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IGF1-PI3k-induced physiological cardiac hypertrophy:Implications for new heart failure therapies,biomarkers,and predicting cardiotoxicity

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Journal of Sport and Health Science 2021年第6期10卷 637-647,I0001页

作者： Sebastian Bass-Stringer Celeste M.k.tai Julie R.McMullen Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVIC 3086Australia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia Department of Physiology and Department of Medicine Alfred Hospital Monash UniversityMelbourneVIC 3004Australia

Heart failure represents the end point of a variety of cardiovascular *** is a growing health burden and a leading cause of death *** date,limited treatment options exist for the treatment of heart failure,but exercise has been well-established as one of the few safe and effective interventions,leading to improved outcomes in ***,a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart *** insulin-like growth factor 1(IGF1)phosphoinositide 3-kinase(PI3k)pathway has been recognized as perhaps the most critical pathway for mediating exercisedinduced heart growth and ***,we discuss how modulating activity of the IGF1PI3k pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the *** outline some of the promising approaches being investigated that utilize PI3k-based therapy for the treatment of heart *** discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced PI3k ***,we discuss the use of animal models of cardiac health and disease,and genetic mice with increased or decreased cardiac PI3k activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.

关键词： Cardiac protection Cardiotoxicity Exercise Heart failure IGF1 PI3k Therapies

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Synthesis of Magnetic Nanoparticles for Application of Retroviral Vectors Mediated Gene Therapy

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过程工程学报 2004年第Z1期4卷 122-122页

作者： Huan-Chiu ku Ming-Fong tai k.-H. William Lau David Baylink Shin-tai Chen Department of Physics Ting-Hua University Hsin-Chu China Department of Physics WeFeng Institute of Technology Chia-yi China Musculoskeletal Diseases Center J. L. Pettis VA Medical Center Loma Linda CA 92357 USA

　　Successful gene therapy depends on accurate delivery of therapeutic genes to target sites. In this report, we used magnetic nanopartieles to achieve this goal by developing magnetic Moloney leukemia virus-based (MRV) vectors. The vectors are combined by magnetic nanoparticles with the MRV viral vectors and can be guided to a specific site by an external magnetic filed.……

关键词： Gene Therapy Retroviral Vectors magnetic nanoparticles gene therapy

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Size-dependent Heterogeneity Benefits the Mechanical Performance of Bone

Size-dependent Heterogeneity Benefits the Mechanical Perform...

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The 16th Annual Conference of Hong kong Society of Theoretical and Applied Mechanics 2012、The 1st Mainland-Hong kong Youth Forum on Mechanics 2012、The 8th Shanghai-Hong kong Forum on Mechanics and Its Application 2012

作者： H.Yao M.Dao D.Carneli k.tai C.Ortiz Department of Mechanical Engineering the Hong Kong Polytechnic UniversityHong KongChina Department of Material Sciences and Technology Massachusetts Institute of TechnologyCambridgeUSA

Heterogeneity of biological materials,such as bone,tooth,and mollusc shells,plays a key role in determining their mechanical performance（*** strength,damage tolerance,etc.）.Here,we quantify heterogeneities in elasticity and inelasticity of bovine cortical bone between 100 nm up to a few microns and identify a characteristic length scale（λ） of approximately 200 *** shown in Fig.1,belowλ the mechanical heterogeneity of bone is pronounced and exhibits a strong nonlinear size-dependence,while aboveλ the heterogeneity is much *** size-dependent heterogeneity benefits the mechanical performance of bone since it not only promotes the energy dissipation at nanoscale but also suppresses heterogeneity-induced stress concentration and strain localization at larger length *** is one of the possible mechanisms functioning at multiple length scales that makes bone a well-designed tough natural *** experimentally measured data, systematic computational simulations were carried out,showing that the heterogeneity in inelasticity, rather than elasticity,plays a dominant role in promoting energy dissipation during deformation. Possible parameters that determine the inelasticity heterogeneity（*** value and standard deviation of heterogeneous yield stress） and therefore affect energy dissipation are investigated under typical deformation modes of *** analysis presented suggests that there exists an optimum ratio of macroscopic strength to elastic modulus for improving energy dissipation under *** these findings are of great value to the design and synthesis of improved bio-inspired composites.

关键词： Size-dependent Heterogeneity Benefits the Mechanical Performance of Bone

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硅中BF_2^+注入束流效应的掠角背散射沟道分析

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核技术 1991年第4期14卷 217-220页

作者：李晓勤林成鲁杨根庆周祖尧邹世昌 E.ktai 中国科学院上海冶金研究所 Central Research Institute For Physics of the Hungarian Academy of Sciences

本文用掠角背散射沟道分析技术研究了能量为147keV,剂量为2×10^(15)/cm^2,束流为20—140μA(束流强度0.41—2.86μA/cm^2)的BF_2^+注入后的Si样品,分析了离子注入损伤的深度分布和移位原子浓度的变化,发现了用常规背散射沟道分析技术... 详细信息

本文用掠角背散射沟道分析技术研究了能量为147keV,剂量为2×10^(15)/cm^2,束流为20—140μA(束流强度0.41—2.86μA/cm^2)的BF_2^+注入后的Si样品,分析了离子注入损伤的深度分布和移位原子浓度的变化,发现了用常规背散射沟道分析技术所不能观测到的表层损伤的束流效应细节,并对这些现象进行了讨论。

关键词：硅 BF2^+ 分子离子注入束流效应

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An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： tai Liu Zhe Wang MengXi Shi Willie Soon ShiCan Qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELkH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

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Rare Earth Elements in Dinosaur bones across the embryo-adult spectrum

Rare Earth Elements in Dinosaur bones across the embryo-adul...

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第十七届全国稀土分析化学学术研讨会

作者： Shuanglong Wang Runhan Yan Huanwen Chen Shitao Zhang Xiaobo Li László kótai Timothy D.Huang Robert R.Reisz Jiangxi key Laboratory for Mass Spectrometry and Instrumentation East China University of Technology International Center of Future Science Jilin University kunming Science and Technology University Hungarian Academy of Science Department of Life Sciences National Chung Hsing University University of Toronto Mississauga

There is broad consensus that many bones of extinct vertebrates contain Rare Earth Elements(REE)and other trace minerals that have been incorporated and enriched into the fossil during *** fossilization,apatite minerals in vertebrate bones recrystallize from metastable biogenic forms to thermodynamically more stable inorganic apatite minerals while incorporating REEs from their *** than-95% of the REE in fossil bones are diagenetically incorporated postmortem and bones in different environments have different and distinct REE signatures,generally viewed to be controlled by sedimentological and taphonomic *** REE pattern in fossils is generally stable and the normalized concentration patterns provide unique "fingerprints" or signatures that have been used for various geological and paleontological *** we compare REE patterns in bones from two distinct sites in Yunnan,China,both preserving embryonic and adult bones of Early Jurassic sauropodomorph *** discovery of embryos and their adults at the same site,a rare occurrence in the fossil record,allowed us to compare for the first time the relationship between REE concentrations in the same taxon at widely differing ontogenetic *** dinosaurs are closely related to each other and close in geological age,and their bones show similar REE ***,the embryonic bones have significantly lower levels of total REEs when compared to their adult *** attribute the tenfold difference to the level of ossification of the bones and the dramatically lower concentration of apatites in the embryonic than in the adult *** conclude that the ontogenetic stage of fossil materials can have a significant impact on REE concentrations,and discuss the impact of these results on future work.

关键词： Rare Earth Elements fossils Early Jurassic dinosaurs

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Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期 152-156页

作者： Lihua Zhang Lingjing Chen Huatian Shi Yue Wei Gui Chen tai-Chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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The Citron homology domain of MAP4ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4k-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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α-TiCl3晶体的极化能和晶格能

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厦门大学学报(自然科学版) 1964年第1期 1-10页

作者：周泰锦蔡启瑞厦门大学化学系 1963年毕业生

本文根据离子晶体模型,计算了α-TiCl3层状晶体内氯离子格点上的极化电场强度(E⊥=13.2×108伏/厘米,E11=3.3×108伏/厘米),以及晶体的极化能(Up⊥=-102千卡/克分子,Up11=-167千卡/克分子)和晶格能（U=-1206千卡/克分子）.计算出的U值与... 详细信息

本文根据离子晶体模型,计算了α-TiCl3层状晶体内氯离子格点上的极化电场强度(E⊥=13.2×108伏/厘米,E11=3.3×108伏/厘米),以及晶体的极化能(Up⊥=-102千卡/克分子,Up11=-167千卡/克分子)和晶格能（U=-1206千卡/克分子）.计算出的U值与由Born循环估计出的实验值（U实=-1215千卡/克分子）相当接近.讨论了α-烯烃在α-TiCl3-AIR3催化剂上聚合时晶体极化电场对于烯键的极化作用和对于α-烯烃分子排列的定向作用。

关键词：离子晶体极化能氯离子 TiCl3 烯键极化作用阴离子晶格能格点

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基于世界模拟的政治非稳态:Sora的智能影像生成与历史重塑

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 70-78页

作者：高奇琦台润泽华东政法大学政府管理学院上海201620 华东政法大学政治学研究院上海201620

OpenAI发布的文字转视频模型Sora在智能影像生成领域取得突破,被认为具备“世界模拟”能力。这种对现实物理世界的逼真模拟能力,引发人类对“真实性”的重新评估。通过模拟现实场景和历史事件,Sora在展示其应用潜力的同时,对真实性、历... 详细信息

OpenAI发布的文字转视频模型Sora在智能影像生成领域取得突破,被认为具备“世界模拟”能力。这种对现实物理世界的逼真模拟能力,引发人类对“真实性”的重新评估。通过模拟现实场景和历史事件,Sora在展示其应用潜力的同时,对真实性、历史真相和公众信任等带来挑战。文本介绍了Sora的技术背景,探讨了智能影像与虚假信息结合的风险。这一结合可能通过社会媒介影响公众信念和政治秩序,引发社会极化和分化。此外,在重塑历史记忆与认同时,可能导致信息的扭曲和伪造问题,或将社会推向政治非稳态。为应对技术带来的挑战,文本强调在迈向通用人工智能时代的过程中平衡技术创新与社会责任的重要性。通过深入分析Sora等智能影像生成的可能影响与挑战,提醒社会关注生成式人工智能技术的监管和伦理,确保技术发展的同时维护历史的真实性,保障社会福祉。

关键词： Sora 智能影像生成人工智能政治秩序

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