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Variation in patient dose due to differences in calibration and dosimetry protocols

Nuclear Science and Techniques 2018年第5期29卷 44-49页

作者： Wazir Muhammad Asad Ullah Gulzar khan tahir zeb khan Tauseef Jamaal Fawad Ullah Matiullah khan Amjad Hussain Department of Therapeutic Radiology Yale-School of MedicineYale UniversityNew HavenCT 06520-8040USA Heath Physics Division(HPD) Pakistan Institute of Nuclear Science and Technology(PINSTECH)Islamabad 45650Pakistan Department of Physics Abul Wali Khan UniversityMardan 23200Pakistan Pakistan Institute Nuclear Science&Technology(PIEAS) Islamabad 45650Pakistan Department of Physics Kohat University of Science and TechnologyKohat 26000Pakistan Department of Medical Physics CancerCare ManitobaBrandonMB R7A 2B3Canada

For precise and accurate patient dose delivery,the dosimetry system must be calibrated properly according to the recommendations of standard dosimetry protocols such as TG-51 and TRS-398. However, the dosimetry protocol followed by a calibration laboratory is usually different from the protocols that are followed by different clinics, which may result in variations in the patient *** prime objective in this study was to investigate the effect of the two protocols on dosimetry *** measurements were performed for a Co-60 teletherapy unit and a high-energy Varian linear accelerator with 6 and 15 MV photon and 6, 9, 12, and 15 MeV electron beams, following the recommendations and procedures of the AAPM TG-51 and IAEA TRS-398 dosimetry protocols. The dosimetry systems used for this study were calibrated in a Co-60 radiation beam at the Secondary Standard Dosimetry Laboratory(SSDL) PINSTECH,Pakistan, following the IAEA TRS-398 protocol. The ratio of the measured absorbed doses to water in clinical setting,D_w(TG-51/TRS-398), was 0.999 and 0.997 for 6 and15 MV photon beams,whereas these ratios were 1.013,1.009, 1.003, and 1.000 for 6, 9, 12, and 15 MeV electron beams, respectively. This difference in the absorbed dosesto-water D_w ratio may be attributed mainly due to beam quality(K_Q) and ion recombination correction factor.

关键词： Radiation dosimetry Dosimetry systems calibrations Patient dose Absorbed dose-to-water ratio AAPM TG-51 IAEA TRS-398

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Advances in Zika virus vaccines and therapeutics:A systematic review

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 97-109页

作者： Shiza Malik Khalid Muhammad Omar Ahsan Muhammad tahir khan Ranjit Sah Yasir Waheed Bridging Health Foundation Rawalpindi 46000Pakistan Department of Biology College of SciencesUAE University15551Al AinUnited Arab Emirates Department of Medicine Foundation University Medical CollegeFoundation University IslamabadIslamabad 44000Pakistan INTI International University Persiaran Perdana BBN Putra Nilai71800 NilaiNegeri SembilanMalaysia Institute of Molecular Biology and Biotechnology the University of LahoreKM Defence RoadLahore 58810Pakistan Zhongjing Research and Industrialization Institute of Chinese Medicine Zhongguancun Scientific ParkNanyang 473006China Department of Microbiology Tribhuvan University Teaching HospitalInstitute of MedicineKathmandu 44600Nepal Department of Microbiology Dr.D.Y.Patil Medical CollegeHospital and Research CentreDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American UniversityByblos 1401Lebanon

Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults *** wide transmission route and alarming spread rates are of great concern to the scientific *** trials have been conducted to develop treatment options for ZIKV *** review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection.A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic *** results indicate that several therapeutic interventions are being tested against ZIKV infection,such as DNA vaccines,subunit vaccines,live-attenuated vaccines,virus-vector-based vaccines,inactivated vaccines,virus-like particles,and mRNA-based *** addition,approved anti-ZIKV drugs that can reduce the global burden are *** many vaccine candidates for ZIKV are at different stages of development,none of them have received Food and Drug Authority approval for use up to *** issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway.

关键词： Zika virus Infection Therapeutics Antiviral agents Vaccines Therapies Treatment Novel therapeutic Clinical management

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First Record of Middle Eocene Elephant Ancestors’Footprints in the Gonjo Basin,East Tibet Plateau

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Journal of Earth Science 2024年第4期35卷 1224-1235页

作者： Asma tahir Huazhou Yao Junaid khan Yangui Li He Zhao Yue Yu Tang Yuan Institute of Geological Survey China University of GeosciencesWuhan430074China Wuhan Center China Geological SurveyWuhan430205China State Key Laboratory of Geological Processes and Mineral Resources Wuhan430078China Chengdu Center China Geological SurveyChengdu610081China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing100101China

It is the first time that the fossil footprints of a group of Middle Eocene elephant ancestors have been discovered in the Gonjo Basin,East Tibet *** Gonjo Formation is attributed to the Middle Eocene Epoch(U-Pb age=44.7±1.2 Ma)and consists mainly of purplish-red,medium-to coarse-grained sandstones,siltstones interbedded with mudstones,and conglomerates with sedimentary structures like ripple marks,rip-up clasts,and trough-cross bedding,suggesting fluvial-lacustrine *** group of fossil footprints has a characteristic oval-concave shape,and the toe impressions are *** fossil footprints are overstepped with a pockmarked texture resembling Proboscipeda *** than 165 fossil footprints of the group are relatively well-preserved with different diameters,which is evidence of highly social behavior and trackmakers of different ages,including calves,juveniles,adolescents,and *** size frequency of the fossil footprints enabled us to deduce the body mass,shoulder height,and hip-height distribution of the trackmakers that crossed the East Tibet Plateau 44.7 Ma *** trackmakers comprised an estimated average hip-height of 111.8 cm,an average shoulder height of 172.8 cm for males/155.9 cm for females,and an average body mass of approximately 1218.1 kg for males/907.8 kg for *** abundance of fossil footprints reveals that in the Middle Eocene Epoch,the environment was extraordinarily conducive for the elephant ancestors to live in the East Tibet region.

关键词： Proboscipeda enigmatica East Tibet Plateau Gonjo Formation fossil footprints fluvial-lacustrine

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Weathering and accumulation of trace elements in the soils of the Porali Plain, Balochistan: repercussions in agriculture

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Acta Geochimica 2024年第2期43卷 214-234页

作者： Maria Kaleem Erum Bashir Shahid Naseem tahir Rafique Bushra Shahab Department of Geology University of KarachiKarachi 75270Pakistan Applied Chemistry Research Centre PCSIR Laboratories ComplexKarachi 75280Pakistan

This study is theﬁrst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by multi-variate analysis based on geochemical *** outcomes of this study are expected to help farmers in soil manage-ment and selecting suitable crops for the ***-ﬁve soil samples were collected,mainly from the arable land of the Porali *** drying and coning-quarter-ing,soil samples were analyzed for major and trace ele-ments using the XRF technique;sieving and hydrometric methods were employed for granulometric ***-mated data were analyzed using Excel,SPSS,and Surfer software to calculate various indices,correlation matrix,and spatial *** granulometric analysis showed that 76%of the samples belonged to loam types of soil,12%to sand type,and 8%to silt *** indices:CIA,CIW,PIA,PWI,WIP,CIX,and ICV were calculated to infer the level of *** indices reﬂect mod-erate to intense weathering;supported by K_(2)O/AI_(2)O_(3),Rb/K_(2)O,Rb/Ti,and Rb/Sr *** of the geo-ac-cumulation and Nemerow Pollution indices pinpoint rela-tively high concentrations of Pb,Ni,and Cr concentration in the *** correlation matrix and Principal Compo-nent Analysis show that the soil in this study area is mainly derived from the weathering of igneous rocks of Bela Ophiolite(Cretaceous age)and Jurassic sedimentary rocks of Mor Range having SEDEX/MVT type *** may result in the undesirable accumulation of certain trace elements which adversely affects crops.

关键词： Weathering indices Pollution indices Accumulation Repercussions Trace elements Multivariate analyses Porali Plain Balochistan

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Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

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World Journal of Transplantation 2024年第1期14卷 154-163页

作者： Ameet Kumar Jesrani Syed M Faiq Rahma Rashid Tariq Ali Kalwar Rehan Mohsin tahir Aziz Nida Amin khan Muhammed Mubarak Department of Radiology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Pathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Transplantation Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Urology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

BACKGROUND Detection of early chronic changes in the kidney allograft is important for timely intervention and long-term *** and novel ultrasound-based investigations are being increasingly used for this purpose with variable *** To compare the diagnostic performance of resistive index(RI)and shear wave elastography(SWE)in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological *** This is a cross-sectional and comparative study.A total of 154 kidney transplant recipients were included in this study,which was conducted at the Departments of Transplantation and Radiology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from August 2022 to February *** consecutive patients with increased serum creatinine levels and reduced glomerular filtration rate(GFR)after three months of transplantation were enrolled in this *** and RI were performed and the findings of these were evaluated against the kidney allograft biopsy results to determine their diagnostic *** The mean age of all patients was 35.32±11.08 *** these,126(81.8%)were males and 28(18.2%)were *** mean serum creatinine in all patients was 2.86±1.68 mg/dL and the mean estimated GFR was 35.38±17.27 mL/min/1.73 *** allograft biopsy results showed chronic changes in 55(37.66%)*** sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of SWE for the detection of chronic allograft damage were 93.10%,96.87%%,94.73%,and 95.87%,respectively,and the diagnostic accuracy was 95.45%.For RI,the sensitivity,specificity,PPV,and NPV were 76.92%,83.33%,70.17%,and 87.62%,respectively,and the diagnostic accuracy was 81.16%.CONCLUSION The results from this study show that SWE is more sensitive and specific as compared to RI in the evaluation of chronic allograft *** can be of great help during the routine follow-up of kidney transplant recipients for screening a

关键词： Shear wave Sonoelastography Resistive index Chronic allograft changes Biopsy Histopathology

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Targeted Research on the Integration of Ideological and Political Education and Chinese Excellent Traditional Culture in Universities in Henan Province

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Journal of Contemporary Educational Research 2024年第7期8卷 100-106页

作者： Li Ma Suhaidah Binti tahir Chuanwei Zhang Faculty of Education and Liberty Studies City University Malaysia46100 Petaling JayaSelangorMalaysia City Graduate School City University Malaysia46100 Petaling JayaSelangorMalaysia

This study aims to explore the integration of excellent traditional Chinese culture with ideological and political education in universities in Henan Province,focusing on the unique challenges and opportunities presented by the local *** a combination of quantitative and qualitative methods,the study analyzes the impact of cultural elements on political ideology and education in the *** study contributes to a broader discussion of educational reform in China and provides insights for policymakers and educators seeking to develop well-rounded,culturally informed citizens.

关键词： Ideological and political education Traditional culture Integration

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Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal Ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad tahir Lysien Zambrano Mumtaz Ali khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

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LDH-based nanomaterials for photocatalytic applications:A comprehensive review on the role of bi/trivalent cations, anions,morphology, defect engineering, memory effect, and heterojunction formation

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Journal of Energy Chemistry 2023年第9期84卷 242-276页

作者： Azmat Ali khan Muhammad tahir Nazish khan Baluchistan University of Information Technology Engineering and Management Sciences(BUITEMS)P.O.Box 87100QuettaPakistan Chemical and Petroleum Engineering Department UAE UniversityP.O.Box 15551Al AinUnited Arab Emirates The University of Agriculture Swat P.O.Box 19040Pakistan

Using sunlight to drive chemical reactions via photocatalysis is paramount for a sustainable *** several photocatalysts,employing layered double hydrides(LDH) for photocatalytic application is most straightforward and desirable owing to their distinctive two-dimensional(2D) lamellar structure and optical *** article reviews the advancements in bimetallic/trimetallic LDHs and various strategies to achieve high efficiency toward an outstanding performing ***,the tuning of LDH components that control the electro nic and structural properties is *** tu ning obtained through the adoption,combination,and incorporation of different cations and anions is also *** progress of modification methods,such as the adoption of different morphologies,delamination,and defect engineering towards enhanced photocatalytic activities,is discussed in the *** band engineering,structural characteristics,and redox tuning are further deliberated to maximize solar energy harvesting for different photocatalytic ***,the progress obtained in forming hierarchical heterostructures through hybridization with other semiconductors or conducting materials is systematically disclosed to get maximum photocatalytic ***,the structural changes during the in-situ synthesis of LDH and the stability of LDH-based photocatalysts are *** review also summarizes the improvements in LDH properties obtained through modification tactics and discusses the prospects for future energy and environmental applications.

关键词： LDH Properties Potential photocatalyst Photocatalytic application Photocatalytic properties Improvement strategies

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Synthesis and Charcterization of Silane Crosslinked Hydrogel to pH Sensitive Study

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American Journal of Analytical Chemistry 2024年第5期15卷 165-176页

作者： Muhammad Awais Shahid Abdul Haseeb tahir Zeeshan Ahmad Muhammad Arslan Department of Physics The University of Lahore Lahore Punjab Pakistan Department of Chemistry Minhaj University Lahore Lahore Pakistan Department of Physics University of Punjab Lahore Pakistan

Eco-friendly and biodegradable novel hydrogel were prepared by blending and solution casting method. The designed hydrogel is based on chitosan/ PEG600/Gurgam with carbon nanofiller along silane crosslinked (TEOS) with pH sensitive response to controlled release of drug in biomedical materials and agriculture industry. The various concentration of carbon nanofiller is used to analyze its effect on the fabricated hydrogel characteristics by using FTIR, SEM, TGA, swelling studies (water, buffer and ionic solution). Spectra of FTIR reflected both established and newly developed groups (like hydrogel). COOH group presence is clearly observed in this range in the carbon filler reinforced hydrogel. The SEM micrographs show that CPG0.003 had a collection of polysaccharide chains as thin helices, which is attributed to the increase in the size of porosity. TGA shows to increase concentration of nanofiller enhanced the thermal stability of the designed hydrogels at temperature 25˚C to 550˚C mass loss percentage decrease upto 20% and increase thermal stability. This pH response made these resultant hydrogels as fruitful competitor against the many reported controlled release application.

关键词： Chitosan Guargum Hydrogel Carbon Nano Filler Silane Cross Linker pH Sensitive

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利用纳米气泡控制农业废水灌溉系统复合污垢的机制

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Engineering 2024年第4期35卷 214-225页

作者： Yang Xiao Bo Zhou Siyuan Tan Lei Li tahir Muhammad Buchun Si Changjian Ma Sunny C.Jiang Yunkai Li College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China Engineering Research Center for Agricultural Water-Saving and Water Resources(Ministry of Education of the People’s Republic of China) China Agricultural UniversityBeijing 100083China School of Environment and Civil Engineering Dongguan University of TechnologyDongguan 523808China State Key Laboratory of Nutrient Use and Management Institute of Agricultural Resources and EnvironmentShandong Academy of Agricultural SciencesJinan 250100China Department of Civil and Environmental Engineering University of California-IrvineIrvineCA 92617USA

The increasing demand for wastewater treatment has become a notable trend for addressing global water ***,fouling is a significant challenge for wastewater distribution engineering *** study provides an approach using nanobubbles(NBs)to control *** antifouling capacities of three types of NBs,six oxygen concentrations,and two application procedures(prevention and removal)are *** results show that NBs effectively mitigate composite fouling—including biofouling,inorganic scaling,and particulate fouling—in comparison with the non-NBs *** specifically,hydroxyl radicals generated by the self-collapse of NBs oxidize organics and kill microorganisms in *** negatively charged surfaces of the NBs transform the crystalline form of CaCO_(3)from calcite to looser aragonite,which reduces the likelihood of ion ***,the NBs gas-liquid interfaces act as gas"bridges"between colloidal particles,enhancing the removal of particles from ***,although the NBs inhibit the growth of fouling,they do not significantly remove the already adhered fouling in non-NBs treated *** study anticipates that the application of NBs will address the significant fouling issue for various wastewater distribution engineering systems in order to meet the global challenge of sustainable water supplies.

关键词： Biofouling Scaling Colloidal fouling Wastewater Antifouling mechanism

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