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Pyloric-gland metaplasia may be an origin of cancer and intestinal metaplasia with possible CDX2 expression

Gastroenterology Report 2021年第4期9卷 370-373,I0003页

作者： Kazuyoshi Yagi Atsunori Tsuchiya Satoru Hashimoto taisuke kato Osamu Onodera Shuji Terai Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalNiigataJapan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigataJapan Department of System Pathology for Neurological Disorders Brain Science BranchBrain Research InstituteNiigata UniversityNiigataJapan Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Introduction The majority of cases of gastric cancer are thought to develop due to chronic inflammation from Helicobacter pylori(***)infection leading to intestinal metaplasia,termed the intestinal metaplasia–dysplasia–cancer sequence[1].Chronic inflammation from *** infection causes mucin core protein 6-positive(MUC6t)pyloric-gland metaplasia;however,its origin is *** MUC6t pyloric-gland metaplasia is similar to spasmolytic polypeptide-expressing metaplasia in mouse studies[2–4].

关键词：肠上皮化生幽门腺 Helicobacter CDX2

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Cats as a potential source of emerging influenza virus infections

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Virologica Sinica 2015年第3期30卷 221-223页

作者： taisuke Horimoto Fumihiro Gen Shin Murakami Kiyoko Iwatsuki-Horimoto Kentaro kato Masaharu Hisasue Masahiro Sakaguchi Chairul A. Nidom Yoshihiro Kawaoka Department of Veterinary Microbiology University of Tokyo Division of Virology Institute of Medical Science University of Tokyo National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary Medicine Department of Internal Medicine II Azabu University Department of Veterinary Microbiology I Azabu University Avian Influenza Research Center Airlangga University

Dear Editor,Historically,the influenza virus has not been regarded as a major pathogen of ***,since 2003,natural infections of domestic cats with highly pathogenic H5N1 avian virus causing fatal cases have been reported(Songserm et al.,2006;Yingst et al.,2006;Klopfleisch et al.,2007).Furthermore,infections of this animal with A(H1N1)pdm09 virus,causing respiratory illness with some fatal cases,have also been reported in various parts

关键词： pathogenic avian fatal illness causing seasonal serological emerging chicken clade

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Characterization of a recombinant Akabane mutant virus with knockout of a nonstructural protein NSs in a pregnant goat model

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Virologica Sinica 2016年第3期31卷 274-277页

作者： Akiko Takenaka-Uema Norasuthi Bangphoomi Chieko Shioda Kazuyuki Uchida Fumihiro Gen Kentaro kato Takeshi Haga Shin Murakami Hiroomi Akashi taisuke Hoimoto Department of Veterinary Microbiology Graduate School of Agricultural and Life SciencesThe University of Tokyo Department of Infection Control and Disease Prevention Graduate School of Agricultural and Life SciencesThe University of Tokyo Department of Preclinical and Applied Animal Science Faculty of Veterinary ScienceMahidol University Department of Veterinary Pathology Graduate School of Agricultural and Life SciencesThe University of Tokyo National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary Medicine

Dear Editor,Akabane virus(AKAV),an orthobunyavirus,is transmitted primarily by biting midges and is widely distributed throughout the world except the *** was first isolated from mosquitoes in Japan(Oya et al.,1961).Although pregnant cows,ewes,and goats infected with AKAV exhibit no clinical signs of disease,in utero infections result in abortion,premature birth,stillbirth。

关键词： pregnant mutant abortion premature birth primarily vaccine throughout removed inoculated

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Induction chemotherapy with docetaxel,cisplatin and fluorouracil followed by concurrent chemoradiotherapy for unresectable sinonasal undifferentiated carcinoma: Two cases of report

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World Journal of Clinical Cases 2019年第6期7卷 765-772页

作者： Sho Watanabe Yoshitaka Honma Naoya Murakami Hiroshi Igaki taisuke Mori Hidekazu Hirano Natsuko Okita Hirokazu Shoji Satoru Iwasa Atsuo Takashima Ken kato Kenya Kobayashi Fumihiko Matsumoto Seiichi Yoshimoto Jun Itami Narikazu Boku Department of Head and Neck Medical Oncology National Cancer Center Hospital Department of Radiation Oncology National Cancer Center Hospital Department of Pathology and Clinical Laboratories National Cancer Center Hospital Department of Gastrointestinal Medical Oncology National Cancer Center Hospital Department of Head and Neck Surgery National Cancer Center Hospital

BACKGROUND Sinonasal undifferentiated carcinoma(SNUC) is a rare aggressive tumor that is often unresectable. Optimal treatment for patients with unresectable,locally advanced SNUC(LA-SNUC) has not been established,and the patient outcome remains poor. We report two cases of unresectable LA-SNUC in which induction chemotherapy with docetaxel,cisplatin and fluorouracil(TPF) followed by radiotherapy with concurrent cisplatin(CCRT),a standard treatment option for locally advanced head and neck cancer,demonstrated promising *** SUMMARY A 39-year-old man presented with tearing and pain in the right eye. A biopsy of the tumor invading the sinonasal cavities,right orbit and cranial base confirmed the diagnosis of LA-SNUC. Induction TPF chemotherapy induced remarkable tumor shrinkage and rapidly improved the symptoms. He subsequently received CCRT and achieved complete remission of the disease. The other case is a 21-year-old man who presented with worsening vision. The unresectable tumor involving the nasal septum and cranial base was pathologically diagnosed as SNUC. TPF chemotherapy followed by CCRT yielded complete remission of the disease with preserved visual function. Both patients have been disease-free for44 *** Induction TPF chemotherapy followed by CCRT may remarkably improve the outcomes in LA-SNUC patients.

关键词： Sinonasal undifferentiated carcinoma Chemotherapy with docetaxel, cisplatin and fluorouracil chemotherapy Docetaxel Cisplatin Fluorouracil Intensity-modulated radiotherapy Chemoradiotherapy Case report

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A Study on Improvement of RANS Analysis for Erosion of Density Stratified Layer of Multicomponent Gas by Buoyant Jet in a Containment Vessel

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Journal of Energy and Power Engineering 2015年第7期9卷 599-607页

作者： Satoshi Abe Masahiro Ishigaki Yasuteru Sibamoto taisuke Yonomoto Thermalhydraulic Safety Research Group Nuclear Safety Research Center Japan Atomic Energy Agency Ibaraki 319-1195 Japan

The analysis on a density stratification layer consisting of multiple gases in the reactor containment vessel is important for the safety assessment of sever accidents. The JAEA （Japan Atomic Energy Agency） has started the project on the containment thermal hydraulics. We carried out CFD （computational fluid dynamics） analyses in order to investigate the erosion of the density stratification layer by a vertical buoyant jet under this project. We used the RANS （Reynolds averaged numerical simulation） and LES （large eddy simulation） models to analyze the erosion of a density stratification layer by a vertical buoyant jet in a small vessel which represents a containment vessel. This numerical study calculates the turbulent mixing of a two-component （air and helium） gas mixture. The turbulence models used for the RANS analyses are two types of k-ε models. The first model is the low Reynolds number k-ε model developed by Launder and Sharma. The second model is modified from the first model in order to accurately consider the turbulent production and damping in a stratification layer. The results indicated while the erosion rate calculated by the low-Re k-ε model was much faster than that of the LES model, the modified k-ε model could calculate the erosion rate similar to the LES result.

关键词： Density stratification layer containment vessel CFD kato-Launder modification Katsuki model

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