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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

亚临床甲状腺功能减退与冠状动脉旁路移植术后患者院内治疗相关性研究

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中国循环杂志 2016年第9期31卷 870-873页

作者：王恒李立环姚允泰周程辉方能新陈东中国医学科学院北京协和医学院国家心血管病中心阜外医院麻醉科北京市100037

目的：研究亚临床甲状腺功能减退（简称：亚临床甲减）与冠状动脉旁路移植术（CABG）患者术后治疗的相关性。方法：收集2010-07至2014-03我院同一手术团队1 500例单纯行CABG患者资料,其中亚临床甲减组107例,甲状腺功能正常组1 393例,... 详细信息

目的：研究亚临床甲状腺功能减退（简称：亚临床甲减）与冠状动脉旁路移植术（CABG）患者术后治疗的相关性。方法：收集2010-07至2014-03我院同一手术团队1 500例单纯行CABG患者资料,其中亚临床甲减组107例,甲状腺功能正常组1 393例,经1：4比例倾向性评分匹配后,共104对行CABG患者最终纳入研究。观察项目包括：主动脉内球囊反搏（IABP）置入率、围术期的输血率、机械呼吸辅助时间、新发脑梗死、新发心肌梗死、新发心房颤动、恶性心律失常、急性肾功能不全、院内死亡等事件。本研究比较了经倾向性匹配后的两组术后事件,并对治疗结果进行单因素和多因素分析。结果：经倾向性匹配后,亚临床甲减组的机械辅助呼吸时间明显长于甲状腺功能正常组（23.3±47.9 vs 15.0±5.5,P〈0.05）,机械辅助呼吸时间〉12 h率高于甲状腺功能正常组（89.4%vs 78.8%,P〈0.05）,IABP置入高于甲状腺功能正常组（3.8%vs 0.72%,P〈0.05）,且与亚临床甲减存在相关性[比值比（OR）值分别为2.363及6.126,95%可信区间（95%CI）分别为1.183～4.516及1.190～31.537）。包括院内死亡等其他事件两组差异无统计学意义（P〉0.05）。结论：基于本研究两组资料,亚临床甲减组与机械辅助呼吸时间及IABP置入比率存在相关性。

关键词：甲状腺功能减退症冠状动脉旁路移植术并发症

Micromechanism study on electronic and magnetic properties of silicene regulated by oxygen

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Journal of Materials Science & Technology 2019年第8期35卷 1803-1808页

作者： Li-Ping Ding Peng Shao Lin-tai Yang Wei Guo Sun fang-hui Zhang Cheng Lu College of Elecrical & Information Engineering Shaanxi University of Science & Technology Xi’an 710021 China Department of Physics Nanyang Normal University Nanyang 473061 China Department of Physics and High Pressure Science and Engineering Center University of Nevada Las Vegas NV 89154 United States

Silicene, a two-dimensional(2D) silicon counterpart of graphene with attractive electronic properties, has attracted increasing attention. Understanding of its interaction with oxygen is of fundamental importance for nano-electronics in silicon-based technology. Here, we have systematically studied the structural,electronic and magnetic properties of silicene with oxygen atoms adsorption by using an unbiased structure search method coupled with First-principles calculations. The results show that the most favorable oxygen adsorption site on silicene surface is bridge site and oxygen atoms tend to chemisorb on silicene.A detailed analysis of the electronic band structure and density of state(DOS) suggests that there is a band gap opening near Fermi level after oxygen adsorption, which lead to pristine silicene changing from a gapless semiconductor to a direct or indirect bandgap semiconductor. The important finding is that two and six oxygen atoms adsorbed silicene are more advantageous due to the relatively large direct band gaps at the K point. The calculated magnetic moments and spin density isosurfaces reveal that the total magnetic moments are mostly localized on silicene sheet. This finding provides new insights for further materials design based on two-dimensional silicon systems.

关键词： Silicene CALYPSO method Band gap Oxygen adsorption

IMAGE SEGMENTATION BY PIECEWISE CONSTANT MUMFORD-SHAH MODEL WITHOUT ESTIMATING THE CONSTANTS

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Journal of Computational Mathematics 2006年第3期24卷 435-443页

作者： Xue-cheng tai Chang-hui Yao CIPR Department of Mathematics University of Bergen Norway Department of Mathematics University of Bergen Norway

In this work, we try to use the so-called Piecewise Constant Level Set Method （PCLSM） for the Mumford-Shah segmentation model. For image segmentation, the Mumford-Shah model needs to find the regions and the constant values inside the regions for the segmen- tation. In order to use PCLSM for this purpose, we need to solve a minimization problem using the level set function and the constant values as minimization variables. In this work, we test on a model such that we only need to minimize with respect to the level set function, i.e., we do not need to minimize with respect to the constant values. Gradient descent method and Newton method are used to solve the Euler-Lagrange equation for the minimization problem. Numerical experiments are given to show the efficiency and advantages of the new model and algorithms.

关键词： PCLSM Image Segmentation Mumford-Shah model.

On the Fekete and Szego Problem for Starlike Mappings of Order α

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Acta Mathematica Sinica,English Series 2017年第4期33卷 554-564页

作者： Qing Hua XU fang fang tai Shun LIU College of Mathematics and Information Science JiangXi Normal University Nanchang 330022 P. R. China Department of Mathematics Huzhou University Huzhou 313000 P. R. China

Let Sα*be the familiar class of normalized starlike functions of order α in the unit disk. In this paper, we establish the Fekete and Szeg? inequality for the class Sα*, and then we generalize this result to the un... 详细信息

关键词： Fekete–Szego problem starlike mappings of order α sharp coefficient bound

Cross-Entropy Loss for Recommending Efficient Fold-Over Technique

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Journal of Systems Science & Complexity 2021年第1期34卷 402-439页

作者： WENG Lin-Chen ELSAWAH A M fang Kai-tai Division of Science and Technology Beijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519085China Department of Mathematics Faculty of ScienceZagazig UniversityZagazig 44519Egypt The Key Lab of Random Complex Structures and Data Analysis Chinese Academy of SciencesBeijing 100190China

Due to the limited resources and budgets in many real-life projects, it is unaffordable to use full factorial experimental designs and thus fractional factorial(FF) designs are used instead. The aliasing of factorial effects is the price we pay for using FF designs and thus some significant effects cannot be estimated. Therefore, some additional observations(runs) are needed to break the linages among the factorial effects. Folding over the initial FF designs is one of the significant approaches for selecting the additional runs. This paper gives an in-depth look at fold-over techniques via the following four significant contributions. The first contribution is on discussing the adjusted switching levels foldover technique to overcome the limitation of the classical one. The second contribution is on presenting a comparison study among the widely used fold-over techniques to help experimenters to recommend a suitable fold-over technique for their experiments by answering the following two fundamental questions:Do these techniques dramatically lessen the confounding of the initial designs, and do the resulting combined designs(combining initial design with its fold-over) via these techniques have considerable difference from the optimality point of view considering the markedly different searching domains in each technique? The optimality criteria are the aberration, confounding, Hamming distance and uniformity. Many of these criteria are given in sequences(patterns) form, which are inconvenient and costly to represent and compare, especially when the designs have many factors. The third innovation is on developing a new criterion(dictionary cross-entropy loss) to simplify the existing criteria fromsequence to scalar. The new criterion leads to a more straightforward and easy comparison study. The final contribution is on establishing a general framework for the connections between initial designs and combined designs based on any fold-over technique.

关键词： Aberration confounding cross-entropy dictionary ordering fold-over Hamming distance loss function uniformity

Loading single lanthanide ion into aluminum molecular rings:water-stable sodalite cage for removal of nuclear-industry anions

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Science China Chemistry 2023年第5期66卷 1384-1393页

作者： Yi-Fan Sun Ya-Jie Liu San-tai Wang Xiao-Yu Liu Chao Ma Wei-hui fang Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Based on our discovery of neutral aluminum molecular rings,we herein introduce rare earth ions into the center of the ring and reveal their structural *** resulting yoyo-like cationic macrocycles are highly adaptive to guests,creating unusual supramolecular *** first category is stacked with singly oriented rhombohedral channels,which exhibit fast and reversible solvent-triggered molecular motions and structural *** second type of assembly is that yoyo macrocycles and guest molecules form a nested host-guest sodalite cage supramolecular *** is uncommon for guest molecules to be well-defined within cages although caged structures have been *** host-guest interaction discussion reveals the self-adaptation and flexibility of the yoyo *** their good water stability,we investigated their anion exchange *** results show that they have significant exchange capacity for KI/I_(2),ReO_(4)^(-),and MnO_(4)^(-),revealing their potential application in water purification and nuclear waste treatment.

关键词： aluminum molecular ring lanthanide structural adaptability sodalite cage iodine capture

Mixing times in single and multi-orifice-impinging transverse(MOIT) jet mixers with crossflow

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Chinese Journal of Chemical Engineering 2016年第7期24卷 825-831页

作者： Peicheng Luo Yuncui tai Yi fang Hua Wu School of Chemistry & Chemical Engineering Southeast University Nanjing 211189 China Institute for Chemical and Bioengineering Department of Chemistry and Applied Bioscience ETH Zurich 8093 Zurich Switzerland

We study the macromixing behavior of single and multi-orifice-impinging transverse(MOIT) jet mixers with crossflow, in particular, the overall mixing time and the back-splash mixing time of the injected flow with the crossflow, using the PLIF technique. It is found that for a given mixer configuration, there is a critical jet-tocrossflow velocity ratio rcat which the back-splash begins to occur. Further increase in the velocity ratio r leads to sharp increase in the back-splash mixing time, which can offset the intensification of the downstream mixing. The dimensionless overall mixing time decreases as r increases to reach either a plateau or a local minimum, and the corresponding r value represents the optimal velocity ratio roptfor the macromixing. The momentum ratio of the two liquid streams is a key factor determining rcand ropt. For a larger scale mixer, a higher momentum ratio is required to achieve the optimal macromixing with the minimum dimensionless overall mixing time.

关键词： MixingChemical reactorsMixing timeJet mixerPlanar laser induced fluorescence (PLIF)

The largest aluminum molecular rings:Phenol-thermal synthesis,photoluminescence,and optical limiting

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Aggregate 2023年第2期4卷 206-215页

作者： San-tai Wang Ya-Jie Liu Cheng-Cheng Feng Wei-hui fang Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouP.R.China

It is of great interest to modulate the photophysical properties by atomically precise chemical *** incorporation of conjugated ligands into crystalline materials provides a platform for molecular-level interpretation of the structure-activity ***,we reported the phenol-thermal and scale-up synthesis of a new family of remarkably stable aluminum molecular *** are assembled by twenty Al^(Ⅲ) ions with large conjugated ligands and phenols,representing the currently largest sizes(up to 4 nm in diameter)in the field of main group metal oxo *** are not only reaction medium but also auxiliary bridging ligands on the surface of macrocyclic *** addition,they are either parallel to the center of the molecular ring or inserted into the molecular ring,or form dimers/tetramers that bind macrocyclic molecules to form supramolecular *** macrocyclic rings are hydrophobic and ultra-stable,evidenced by retaining their morphology and crystalline when exposed to air for more than a *** with the pristine conjugated ligands,they exhibit coordination-enhanced *** dispersing them into a polydimethylsiloxane(PDMS)matrix,we prepared transparent and flexible PDMS thin films for coupling flexible display and nonlinear optical *** discovery of such atomically precise rings provides a platform for the fine-tuning of photo-related performances.

关键词： aluminum macrocycles optical limiting