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Current Medical Science 2020年第3期40卷 539-547页

作者： Hou-gang LI Peng-tao YOU Yu XI Yu CAI Yi-jun TU Meng-heng WANG Wan-ci SONG tai-min quan Hui-ying REN Yan-wen LIU Han-xiong DAN Shi-qing XU Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine Hubei University of Chinese MedicineWuhan430065China College of Pharmacy Hubei University of Chinese MedicineWuhan430065China Wuhan Junan Pharmaceutical Co. Ltd.Wuhan430023China

Yu Gan Long(YGL)is a Chinese traditional herbal formula which has been reported to attenuate liver fibrosis for many years and we have explored its anti-fibrotic mechanism through blocking transforming growth factor(TGF-β)in the previous *** the mechanisms associated with platelet-derived growth factor(PDGF)-BB remain *** this study,we further investigated the mechanism of YGL reducing carbon tetrachloride(CCl4)-induced liver fibrosis in *** results showed that YGL suppressed CCl4-induced upregulation of collagen IV(Col IV),type HI precollagen(PCHI),hyaluronuc acid(HA)and laminin(LN),which are implicated in liver ***,YGL reduced theα-smooth muscle actin(α-SMA)expression,which acts as the indicator of liver ***,YGL decreased the serum levels of hepatic stellate cell(HSC)mitogen PDGF-BB and inflammation cytokines,including TNF-α,IL-1β,*** involved in liver fibrosis,such as Ras,p-Raf-1,p-ERK1/2,p-JNK,p-P38,p-PI3K,p-AKT,p-JAKl,p-STAT3 were downregulated significantly after treatment with *** results indicated that YGL ameliorated CCl4-induced liver fibrosis by reducing inflammation cytokines production,and suppressing Ras/ERK,PI3K/AKT,and JAK1/STAT3 signaling pathways,which provided further evidence towards elucidation of the anti-fibrotic mechanism of YGL.

关键词： Yu Gan Long traditional Chinese herbal therapy liver fibrosis Ras/ERK PI3K/AKT JAK1/STAT3

Experimental and numerical study on protective effect of RC blast wall against air shock wave

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Defence Technology（防务技术） 2024年第1期31卷 567-579页

作者： Xin-zhe Nian quan-min Xie Xin-li Kong Ying-kang Yao Kui Huang State Key Laboratory of Precision Blasting Jianghan UniversityWuhan430056China Hubei Key Laboratory of Blasting Engineering Jianghan UniversityWuhan430056China Hubei(Wuhan)Institute of Explosion and Blasting Technology Jianghan UniversityWuhan430056China College of Defense Engineering Army Engineering University of PLANanjing210007China Institute of Defense Engineering AMSPLALuoyang471023China

Prototype experiments were carried out on the explosion-proof performance of the RC blast *** mass of TNT detonated in the experiments is 5 kg and 20 kg *** shock wave overpressure was tested in different *** above experiments were numerically simulated,and the simulated shock wave overpressure waveforms were compared with that tested and given by CONWEP *** results show that the numerically simulated waveform is slightly different from the test waveform,but similar to CONWEP *** dimensional analysis and numerical simulation under different working conditions,the equation for the attenuation rate of the diffraction overpressure behind the blast wall was *** to the corresponding standards,the degree of casualties and the damage degree of the brick concrete building at a certain distance behind the wall can be determined when parameters are *** above results can provide a reference for the design and construction of the reinforced concrete blast wall.

关键词： Blast wall Shock wave Diffraction Overpressure Protection

Matrix metalloproteinase 2 degrades collagen I to regulate ovarian development by association with an insulin-like peptide

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Insect Science 2024年第4期31卷 1090-1106页

作者： Yi Wei Xiao-Lin Zhou Peng Chen tai-Hang Liu Cheng Lu min-Hui Pan State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqingChina Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural ministry Southwest UniversityChongqingChina Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang ProvinceChina

The ovary generally undergoes tissue remodeling during larval to pupal transition,which includes membrane degeneration and ovariole *** the same time,the hormones produced by insects significantly change during ***,the regulatory mechanism for ovarian development and hormones is not fully understood in ***,we found that matrix metalloproteinase 2(MMP2)was highly expressed in the ovarian capsules and ovarioles,and the development was abnormal after knocking out MMP2 in Bombyx *** process of abnormal degradation of collagen I due to MMP2 deletion,which resulted in abnormal development of ovarioles and eggs,was analyzed in *** proteomics of ovaries in the MMP2-knock out and wild type strains showed a critically significant difference in the expression of a protein,insulin-like peptide(ILP).Additional analysis revealed significant alteration of ILP during ovarian development,and abnormal expression of ILP significantly affected ovarian development in vivo and MMP2 expression in vitro and in *** results showed that MMP2 regulation of ovarian tissue remodeling is closely related to ILP *** study provides new insights into the regulatory mechanism of MMP2 and ovarian development in ***.

关键词： Bombyx mori collagen I insulin-like peptide matrix metalloproteinase ovarian development

Constructing energetic covalent organic frameworks with high stability and low sensitivity

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Chinese Chemical Letters 2024年第3期35卷 544-548页

作者： Hui-min Guo Xiao-Yu Dong Shan Wang Qian-You Wang Shuang-quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Green Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China

Developing new functional explosives that display high stability,good energy performance,and low sensitivity are one of the key directions of energetic materials *** this work,two-dimensional(2D)Schiff-based energetic covalent organic frameworks(COFs)are prepared based on triaminoguanidine salts with different anions as building *** from the robust covalent bond in 2D extended polygons and strongπ-πinteractions in the eclipsed interlayers,the synthesized energetic COFs showed higher thermal stability and lower mechanical sensitivity than their precursor *** importantly,incorporating triaminoguanidine salts into COFs effectively increase the corrosion resistance to metal under high humidity conditions,which is due to the imine moieties in COFs functioning asπacceptors and offering strong bonding with metallic *** work provides a new pathway for the development of high-performance energetic materials.

关键词： Covalent organic frameworks Energetic materials High thermal stability Low sensitivity Corrosion resistance

In Situ Atomic Reconstruction Engineering Modulating Graphene-Like MXene-Based Multifunctional Electromagnetic Devices Covering Multi-Spectrum

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Nano-Micro Letters 2024年第9期16卷 247-261页

作者： Ting‑Ting Liu Qi Zheng Wen‑Qiang Cao Yu‑Ze Wang min Zhang quan‑Liang Zhao Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Department of Physics Beijing Technology and Business UniversityBeijing 100048People’s Republic of China School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144People’s Republic of China

With the diversified development of big data,detection and precision guidance technologies,electromagnetic(EM)functional materials and devices serving multiple spectrums have become a hot *** the multispectral response of materials is a challenging and meaningful scientific *** this study,MXene/TiO_(2)hybrids with tunable conduction loss and polarization relaxation are fabricated by in situ atomic reconstruction *** importantly,MXene/TiO_(2)hybrids exhibit adjustable spectral responses in the GHz,infrared and visible spectrums,and several EM devices are constructed based on *** antenna array provides excellent EM energy harvesting in multiple microwave bands,with|S11|up to−63.2 dB,and can be tuned by the degree of *** ultra-wideband bandpass filter realizes a passband of about 5.4 GHz and effectively suppresses the transmission of EM signals in the *** infrared stealth device has an emissivity of less than 0.2 in the infrared spectrum at wavelengths of 6-14μ*** work can provide new inspiration for the design and development of multifunctional,multi-spectrum EM devices.

关键词： Graphene-like MXene hybrids Multi-spectral response Multi-function antenna Ultra-wideband bandpass filter Electromagnetic device

A novel method for extracting and optimizing the complex permittivity of paper-based composites based on an artificial neural network model

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Science China Technological Sciences 2024年第10期67卷 3190-3204页

作者： XIA ChenBin SHEN JunYi LIAO ShaoWei WANG Yi HUANG ZhengSheng XUE quan TANG min LONG Jin HU Jian School of Light Industry and Engineering South China University of Technology School of Electronic and Information Engineering South China University of Technology

Measuring the complex permittivity of ultrathin, flexible materials with a high loss tangent poses a substantial challenge with precision using conventional methods, and verifying the accuracy of test results remains difficult. In this study, we introduce a methodology based on a back-propagation artificial neural network(ANN) to extract the complex permittivity of paper-based composites(PBCs). PBCs are ultrathin and flexible materials exhibiting considerable complex permittivity and dielectric loss tangent. Given the absence of mature measurement methods for PBCs and a lack of sufficient data for ANN training, a mapping relationship is initially established between the complex permittivity of honeycomb-structured microwave-absorbing materials(HMAMs, composed of PBCs) and that of PBCs using simulated data. Leveraging the ANN model, the complex permittivity of PBCs can be extracted from that of HMAMs obtained using standard measurement. Subsequently, two published methods are cited to illustrate the accuracy and advancement of the results obtained using the proposed approach. Additionally, specific error analysis is conducted, attributing discrepancies to the conductivity of PBCs, the homogenization of HMAMs, and differences between the simulation model and actual objects. Finally, the proposed method is applied to optimize the cell length parameters of HMAMs for enhanced absorption performance. The conclusion discusses further improvements and areas for extended research.

关键词： paper-based composite honeycomb complex permittivity artificial neural networks inverse modeling

Design and fabrication of self-suspending aluminum-plastic/semiconductor photocatalyst devices for solar energy conversion

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Journal of Environmental Sciences 2024年第2期136卷 615-625页

作者： Zhi-Ang Zhao Jingyun Mao Chengjing Lu Shuangqiao Yang Qingrong Qian Qinghua Chen Hun Xue Xiaoli Sun min-quan Yang College of Environmental and Resource Sciences College of Carbon Neutral Modern IndustryFujian Key Laboratory of Pollution Control and Resource ReuseFujian Normal UniversityFuzhou 350007China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengdu 610065China

The design and synthesis of self-suspending photocatalyst device with easy recyclability is important for practical ***,this work utilizes aluminum-plastic package waste as raw material to prepare an aluminum-plastic supported TiO_(2)(AP-TiO_(2))photocatalyst device through 3D printing design and surface deposition method.A series of characterizations were carried out to explore the structure,morphology and performance of the AP-TiO_(2)*** UV light illumination,the AP-TiO_(2)-50 efficiently degrade 93.6%tetracycline hydrochloride(THC)after 4 hr,which increases by 8.3%compared with that of TiO_(2)powder suspension system with the same catalyst *** on it,AP-ZnO,AP-CdS,AP-g-C_3N_4and AP-Pt-TiO_(2)are also fabricated,and applied in photocatalytic degradation and hydrogen evolution,which all exhibit higher photoactivities than powder suspension *** work provides a new avenue for the fabrication of advanced recyclable photocatalyst ***,the work offers a novel sight for the high-value utilization of aluminum-plastic package waste,which has positive implications for environmental protection.

关键词： TiO_(2) Self-suspending Photocatalyst device Aluminum plastic

Top-quark rare decays with flavor violation

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Chinese Physics C 2024年第9期48卷 68-81页

作者： ming-Yue Liu Shu-min Zhao Song Gao Xing-Yu Han tai-Fu Feng Department of Physics Hebei UniversityBaoding 071002China Hebei Key Laboratory of High-precision Computation and Application of quantum Field Theory Baoding 071002China Hebei Research Center of the Basic Discipline for Computational Physics Baoding 071002China Department of Physics Chongqing UniversityChongqing 401331China

In the present study,we investigated the decays of the top quark:t→cy,t→cg,t→cZ,and t→*** are extremely rare processes in the standard model(SM).As the U(1)extension of the minimal supersymmetric standard model(MSSM),the U(1)_X SSM features new superfields such as the right-handed neutrinos and three Higgs *** analyzed the effects of different sensitive parameters on the results and made reasonable theoretical predictions,thereby providing a useful reference for future experimental *** the constraint set by the updated experimental data,the numerical results show that the branching ratios of the four proccsscs,i.e.,t→cγ,cg,cZ,ch,can reach the same order of magnitude as their experimental upper *** them,tanβhas the most evident effect on these processes and is the main parameter;g_(X),g_(YX),μ,M_(2),λ_(H),M_(U23)^(2),and M_(Q23)^(2) are also important parameters for the processes,and have effects on the numerical results.

关键词： Top quark flavor violation U(1)_(X)SSM new physics

Revealing the Structure-Property Difference of Natural Rubber Prepared by Different Methods: Protein and Gel Content are Key Factors

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Chinese Journal of Polymer Science 2024年第4期42卷 457-467页

作者： Shao-Qi Huang Jun-Qi Zhang Yong Zhu Ling-min Kong Lu-Sheng Liao Fu-quan Zhang Zheng-Tian Xie Jin-Rong Wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China Hainan Provincial Key Laboratory of Natural Rubber Processing Agricultural Products Processing Research Institute of Chinese Academy of Tropical Agricultural SciencesZhanjiang524001China

Natural rubber (NR) is widely used in various fields including aerospace, military industry and transportation due to its superior elasticity and comprehensive mechanical properties. Nonetheless, the commercial NR prepared by different methods usually exhibits different mechanical properties, primarily due to variations in processing conditions during the conversion from latex to bulk rubber material. Consequently, this poses challenges in scientific research and industrial production of NR. In order to assess the properties of various commercially available NR and identify key structural and compositional components, this study systematically compares and analyzes four representative NR raw materials: air dried sheet (ADS), ribbed smoked sheets (RSS), constant viscidity NR (CV), and whole field latex rubber (WF). The investigation focuses on evaluating their static mechanical behavior, SIC behavior, wear resistance, and fatigue resistance. The findings indicate that protein and gel content exhibit a crucial influence on the NR properties. These constituents contribute to the formation of a high-crosslinking density region, generating a heterogeneous network structure within the rubber. This structure amplifies strains during deformation, leading to earlier and stronger strain-induced crystallization (SIC). Among the four commercial NR brands, RSS demonstrates superior overall mechanical and dynamic properties owing to its high protein and gel content. This study serves as a valuable reference for comprehending the differences in properties among various commercial NR, thereby offering guidance for the actual processing and selection of NR.

关键词： Natural rubber Processingmethod Protein Gel content Property

Asymptomatic low-grade appendiceal mucinous neoplasm:A case report

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World Journal of Clinical Cases 2024年第2期12卷 361-366页

作者： min-quan Yao Yu-Peng Jiang Yuan-Yu Wang Yi-Ping Mou Jin-Xing Fan Department of Gastrointestinal Surgery Tongxiang First People’s HospitalJiaxing 314500Zhejiang ProvinceChina Department of General Surgery Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Endoscopy Center Tongxiang First People’s HospitalJiaxing 314500Zhejiang ProvinceChina

BACKGROUND Low-grade appendiceal neoplasms(LAMN)are characterized by low incidence and atypical clinical presentations,often leading to misdiagnosis as acute or chronic appendicitis before *** primary diagnostic tool for LAMN is abdominal computed tomography(CT)*** resection remains the cornerstone of LAMN management,necessitating en bloc tumor excision to minimize the risk of iatrogenic ***,known for its minimal invasiveness,reduced postoperative discomfort,and expedited recovery,is a safe and reliable approach for LAMN *** the possibility of pseudomyxoma peritonei development,appendectomy and partial appendectomy generally result in negative tumor margins and favorable outcomes,which can be attributed to the disease’s slow growth and lower *** SUMMARY A 71-year-old male patient was admitted to our hospital with a pelvic spaceoccupying lesion detected 1 mo *** examination showed a soft abdomen without tenderness or rebound and no palpable *** shifting dullness was noted,and digital rectal examination revealed no palpable *** revealed a raised,smooth-surfaced mass measuring 3.0 cm in the *** contrast-enhanced CT showed a markedly thickened and dilated appendix with visible cystic *** surgery was performed and revealed a significantly dilated appendix,leading to laparoscopic resection of the appendix and part of the ***-surgical pathologic analysis confirmed *** patient received symptomatic and supportive post-operative care and was discharged on postoperative day 4 without complications such as abdominal bleeding,intestinal obstruction,or incision *** tumor recurrence was observed during a 7-mo follow-up *** LAMN is a rare disease that lacks specific clinical *** CT plays a crucial role in diagnosing LAMN,and laparoscopic surgery is a safe and effective diagnostic and therapeutic approach.

关键词： Low-grade appendiceal mucinous neoplasm Pseudomyxoma peritonei Computed tomography Laparoscopy appendectomy Case report