检索结果-南通市图书馆

Value of portal hemodynamics and hypersplenism in cirrhosis staging

World Journal of Gastroenterology 2005年第5期11卷 708-711页

作者： Bao-Min Shi Xiu-Yan Wang Qing-Ling Mu tai-huang wu Jian Xu Department of General Surgery Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Center of Ultrasonography Shandong Provincial HospitalJinan 250021Shandong ProvinceChina

AIM: To determine the correlation between portal hemodynamics and spleen function among different grades of cirrhosis and verify its significance in cirrhosis ***: The portal and splenic vein hemodynamics and spleen size were investigated by ultrasonography in consecutive 38 cirrhotic patients with cirrhosis (Child's grades A to C) and 20 normal controls. The differences were compared in portal vein diameter and flow velocity between patients with and without ascites and between patients with mild and severe esophageal varices. The correlation between peripheral blood cell counts and Child's grades was also ***: The portal flow velocity and volume were significantly lower in patients with Child's C (12.25±1.67 cm/s vs 788.59±234 mm/min, respectively) cirrhosis compared to controls (19.55±3.28 cm/s vs 1254.03±410 mm/min,respectively) and those with Child's A (18.5±3.02 cm/s vs1358.48±384 mm/min, respectively) and Child's B (16.0±3.89cm/s vs 1142.23±390 mm/min, respectively)*** with ascites had much lower portal flow velocity and volume (13.0±1.72 cm/s vs 1078±533 mm/min) than those without ascites (18.6±2.60 cm/s vs 1394±354 mm/min).There was no statistical difference between patients with mild and severe esophageal varices. The portal vein diameter was not significantly different among the above *** were significant differences in splenic vein diameter,flow velocity and white blood cell count, but not in spleen size, red blood cell and platelet counts among the various grades of cirrhosis. The spleen size was negatively correlated with red blood cell and platelet counts (r= -0.620and r = -0.8.34, respectively).CONCLUSION: An optimal system that includes parameters representing the portal hemodynamics and spleen function should be proposed for cirrhosis staging.

关键词： Liver cirrhosis Portal vein Splenic vein Hemodynamics Hypersplenism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vascular endothelial growth factor attenuates hepatic sinusoidal capillarization in thioacetamide-induced cirrhotic rats

引用

World Journal of Gastroenterology 2008年第15期14卷 2349-2357页

作者： Hao Xu Bao-Min Shi Xiao-Fei Lu Feng Liang Xing Jin tai-huang wu Jian Xu Department of Hepatobiliary and Pancreas Surgery Shandong Provincial Hospital Clinical College of Shandong University Jinan 25002 l Shandong Province China Department of Vascular Surgery Shandong Provincial Hospital Clinical College of Shandong University Jinan 250021 Shandong Province China

AIM: To investigate the effect of vascular endothelial growth factor (VEGF) transfection on hepatic sinusoidal capillarization. METHODS: Enhanced green fluorescent protein (EGFP)/ VEGF transfection was confirmed by immunofluorescence microscopy and immunohistoche-mistry both in primary hepatocytes and in normal liver. Cirrhotic rats were generated by thioacetamide (TAA) administration and then divided into a treatment group, which received injections of 400 μg of plasmid DNA encoding an EGFP- VEGF fusion protein, and a blank group, which received an equal amount of normal saline through the portal vein. The portal vein pressure was measured in the normal and cirrhotic state, in treated and blank groups. The average number of fenestrae per hepatic sinusoid was determined using transmission electron microscopy (TEM), while the relative abundance of VEGF transcripts was examined by Gene array. RESULTS: Green fluorescent protein was observed in the cytoplasms of liver cells under immunofluorescence microscopy 24 h after transfection with EGFP/VEGF plasmid in vitro. Staining with polyclonal antibodies against VEGF illustrated that hepatocytes expressedimmunodetectable VEGF both in vitro and in vitro. There were significant differences in the number of fenestrae and portal vein pressures between normal and cirrhotic rats (7.40 ± 1.71 vs 2.30 ± 1.16 and 9.32 ± 0.85 cmH2O vs 17.92 ± 0.90 cmH2O, P < 0.01), between cirrhotic and treated rats (2.30 ± 1.16 cmH2O vs 4.60 ± 1.65 and 17.92 ± 0.90 cmH2O vs 15.52 ± 0.93 cmH2O, P < 0.05) and between the treatment group and the blank group (4.60 ± 1.65 cmH2O vs 2.10 ± 1.10 cmH2O and 15.52 ± 0.93 cmH2O vs 17.26 ± 1.80 cmH2O, P < 0.05). Gene- array analysis revealed that the relative abundance of transcripts of VEGF family members decreased in the cirrhotic state and increased after transfection. CONCLUSION: Injection of a plasmid encoding VEGF through the portal vein is an effective method to induce the formation of fenestrae and decre

关键词： Liver cirrhosis Hepatic sinusoid capillari-zation Fenestrae Vascular endothelial growth factor Transmission electrical microscopy Ultrastructure Genearray

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高速铁路采空区桥基沉降变形数值模拟分析

引用

铁道标准设计 2014年第3期58卷 71-76页

作者：黄太武中铁第四勘察设计院集团有限公司武汉430063

通过对采空区桥梁群桩基础沉降进行数值模拟,分析采空区桩基在荷载作用下变形过程及特点,揭示不同工况下的基础变形规律。研究结果表明,基础沉降满足规范要求,沉降主要集中在浅层土地层中;桩间土与桩顶沉降均匀;采空巷道顶板的沉降与地... 详细信息

通过对采空区桥梁群桩基础沉降进行数值模拟,分析采空区桩基在荷载作用下变形过程及特点,揭示不同工况下的基础变形规律。研究结果表明,基础沉降满足规范要求,沉降主要集中在浅层土地层中;桩间土与桩顶沉降均匀;采空巷道顶板的沉降与地基其他部位沉降基本一致,桩基能够有效限制采空巷道顶板的变形。

关键词：高速铁路采空区群桩基础数值模拟沉降

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Retrospective review of 190 patients treated for parotid tumors： a single institute experience

引用

Chinese Medical Journal 2013年第5期126卷 988-990页

作者： LI Jing-jia ZHANG Ge-hua LIU Xian YE Jin YANG Qin-tai huang Jian-cong wu Si YIN Gen-di Department of Otolaryngology-Head and Neck Surgery ThirdAffiliated Hospital of Sun Yat-sen University GuangzhouGuangdong 510630 China

Salivary gland neoplasms account for 3%-6% of all head and neck neoplasms, and the incidence was estimated to range from 0.4 to 13.5 cases per 100 000 inhabitants annually. Histologically, salivary gland tumors are a diverse group of neoplasms, making it difficult to establish a common standard for diagnosis and treatment. Most of the current studies concerning salivary gland tumors investigated the histological features and clinical manifestations including both major and minor salivary gland tumors, making it difficult to evaluate their real frequency and site distribution. Parotid tumor is the most frequently occurring salivary neoplasms, comprising 60%-80% of all salivary gland tumors. Clinical experience led us to suspect that our epidemiology of parotid tumors in south China may be different from that of other areas in the world. Here, we retrospectively reviewed parotid tumor cases and aimed to summarize the clinical presentation, histological feature, and surgical complications of parotid tumors.

关键词： parotid gland neoplasm surgery complications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expressions of vascular endothelial growth factor in cirrhotic tissues and their relations to proto-oncogene c-fos, c-myc

引用

Hepatobiliary & Pancreatic Diseases International 2002年第3期1卷 388-391页

作者： Bao-Min Shi Xiu-Yan Wang Qing-Ling Mu tai-huang wu Zhen Yang Li Zhang Da-Peng Li the Department of General Surgery, Shandong Provincial Hospital, Jinan 250021, China Department of General Surgery, Tongji Hospital, Tongji Medical University, wuhan 430030, China Department of General Surgery Shandong Provincial Hospital Jinan 250021 China. baomins@***

Objective: To investigate the significance of vascular endothelial growth factor (VEGF) in the pathogene- sis of liver cirrhosis and the correlation between VEGF and proto-oncogene c-fos and c-myc in cir- rhotic liver. Methods: The proteins of VEGF, c-fos, and c-myc were identified immunohistochemically in each tissue section of 53 cases of liver cirrhosis. The correlations between VEGF, c-fos and c-myc were analyzed. The levels of VEGF protein in different Child gradings were also compared. Results: The proteins of VEGF were more highly ex- pressed in Child A and B patients than in Child C patients and controls. The expressions of both c-fos and c-myc were not statistically significant between VEGF positive and negative patients. Conclusions: The protein level of VEGF can reflect the compensation status of cirrhosis patients and may act as an anti-cirrhotic factor. The proto-oncogene c- fos, c-myc and VEGF may have different mecha- nisms in the course of cirrhosis or hepatic tumorigen- esis.

关键词： vascular endothelial growth factor liver cirrhosis c-fos c-myc Child grading

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

引用

Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

十堰市1991～2003年急性驰缓性麻痹病例监测分析

引用

疾病控制杂志 2005年第5期9卷 479-480页

作者：赵国兵黄太武十堰市疾病预防控制中心湖北十堰442000

1991年十堰市建立了急性弛缓性麻痹(acute flaccid paralysis,AFP)病例监测系统,2000年7月完成了消灭脊髓灰质炎(脊灰)的证实工作.自建立AFP监测系统以来,监测的及时性、敏感性、完整性不断提高,各项监测指标都达到了世界卫生组织及国... 详细信息

1991年十堰市建立了急性弛缓性麻痹(acute flaccid paralysis,AFP)病例监测系统,2000年7月完成了消灭脊髓灰质炎(脊灰)的证实工作.自建立AFP监测系统以来,监测的及时性、敏感性、完整性不断提高,各项监测指标都达到了世界卫生组织及国家卫生部的规定指标.自1992年丹江口市发生最后1例脊髓灰质炎后,十堰市已连续12年无脊髓灰质炎野病毒病例报告.为了总结经验,进一步巩固消灭脊髓灰质炎工作成果,现将该市1991～2003年AFP病例监测工作进行分析.

关键词：脊髓灰质炎流行病学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

1995～2006年十堰市病毒性肝炎资料分析

引用

预防医学论坛 2008年第2期14卷 157-158,161页

作者：刘光明黄太武湖北省十堰市疾病预防控制中心湖北十堰442000

[目的]了解十堰市病毒性肝炎流行状况,为制定防治策略和措施提供科学依据。[方法]对1995～2006年十堰市病毒性肝炎资料进行统计分析。[结果]1995～2006年十堰市报告病毒性肝炎病例49838例,年平均报告发病率为121.86/10万,各年份间发病... 详细信息

[目的]了解十堰市病毒性肝炎流行状况,为制定防治策略和措施提供科学依据。[方法]对1995～2006年十堰市病毒性肝炎资料进行统计分析。[结果]1995～2006年十堰市报告病毒性肝炎病例49838例,年平均报告发病率为121.86/10万,各年份间发病率的差异有统计学意义(P<0.01),各县(市、区)平均报告发病率的差异有统计学意义(P<0.01)。2000年起报告发病率呈上升趋势,主要因乙型肝炎报告发病率上升所致,乙型肝炎构成比上升至91.98%。15岁以下年龄组报告发病率呈缓慢下降趋势。病例主要集中在15～39岁年龄组,男性多于女性,职业以农民居多。[结论]十堰市病毒性肝炎报告发病率较高。要加强新生儿免费乙肝疫苗接种,规范乙型肝炎的诊疗和疫情监测,加强乙型肝炎传染源的管理,以降低乙型肝炎的发病率。

关键词：病毒性肝炎病例发病率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高速铁路采空区群桩受力机理数值模拟

引用

铁道标准设计 2014年第5期58卷 49-54页

作者：梁鑫程谦恭杨颋李传宝黄太武西南交通大学成都610031 广西科技大学柳州545006 中铁第四勘察设计院集团有限公司武汉430063

对高速铁路采空区桥梁群桩基础的受力机理研究,目前还非常少见。以合肥至福州高速铁路官山底特大桥采空区群桩基础为原型,通过数值模拟获得群桩受力规律。研究表明:随着荷载增大,桩上部轴力变化明显,桩身轴力沿深度逐渐减小,在采空巷道... 详细信息

对高速铁路采空区桥梁群桩基础的受力机理研究,目前还非常少见。以合肥至福州高速铁路官山底特大桥采空区群桩基础为原型,通过数值模拟获得群桩受力规律。研究表明:随着荷载增大,桩上部轴力变化明显,桩身轴力沿深度逐渐减小,在采空巷道内桩身轴力不变,所有桩均为端承摩擦桩;桩侧摩阻力沿桩身先增大后减小,整个桩的侧摩阻力分布重心下移,穿过采空区的桩侧摩阻力分布重心比未穿越采空区的桩下移深度略深;承台下中部的桩间土应力要大于承台边角位置的桩间土应力,随着荷载增大,桩间土应力增长速率小于桩顶应力,桩身开始承担更多荷载。

关键词：高速铁路采空区群桩基础受力机理数值模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insights into spinal muscular atrophy from molecular biomarkers

引用

Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian wu Xiaohui huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：