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Inhibitory Effect of Isoflavones on Prostate Cancer Cells and PTEN Gene

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Biomedical and Environmental Sciences 2006年第1期19卷 35-41页

作者： FENG cao tai-YI JIN YUAN-FEN ZHOU Department of Occupational Health and Toxicology School of Public Health Fudan University Shanghai 200032 China

Objective To explore the mechanisms by which genistein and daidzein inhibit the growth of prostate cancer cells. Methods LNCaP and PC-3 cells were exposed to genistein and daldzein and cell viability was determined by MTF assay and cytotoxicity of the drugs by LDH test. Flow cytometry （FCM） was used to assess the cell cycle in LNCaP and PC-3 cells. Reverse transcription-polymerase chain reaction （RT-PCR） was applied to examine the expression of PTEN gene （a tumor suppressor gene）, estrogen receptor alpha gene （ERα）, estrogen receptor beta gene （ERβ）, androgen receptor gene （AR） and vascular endothelial growth factor gene （VEGF）. Results The viability of PC-3 and LNCaP cells decreased with increasing concentrations and exposure time of genistein and daidzein. Genistein increased G2/M phase cells in PC 3 cells while decreased S phase cells in LNCaP cells in a dose-dependent manner. Daidzein exerted no influence on the cell cycle of LNCaP and PC-3 cells, but the apoptosis percentage of LNCaP cells was elevated significantly by daidzein, Genistein induced the expression of PTEN gene in PC-3 and LNCaP cells. Daidzein induced the expression of PTEN gene in LNCaP but not in PC-3 cells. The expression of VEGF, ERα and ERβ genes decreased and AR gene was not expressed after incubation with genistein and daldzein in PC-3 cells. In LNCaP cells, the expression of VEGF and AR gene decreased but there was no change in the expression of ERα and ERβ gene after incubation with genistein and daidzein. Conclusion Genistein and daidzein exert a timeand dose-dependent inhibitory effect on PC-3 and LNCaP cells. The down-regulation of ER gene by daidzein influences the growth of PC-3 ceils directly, The inhibition of PC-3 cells by genistein and that of LNCaP cells by genistein and daidzein may be via Alct pathway that is repressed by PTEN gene, which subsequently down-regulates the expression of AR and VEGF genes. Our results suggest that the expression of PTEN gene plays a key role and s

关键词： Isoflavones Genistein Daidzein PC-3 LNCaP PTEN ERα ERβ VEGF

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带簇式推力室的固液火箭发动机装药设计

推进技术 2000年第3期21卷 60-62页

作者：曹泰岳国防科技大学航天与材料工程学院湖南长沙410073

讨论了带簇式推力室的固液火箭发动机多孔装药的设计方法 ,并针对某 HTPB/ L OX(或 GOX)发动机给出了不同推力室数和不同孔数情形下某些参数随时间的变化 ,以及另一些参数的总体值或平均值 ,表明簇式推力室方案是可行的。

关键词：混合推进剂火箭发动机簇式推力室装药设计

“五唯”问题:高校教师评价的后果、根源及解困路向

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大学教育科学 2019年第1期 27-32页

作者：操太圣南京大学教育研究院

考核评价政策是调动教师工作积极性、主动性的"指挥棒"。在国家有关人事制度和分配制度改革政策的牵引下,高校逐步强化对教师的考核评价制度,在一定程度上调动了教师队伍的积极性和竞争意识,但也衍生出考核评价中"唯论文、唯帽子、唯职... 详细信息

考核评价政策是调动教师工作积极性、主动性的"指挥棒"。在国家有关人事制度和分配制度改革政策的牵引下,高校逐步强化对教师的考核评价制度,在一定程度上调动了教师队伍的积极性和竞争意识,但也衍生出考核评价中"唯论文、唯帽子、唯职称、唯学历、唯奖项"的"五唯"导向偏差问题。这与20世纪80年代以来新自由主义的发展催生的"市场文化"、审计文化背景下的"数字崇拜"不无相关。深入剖析"五唯"问题的文化根源和弊端,对于指导开展清理"五唯"行动具有重要的现实意义。当前,有效开展清理"五唯"行动,各级教育部门和高校必须着力增进对高校教师的信任,推动实施增能式教师评价,牢固树立多元学术观;同时,学术界自身也应加强反思,高校教师应当坚守学术立场、培育公共性、加强道德自律。

关键词：清理“五唯” 教师评价审计社会专业信任绩效考核

Atomically dispersed Ni anchored on polymer-derived mesh-like Ndoped carbon nanofibers as an efficient CO_(2) electrocatalytic reduction catalyst

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Nano Research 2022年第5期15卷 3959-3963页

作者： tai cao Rui Lin Shoujie Liu Weng-Chon(Max)Cheong Zhi Li Konglin Wu Youqi Zhu Xiaolu Wang Jian Zhang Qiheng Li Xiao Liang Ninghua Fu Chen Chen Dingsheng Wang Qing Peng Yadong Li Department of Chemistry Tsinghua UniversityBeijing 100084China College of Chemistry and Materials Science Anhui Normal UniversityWuhu 241000China Department of Physics and Chemistry Faculty of Science and TechnologyUniversity of MacaoMacao SARChina Research Center of Materials Science Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green ApplicationsBeijing Institute of TechnologyBeijing 100081China

Efficient electroreduction of CO_(2) into CO and other chemicals turns greenhouse gases into fuels and value-added chemicals,holding great promise for a closed carbon cycle and the alleviation of climate ***,there are still challenges in the large-scale application of CO_(2) electroreduction due to the sluggish *** we develop a self-assembly strategy to synthesize a highly efficient CO_(2) reduction electrocatalyst with atomically dispersed Ni-N_(4) active centers anchored on polymerderived mesh-like N-doped carbon nanofibers(Ni-N_(4)/NC).The Ni-N_(4)/NC exhibits high selectivity for CO_(2) reduction reaction with CO Faradaic efficiency(CO FE)above 90% over a wide potential range from−0.6 to−1.0 V *** catalyst reaches a maximum CO FE up to 98.4% at−0.8 V with a TOF of 1.28×10^(5) h^(–1) and Tafel slope of 113 mV·dec^(–1).The catalyst also exhibits remarkable stability,with little change in current density and CO FE over a 10-hour durability test at–0.8 V *** method provides a new route for the synthesis of highly efficient CO_(2) reduction electrocatalyst.

关键词： CO_(2)reduction reaction Ni-N_(4)site Ni single atoms self-assembly

Decoupling Control Strategy for Single Phase SPWM Parallel Inverters

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Journal of Electronic Science and Technology of China 2009年第3期7卷 258-262页

作者： Shun-Gang Xu Jian-Ping Xu tai-Qiang cao School of Electrical Engineering Southwest Jiaotong University Chengdu 610031 China College of Physics and Information Technology Chongqing Normal University Chongqing 400047 China 不详

A deconpling control strategy of inverter parallel system is proposed based on the equivalent output impedance of single phase voltage source SPWM （sinusoidal pulse width modulation） inverter. The active power and reactive power are calculated in terms of output voltage and current of the inverter, and sent to the other inverters in the parallel system via controller area network （CAN） bus. By calculating and decoupling the circumfluence of the active power and reactive power, the inverters can share load current via the regulation of the reference-signal phase and amplitude. Experimental results of an 110V/2kVA inverter parallel system show the feasibility of the decoupling control strategy.

关键词： CAN bus current sharing inverters parallel operation

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三相逆变电源不平衡负载控制方法的研究

电机与控制学报 2012年第4期16卷 50-55页

作者：曹太强祁强王军西华大学电气信息学院四川成都610039

针对对称分量法实现三相逆变器在不平衡负载下输出电压的正、负、零序分量补偿,以维持三相输出电压的平衡,该方法在三相负载严重不平衡时,其不平衡度仍然较大,且运算量大,适时性差,不易控制等问题。本文提出了一种三相逆变电源的输出电... 详细信息

针对对称分量法实现三相逆变器在不平衡负载下输出电压的正、负、零序分量补偿,以维持三相输出电压的平衡,该方法在三相负载严重不平衡时,其不平衡度仍然较大,且运算量大,适时性差,不易控制等问题。本文提出了一种三相逆变电源的输出电压分相控制的方法,分别对三相逆变器输出的线电压进行控制,以实现三相电压的平衡。理论和仿真分析表明,该方法能够使三相最大不平衡度从传统对称分量法的5.49%降到1%左右,在负载不平衡度达到200%的情况下,三相电压输出也能适时、稳定、可靠的达到平衡,有效地补偿因不平衡负载引起的逆变器输出电压畸变,从而保证逆变器在带任意不平衡负载时仍能维持三相平衡的输出电压。

关键词：三相逆变器不平衡负载电压对称性分相控制

Two-dimensional SnO_2/graphene heterostructures for highly reversible electrochemical lithium storage

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Science China Materials 2018年第12期61卷 1527-1535页

作者： Youqi Zhu tai cao Zhi Li Chen Chen Qing Peng Dingsheng Wang Yadong Li Department of Chemistry Tsinghua University

The ever-growing market demands for lithium ion batteries have stimulated numerous research efforts aiming at the exploration of novel electrode materials with higher capacity and long-term cycling ***-dimensional (2D)nanomaterials and their heterostructures are an intense area of study and promise great potential in electrochemical lithium storage owing to their unique properties that result from structural planar *** we report a microwave chemistry strategy to integrate ultrathin SnO2 nanosheets into graphene layer to construct surface-to-surface 2D heterostructured architectures,which can provide unique structural planar confinement for highly reversible electrochemical lithium *** as-synthesized 2D SnO2/graphene heterostructures can exhibit high reversible capacity of 688.5mAh g^-1 over 500cycles with excellent long-term cycling stability and good rate capability when used as anode materials for lithium ion *** present work definitely reveals the advantages of 2D heterostructures featured with a surface-to-surface stack between two different nanosheets in energy storage and conversion devices.

关键词： two-dimensional heterostructures graphene tin oxide microwave chemistry,electrochemical lithinm storage