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Development of a semi-quantitative food frequency questionnaire for middle-aged inhabitants in the Chaoshan area, China

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World Journal of Gastroenterology 2005年第26期11卷 4078-4084页

作者： Feng-YanSong TakezakiToshiro KeLi PingYu Xu-KaiLin He-LinYang Xiao-LingDeng Yu-QiZhang Lai-WenLv Xin-EnHuang tajimakazuo DepartmentofPreventiveMedicine ShantouMedicalUniversityShantou515041GuangdongProvinceChina DepartmentofInternationalIslandandCommunityMedicine KagoshimaUniversityGraduateSchoolofMedicalandDentalSciences8-35-1SakuragaokaKagoshima890-8544Japan ShantouDiseasePreventiveandControlCenter Shantou515031GuangdongProvinceChina theBoardofHealthNan'aoCounty Shantou515000GuangdongProvinceChina JiangsuProvinceCancerHospital Nanjing210009JiangsuProvinceChina DivisionofEpidemiologyandPrevention AichiCancerCenterResearchInstituteAichi464-8681NagoyaJapan

AIM:This paper aims to develop a data-based semi-quantitative food frequency questionnaire (SQFFQ) covering both urban and rural areas in the Chaoshan region of Guangdong Province, China, for the investigation of relationships between food intake and lifestyle-related diseases among middle-aged Chinese. METHODS: We recruited 417 subjects from the general population and performed an assessment of the diet, using a 3-d weighed dietary record survey. We employed contribution analysis (CA) and multiple regression analysis (MRA) to select food items covering up to a 90% contribution and a 0.90 R2, respectively. The total number of food items consumed was 523 (443 in the urban and 417 in the rural population) and the intake of 29 nutrients was calculated according to the actual consumption by foods/ recipes. RESULTS: The CA selected 233,194, and 183 foods/recipes for the combined, the urban and the rural areas, respectively, and then 196,157, and 160 were chosen by the MRA. Finally, 125 foods/recipes were selected for the final questionnaire. The frequencies were classified into eight categories and standard portion sizes were also calculated. CONCLUSION: For adoption of the area-specific SQFFQ, validity and reproducibility tests are now planned tc determine how the combined SQFFQ performs in actual assessment of disease risk and benefit.

关键词： Nutrients Weighed diet records Contribution analysis Multiple regression analysis

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Methylenetetrahydrofolate Reductase Genotypes, Dietary Habits and Susceptibility to Stomach Cancer

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Chinese Journal of Clinical Oncology 2004年第3期1卷 162-166页

作者： ChangmingGao TakezakiToshiro JianzhongWu JianhuoDing YantingLiu SupingLi PingSu XuHu TianliongXu HamajimaNobuyuki tajimakazuo DivisionofEpidemiology JiangsuProvinceInstituteofCancerResearchNanjing210009China. DivisionofEpidemiologyandPrevention AichiCancerCenterResearchInstituteNagoya464-8681Japan. PublicHealthCenterofChuzhouDistrict Huaian221300China.

OBJECTIVE To study the relation among methylenetetrahydrofolate reductase (MTHFR) C677T genotypes, dietary habits and the risk of stomach cancer (SC).METHODS A case-control study was conducted with 107 cases of SC and 200 population-based controls in Chuzhou district, Huaian, Jiangsu province, China. The epidemiological data were collected, and DNA of peripheral blood leukocytes was obtained from all of the subjects..MTHFR genotypes were detected by PCR-RFLP. RESULTS (1) The prevalence of the MTHFR C/T or T/T genotypes was found to be significantly different between controls (68.5%) and SC cases (79.4%,P=0.0416), the increased risk had an adjusted OR of 1.79 (95%C1:1.01-3.19). (2) Among subjects who had a low intake of garlic or Chinese onion, MTHFR C/T or T/T genotypes significantly increased the risk of developing SC. Among non-tea drinkers or among subjects who had a frequent intakeof meat, the carriers of the MTHFR C/T or T/T genotypes had a higher risk of SC than individuals with the C/C type MTHFR. CONCLUSION The polymorphism of MTHFR C677T was associated with increased risk of developing SC, and that individuals with differing genotypes may have different susceptibilities to SC, based on their exposure level to environmental factors.

关键词：亚甲基四氢叶酸还原酶基因型饮食习惯易感性胃癌肿瘤

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