检索结果-南通市图书馆

EPR and UV-vis studies of biomimetic complexes of molybdoenzyme and tungstoenzyme

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2003年第7期48卷 649-651页

作者： LU Xiaoming LIU Shuncheng mao Xi YE Zhaohui LU Jingfen Department of Chemistry Capital Normal University Beijing 100037 China Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences. Wuhan 43007I China State Key Laboratory of Natural and Biomimetic Drugs Medicine Science Center Peking University Beiing 100083 China

The Mo(Ⅴ) and W(Ⅵ) complexes of (NH3CH2- CH2NH2)3[Mo(Ⅴ)O2(OC6H4O)2] (1), (NH3CH2CH2NH2)2.5 [Mo(Ⅴ) 0.5W(Ⅵ)0.5O2(OC6H4O)2] (2) and (NH3CH2CH2NH2)2- [W(Ⅵ)O2(OC6H4O)2] (3) were synthesized by choosing cate-chol ligand which shows a good reductive property and tak-ing advantage of EMo > EW. Their EPR and UV-vis spectra were compared with the oxidized UV-vis spectra of xanthine dehydrogenase from chicken liver and xanthine oxidase from milk and the EPR spectrum of flavoenzyme from milk.

关键词：钼钨化合物仿生物质仿生合成邻苯二酚电子顺磁共振紫外光谱

Federated Dynamic Client Selection for Fairness Guarantee in Heterogeneous Edge Computing

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2024年第1期39卷 139-158页

作者：毛莺池沈莉娟吴俊平萍吴杰 Key Laboratory of Water Big Data Technology of Ministry of Water Resources Hohai UniversityNanjing 211100China College of Computer and Information Hohai UniversityNanjing 211100China Center of Networked Computing Temple UniversityPhiladelphiaPA 19122-6096U.S.A

Federated learning has emerged as a distributed learning paradigm by training at each client and aggregat-ing at a parameter *** heterogeneity hinders stragglers from responding to the server in time with huge com-munication *** client grouping in federated learning can solve the straggler problem,the stochastic selection strategy in client grouping neglects the impact of data distribution within each ***,current client grouping ap-proaches make clients suffer unfair participation,leading to biased performances for different *** order to guaran-tee the fairness of client participation and mitigate biased local performances,we propose a federated dynamic client selec-tion method based on data representativity(FedSDR).FedSDR clusters clients into groups correlated with their own lo-cal computational *** estimate the significance of client datasets,we design a novel data representativity evalua-tion scheme based on local data ***,the two most representative clients in each group are selected to optimize the global ***,the DYNAMIC-SELECT algorithm updates local computational efficiency and data representativity states to regroup clients after periodic average *** on real datasets show that FedS-DR improves client participation by 27.4%,37.9%,and 23.3%compared with FedAvg,TiFL,and FedSS,respectively,tak-ing fairness into account in federated *** addition,FedSDR surpasses FedAvg,FedGS,and FedMS by 21.32%,20.4%,and 6.90%,respectively,in local test accuracy variance,balancing the performance bias of the global model across clients.

关键词： federated learning fairness computational efficiency data distribution client selection client grouping

Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/ BRAF/tak1/ERK/ETV4 signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第5期19卷 669-684页

作者： Panpan Ma Xinxin Jin Zhiwei Fan Zhou Wang Suhui Yue changyue Wu Shiyin Chen Yuanyuan Wu Miaomiao Chen Donghua Gu Siliang Zhang Renfang mao Yihui Fan Laboratory of Medical Science School of MedicineNantong UniversityNantong 226001China Department of Pathogenic Biology School of MedicineNantong UniversityNantong 226001China Department of Clinical Laboratory Yancheng No.1 People’s HospitalYancheng 224005China School of Life Sciences Nantong UniversityNantong 226001China Department of Dermatology Affiliated Hospital of Nantong UniversityNantong UniversityNantong 226001China The Department of Urology the Second Affiliated Hospital of Nantong UniversityNantong UniversityNantong 226001China The Department of Radiotherapy Oncology Harbin Medical University Cancer HospitalHarbin 150086China Department of Pathophysiology School of MedicineNantong UniversityNantong 226001China

Objective:PD-L1 and PD-L2 expression levels determine immune evasion and the therapeutic efficacy of immune checkpoint *** factors that drive inducible PD-L1 expression have been extensively studied,but mechanisms that result in constitutive PD-L1 expression in cancer cells are largely ***:DNA elements were deleted in cells by CRISPR/Cas9-mediated *** function was inhibited by chemical *** levels were examined by Western blot,mRNA levels were examined by real-time RT-PCR,and surface protein expression was determined by cellular immunofluorescence and flow *** evasion was examined by in vitro T cell-mediated ***:We determined the core regions(chr9:5,496,378–5,499,663)of a previously identified PD-L1L2-super-enhancer(SE).Through systematic analysis,we found that the E26 transformation-specific(ETS)variant transcription factor(ETV4)bound to this core DNA region but not to DNA surrounding *** knockout of ETV4 dramatically reduced the expressions of both PD-L1 and ***4 transcription was dependent on ERK activation,and BRAF/tak1-induced ERK activation was dependent on extracellular signaling fromαvβ3 integrin,which profoundly affected ETV4 transcription and PD-L1/L2 *** silencing or pharmacological inhibition of components of the PD-L1L2-SE-associated pathway rendered cancer cells susceptible to T cell-mediated ***:We identified a pathway originating from the extracellular matrix that signaled via integrin/BRAF/tak1/ERK/ETV4 to PD-L1L2-SE to induce PD-L1-mediated immune *** results provided new insights into PD-L1L2-SE activation and pathways associated with immune checkpoint regulation in cancer.

关键词： PD-L1 super-enhancer ETV4 ERK αvβ3 integrin BRAF tak1

The Nano Research Young Innovators Awards in bio-inspired nanomaterials

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

Motion-Inspired Real-Time Garment Synthesis with Temporal-Consistency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2023年第6期38卷 1356-1368页

作者：魏育坤石敏冯文科朱登明毛天露 School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

Synthesizing garment dynamics according to body motions is a vital technique in computer ***-based simulation depends on an accurate model of the law of kinetics of cloth,which is time-consuming,hard to implement,and complex to *** data-driven approaches either lack temporal consistency,or fail to handle garments that are different from body *** this paper,we present a motion-inspired real-time garment synthesis workflow that enables high-level control of garment *** a sequence of body motions,our workflow is able to gen-erate corresponding garment dynamics with both spatial and temporal *** that end,we develop a transformer-based garment synthesis network to learn the mapping from body motions to garment ***-level attention is employed to capture the dependency of garments and body ***,a post-processing procedure is further tak-en to perform penetration removal and ***,textured clothing animation that is collision-free and tempo-rally-consistent is *** quantitatively and qualitatively evaluated our proposed workflow from different *** experiments demonstrate that our network is able to deliver clothing dynamics which retain the wrinkles from the physics-based simulation,while running 1000 times ***,our workflow achieved superior synthesis perfor-mance compared with alternative *** stimulate further research in this direction,our code will be publicly available soon.

关键词： clothing animation computer graphics transformer temporal consistency

Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2023年第1期13卷 368-381页

作者： Tian Lan Wen Wang De-Lian Huang Xi-Xi Zeng Xiao-Xiao Wang Jian Wang Yu-Hua Tong Zhu-Jun mao Si-Wei Wang The Joint Innovation Center for Health and Medicine Quzhou People’s HospitalThe Quzhou Affiliated Hospital of Wenzhou Medical UniversityNo.100 Minjiang RoadQuzhou 324000China Preventive Treatment Center Zhejiang Chinese Medical University Affiliated Four-provinces Marginal Hospital of Traditional Chinese MedicineQuzhou Hospital of Traditional Chinese MedicineQuzhou 324000China School of Medical Technology and Information Engineering Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Drug Analysis Center Quzhou Institute for Food and Drug ControlQuzhou 324000China Department of Ophthalmology Quzhou People’s HospitalThe Quzhou Affiliated Hospital of Wenzhou Medical UniversityQuzhou 324000China College of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityNo.548 Binwen RoadHangzhou 310053China

Quzhou Aurantii Fructus(QAF)has a long history as a folk medicine and food for the treatment of liver *** our earlier study provided evidence of hepatoprotective properties contained within the flavonoids and limonins constituents in QAF,the potential preventative effects afforded by essential oil components present within QAF remains *** this study,we prepared Quzhou Aurantii Fructus essential oil(QAFEO)and confirmed its anti-inflammatory effects on liver inflammation through experimentation on lipopolysaccharide and D-galactosamine(LPS/D-GalN)induced acute liver failure(ALF)mouse *** RNA-sequence(RNA-seq)analysis,we found that QAFEO prevented ALF by systematically blunting the pathways involved in response to LPS and toll-like receptor signaling *** effectively suppressed the phosphorylation of tank-binding kinase 1(TBK1),TGF-beta activated kinase 1(tak1),interferon regulatory factor 3(IRF3),and the activation of mitogen activated kinase-like protein(MAPK)and nuclear factor-kappa B(NF-κB)pathways in vivo and in ***,QAFEO substantially reduced myeloid differentiation primary response gene 88(MyD88)-toll-like receptor 4(TLR4)interaction ***,8 compounds from QAFEO could directly bind to REAL,tak1,MyD88,TBK1,and *** together,the results of our study support the notion that QAFEO exerts a hepatoprotective effect through inhibiting LPS-mediated inflammatory response.

关键词： Quzhou Aurantii Fructus Essential oil Acute liver failure LPS Inflammation

TATB基PBX的准静态拉压非线性本构模型及其应用(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

含能材料 2018年第8期26卷 701-707页

作者：唐维袁洪魏温茂萍赵龙颜熹琳中国工程物理研究院化工材料研究所四川绵阳621999

高聚物粘结炸药(PBX)的应力应变曲线普遍存在非线性显著和对称性较差的特点,本构模型构建困难是炸药材料力学性能研究中的一个难题。以PBX‐901为研究对象,开展了不同温度下的单轴拉伸和单轴压缩试验,根据获得的S型应力应变曲线,基于Bol... 详细信息

高聚物粘结炸药(PBX)的应力应变曲线普遍存在非线性显著和对称性较差的特点,本构模型构建困难是炸药材料力学性能研究中的一个难题。以PBX‐901为研究对象,开展了不同温度下的单轴拉伸和单轴压缩试验,根据获得的S型应力应变曲线,基于Boltzmann函数分别推导建立了一种四参数本构模型和一种双参数本构模型。结果表明:较之于四参数本构模型,双参数本构模型的参数确定不需要参数拟合,仅采用压缩强度和初始段弹性模量解析求解的方式获取即可,描述精度误差低于5%。最后采用ANSYS软件的二次开发模块,实现了双参数本构模型在巴西圆盘试验中的数值模拟应用,试验结果和数值模拟结果的对比分析显示二者的相对误差仅5.11%,表明所建立的双参数本构模型的描述精度满足工程需要。

关键词：高聚物粘结炸药(PBX) 非线性本构模型 Boltzmann函数 S型应力应变曲线巴西圆盘试验

TRIM8 modulates NF-kB activation pathways triggered by proinflammatory cytokines

在线全文

学校读者我要写书评

暂无评论

TRIM8 modulates NF-kB activation pathways triggered by proin...

白果内酯通过TLR4/tak1/NF-κB通路对非酒精性脂肪肝炎大鼠模型肝纤维化的调控作用

2012年中国科协海峡两岸青年科学家学术活动月——第九届海峡两岸细胞生物学学术研讨会

作者： Qi Li Jie Yan Ai-Ping mao Chao Li Yong Ran Hong-Bing Shu 王延轶 College of Life Sciences Wuhan University

The tripartite motif(TRIM)-containing proteins are a family of proteins that have been known to be involved in divergent biological processes,including important roles in immune responses through regulating various si... 详细信息

关键词： TRIM8 tak1 TNF IL-1 NF-κB activation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

沈阳药科大学学报 2019年第8期36卷 716-722页

作者：董志超高琦毛建娜新乡市中心医院消化内科

目的探究白果内酯(BB)对非酒精性脂肪肝炎(NASH)大鼠肝纤维化的作用及机制。方法高脂饲料诱导建立NASH大鼠模型,检测血清高密度脂蛋白(HDL)、甘油三酯(TG)、谷丙转氨酶(ALT)和谷草转氨酶(AST)浓度;HE染色观测肝组织病理变化;免疫组化检... 详细信息

目的探究白果内酯(BB)对非酒精性脂肪肝炎(NASH)大鼠肝纤维化的作用及机制。方法高脂饲料诱导建立NASH大鼠模型,检测血清高密度脂蛋白(HDL)、甘油三酯(TG)、谷丙转氨酶(ALT)和谷草转氨酶(AST)浓度;HE染色观测肝组织病理变化;免疫组化检测α-平滑肌肌动蛋白(α-SMA)的表达,ELISA检测白介素-6(IL-6)、肿瘤坏死因子(TNF-α)和IL-1β表达;Western blot检测基质金属蛋白酶-1(MMP-1)、基质金属蛋白酶抑制剂-1(TIMP-1)和TLR4/tak1/NF-κB通路蛋白的表达。结果与NASH组比较,BB组(中、高剂量)血清TG、ALT和AST浓度明显降低,HDL浓度明显升高;肝组织病理损伤减轻;同时BB组大鼠肝组织α-SM A的阳性表达明显减少;给予BB 8周后,大鼠肝组织MMP-1表达明显增多,TIMP-1表达水平明显降低,炎症因子IL-6、TNF-α和IL-1β表达也明显被抑制;此外,BB还可显著促进NASH大鼠TLR4和tak1表达,升高p-p65/p65比值。结论 BB能通过抑制TLR4/tak1/NF-κB通路激活减轻NASH大鼠肝纤维化程度。

关键词：非酒精性脂肪肝炎肝纤维化白果内酯