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Occurrence of Multi-Drug Resistant Listeria speciesin Faecal Samples of Poultry Chickens in Rural Farms in Lagos State, Nigeria

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Advances in Infectious Diseases 2021年第1期

作者： Emelda E. Chukwu Veronica N. Ibeh olabisi F. Davies-Bolorunduro

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Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria

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Advances in Infectious Diseases 2022年第4期12卷 799-812页

作者： Aigbe Gregory Ohihoin Kazeem Adewale Osuolale Patrick Azuka Okwuraiwe Adesola Zaidat Musa Ayorinde Babatunde James Chika Kingsley Onwuamah Olufemi Samuel Amoo Joseph Ojonugwa Shaibu Fehintola Ige Esther Ngozi Ohihoin Emelda Chukwu Ngozi Mirabel Otuonye tajudeen Bamidele Adeola Olukosi Olusola Ajibaye Yekeen Raheem David Oladele Agatha Nkiru David Babatunde Adewale Rosemary Audu Oliver Ezechi Nkiruka Nnonyelum Odunukwe Richard Adegbola Babatunde Lawal Salako Clinical Sciences Department Nigerian Institute of Medical Research Yaba Lagos Grants and M/E Unit (Biostatistics) Nigerian Institute of Medical Research Yaba Lagos Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Department of Biochemistry and Nutrition Nigerian Institute of Medical Research Yaba Lagos Centre of Infectious Disease Research Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Central Research Laboratory Nigerian Institute of Medical Research Yaba Lagos Department of Molecular Biology and Biotechnology Nigerian Institute of Medical Research Yaba Lagos Clinical Diagnostic Laboratory Nigerian Institute of Medical Research Yaba Lagos Department of Public Health Nigerian Institute of Medical Research Yaba Lagos

Background: Access to testing for SARS-CoV-2 in Nigeria is still highly restricted. Only patients who are symptomatic for SARS-CoV-2 are selected for testing. This pattern of testing will miss a large proportion of individuals with the infection who are asymptomatic and presymptomatic. This study reports the experience of a symptom-based study from a large testing centre in Nigeria. Methods: A cross-sectional study, reviewing data collected from respondents presenting at the Nigerian Institute of Medical Research (NIMR) modified drive-through center for COVID-19 test between the period March 31st and August 31st, 2020 were included in the analysis. Results: A total of 9891 participants were recruited into the study and 2465 participants (24.9%) had a positive PCR result for SARS-CoV-2. The majority of the respondents were above 18 years old, n = 9163 (93.4%). The average age of the respondents was 36.7 years (sd 13.8 years). The age of the participants has a significant effect on SARS-CoV-2 status (AOR = 1.009, CI, 1.005 to 1.012, p = 0.0001). There was a male preponderance, n = 5652 (57.6%). The odds of having a positive status for SARS-CoV-2 were 0.9 times lower for female participants. The majority of the respondents had a history of travel, n = 6788 (68.6%). Cough was the commonest symptom, n = 1062 (10.7%) followed by fever, n = 979 (9.9%). The mortality rate was 0.1%. Among the participants with comorbidity, 31 (51.7%) had positive results for SARS-CoV-2 while 29 (48.3%) had negative results. Conclusion: Symptom-based approach to testing for SARS-CoV-2 in Nigeria revealed a high positivity rate, while mortality from those tested in the study is low. Age and gender appear to play a significant role in the dynamics of the disease.

关键词： SARS-CoV-2 COVID-19 Symptoms RT-PCR Nigeria

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Epigenetics in the etiology and management of infertility

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World Journal of Medical Genetics 2022年第2期10卷 7-21页

作者： tajudeen Olanrewaju Yahaya Danlami M Bashar Esther O Oladele Ja'afar Umar Daniel Anyebe Abdulrazaq Izuafa Department of Biological Sciences Federal University Birnin KebbiKebbi State 23401Nigeria Department of Microbiology Federal University Birnin KebbiKebbi State 23401Nigeria Biology Unit Distance Learning InstituteUniversity of LagosLagos State 23401Nigeria Department of Biochemistry and Molecular Biology Federal University Birnin KebbiKebbi State 23401Nigeria

BACKGROUND Epigenetic disruptions have been implicated in some cases of infertility and can serve as therapeutic ***,the involvement of epigenetics in infertility has not received adequate *** This study aimed to determine the epigenetic basis of infertility in order to enhance public *** Relevant articles on the subject were collected from PubMed,RCA,Google Scholar,SpringerLink,and *** articles were pooled together and duplicates were removed using Endnote *** Available information shows that epigenetic mechanisms,mainly DNA methylation,histone modification,and microRNA interference are necessary for normal gametogenesis and *** a result,epigenetic disruptions in genes that control gametogenesis and embryogenesis,such as DDX3X,ADH4,AZF,PLAG1,D1RAS3,CYGB,MEST,JMJD1A,KCNQ1,IGF2,H19,and MTHFR may result in *** DNA methylation during genomic imprinting and parental epigenetic mark erasures,in particular,may affect the DNA epigenomes of sperm and oocytes,resulting in reproductive *** the sperm may also cause reproductive ***,overexpression or repression of certain microRNAs embedded in the ovary,testis,embryo,as well as granulosa cells and oocytes may impair *** infertility is characterized by spermatogenesis failure,which includes oligozoospermia,asthenozoospermia,and teratozoospermia,while female infertility is characterized by polycystic ovary *** epigenetic modifications can be reversed by deactivating the regulatory enzymes,implying that epigenetic reprogramming could help treat infertility in some *** some disorders,epigenetic drugs are available,but none have been formulated for *** Some cases of infertility have an epigenetic etiology and can be treated by reversing the same epigenetic mechanism that caused *** a result,medical practitioners are urged to come up with epigenetic treatments for

关键词： DNA methylation Gametogenesis Infertility Polycystic ovary syndrome Oligozoospermia Teratozoospermia

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Allophylus africanus和Tragia benthamii的植物化学筛选、抗疟疾及组织病理学研究(英文)

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中国天然药物 2013年第4期11卷 371-376页

作者： Oladosu I.A. Balogun S.O. Ademowo G.O. Department of Chemistry University of IbadanIbadanNigeria Department of Chemistry Obafemi Awolowo UniversityIle-IfeOsun-StateNigeria Institute of Medical Research and Training College of MedicineUniversity of IbadanIbadanNigeria

The anti-malarial potential of different parts of Allophylus africanus *** and Tragia benthamii Baker were determined in vivo for suppressive,curative and cytotoxic activities in mice receiving 0.2 mL of a standard inoculum size of 1 × 107 infected erythrocytes of Plasmodium berghei(NK-65) *** *** extracts suppressed parasitaemia following administration to infected mice by 92.82% 97.81% on day 7 post-infection against 96.81% for *** infected extract-treated animals had significantly moderate(P < 0.05) packed cell volume(PCV) compared with the infected,untreated *** screening revealed a predominance of tannins,saponins,flavonoids and carbohydrates in all parts of ***,and alkaloids instead of flavonoids in the extract of *** results suggest that the extract possesses considerable antimalarial *** results support further studies on ***.

关键词：实验药理学药理病理作用天然药物

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coinfection with Malaria in Selected States in Nigeria

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Advances in Infectious Diseases（传染病进展） 2024年第2期 442页

作者： Oluwagbemiga Olanrewaju Aina Olufemi Samuel Amoo Kazeem Adewale Osuolale Adewale Kayode Ojogbede Azuka Patrick Okwuraiwe David Ayoola Oladele Adesola Zaidat Musa tajudeen Akanji Bamidele Celestina Onyinye Okoyenta Abideen Olurotimi Salako Toyosi Yekeen Raheem Ifeoma Eugenia Idigbe Fehintola Anthonia Ige Joseph Ojonugwa Shaibu Gregory Aigbe Ohihoin Kikelomo Wright Bisola Adebayo Hussein Abdu-Razzaq Abdulrahman Ahmad Mustapha Imam Bashir Bello Tambuwal Muhammad Shuaibu Gobir Richard Ikwuogu Christian Tetsola Gloria Patrick-Ferife Nathaniel Enamuotor Mildred Okowa William Nwachukwu Cornelius Ohonsi Magdalene Egede Chinwe Ochu Ehimario Igumbor Oliver Chukwujekwu Ezechi Babatunde Lawal Salako Rosemary Ajuma Audu

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Microbial Contents and Antibiotics Susceptibilities from Hand Washing Stations during COVID-19 Pandemic in Lagos, Nigeria

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Advances in Infectious Diseases 2023年第1期

作者： tajudeen Akanji Bamidele Bamidele Tolulope Odumosu Princess Temitope Adenola James Ameh Joseph Anejo-Okopi Adesola Zaidat Musa Babatunde Osoba Oliver Chukwujekwu Ezechi Babatunde Lawal Salako

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Labetalol versus Hydralazine in the Management of Severe Pre-Eclampsia at Tertiary Hospitals in a Low-Resource Setting:A Randomised Controlled Trial

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Open Journal of Obstetrics and Gynecology 2023年第6期

作者： Uzoma Otutoaja Adeyemo olabisi Timothy Emmanuel Olumide Adewara Olufunmilayo Victoria Adebara Augustine Adebayo Adeniyi Babatunde Sunday Awoyinka Raymond Akujuobi Okere Idowu Oluseyi Adebara Adewumi Bakare Mojisola Olumide Ayankunle

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Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria

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Advances in Infectious Diseases 2022年第4期

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Malaria Retinopathy among Under-Five Children with Severe and Uncomplicated Malaria in a Tertiary Health Institution in Southwest Nigeria: A Comparative Study

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Advances in Infectious Diseases（传染病进展） 2023年第3期

作者： Olusoji Omotayo Olayinka Philip Olayele Abiodun Tolulope Opeoluwa Jegede Ifedayo olabisi Fasoranti Qasim Olakunle Salau Abiodun John Kareem Juliet Nnenda Olayinka Evbenaye Stanley Obasohan Babatunde David Babalola Adeoye Adeleke Ademuyiwa Foluwakemi Tope Ekogiawe Ikechukwu Sunday Abazu Emmanuel Olasunkanmi Babalola

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