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The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

Answering Reachability Queries on Incrementally Updated Graphs by Hierarchical Labeling Schema

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Journal of Computer Science & Technology 2016年第2期31卷 381-399页

作者： tak-Lam wong Department of Mathematics and Information Technology The Hong Kong Institute of Education Hong Kong China

We proposed a novel solution schema called the Hierarchical Labeling Schema （HLS） to answer reachability queries in directed graphs. Different from many existing approaches that focus on static directed acyclic graphs （DAGs）, our schema focuses on directed cyclic graphs （DCGs） where vertices or arcs could be added to a graph incrementally. Unlike many of the traditional approaches, HLS does not require the graph to be acyclic in constructing its index. Therefore, it could, in fact, be applied to both DAGs and DCGs. When vertices or arcs are added to a graph, the HLS is capable of updating the index incrementally instead of re-computing the index from the scratch each time, making it more efficient than many other approaches in the practice. The basic idea of HLS is to create a tree for each vertex in a graph and link the trees together so that whenever two vertices are given, we can immediately know whether there is a path between them by referring to the appropriate trees. We conducted extensive experiments on both real-world datasets and synthesized datasets. We compared the performance of HLS, in terms of index construction time, query processing time and space consumption, with two state-of-the-art methodologies, the path-tree method and the 3-hop method. We also conducted simulations to model the situation when a graph is updated incrementally. The performance comparison of different algorithms against HLS on static graphs has also been studied. Our results show that HLS is highly competitive in the practice and is particularly useful in the cases where the graphs are updated frequently.

关键词： graph indexing reachability query Hierarchical Labeling Schema (HLS) incremental update directed cyclic graph

Socioeconomic Distribution of Health and Health Care Utilization in a New Town in Hong Kong, China

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Biomedical and Environmental Sciences 2004年第2期17卷 234-245页

作者： tak SUN IGNATIUS YU TZE WAI wong Department of Community and Family Medicine the Chinese University of Hong Kong Shatin N. T. Hong Kong SAR ChinaDepartment of Community and Family Medicine the Chinese University of Hong Kong Shatin N. T. Hong Kong SAR China

Objectives To assess the association of socioeconomic indicators with various chronic and acute illnesses and the utilization of public health care in a new town in Hong Kong, China. Methods Illness experience and socioeconomic and demographic data of 7570 residents from 2022 randomly selected households were collected through telephone interviews. The relationships between socioeconomic indicators and illnesses/choice of health care were explored using stepwise logistic regressions after adjusting for sex and age. Results Significant positive associations were noted between low household income and diabetes mellitus, any chronic illnesses among adults and flu among younger subjects; low educational level and accident-related illness among adults; being born in Chinese mainland and flu, any acute illness in adults. For the utilization of public health care, low household income was the most consistent risk factor. Conclusion This study did not demonstrate a unidirectional socioeconomic gradient in healt

关键词： Socioeconomic indicators Health status Health care need Health care utilization

Use of graphene-based materials as carriers of bioactive agents

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Asian Journal of Pharmaceutical Sciences 2021年第5期16卷 577-588页

作者： Wing-Fu Lai Wing-tak wong Ciechanover Institute of Precision and Regenerative Medicine School of Life and Health SciencesThe Chinese University of Hong Kong(Shenzhen)Shenzhen 518172China Department of Applied Biology and Chemical Technology Hong Kong Polytechnic UniversityHong KongSpecial Administrative RegionChina

Graphene possesses a large specific surface area, a high Young’s modulus, high fracture strength, high electrical conductivity, and excellent optical performance. It has been widely studied for biomedical use since its first appearance in the literature. This article offers an overview of the latest advances in the design of graphene-based materials for delivery of bioactive agents. To enhance the translation of these carriers into practical use, the toxicity involved is needed to be examined in future research in more detail. In addition, guidelines for standardizing experimental conditions during the evaluation of the performance of graphene-based materials are required to be established so that candidates showing higher practical potential can be more effectively identified for further development. This can streamline the optimization and use of graphene-based materials in delivery applications.

关键词： Graphene Carbon Nanomaterial Loading Controlled release

Facile design of Au@Pt core-shell nanostructures： Formation of Pt submonolayers with tunable coverage and their applications in electrocatalysis

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Nano Research 2014年第3期7卷 410-417页

作者： Fulin Zheng Wing-tak wong Ka-Fu Yung Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hung Hom Hong Kong SAR China

A facile design of Pt nanostructures from submonolayer to monolayer has been realized by ion adsorption-in situ electrochemical reduction on Au nanoparticles supported on multiwall carbon nanotubes （CNTs）. The as prepared Au@Pt/CNTs catalysts display coverage-specific electrocatalysis. Au@Pt/CNTs with low Pt coverage is inactive towards methanol oxidation whereas it oxidizes formic acid effectively through a direct pathway with mass specific activity 90 times that of a commercial Pt/C catalyst. Due to its inertness to methanol, it shows high performance in the oxygen reduction reaction （ORR） with high methanol tolerance. In contrast, simply increasing the Pt coverage to above 40% switches the formic acid oxidation process to both direct and indirect catalytic pathways, and also results in high methanol oxidation activity.

关键词： electrocatalysis platinum submonolayer fuel cell

New tricyanoiron(Ⅲ) building blocks for the construction of molecule-based magnets

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Science China Chemistry 2010年第10期53卷 2106-2111页

作者： LAU Pui-Ha wong Wing-tak LAU Tai-Chu Department of Biology and Chemistry City University of Hong Kong Department of Chemistry The University of Hong Kong

A series of tricyanoiron(Ⅲ) complexes with the general formula mer-[FeⅢ(5-Xsap)(CN)3]2-(X = H, Me, MeO, Cl or Br, sapH2 = N-salicylidene-o-aminophenol) have been synthesized. These complexes were characterized by IR, ESI-MS, UV/Vis, elemental analysis and magnetic measurements. The structures of (PPh4)2[FeⅢ(sap)(CN)3] and (PPh4)2[FeⅢ(5-Mesap)(CN)3] have been determined by X-ray crystallography. These low-spin d5 tricyanoiron(Ⅲ) complexes are potential building blocks for the construction of molecule-based magnets.

关键词： cyano iron Schiff base building block molecule-based magnet

Synthesis and structural characterization of lanthanide coordination polymers constructed from a 13-membered macrocycle

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Chinese Science Bulletin 2007年第4期52卷 467-470页

作者： YAO YingMing SHEN Qi wong Wing tak Department of Chemistry and Chemical Engineering Dushu Lake Campus Suzhou University Suzhou 215123 China Department of Chemistry The University of Hong Kong Polkfulam Road Hong Kong China

The lanthanide coordination polymers bearing a 13-membered macrocycle, [(13-EDTA-pnOH)H2] were synthesized. The products [Ln(13-EDTA-pnOH)(H2O)2·NO3]n (Ln = Eu(1), Tb(2), Dy(3)) have been obtained by MS, IR and element analyses. The solid-state structure of 1 was established by single-crystal X-ray analysis. The coordination geometry around the central metal atom in complex 1 is a nine-coor-dinated, tricapped-trigonal prism having six donor atoms (two amine nitrogen atoms, two amide oxygen atoms and two carboxymethyl oxygen atoms) from one ligand, one oxygen atom from a neighboring ligand, and two more oxygen atoms from two water molecules. The europium atoms are linked by―Eu―O―C―O―Eu―bridges to form an infinite chain.

关键词：镧系元素复合物配位聚合物官能化大环合成结构表征

Rapid testing methods for food contaminants and toxicants

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Journal of Integrative Agriculture 2015年第11期14卷 2243-2264页

作者： Jiachi Chiou Arthur Ho Hon Leung Hang Wai Lee Wing-tak wong Department of Applied Biology and Chemical Technology Food Safety and Technology Research CenterThe Hong Kong Polytechnic University Shenzhen Key Laboratory for Food Biological Safety Control Food Safety and Technology Research CentreThe Hong Kong Polytechnic University Shenzhen Research Institute

Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures, long analysis time, large instruments and professional personnel to meet the increasing demands. In this review, we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents, toxic ions, pesticides, veterinary drugs and preservatives, as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid, accurate, easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system.

关键词： rapid testing food contaminants and toxins microbial agents pesticides veterinary drugs preservatives formaldehyde nitrite nitrate test strips

Intramolecular (4+3) cycloadditions of nitrogen-tethered epoxy enosilanes for the synthesis of heteropolycycles

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Chinese Chemical Letters 2019年第8期30卷 1523-1526页

作者： Jiayun He Shuk Mei Lam Jerome PLNg Wing-tak wong Pauline Chiu State Key Laboratory of Synthetic Chemistry Department of ChemistryThe University of Hong KongHong KongChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Furans bearing epoxy enolsilane units via a tether that incorporates a nitrogen heteroatom,undergo intramolecular(4+3)cycloadditions to generate bis-heteroatomic polycyclic adducts having piperidine moieties in their *** cycloadducts,ultimately derived from furfural,a renewal chemical feedstock,are obtained with up to 4:1 dr and with ee retained from the epoxide.

关键词： Heterocycles (4+3)cycloaddition Furan Intramolecular Epoxides Piperidine Polycyclic compounds