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China Geology 2018年第2期1卷 286-303页

作者： yi-wen Ju Cheng huang Yan Sun Cai-neng Zou hong-ping He Quan Wan Xue-qiu Wang Xian-cai Lu Shuang-fang Lu Jian-guang Wu hong-tai Chao Hai-ling liu Jie-shan Qiu Fei huang hong-jian Zhu Jian-chao Cai Yue Sun Key Laboratory of Computational Geodynamics Chinese Academy of SciencesCollege of Earth and Planetary SciencesUniversity of Chinese Academy of SciencesBeijing 100049 China Key Laboratory of Marginal Sea Geology of South China Sea Institute of Oceanology Chinese Academy of SciencesCruangzhou 510301China Carbon Research Laboratory School of Chemical EngineeringDalian University of TechnologyDalian 116012China Key Laboratory of Ministry of Education on Safe Mining of Deep MetalMines School of Resources and Civil EngineeringNorthwestern UniversityShenyang 110819China Institute of Geophysies and Geomatics China University ofGeosciences(Wuhan)Wuhan 430074China School of Earth Sciences and Engineering State Key Laboratory for Mineral Deposits ResearchNanjing UniversityNanjing 210093China PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Institute of Geophysical and Geochemical Exploration CAGSKey Laboratory of Geochemical ExplorationMinistry of Land and ResourcesLangfang 065000China Research Institute of UnconventionalPetroleum and Renewable Energy Chinese University of Petroleum (East China)Qingdao 266580China China United CoalbedMethane Co. Ltd.Beijing 100011China Earthquake Administration of shandong Province Jinan 250014China

Nanogeology is a subject that is a combination of geology and nanoscale science,and it has been a frontier field in recent *** is also a new subject with the features of intersectionality and multidisciplinary. Digging deeper into geological problems and nanoscale phenomena helps better revealing the more essential mechanisms and processes in geological science,which is also an evitable path in the development of *** this paper,we elaborate the concept,feature and main subdisciplines,and summarize three stages ofnanogeology development from preliminary research in the 1990s to subject formation in *** summarizing the researchers'achievements in this field,we illustrate some primary research progresses of nanogeology in China as eight *** the basis of the above content,we propose the development prospect of nanogeology in *** are many geologic problems with scientific values and economic benefits,such as research of geologic fundamental problems,resource exploration and development,mechanism study and prediction of geological activities (disasters),mechanism research and management of environmental pollution and *** has a great potential in China to solve all of these *** a result,the theories and methods of nanogeology will become enriching and *** offers important theoretical basis and technological methods to deal with major issues concerning the national economy and the people's livelihoods,such as the prediction of geological activities,as well as resource dislribution and its exploration and utilization.

关键词： Nanogeology Nanoparticle Nanostructure Scientific frontier Research progress Research prospect

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Investigation of natural contamination layer growth on optical substrates

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Chinese Physics C 2018年第11期42卷 107-119页

作者： li Jiang Qiu-Shi huang Igor V.Kozhevnikov yi-Yun Yao Jiang-Tao Feng Yu-Fei Feng Bin Ma hong-Fei Jiao hong Chen Zhong Zhang Zhan-shan Wang Key Laboratory of Advanced Micro-Structured Materials MOE Institute of Precision Optical Engineering School of Physics Science and Engineering Tongji University Shanghai 200092 China Shubnikov Institute of Crystallography of Federal Scientific Research Centre "Crystallography and Photonics" of the Russian Academy of Sciences Leninskiy pr. 59 Moscow 119333 Russia

The surface contamination layer on mirrors can cause significant degradation of the optical performance, which is widely observed in applications, particularly in the fabrication of X-ray focusing telescopes. In this paper, we study the natural contamination layer arising from adsorption precipitation of hydrocarbons or other organic and water molecules in the absence of any external factor. Temporal evolution of the layer formed on super-smooth fused silica, borosilicate glass, and silicon substrates is studied by X-ray reflectometry, atomic force microscopy, and transmission electron microscopy for a one-year period after surface cleaning. The general characteristics of adhesion layer growth are established and discussed. The reconstructed dielectric constant profiles demonstrate that an increase in the adhesion layer thickness, deposited mass and density over time obeys power laws with extremely small exponents. Therefore, the adhesion layer growth is rapid immediately after surface cleaning, with a - 1 nm thick layer formed within the first day on all three substrates studied, while the layer density is low （- 1 g/cm^3）. The layer growth on the fused silica and silicon substrates became very slow in the succeeding days, with only a 1.4-1.5 nm thick layer and 1.2-1.3 g/cm^3 density after one year of storage in air. At the same time, the adhesion layer growth on the glass substrate showed unexpected acceleration about two months after cleaning, so that the layer thickness reached - 2.2 nm after one year of storage. The reason for this effect, which is connected with leaching of the glass, is discussed briefly.

关键词： X-ray telescope surface contamination surface dynamics X-ray reflectometry inverse problem

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Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

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Bone Research 2019年第3期7卷 296-309页

作者： Chun-Yuan Chen shan-shan Rao yi-Juan Tan Ming-Jie Luo Xiong-Ke Hu Hao yin Jie huang yin Hu Zhong-Wei Luo Zheng-Zhao liu Zhen-Xing Wang Jia Cao yi-Wei liu hong-Ming li Yang Chen Wei Du Jiang-Hua liu Yan Zhang Tuan-Hui Chen Hao-Ming liu Ben Wu Tao Yue yi-yi Wang Kun Xia Peng-Fei Lei Si-Yuan Tang Hui Xie Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China Xiangya School of Nursing Central South University Changsha Hunan 410013 China Department of Sports Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Rehabilitation Xiangya Hospital Central South University Changsha Hunan 410008 China Hunan Key Laboratory of Organ Injury Aging and Regenerative Medicine Changsha Hunan 410008 China Hunan Key Laboratory of Bone Joint Degeneration and Injury Changsha Hunan 410008 China National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan 410008 China

Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a "factory" to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG.

关键词： stem cells USCs bone loss

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Enhancement of DNA vaccine-induced immune responses by a 72-bp element from SV40 enhancer

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Chinese Medical Journal 2007年第6期120卷 496-502页

作者： li Hai-shan liU Yong li Ding-feng ZHANG Ran-ran TANG Hai-li ZHANG Yu-wei huang Wei liU ying PENG hong XU Jian-qing hong Kun-xue SHAO yi-ming State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease 100050 China

Background Although DNA vaccine is considered as the next generation of vaccine, most DNA vaccine candidates are still suffering from the relatively weak immunogenicity despite the increased dosage of plasmid DNA administered. In order to enhance the immune responses elicited by a codon-optimized HIV gag DNA vaccine, a modified plasmid vector pDRVI1.0 and a booster immunization with replicating Tiantan vaccinia （RTV） strain expressing the same gene were employed. Methods Vector pDRVI1.0 was constructed through inserting the 72-bp element from the SV40 enhancer, which was reported promoting nuclear transport of plasmid DNA, to the upstream of cytomegalovirus enhancer/promoter region of the plasmid vector pVR1012. Gene expression levels from expression plasmids based on pDRVI1.0 and pVR1012 were tested. Humoral and cellular immune responses induced by DNA vaccine alone or DNA prime-RTV boost regimen were determined in mice. Results It was shown that the 72-bp element significantly enhanced the gene expression level in non-dividing cells. gag-specific humoral and cellular immune responses induced by DNA vaccination were both significantly improved, while the Thl/Th2 balance was not obviously affected by the 72-bp element. RTV boosting further significantly enhanced DNA vaccine-palmed antibody and T cell responses in a Thl-biased manner. Conclusions The 72-bp SV40 enhancer element should be included in the DNA vaccine vector and RTV strain is a very efficient live vector for boosting immunization.

关键词： DNA vaccines SV40 enhancer prime-boost vaccinia Tiantan strain

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Ultrafast optical spectroscopy evidence of pseudogap and electronphonon coupling in an iron-based superconductor KCa_(2)Fe_(4)As_(4)F_(2)

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 92-98页

作者： Chen Zhang Qi-yi Wu Wen-shan hong Hao liu Shuang-Xing Zhu Jiao-Jiao Song yin-Zou Zhao Fan-ying Wu Zi-Teng liu Shu-Yu liu Ya-Hua Yuan Han huang Jun He Shiliang li Hai-Yun liu Yu-Xia Duan Hui-Qian Luo Jian-Qiao Meng School of Physics and Electronics Central South UniversityChangsha 410083China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Beijing Academy of Quantum Information Sciences Beijing 100193China

We use ultrafast optical spectroscopy to study the nonequilibrium quasiparticle relaxation dynamics of the iron-based superconductor KCa_(2)Fe_(4)A_(s4)F_(2)with T_(c)= 33.5 K. Our results reveal a possible pseudogap(△_(PG)=(2.4 ± 0.1) me V) below T*≈ 50 K but prior to the opening of a superconducting gap(△SC(0) ≈(4.3 ± 0.1) me V). Measurements under high pump fluence reveal two distinct, coherent phonon oscillations with 1.95 and 5.51 THz frequencies, respectively. The high-frequency A1 g(2) mode corresponds to the c-axis polarized vibrations of Fe As planes with a nominal electron-phonon coupling constant λA1 g(2)= 0.194 ± *** findings suggest that the pseudogap is likely a precursor of superconductivity, and the electron-phonon coupling may play an essential role in the superconducting pairing in KCa_(2)Fe_(4)A_(s4)F_(2).

关键词： KCa_(2)Fe_(4)A_(s4)F_(2) ultrafast spectroscopy electron-phonon coupling superconductivity

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Bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu Zou Ran liu Mei huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min huang yi-li Xu ling liu Yu-Chen Sun Mi Yang Qi Guo Yan huang Tian Su Ye Xiao Wei-shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo Chang-Jun li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key Laboratory of Joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain *** this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture *** injection of human rGCA in young mice induced SSPC senescence and delayed fracture *** deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC ***,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular *** of Plxnb2 in SSPCs impaired fracture *** of GCA-neutralizing antibody enhanced fracture healing in aged ***,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

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MiR-125b increases nasopharyngeal carcinoma radioresistance by targeting A20/NF-kB signaling pathway

MiR-125b increases nasopharyngeal carcinoma radioresistance ...

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2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： li-Na li Ta Xiao hong-Mei yi Zhen Zheng Jia-Quan Qu Wei huang Xu Ye hong yi shan-shan Lu Xin-Hui li Zhi-Qiang Xiao Research Center of Carcinogenesis and Targeted Therapy Xiangya HospitalCentral South University Department of Pathology Changzhi Medical College Department of Dermatology Xiangya HospitalCentral South University Department of Oncology Qianjiang Central Hospital of ChongqingJishou University

Radioresistance poses a major challenge in nasopharyngeal carcinoma(NPC) treatment, but little is known about how miRNA regulates this phenomenon. In this study, we investigated the function and mechanism of miR-125 b in NPC radioresistance, one of upregulated miRNAs in the radioresistant NPC cells identified by our previous microarray analysis. We observed that miR-125 b was frequently upregulated in the radioresistant NPCs, and its increment was significantly correlated with NPC radioresistance, and was an independent predictor for poor patient survival. In vitro radioresponse assays showed that miR-125 b inhibitor decreased while miR-125 b mimic increased NPC cells radioresistance. In a mouse model, therapeutic administration of miR-125 b antagomir dramatically sensitized NPC xenografts to irradiation. Mechanistically, we confirmed that A20 was a direct target of miR-125 b, and found that miR-125 b regulated NPC cells radioresponse by targeting A20/NF-?B signaling. With a combination of loss-of-function and gain-of-function approaches, we further showed that A20 overepression decreased while A20 knockdown increased NPC cells radioresistance both in vitro and in vivo. Moreover, A20 was significantly downregulated while p-p65(RelA) significantly upregulated in the radioresistant NPCs relative to radiosensitive NPCs, and miR-125 b expression level was negatively associated with A20 expression level, whereas positively associated with p-p65(RelA) level. Our data demonstrate that miR-125 b and A20 are critical regulators of NPC radioresponse, and high mi R-125 b expression enhances NPC radioresistance through targeting A20 and then activating NF-?B signaling pathway, highlighting the therapeutic potential of miR-125 b/A20/NF-?B axis in clinical NPC radiosensitization.

关键词： nasopharyngeal carcinoma radioresistance miR-125b A20 NF-?B

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一类时滞微分系统有界解的收敛性

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湖南大学学报（自然科学版） 2005年第6期32卷 116-117页

作者：黄立宏韦志坚易泰山湖南大学数学与计量经济学院湖南长沙410082

研究了一类时滞微分系统解的渐近性态.在一些比已有文献通常附加的局部李普希兹条件更弱的条件下,证明了此系统的每个有界解趋于某平衡态.我们的结果推广了已有的一些结论.

关键词：时滞微分系统有界解渐近性态平衡态

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Ser-897 phosphorylation of EphA2 promotes metastasis and CSCs-like properties by AKT/Stat3/Sox-2 and c-Myc signaling in nasopharyngeal carcinoma

Ser-897 phosphorylation of EphA2 promotes metastasis and CSC...

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2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Jiao-Yang li Yuan-Yuan Wang hong-Mei yi hong yi Ta Xiao Juan Feng Jin-Feng Zhu Wei huang shan-shan Lu Yan-hong Zhou Zhi-Qiang Xiao Research Center of Carcinogenesis and Targeted Therapy Xiangya HospitalCentral South University The Higher Educational Key Laboratory for Cancer Proteomics and Translational Medicine of Hunan Province Xiangya HospitalCentral South University Department of Dermatology Xiangya HospitalCentral South University Cancer Research Institute Xiangya Medical SchoolCentral South University

Our quantitative plasma membrane phosphoproteomics identified that phosphorylation of EphA2 at serine 897(p-EphA2-S897) was significantly upregulated in the high metastatic nasopharyngeal carcinoma(NPC) cells relative to non-metastatic NPC cells. P-EphA2-S897 has been proposed as a key reaction in the ligandindependent tumor promotion of EphA2. However, the role and underlying mechanism of p-EphA2-S897 in tumor metastasis and cancer stem cells(CSCs) properties maintenance remains poorly understood. In this study, with a combination of loss-of-function(EphA2-S897 A, phosphorylation-inactivation) and gain-offunction(EphA2-S897 D, phosphomimetic) approaches, we observed that p-EphA2-S897 in NPC cells promoted tumor cells in vitro invasion and in vivo metastasis in a mouse lung metastasis model, and maintained CSCs-like properties, i.e. increasing side-population cell fraction, tumorsphere formation, the three known NPC stem markers expression, EMT-like alterations and the tumor initiating capacity of NPC cells in vivo. Using phospho-kinase antibody array to identify signaling downstream of p-S897-EphA2, we found that AKT/Stat3 signaling mediated p-EphA2-S897-dependent NPC cells invasion and CSCs-like properties maintenance, and Sox-2 and c-Myc were the effectors of p-EphA2-S897. Moreover, p-EphA2-S897 was significantly increased in the NPCs with metastasis relative to NPCs without metastasis and correlated with poor patient survival, and there were positive correlations among p-EphA2-S897, p-AKT, pStat3, Sox-2 and c-Myc expressions in the NPC tissues. Collectively, our data establish the role and mechanistic basis for p-EphA2-S897-dependent NPC invasion and metastasis and CSCs-like function maintenance, suggesting p-EphA2-S897 as an attractive therapeutic target in NPC and perhaps in other cancers.

关键词： nasopharyngeal carcinoma metastasis cancer stem cells phospho-EphA2(S897) AKT Stat3

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Impact of a nationwide training program for neonatal resuscitation in China

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Chinese Medical Journal 2012年第8期125卷 1448-1456页

作者： XU Tao WANG Hui-shan YE hong-mao YU Ren-jie huang Xing-hua WANG Dan-hua Wang li-xin FENG Qi GONG li-min MA yi William Keenan Susan Niermeyer National Center for Women and Children＇s Health Chinese Center for Disease Control and Prevention Beijing 100089 China Department of Pediatrics Peking University Third Hospital Beijing 100191 China Department of Pediatrics Tsinghua University First Hospital Beijing 100016 China Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University Beijing 100026 China Department of Pediatrics Peking Union Medical College Hospital Beijing 100730 China Department of Pediatrics Peking University First Hospital Beijing 100034 China Cardinal Glennon Children＇s Hospital and St. Louis University School of Medicine St. Louis Missouri USA Section of Neonatology Children＇s Hospital and University of Colorado Denver School of Medicine Colorado School of Public Health13121 E. 17th Avenue Mail Stop 8402 Aurora Colorado 80045 USA

Background Seventeen million births occur in China each year. Neonatal mortality is the leading cause of under 5-year-old child deaths, and intrapartum-related injury accounts for much of mental retardation in young children. The Chinese Ministry of Health sought to improve infant and child survival through a nationwide initiative to have at least one person trained in neonatal resuscitation at every birth. The aim of the current study was to evaluate the impact of China Neonatal Resuscitation Program （NRP） on policy and infrastructure changes and its effectiveness in decreasing the incidence of mortality among newborn infants. Methods The Chinese NRP incorporated policy change, professional education, and creation of a sustainable health system infrastructure for resuscitation. Multidisciplinary teams from all 31 provinces and municipal states disseminated NRP in a train-the-trainer cascade. The intervention targeted 20 provinces with high neonatal mortality and programs to reduce maternal mortality. Program evaluation data came from 322 representative hospitals in those provinces. Results Changes in policy permitted midwives to initiate resuscitation and required resuscitation training for licensure. From 2004 through 2009 more than 110 659 professionals received NRP training in the 20 target provinces, with 94% of delivery facilities and 99% of counties reached. Intrapartum-related deaths in the delivery room decreased from 7.5 to 3.4 per 10 000 from 2003 to 2008, and the incidence of Apgar 〈7 at 1 minute decreased from 6.3% to 2.9%. Conclusions The Chinese NRP achieved policy changes promoting resuscitation, trained large numbers of professionals, and contributed to reduction in delivery room mortality. Improved adherence to the resuscitation algorithm, extension of training to the township level, and coverage of births now occurring outside health facilities can further increase the number of lives saved.

关键词： resuscitation infant, newborn asphyxia neonatorum neonatal mortality in-service training, China

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