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Efficacy of praziquantel in the treatment of Schistosoma haematobium infection among school-age children in rural communities of Abeokuta, Nigeria

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Infectious Diseases of Poverty 2014年第1期3卷 286-293,285页

作者： Olusola ojurongbe Olawunwi Risqat Sina-Agbaje Abass Busari Patricia Nkem Okorie taiwo adetola ojurongbe Akeem Abiodun Akindele Department of Medical Microbiology and Parasitology Ladoke Akintola University of TechnologyOsogboNigeria Department of Medical Microbiology and Parasitology General HospitalIjayeAbeokutaNigeria Department of Medical Laboratory Services Olikoye Ransome-Kuti HospitalAbeokutaNigeria Institute for Advanced Medical Research and Training College of MedicineUniversity of IbadanIbadanNigeria Department of Mathematical and Physical Sciences Osun State UniversityOsogboNigeria

Background:Chemotherapy with praziquantel(PZQ)has been the cornerstone of schistosomiasis control over the last two *** the only available drug for the treatment of over 200 million people worldwide,continuous monitoring of PZQ efficacy under the pressure of widespread use is therefore ***:The efficacy of taking two doses of oral PZQ for the treatment of Schistosoma haematobium was examined among school children in *** specimens were collected from 350 school children and examined using the filtration *** was collected for packed cell volume(PCV)estimation,and the weight and height of each child were *** egg positive pupils were treated with two oral doses of PZQ at 40 mg/kg with a four-week interval in *** efficacy was determined based on the egg reduction rate(ERR).Results:Among 350 school children,245(70.0%)-of which 132 were males and 113 were females,with an age range of 4 to 15 years-were diagnosed with *** the 245 infected children received a single oral dose of 40 mg/kg PZQ twice with a four-week interval in between and were followed up for 12 *** four,eight and twelve weeks post treatment,the ERR was 57.1%,77.6%and 100%,*** ERR was significantly higher among the children with a light infection compared to those with a heavy *** hundred and twenty-one children were egg negative at four weeks post treatment,among which 1(6.3)and 120(52.4%)had heavy and light infections,*** the second round of treatment,the cure rate at eight weeks and twelve weeks was 85.3%and 100%,***:This study demonstrated the efficacy of taking two doses of oral PZQ for the treatment of urinary schistosomiasis among school children in Nigeria.

关键词： Urinary schistosomiasis Praziquantel Drug efficacy School children Nigeria

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Stability Analysis of an SIR Epidemic Model with Non-Linear Incidence Rate and Treatment

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Open Journal of Modelling and Simulation 2015年第3期3卷 104-110页

作者： Olukayode Adebimpe Kehinde Adekunle Bashiru taiwo adetola ojurongbe Department of Industrial Mathematics Landmark University Omuaran Nigeria Department of Mathematical and Physical Science Osun State University Osogbo Nigeria

We consider a SIR epidemic model with saturated incidence rate and treatment. We show that if the basic reproduction number, R0 is less than unity and the disease free equilibrium is locally asymptotically stable. Moreover, we show that if R0 > 1, the endemic equilibrium is locally asymptotically stable. In the end, we give some numerical results to compare our model with existing model and to show the effect of the treatment term on the model.

关键词： SIR Epidemic Model Basic Reproduction Number Local Stability Treatment Saturated Incidence Rate

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