaido Cancer CenterSapporo 003-0804Japan Department of Molecular Pathology Oita University Faculty of MedicineYufu 879-5593Japan Dominican-Japanese Digestive Disease Center Dr Luis E.Aybar Health and Hygiene CitySanto Domingo 10302Dominican Republic Department of Medicine Gastroenterology and Hepatology SectionBaylor College of MedicineHoustonTX 77030United States

BACKGROUND Helicobacter pylori(***)colonizes the human stomach and is a major cause of peptic ulcer disease and gastric ***,although the prevalence of *** is high in Africa,the incidence of gastric cancer is low,and this phenomenon is called to be African *** CagA protein produced by *** is the most studied virulence *** carcinogenic potential of CagA is associated with the Glu-Pro-Ile-Tyr-Ala(EPIYA)patterns and CagAmultimerization(CM)*** To better understand the EPIYA patterns and CM motifs of the cagA *** Gastric mucosal biopsy specimens were obtained from 258 patients with dyspepsia living in the Dominican Republic,from which 120 *** strains were *** the bacterial DNA extraction,the EPIYA pattern and CM motif genotypes were determined using a polymerase chain reaction-based *** population structure of the Dominican Republic strains was analyzed using multilocus sequence typing(MLST).Peptic ulcer disease and gastric cancer were identified via endoscopy,and gastric cancer was confirmed by *** scores of the gastric mucosa were evaluated using the updated Sydney *** All CagA-positive strains carried the Western-type CagA according to the identified EPIYA ***-seven kinds of CM motifs were *** the typical Western CM motif(FPLKRHDKVDDLSKVG)was observed most frequently,the typical East Asian CM motif(FPLRRSAAVNDLSKVG)was not ***,“FPLRRSAKVEDLSKVG”,similar to the typical East Asian CM motif,was found in 21 *** this type was significantly more frequent in strains classified as hpAfrica1 using MLST analysis(P=0.034),we termed it Africa1-CM(Af1-CM).A few hpEurope strains carried the Af1-CM motif,but they had a significantly higher ancestral Africa1 component than that of those without the Af1-CM motif(P=0.030).In 30 cagA-positive strains,the"GKDKGPE"motif was observed immediately upstream of the EPIYA motif in

关键词： Helicobacter pylori CagA CagA 3'region CagA-multimerization motif Glu-Pro-Ile-Tyr-Ala motif Dominican Republic

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Temporal Fossa Abscess Caused by Apical Periodontitis: A Case Report

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Open Journal of Clinical Diagnostics 2018年第4期8卷 47-51页

作者： Sayaka Yoshiba takaaki Kamatani Tatsuo Shirota Department of Dental and Oral Surgery Showa University Northern Yokohama Hospital Tokyo Japan Department of Oral and Maxillofacial Surgery Showa University School of Dentistry Tokyo Japan

According to the progress of the antibiotic medicine, the severe infection case is decreasing recently. We recently experienced a case of temporal fossa abscess caused by periapical periodontitis the upper left side of the second molar. A 79-year-old woman visited to Showa University Dental Hospital complaining of the painful swelling at the left side of the temporal and trismus. The routine blood test exhibited a severe inflammation. We performed drainage treatment at temporal skin and normal oral bacterial flora was detected by the bacteriological examination. Under treatment included the administration of antibiotics, the inflammation healed without serious complication and she recovered completely.

关键词： Temporal Fossa Abscess Odontogenic Infection Apical Periodontitis

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Augmented reality: The use of the PicoLinker smart glasses improves wire insertion under fluoroscopy

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World Journal of Orthopedics 2017年第12期8卷 891-894页

作者： Takafumi Hiranaka takaaki Fujishiro Yuichi Hida Yosaku Shibata Masanori Tsubosaka Yuta Nakanishi Kenjiro Okimura Harunobu Uemoto Department of Orthopaedic Surgery and Joint Surgery CenterTakatsuki General Hospital

AIM To demonstrate the feasibility of the wearable smart glasses, Pico Linker, in guide wire insertion under fluoroscopic guidance. METHODS Under a fluoroscope, a surgeon inserted 3 mm guide wires into plastic femurs from the lateral cortex to the femoral head center while the surgeon did or did not wear Pico Linker, which are wearable smart glasses where the fluoroscopic video was displayed(10 guide wires each). RESULTS The tip apex distance, radiation exposure time and total insertion time were significantly shorter while wearing the Pico Linker smart glasses. CONCLUSION This study indicated that the Pico Linker smart glasses can improve accuracy, reduce radiation exposure time, and reduce total insertion time. This is due to the fact that the Pico Linker smart glasses enable surgeons to keep their eyes on the operation field.

关键词： Smart glasses Imaging Wearable devices Fluoroscopy Guide wire insertion

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Correlation between Aerodynamic Noise and Velocity Fluctuation of Tip Leakage Flow of Axial Flow Fan

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Open Journal of Fluid Dynamics 2012年第4期2卷 228-234页

作者： Hiromitsu Hamakawa Masatomo Shiotsuki takaaki Adachi Eru Kurihara Department of Mechanical Engineering Oita University Oita Japan

In the present paper the attention is focused on correlation between fan noise and velocity fluctuations of tip leakage vortex around rotor blade of a low pressure axial flow fan at the maximum pressure operating point. We measured time fluctuating velocity near the rotor tip around the rotor blades by using a hot-wire sensor from a relative flame of refer- ence fixed to the rotor blades. As the results, it is clear that the velocity fluctuation due to tip leakage vortex has weak periodicity and the hump portion appeared in its spectrum. If the flow rate was lower than the design condition, the tip leakage flow became to attach to the following blade and the sound pressure level at frequency of velocity fluctuation of this flow was increased. The correlation measurements between the velocity fluctuation of tip leakage flow and the aerodynamic noise were made using a rotating hot-wire sensor near the rotor tip in the rotating frame. The correlation between the velocity fluctuation due to tip leakage flow and acoustic pressure were increased due to generation of weak acoustic resonance at the maximum pressure operating point.

关键词： Fan Noise Tip Leakage Flow Relative Flow Measurement Correlation Measurement Acoustic Resonance

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