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Verification of Subseasonal-to-Seasonal Forecasts for Major Stratospheric Sudden Warmings in Northern Winter from 1998/99 to 2012/13

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Advances in Atmospheric Sciences 2020年第3期37卷 250-258页

作者： Masakazu taguchi Department of Earth Science Aichi University of Education

This study reports verification results of hindcast data of four systems in the subseasonal-to-seasonal(S2S)prediction project for major stratospheric sudden warmings(MSSWs)in northern winter from 1998/99 to 2012/*** report deals with average features across all MSSWs,and possible differences between two MSSW types(vortex displacement and split types).Results for the average features show that stratospheric forecast verifications,when further averaged among the four systems,are judged to be successful for lead times around 10 d or *** systems are skillful for lead times around 5 d,whereas the results vary among the systems for longer lead times.A comparison between the MSSW types overall suggests larger forecast errors or lower skill for MSSWs of the vortex split type,although the differences do not have strong statistical significance for almost all *** limitation is likely to at least partly reflect the small sample size of the MSSWs available.

关键词： major stratospheric sudden warmings forecast verification subseasonal-to-seasonal prediction project vortex displacement and split warmings

An extended computational approach for point-defect equilibria in semiconductor materials

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npj Computational Materials 2022年第1期8卷 746-756页

作者： Takafumi Ogawa Ayako taguchi Akihide Kuwabara Nanostructures Research Laboratory Japan Fine Ceramics Center2-4-1 MutsunoAtsuta-kuNagoya456-8587Japan

Concentrations of intrinsic and extrinsic point defects in crystalline materials with a bandgap are typically calculated in a constant-μapproach from defect formation energies based on density functional *** this work,calculations of thermal and charge equilibria among point defects are extended to a constant-N *** two approaches for point-defect equilibria are comparatively demonstrated in the application to Mg_(2)Si doped with Li,Na,and Ag,which is a lightweight and environmentally friendly thermoelectric candidate *** results reveal the systematic behavior of defect and carrier *** dopant atoms form interstitial defects at similar concentrations to substitutional defects at the Mg sites,resulting in significantly reduced free-carrier concentrations compared to the expected *** developed procedures could be utilized to find an optimal avenue for achieving higher carrier concentrations,e.g.,with regard to annealing temperature and the concentration of dopant atoms,in various semiconductors and insulators.

关键词： defect equilibria point

Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

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Assessment of Lung Cancer Risk on the Basis of a Biomarker P...

Yield of OH radicals in water under heavy ion *** on mass,specific energy,and elapsed time

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： sun,nan Florence,Guida Bantis,LeonidasE. Muller,DavidC. Li,Peng taguchi,ayumu Dhillon,Dilsher Kundnani,DeepaliL. Patel,NikulJ. Yan,Qingxiang Byrnes,Graham Moons,KarelG.M. Tj?nneland,Anne Panico,Salvatore Claudia ,Agnoli Vineis,Paolo Palli,Domenico Bueno-de-Mesquita,Bas Peeters,PetraH. Agudo,Antonio Huerta,JoseM. Dorronsoro,Miren Barranco,MiguelRodriguez Ardanaz,Eva Travis,RuthC. Byrne,KarlSmith Boeing,Heiner Steffen,Annika Kaaks,Rudolf Hüsing,Anika Trichopoulou,Antonia Lagiou,Pagona LaVecchia,Carlo Severi,Gianluca Boutron-Ruault,Marie-Christine Sandanger,TorkjelM. Weiderpass,Elisabete N?st,ThereseH. Tsilidis,Kostas Riboli,Elio Grankvist,Kjell Johansson,Mikael Goodman,GaryE. Feng,Ziding Brennan,Paul Johansson,Mattias Hanash,Samir M. The University of Texas MD Anderson Cancer Center Genetic Epidemiology Group International Agency for Research on Cancer Department of Biostatistics The University of Texas MD Anderson Cancer Center Department of Epidemiology and Biostatistics Imperial College London School of Public Health Laboratory of Population Health Max Planck Institute for Demographic Research Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Environment and Radiation Section International Agency for Research on Cancer Department of Epidemiology Julius Center for Health Sciences and Primary CareUniversity Medical Center Unit of Diet Genesand EnvironmentDanish Cancer Society Research Center Department of Clinical Medicine and Surgery Federico Ⅱ University Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Molecular and Genetic Epidemiology Unit Human Genetics Foundation Cancer Risk Factors and Life-Style Epidemiology Unit Cancer Research and Prevention Institute-Istituto per lo Studio ela Prevenzione Oncologica Department for Determinants of Chronic Diseases National Institute for Public Health and the Environment Unit of Nutirition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of OncologyBellvitge Institute for Biomedical Research (IDIBELL)L’Hospitalet de Llobregat Department of Epidemiology Murcia Regional Health Council Biomedical Research Institute of Murcia(IMIB-Arrixaca) Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP) Public Health Direction and Biodonostia Research Institute-CIBERESP Escuela Andaluza de Salud Pública Instituto de Investigación Biosanitaria Hospitales Universitarios de Granada/Universidad de Granada Epidemiology Preventionand Promotion Health ServiceNavarra Public Health Institute Instituto de Investigación Sanitaria de Navarra (IdiSNA) Navarra Institute for Health Research Cancer Epidemiology Unit Nuffield Department of Population HealthUniversity of Oxford Department of Epidemi

IMPORTANCE:There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of ***:To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria.

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Nuclear Science and Techniques 2007年第1期18卷 35-38页

作者： Mitsumasa taguchi Takuji KOJIMA Organic Pollutant Removal Technology Group Japan Atomic Energy Agency1233 WatanukiTakasakiGunma370-1292 Japan

Dependence of yields of OH (hydroxyl) radicals on the mass and specific energy of heavy ions and elapsed time after irradiation was investigated,to understand chemical reactions of aqueous *** yields of irradiation products of phenol,super-linearly increased with the incident energy of He,C,and Ne ions ranging from 2 to 18 MeV/*** yields of the OH radicals were estimated by analyzing the yields of the irradiation products of phenol. The yields of the OH radicals increased with the specific energy for each ion,but decreased both with the mass of each ion at the same specific energy and elapsed time after irradiation.

关键词：重离子辐射水辐射分解羟自由基产率质量耗用时间

Comparative Gene Expression Analysis of Mouse and Human Cardiac Maturation

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 207-215页

作者： Hideki Uosaki Y-h taguchi Division of Cardiology The Johns Hopkins University School of Medicine Department of Physics Chuo University

Understanding how human cardiomyocytes mature is crucial to realizing stem cell-based heart regeneration, modeling adult heart diseases, and facilitating drug discovery. However, it is not feasible to analyze human samples for maturation due to inaccessibility to samples while cardiomyocytes mature during fetal development and childhood, as well as difficulty in avoiding variations among individuals. Using model animals such as mice can be a useful strategy; nonetheless, it is not well-understood whether and to what degree gene expression profiles during maturation are shared between humans and mice. Therefore, we performed a comparative gene expression analysis of mice and human samples. First, we examined two distinct mice microarray platforms for shared gene expression profiles, aiming to increase reliability of the analysis. We identified a set of genes displaying progressive changes during maturation based on principal component analysis. Second, we demonstrated that the genes identified had a differential expression pattern between adult and earlier stages （e.g., fetus） common in mice and humans. Our findings provide a foundation for further genetic studies of cardiomyocyte maturation.

关键词： Cardiac maturation Comparative gene expressionanalysis Microarray meta analysis Principal component analysis Feature selection

Involvement of insulin receptor substrates in cognitive impairment and Alzheimer’s disease

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Neural Regeneration Research 2019年第8期14卷 1330-1334页

作者： Daisuke Tanokashira Wataru Fukuokaya Akiko taguchi Department of Integrative Aging Neuroscience National Center for Geriatrics and Gerontology Obu Aichi Japan Division of Neurology Endocrinology and Metabolism Faculty of Medicine University of Miyazaki Miyazaki Japan

Type 2 diabetes一associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)一is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin receptor and/or IGF1 receptor to multiple intracellular signaling pathways, including AKT/protein kinase B and extracellular-signal-regulated kinase cascades. Of the four IRS proteins in mammals, IRS1 and IRS2 play key roles in regulating growth and survival, metabolism, and aging. Meanwhile, the roles of IRS1 and IRS2 in the central nervous system with respect to cognitive abilities remain to be clarified. In contrast to IRS2 in peripheral tissues, inactivation of neural IRS2 exerts beneficial effects, resulting in the reduction of amyloid p accumulation and premature mortality in AD mouse models. On the other hand, the increased phosphorylation of IRS 1 at several serine sites is observed in the brains from patients with AD and animal models of AD or cognitive impairment induced by type 2 diabetes. However, these serine sites are also activated in a mouse model of type 2 diabetes, in which the diabetes drug metformin improves memory impairment. Because IRS1 and IRS2 signaling pathways are regulated through complex mechanisms including positive and negative feedback loops, whether the elevated phosphorylation of IRS1 at specific serine sites found in AD brains is a primary response to cognitive dysfunction remains unknown. Here, we examine the associations between IRS 1 /1 RS2-mediated signaling in the central nervous system and cognitive decline.

关键词： type 2 diabetes insulin/insulin^like growth factor-1 insulin receptor substrate Alzheimer's disease aging serine phosphorylation metformin neuroprotective effects high-fat-diet

Experiment study on RC frame retrofitted by the external structure

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Earthquake Engineering and Engineering Vibration 2016年第3期15卷 563-574页

作者： Liu Chunyang Shi Junji Hiroshi Kuramoto taguchi Takashi Kamiya Takashi College of Civil Engineering Shandong Jianzhu University Division of Global Architecture Graduate School of Engineering Osaka University Earthquake Engineering Technology Institute Yahagi Construction Co. Ltd

A new retrofitting method is proposed herein for reinforced concrete （RC） structures through attachment of an external structure. The external structure consists of a fiber concrete encased steel frame, connection slab and transverse beams. The external structure is connected to the existing structure through a connection slab and transverse beams. Pseudo- static experiments were carried out on one unretrofitted specimen and three retrofitted frame specimens. The characteristics, including failure mode, crack pattern, hysteresis loops behavior, relationship of strain and displacement of the concrete slab, are demonstrated. The results show that the load carrying capacity is obviously increased, and the extension length of the slab and the number of columns within the external frame are important influence factors on the working performance of the existing structure. In addition, the displacement difference between the existing structure and the outer structure was caused mainly by three factors： shear deformation of the slab, extraction of transverse beams, and drift of the conjunction part between the slab and the existing frame. Furthermore, the total deformation determined by the first two factors accounted for approximately 80% of the damage, therefore these factors should be carefully considered in engineering practice to enhance the effects of this new retrofitting method.

关键词： extemal structure seismic retrofitted pseudo-static experiment seismic performance deformation analysis

Microstructure and Electrochemical Corrosion Behavior of Fe-Cr System Alloys as Substitutes for Ni-Based Brazing Filler Metal

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Acta Metallurgica Sinica(English Letters) 2016年第8期29卷 697-706页

作者： kangdao shi takahiro tsunoda ikuo shohji kotaro matsu yasuhiro taguchi Graduate School of Engineering Gunma UniversityKiryuGunma 376-8515Japan Graduate School of Science and Technology Gunma UniversityKiryuGunma 376-8515Japan Tokyo Braze Co LtdShikiSaitarma 353-0001Japan

Two new Fe-Cr system alloys,Fe-20Cr-43Ni-10P（mass%）and Fe-20Cr-20Ni-8P-5Si-2Mo（mass%）,have been developed as substitutes for the expensive Ni-based brazing filler metal used in brazing exhaust gas recirculation *** microstructures and melting properties of the alloys were analyzed by electron probe X-ray microanalyzer and differential scanning *** electrochemical characteristics of the alloys were investigated by potentiodynamic polarization testing in an electrolyte solution made in accordance with the standards of the Automobile Manufacturers Association of ***,the corrosion behaviors of the alloys were investigated by constant-potential polarization testing and surface *** is found that both alloys are composed of solid-solution phases and phosphide *** solid-solution phases serve as the anode,and the phosphide phases serve as the cathode in the corrosion reaction for both ***-20Cr-43Ni-10 P exhibits galvanic corrosion on the entire *** contrast,Fe-20Cr-20Ni-8P-5Si-2Mo is attacked at a few localized areas so that the cavities form on the *** corrosion potential（E_（corr）） is lower than that of Ni-29Cr-6P-4Si（mass%）for both *** means that the Fe-Cr system alloys are more easily corroded than *** corrosion rate and corrosion resistance cannot be investigated by the corrosion current density（i_（corr）） and polarization resistance（R_p）,respectively,because of localized corrosion of the two alloys.

关键词： Iron-chromium system alloy Microstructure Electrochemical corrosion Brazing

The optimal stent pusher position to achieve successful ureteral stent insertion under fluoroscopic guidance

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Asian Journal of Urology 2024年第2期11卷 311-315页

作者： Makoto taguchi Kaneki Yasuda Hidefumi Kinoshita Department of Urology Osaka Saiseikai Izuo Hospital Based on Social Welfare Organization“Saiseikai”Imperial Gift Foundation Inc.OsakaJapan Department of Urology and Andrology Kansai Medical UniversityHirakataOsakaJapan

Objective: To examine factors to predict the optimal stent pusher position when inserting ureteral stents under ***: We retrospectively reviewed 327 patients who underwent ureteral stent insertion. We considered the pubic bone as a useful anatomical landmark to insert ureteral stents under fluoroscopic guidance. Thus, we categorized patients into three groups (proximal, middle, and distal groups) according to the position of the radiopaque tip of the push catheter when inserting the ureteral stent. Success was defined as a completely curled ureteral stent tail. We compared stent insertion success rates among the three groups. A multivariate analysis was performed to identify the factors affecting stent insertion ***: In men, 36 (63.2%) cases were deemed successful in the proximal group compared with 40 (80.0%) cases in the middle group and 12 (20.7%) cases in the distal group (p<0.001). In women, 26 (45.6%) cases were deemed successful in the proximal group compared with 54 (98.2%) cases in the middle group and 38 (76.0%) cases in the distal group (p<0.001). With the multivariate analysis, the stent pusher position was the most significant factor influencing successful stent insertion (men: odds ratio 6.00, 95% confidence interval 2.66-13.51, p<0.001;women: odds ratio 37.80, 95% confidence interval 4.94-289.22, p<0.001).Conclusion: The position of the stent pusher affects stent insertion success. The middle of the pubic symphysis is the optimal position for the radiopaque tip of the pusher when inserting ureteral stents under fluoroscopic guidance.

关键词： Stent Cystoscopy Fluoroscopy Ureter