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Early prediction of myocardial viability after acute myocardial infarction by two-dimensional speckle tracking imaging

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Journal of Geriatric Cardiology 2015年第5期12卷 474-481页

作者： Jong Shin Woo tae-Kyung Yu Woo-Shik Kim kwon Sam Kim Weon Kim Division of Cardiology Department of lnternal Medicine Kyung Hee University Hospital Kyung Hee University Seoul South Korea

Background Identifying the transmural extent of myocardial necrosis and the degree of myocardial viability in acute myocardial infarction （AMI） is important clinically. The aim of this study was to assess myocardial viability using two-dimensional speckle tracking imaging （2D-STI） in patients with AMI. Methods 2D-STI was performed at initial presentation, three days, and six months after primary percutaneous coronary intervention （PCI） in 30 patients with AMI, who had a left anterior descending coronary artery （LAD） culprit lesion. In addition, 20 patients who had minimal stenotic lesions （〈 30% stenosis） on coronary angiography were also included in the control group. At six months dobutamine echocardiography was performed for viability assessment in seven segments of the LAD territory. According to the recovery of wall motion abnormality, segments were classified as viable or non-viable. Results A total of 131 segments were viable, and 44 were nonviable. Multivariate analysis revealed significant differences between the viable and nonviable segments in the peak systolic strain, the peak systolic strain rate at initial presentation, and peak systolic strain rate three days after primary PCI. Among these, the initial peak systolic strain rate had the highest predictive value for myocardial viability （hazard ratio： 31.22, P 〈 0.01）. Conclusions 2D-STI is feasible for assessing myocardial viability, and the peak systolic strain rate might be the most reliable predictor of myocardial viability in patients with AMI.

关键词： Acute myocardial infarction Two-dimensional speckle tracking imaging Viable myocardium

Flux Optimization During Tapping in BOF Process

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Journal of Iron and Steel Research International 2011年第S2期18卷 148-152页

作者： Hyun-Seo PARK Sung-Mo SEO Ji-tae kwon Joo CHOI Steelmaking Research Group POSCO Technical Research Laboratories 699 Gumho-dong Gwangyang-si Jeonnam 545-090 Korea Technology development team plate rolling department Gwangyang Steelworks POSCO Gumho-dong Gwangyang-si Jeonnam 545-711 Korea

An integrated Plate Mill has started it’s operation on July 7, 2010 in Gwangyang Steelworks, POSCO. The production capability is about 2.5 million tons per year and the main stream consists of Blast Furnace, Hot metal pretreatment (KR), Converter, Bubbling Station, RH/VTD and Continuous Casting. Particularly, it is possible to control sulfur concentration at excellent level in BOF without any further treatment in LF or VTD, which is attained by unique KR process and scrap usage strategy in BOF. In this paper, desulfurization efficiency and steel cleanliness was introduced by optimizing flux amount during tapping in BOF process. In addition, the effect of the flux addition on the refractory of ladle was investigated based on EPMA analyses with the viewpoint of phase diagram. The cleanliness of each sample was examined using optical emission spectrometry and oxygen nitrogen determinator.

关键词： plate mill steel cleanliness flux tapping

Identification of crash hotspots using kernel density estimation and kriging methods:a comparison

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Journal of Modern Transportation 2015年第2期23卷 93-106页

作者： Lalita Thakali tae J.kwon Liping Fu Department of Civil & Environmental Engineering University of Waterloo School of Transportation and Logistics Southwest Jiaotong University

This paper presents a study aimed at comparing the outcome of two geostatistical-based approaches, namely kernel density estimation （KDE） and kriging, for identifying crash hotspots in a road network. Aiming at locating high-risk locations for potential intervention, hotspot identification is an integral component of any comprehensive road safety management programs. A case study was conducted with historical crash data collected between 2003 and 2007 in the Hennepin County of Min- nesota, U.S. The two methods were evaluated on the basis of a prediction accuracy index （PAI） and a comparison in hotspot ranking. It was found that, based on the PAI measure, the kriging method outperformed the KDE method in its ability to detect hotspots, for all four tested groups of crash data with different times of day. Further- more, the lists of hotspots identified by the two methods were found to be moderately different, indicating the im- portance of selecting the right geostatistical method for hotspot identification. Notwithstanding the fact that the comparison study presented herein is limited to one case study, the findings have shown the promising perspective of the kriging technique for road safety analysis.

关键词： Crash hotspots Kernel density Kriging Performance measures

Wearable EEG electronics for a Brain–AI Closed-Loop System to enhance autonomous machine decision-making

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npj Flexible Electronics 2022年第1期6卷 296-307页

作者： Joo Hwan Shin Junmo kwon Jong Uk Kim Hyewon Ryu Jehyung Ok SJoon kwon Hyunjin Park tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Electrical and Computer Engineering Sungkyunkwan University(SKKU)Suwon 16419Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan University(SKKU)Suwon 16419Korea Center for Neuroscience Imaging Research Institute for Basic ScienceSuwon 16419Korea Biomedical Institue for Convergence(BICS)SKKU Suwon 16419Korea

Human nonverbal communication tools are very ambiguous and difficult to transfer to machines or artificial intelligence(AI).If the AI understands the mental state behind a user’s decision,it can learn more appropriate decisions even in unclear *** introduce the Brain-AI Closed-Loop System(BACLoS),a wireless interaction platform that enables human brain wave analysis and transfers results to AI to verify and enhance AI *** developed a wireless earbud-like electroencephalography(EEG)measurement device,combined with tattoo-like electrodes and connectors,which enables continuous recording of high-quality EEG signals,especially the error-related potential(ErrP).The sensor measures the ErrP signals,which reflects the human cognitive consequences of an unpredicted machine *** AI corrects or reinforces decisions depending on the presence or absence of the ErrP signals,which is determined by deep learning classification of the received EEG *** demonstrate the BACLoS for AIbased machines,including autonomous driving vehicles,maze solvers,and assistant interfaces.

关键词： autonomous EEG enable

Prognostic implications of FGFR1 and MYC status in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2016年第44期22卷 9803-9812页

作者： Dohee kwon Ji Yun Yun Bhumsuk Keam Young tae Kim Yoon Kyung Jeon Department of Pathology Seoul National University Hospital Seoul National University College of Medicine Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Department of Thoracic Surgery Seoul National University Hospital Cancer Research Institute Genomic Medicine Institute Seoul National University College of Medicine Seoul National University College of Medicine

AIM To investigate the clinicopathological features and prognostic implications of combined MYC and fibroblast growth factor receptor 1(FGFR1) status in esophageal squamous cell carcinomas(ESCCs). METHODS All patients with ESCC(n = 180) underwent surgical resection at Seoul National University Hospital sometime between 2000 and 2013. A tissue microarray was constructed using cores obtained from representative tumor areas of formalin-fixed, paraffin-embedded tissue blocks. FGFR1 and MYC copy numbers were quantified using fluorescence in situ hybridization. The level of MYC expression was determined using immunohistochemistry. FGFR1 and MYC amplification status was compared between primary and metastatic lymph nodes. Univariate and multivariate survival analyses were performed according to adjuvant therapy *** FGFR1 and MYC amplifications were observed in 21.4%(37/173) and 54.2%(91/168) of patients, respectively, while MYC expression was observed in 58.9%(106/180) of patients. There was a positive correlation between MYC amplification and overexpression(P = 0.002). Although FGFR1 amplification was not associated with MYC amplification or expression, 12.3%(20/163) of patients exhibited both FGFR1 amplification and MYC expression. There was also a correlation in FGFR1 amplification status between matched primary tumors and metastatic lymph nodes(P < 0.001). MYC expression was higher in ESCCs with p T1(P < 0.001) and in those with no lymph node metastasis(P = 0.023). MYC expression was associated with prolonged diseasefree survival(P = 0.036) and overall survival(OS)(P = 0.017) but was not an independent prognostic factor. FGFR1 amplification was an independent predictor for prolonged OS in all patients(P = 0.029) and in those who did not receive adjuvant therapy(P = 0.013). Combined FGFR1 amplification and MYC expression predicted better OS in patients who did not receive adjuvant therapy(P = 0.034) but not in those who did receive adjuvant ***

关键词： Receptor tyrosine kinase Fibroblast growth factor receptor 1 MYC Esophageal squamous cell carcinoma Gene amplification Prognosis Fluorescent in situ hybridization

Ischemic colitis during interferon-ribavirin therapy for chronic hepatitis C:A case report

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World Journal of Gastroenterology 2012年第31期18卷 4233-4236页

作者： Su Jung Baik tae Hun Kim kwon Yoo Il Hwan Moon Min-Sun Cho Department of Gastroenterology Health Promotion CenterYonsei University Gangnam Severance HospitalSeoul 158-050South Korea Department of Internal Medicine Ewha Medical Research InstituteEwha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea Department of Pathology Ewha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea

Ischemic colitis is a rare complication of interferon *** 9 cases in 6 reports have been described *** report describes a case of ischemic colitis during pegylated interferon and ribavirin treatment for chronic hepatitis C,and includes a review of the relevant literature.A 48-year-old woman was treated with pegylated interferon-2a and ribavirin for chronic hepatitis C,genotype *** 19 wk of treatment,the patient complained of severe afebrile abdominal pain with *** signs were stable and serum white blood cell count was within the normal *** computed tomography showed diffuse colonic wall thickening from the splenic flexure to the proximal sigmoid colon,which is the most vulnerable area for the development of ischemic *** revealed an acute mucosal hyperemic change,with edema and ulcerations extending from the proximal descending colon to the sigmoid *** mucosal biopsy revealed acute exudative *** chain reaction and culture for Mycobacterium tuberculosis were negative and the cultures for cytomegalovirus,Salmonella and Shigella species were *** discontinuation of interferon and ribavirin therapy,abdominal pain and hematochezia subsided and,following colonoscopy showed improvement of the mucosal *** colitis cases during interferon therapy in patients with chronic hepatitis C reported so far have all involved the descending *** colitis is a rarely encountered complication of interferon administration in patients with chronic hepatitis C and should be considered when a patient complains of abdominal pain and hematochezia.

关键词： Ischemia Hepatitis C Interferon

Acupuncture for Bell's Palsy:A Systematic Review and Meta-analysis

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Chinese Journal of Integrative Medicine 2012年第1期18卷 48-55页

作者： Jong-In Kim Myeong Soo Lee tae-Young Choi Hyangsook Lee Hyo-Jung kwon Department of Acupuncture and Moxibustion College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea Brain Disease Research Center Korea Institute of Oriental Medicine DaejeonRepublic of Korea Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea

Objective： To assess the clinical evidence for and against acupuncture as a treatment for Bell＇s palsy. Methods： We conducted a literature search of 15 databases from their inception to December 2010 without language restrictions. We included all randomized clinical trials （RCTs） regardless of their controls. Methodological quality was evaluated using the Cochrane risk of bias assessment tool. Results： Of the 3 474 articles, only eight RCTs met our inclusion criteria. Four RCTs tested the effects of acupuncture against drug therapy on disease response rate. The meta-analysis of these data showed significant improvements in the acupuncture group [n=463, risk ratio （RR）=1.07, 95% CI： 1.02 to 1.13; P=0.006, I^2=0%]. Six RCTs tested the effects of acupuncture plus drug therapy versus drug therapy alone. The meta-analysis of this set of RCTs also showed the favorable effects of acupuncture on disease response rate （n=512, RR=1.11, 95% CI： 1.05 to 1.17; P=0.001, I^2=13%）. Conclusions： The evidence supporting the effectiveness of acupuncture for treating Bell＇s palsy is limited. The number and quality of trials are too low to form firm conclusions. Further rigorous RCTs are warranted but need to overcome the many limitations of the current evidence.

关键词： acupuncture Bell's palsy systematic review

Molecular approaches for the detection and monitoring of microbial communities in bioaerosols:A review

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Journal of Environmental Sciences 2017年第1期29卷 234-247页

作者： Keunje Yoo tae kwon Lee Eun Joo Choi Jihoon Yang Sudheer Kumar Shukla Sang-il Hwang Joonhong Park Department of Civil and Environmental Engineering Yonsei UniversitySeoul 03722South Korea Department of Environmental Engineering Yonsei UniversityWonju 26493South Korea Department of Systems Biology Yonsei UniversitySeoul 03722South Korea Department of Built and Natural Environment Caledonian College of EngineeringSultanate of Oman Division of Natural Resources Conservation Korea Environment InstituteSejong-si 30147South Korea

Bioaerosols significantly affect atmospheric processes while they undergo long-range vertical and horizontal transport and influence atmospheric chemistry and physics and climate *** evidence suggests that exposure to bioaerosols may cause adverse health effects,including severe *** of bioaerosols have primarily focused on their chemical composition and largely neglected their biological composition and the negative effects of biological composition on ecosystems and human ***,current molecular methods for the identification,quantification,and distribution of bioaerosol agents are *** developments in environmental microbiology technology would be favorable in elucidation of microbial temporal and spatial distribution in the atmosphere at high *** addition,these provide additional supports for growing evidence that microbial diversity or composition in the bioaerosol is an indispensable environmental aspect linking with public health.

关键词： Bioaerosol Airborne microbial community Molecular methods Metagenomics

Optical Gain Analysis of Graded InGaN/GaN Quantum-Well Lasers

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Chinese Physics Letters 2011年第7期28卷 319-322页

作者： Seoung-Hwan Park Yong-tae Moon Jeong Sik Lee Ho Ki kwon Joong Seo Park Doyeol Ahn Department of Electronics Engineering Catholic University of DaeguHayangKyeongsanKyeongbuk 712-702Republic of Korea SLED R&D Center LG Innotek16 Woomyeon-dongSeocho-guSeoul 137-140Republic of Korea Department of Electrical and Computer Engineering University of SeoulSeoul 130-743Republic of Korea

Optical properties of graded InGaN/GaN quantum well(QW)lasers are analyzed as improved gain media for laser diodes emitting near 500 *** results are compared with those of conventional InGaN/GaN QW *** heavy-hole effective mass around the topmost valence band is found to nearly not be affected by the inclusion of the graded *** graded InGaN/GaN QW structure shows a much larger matrix element than the conventional InGaN/GaN QW *** radiative current density dependences of the optical gain are similar to each ***,the graded QW structure is expected to have lower threshold current density than the conventional QW structure because the former has a lower threshold carrier density than the latter.

关键词： InGaN/GaN graded Lasers