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Graphene-incorporated hyaluronic acid-based hydrogel as a controlled Senexin A delivery system

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Biomaterials Translational 2022年第2期3卷 152-161页

作者： Panita Maturavongsadit Weiwei Wu Jingyu Fan Igor B.Roninson taixing cui Qian Wang Department of Chemistry and Biochemistry University of South CarolinaColumbiaSCUSA Department of Cell Biology and Anatomy School of Medicine Columbia University of South CarolinaColumbiaSCUSA Department of Drug Discovery&Biomedical Sciences College of PharmacyUniversity of South CarolinaColumbiaSCUSA

Perivascular delivery of therapeutic agents against established aetiologies for occlusive vascular remodelling has great therapeutic potential for vein graft ***,none of the perivascular drug delivery systems tested experimentally have been translated into clinical *** this study,we established a novel strategy to locally and sustainably deliver the cyclin-dependent kinase 8/19 inhibitor Senexin A(SenA),an emerging drug candidate to treat occlusive vascular disease,using graphene oxide-hybridised hyaluronic acid-based *** demonstrated an approach to accommodate SenA in hyaluronic acid-based hydrogels through utilising graphene oxide nanosheets allowing for non-covalent interaction with *** resulting hydrogels produced sustained delivery of SenA over 21 days with tunable release *** vitro assays also demonstrated that the hydrogels were *** novel graphene oxide-incorporated hyaluronic acid hydrogel offers an optimistic outlook as a perivascular drug delivery system for treating occlusive vascular diseases,such as vein graft failure.

关键词： controlled drug delivery graphene oxide hyaluronic acid-based hydrogel Senexin A

Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers

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Burns & Trauma 2023年第1期11卷 479-496页

作者： Hengyu Du Shenghong Li Jinqiang Lu Lingzhi Tang Xiao Jiang Xi He Jiaji Liang Xuan Liao taixing cui Yuesheng Huang Hongwei Liu Department of Plastic Surgery of the First Affiliated Hospital of Jinan University Institute of New Technology of Plastic Surgery of Jinan UniversityKey Laboratory of Regenerative Medicine of Ministry of EducationGuangzhou 510630P.R.China Dalton Cardiovascular Research Center Department of Medical Pharmacology and PhysiologyUniversity of MissouriSchool of Medicine134 Research Park DrColumbiaMO 65211USA Institute of Wound Repair and Regeneration Medicine Southern University of Science and Technology School of Medicineand Department of Wound RepairSouthern University of Science and Technology HospitalShenzhenGuangdong518055China

Background:Angiogenesis is crucial in diabetic wound healing and is often impaired in diabetic foot ulcers(DFUs).Human dermal microvascular endothelial cells(HDMECs)are vital components in dermal angiogenesis;however,their functional and transcriptomic characteristics in DFU patients are not well *** study aimed to comprehensively analyse HDMECs from DFU patients and healthy controls and find the potential regulator of angiogenesis in ***:HDMECs were isolated from skin specimens of DFU patients and healthy controls via magnetic-activated cell *** proliferation,migration and tube-formation abilities of the cells were then compared between the experimental *** bulk RNA sequencing(bulk-seq)and single-cell RNA-seq(scRNA-seq)were used to identify RAB17 as a potential marker of angiogenesis,which was further confirmed via weighted gene co-expression network analysis(WGCNA)and least absolute shrink and selection operator(LASSO)*** role of RAB17 in angiogenesis was examined through in vitro and in vivo ***:The isolated HDMECs displayed typical markers of endothelial *** isolated from DFU patients showed considerably impaired tube formation,rather than proliferation or migration,compared to those from healthy *** set enrichment analysis(GSEA),fGSEA,and gene set variation analysis(GSVA)of bulk-seq and scRNA-seq indicated that angiogenesis was downregulated in *** regression identified two genes,RAB17 and CD200,as characteristic of DFU-HDMECs;additionally,the expression of RAB17 was found to be significantly reduced in DFU-HDMECs compared to that in the HDMECs of healthy *** of RAB17 was found to enhance angiogenesis,the expression of hypoxia inducible factor-1α and vascular endothelial growth factor A,and diabetic wound healing,partially through the mitogen-activated protein kinase/extracellular signal-regulated kinase signalling ***:Our findings

关键词： Human dermal microvascular endothelial cells Angiogenesis Diabetic foot ulcers RAB17 Single-cell RNA-seq Diabetic wound healing

多维度联合一体化护理对剖宫产产妇角色转换、心理状态及母乳喂养率的影响

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实用妇科内分泌电子杂志 2024年第14期11卷 135-137页

作者：谭翠泰兴市人民医院产科江苏泰兴225400

目的探讨多维度联合一体化护理对剖宫产产妇角色转换、心理状态及母乳喂养率的影响。方法选择剖宫产产妇100例为研究对象,依据数字随机表法分为对照组及观察组,每组50例。对照组采用常规护理,观察组采用多维度联合一体化护理。对两组产... 详细信息

目的探讨多维度联合一体化护理对剖宫产产妇角色转换、心理状态及母乳喂养率的影响。方法选择剖宫产产妇100例为研究对象,依据数字随机表法分为对照组及观察组,每组50例。对照组采用常规护理,观察组采用多维度联合一体化护理。对两组产妇角色转换情况、心理状态及母乳喂养率进行比较。结果护理后,观察组各项角色转换评分及各项心理状态评分均优于对照组(P<0.05)。观察组纯母乳喂养率为82.00%,高于对照组的64.00%,人工喂养率为6.00%,低于对照组的22.00%(P<0.05)。结论剖宫产产妇接受多维度联合一体化护理,能有效促进角色转换,改善心理状态,提高母乳喂养率,值得临床推广使用。

关键词：多维度护理一体化护理剖宫产产妇角色转换心理状态母乳喂养率

某双管同沟敷设管线阴极保护系统干扰防护数值模拟研究

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材料保护 2024年第6期57卷 175-185,198页

作者：陈帅李洪福罗小武肖会会时彦杰罗泰星刘艳明王晨吕祥鸿崔光磊西安石油大学材料科学与工程学院陕西西安710065 中国石油新疆油田油气储运分公司新疆克拉玛依834000 东北大学资源与土木工程学院辽宁沈阳110819 东北大学辽宁省深部工程与智能技术重点实验室辽宁沈阳110819

为明确同沟敷设管道阴极保护系统相互干扰规律及干扰防护措施,以新疆油田某双管同沟敷设管道(D219和D457)为模型,设置D219管道的涂层破损率为0.1%,D457管道的涂层破损率为0.1%、0.5%、1.0%,采用数值模拟方法对不同阴极保护设计及阴极保... 详细信息

为明确同沟敷设管道阴极保护系统相互干扰规律及干扰防护措施,以新疆油田某双管同沟敷设管道(D219和D457)为模型,设置D219管道的涂层破损率为0.1%,D457管道的涂层破损率为0.1%、0.5%、1.0%,采用数值模拟方法对不同阴极保护设计及阴极保护干扰防护措施的有效性及适用性进行评估。结果表明:采用浅埋阳极单独阴极保护的同沟敷设管道存在阴极保护系统相互干扰,随着干扰管道D457防腐层破损率的增加,其对并行管道D219的干扰程度增强,施加均压线措施可有效降低干扰;采用浅埋阳极联合阴极保护+均压线措施可消除同沟敷设管道阴极保护系统的相互干扰,当双管同沟管道防腐层破损率相差较大(D2190.1%,D4571.0%)时,改善效果较为显著;对于采用深井阳极联合阴极保护的同沟敷设管道,当D457防腐层破损率较大(1.0%)、土壤电阻率较高(50Ω·m)时,其阴极保护效果较差,采用均压线+牺牲阳极措施对阴极保护效果的改善作用不明显,而增大深井阳极输出电流联合均压线措施可显著改善同沟敷设管道的阴极保护效果。

关键词：双管线平行敷设直流干扰阴极保护排流保护数值模拟

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压应力对非饱和土渗透系数的影响

上海交通大学学报 2004年第6期38卷 982-986页

作者：徐永福叶翠明赵书权夏小和上海交通大学土木工程系上海200030 江苏省泰兴市新型建筑房地产开发公司泰兴225400 江苏省泰兴市扬子房地产开发公司泰兴225400

针对环境工程和岩土工程中非饱和土常常受到各种形式的应力,分析了压应力对渗透系数的影响,并从土体孔隙分布的分形模型导出非饱和土渗透系数的表达式.实验结果表明,孔隙分布的分维值不受压应力影响,但压应力会引起饱和土的渗透系数和... 详细信息

针对环境工程和岩土工程中非饱和土常常受到各种形式的应力,分析了压应力对渗透系数的影响,并从土体孔隙分布的分形模型导出非饱和土渗透系数的表达式.实验结果表明,孔隙分布的分维值不受压应力影响,但压应力会引起饱和土的渗透系数和非饱和土的进气值的改变,从而影响非饱和土的渗透系数.

关键词：非饱和土压应力透水性土体

DETERMINATIONS OF THE BIOCHEMISTRY FOR CYTOPLASMIC MALE-STERILITY AND THE GENETICS FOR THEIR RESTORATION IN MAIZE （Zea mays L.）

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Science in China,Ser.B 1987年第3期30卷 283-296页

作者：曾孟潜杨太兴魏建昆崔汝镜 Institute of Genetics Academia Sinica Beijing Hebei Provincial Academy of Agricultural Sciences Shijiazhuang

On the basis of a group of 'homonucleo-hetero cytoplasmic lines' being budded, C103-cms-T, C103-cms-M, C103-cms-C, C103-cms-17A, C103-cms-19A, C103-cms-21A, C103-cms-22A and C103 （NormalCytoplasm）, the biochemical analyses of anthers have been carried out, showing that mere aspartic acid andless methionine, lysine and proline are contained in CMS lines than in normal line C103 （the maintain-er） while the contents of α-amylase, esterase and peroxidase isozymes in CMS lines are significantly dif-ferent from those in their maintainer. The genetic determination for restoration of the CMS lines indi-cates that types T, S（M）, C, 21A can be distinguished from each other by using normal lines N6, 74-21, 525 as tester in subsequent test-cross. In addition, the correspondence relationship between the dataof biochemical and genetic determinations has also been observed. Therefore, the method of biochemicalanalysis could be used as a supplementary approach to the conventional test-cross method.

关键词： Zea mays L DETERMINATIONS OF THE BIOCHEMISTRY FOR CYTOPLASMIC MALE-STERILITY AND THE GENETICS FOR THEIR RESTORATION IN MAIZE

Anterolateral thigh free flap for simultaneous reconstruction of digital extensor tendon and defect of the dorsal hand： A case report

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Chinese Journal of Traumatology 2016年第5期19卷 309-310页

作者： Man-Yi cui Hui Shen Burns and Plastic Surgery Department Taixing People's Hospital Taixing 225400 China

This paper describes a new technique in the repair of the hand defect with digital extensor tendon injury. The anterolateral thigh flap with the thick femoral fascia has been used in the reconstruction of the composite defect of the dorsal hand, especially the defect of tendon. This technique requires short period of treatment and hence causes less damage to the donor site but shows a better recovery of the hand function. A favorable curative effect has been obtained in this patient.

关键词： Free tissue flaps Tendons Hand Reconstructive surgical procedures

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“太行山”名义考

山西师大学报（社会科学版） 2011年第2期38卷 85-89页

作者：崔建华中国人民大学国学院北京100872

"太行山"的"行"字原本读作xing。"太行"与"五行"有关,意思是天帝的活动,而太行山就是天帝活动的场所。由于前往天帝身边,实际上意味着死亡。因此,后世又以"大(太)行"来表示死亡的含义。传说墓葬中出现的"大行伯"形象,是太行山的主神,他... 详细信息

"太行山"的"行"字原本读作xing。"太行"与"五行"有关,意思是天帝的活动,而太行山就是天帝活动的场所。由于前往天帝身边,实际上意味着死亡。因此,后世又以"大(太)行"来表示死亡的含义。传说墓葬中出现的"大行伯"形象,是太行山的主神,他的作用是引导亡灵升天。历史上出现的"大行人"、"大行令"职官与"大行伯"的职责具有共通性,它们的含义来源均与"太行山"有关。

关键词：太行山五行帝都之山大行伯

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突发疫情远程智能防控诊断平台设计的研究

中国医疗设备 2020年第6期35卷 97-99,116页

作者：高长曌袁太兴崔晶蕾李洪军王辉王中山刘景鑫吉林大学中日联谊医院吉林长春130033 吉林省医学影像工程技术研究中心吉林长春130033

目的建立基于人工智能的远程智能防控诊断平台,可对突发疫情开展预防、诊断、科研和随访等全流程信息服务。方法基于国家重点研发计划项目建立的医学影像质控互认共享云平台,采用人工智能与图像处理技术,研究用于CT影像质控的量化统计... 详细信息

目的建立基于人工智能的远程智能防控诊断平台,可对突发疫情开展预防、诊断、科研和随访等全流程信息服务。方法基于国家重点研发计划项目建立的医学影像质控互认共享云平台,采用人工智能与图像处理技术,研究用于CT影像质控的量化统计分析法、用于DR影像的自动检测法。结果平台实现了影像分析处理、影像互认共享、影像智能质控、新型冠状病毒肺炎(Coronavirus Disease 2019,COVID-19)影像智能诊断以及在线教学培训等功能。结论平台可以开展COVID-19影像远程辅助诊断、提升工作效率,有利于做到早发现、早报告、早隔离、早治疗。

关键词：医学影像新型冠状病毒肺炎智能诊断人工智能