检索结果-南通市图书馆

Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer

引用

World Journal of Clinical Cases 2024年第5期12卷 931-941页

作者： Hongsik Kim Song-Yi Choi tae-young heo Kyeong-Rok Kim Jisun Lee Min young Yoo taek-Gu Lee Joung-Ho Han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Pathology Chungnam National University College of MedicineDaejeon 35015South Korea Information and Statistics Chungbuk National UniversityCheongju 28644South Korea Department of Radiology College of MedicineChungbuk National UniversityChungbuk National University HospitalCheongju-si 28644South Korea Department of Nuclear Medicine School of MedicineInha UniversityIncheon 22332South Korea Department of Surgery Chungbuk National UniversityCollege of MedicineCheongju-si 28644South Korea Department of Internal Medicen Chungbuk National UniversityCollege of medicineCheongju-si 28644South Korea

BACKGROUND There are limited data on the use of glucose transport protein 1(GLUT-1)expre-ssion as a biomarker for predicting lymph node metastasis in patients with colorectal ***-1 and GLUT-3,hexokinase(HK)-II,and hypoxia-induced factor(HIF)-1 expressions may be useful biomarkers for detecting primary tumors and lymph node metastasis when combined with fluorodeoxyglucose(FDG)uptake on positron emission tomography/computed tomography(PET/CT).AIM To evaluate GLUT-1,GLUT-3,HK-II,and HIF-1 expressions as biomarkers for detecting primary tumors and lymph node metastasis with 18F-FDG-PET/*** This retrospective study included 169 patients with colorectal cancer who underwent colectomy and preoperative 18F-FDG-PET/CT at Chungbuk National University Hospital between January 2009 and May *** tissue cores from the central and peripheral areas of the tumors were obtained and were examined by a dedicated pathologist,and the expressions of GLUT-1,GLUT-3,HK-II,and HIF-1 were determined using immunohisto-chemical *** analyzed the correlations among their expressions,various clinicopathological factors,and the maximum standardized uptake value(SUVmax)of PET/*** GLUT-1 was found at the center or periphery of the tumors in 109(64.5%)of the 169 ***-1 positivity was significantly correlated with the SUVmax of the primary tumor and lymph nodes,regardless of the biopsy site(tumor center,P<0.001 and P=0.012;tumor periphery,P=0.030 and P=0.010,respectively).GLUT-1 positivity and negativity were associated with higher and lower sensitivities of PET/CT,respectively,for the detection of lymph node metastasis,regardless of the biopsy ***3,HK-II,and HIF-1 expressions were not significantly correlated with the SUVmax of the primary tumor and lymph *** GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT for primary tumors and lymph *** should consider GLUT-1 expression in preoperative endoscop

关键词： 18F-FDG-PET-CT Biomarker Colorectal neoplasms Glucose transporter type 1 Lymph node

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identifying MicroRNA and mRNA Expression Profiles in Embryonic Stem Cells Derived from Parthenogenetic,Androgenetic and Fertilized Blastocysts

引用

Journal of Genetics and Genomics 2013年第4期40卷 189-200页

作者： Xiang-Shun Cui Xing-Hui Shen Shao-Chen Sun Sun-Wha Cho young-tae heo Yong-Kook Kang Teruhiko Wakayama Nam-Hyung Kim Department of Animal Science Chungbuk National UniversityGaeshin-dongCheongjuChungbuk 361-763South Korea Department of Histology and Embryology Harbin Medical UniversityHarbin 150081China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China Laboratory of Development and Differentiation Korea Research Institute of Bioscience and BiotechnologyDaejeon 305-806South Korea Center for Developmental Biology RIKEN KobeKobe 650-0047Japan

MicroRNAs（miRNAs） are a class of highly conserved small non-coding RNA molecules that play a pivotal role in several cellular *** this study,miRNA and messenger RNA（mRNA） profiles were examined by Illumina microarray in mouse embryonic stem cells（ESCs） derived from parthenogenetic,androgenetic,and fertilized *** global analysis of miRNA-mRNA target pairs provided insight into the role of miRNAs in gene *** showed that a total of 125 miRNAs and 2394 mRNAs were differentially expressed between androgenetic ESCs（aESCs） and fertilized ESCs（fESCs）,a total of 42 miRNAs and 87 mRNAs were differentially expressed between parthenogenetic ESCs（pESCs） and fESCs,and a total of 99 miRNAs and 1788 mRNAs were differentially expressed between aESCs and *** addition,a total of 575,5 and 376 miRNA-mRNA target pairs were observed in aESCs ***,pESCs ***,and aESCs ***,***,15 known imprinted genes and 16 putative uniparentally expressed miRNAs with high expression levels were confirmed by both microarray and real-time ***,transfection of miRNA inhibitors was performed to validate the regulatory relationship between putative maternally expressed miRNAs and target mRNAs. Inhibition of miR-880 increased the expression of Peg3,Dyrklb,and Prrg2 mRNA,inhibition of miR-363 increased the expression of Nfat5 and Soatl mRNA,and inhibition of miR-883b-5p increased Nfat5,Tacstd2,and Ppapdc1 *** results warrant a functional study to fully understand the underlying regulation of genomic imprinting in early embryo development.

关键词： Embryonic stem cell Parthenogenetic Androgenetic Fertilized Microarray miRNA-mRNA network

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Production of Transgenic Korean Native Cattle Expressing Enhanced Green Fluorescent Protein Using a FIV-Based Lentiviral Vector Injected into MII Oocytes

引用

Journal of Genetics and Genomics 2013年第1期40卷 37-43页

作者： Yong-Nan Xu Sang-Jun Uhm Bon-Chul Koo Mo-Sun Kwon Ji-Yeol Roh Jung-Seok Yang Hyun-Yong Choi young-tae heo Xiang-Shun Cui Joon-Ho Yoon Dae-Hwan Ko Teoan Kim Nam-Hyung Kim Department of Animal Sciences Chungbuk National University361-763Republic of Korea Department of Animal Science and Biotechnology Sangji Youngseo College220-713Republic of Korea Department of Physiology Catholic University of Daegu School of Medicine712-702Republic of Korea Department of Animal Resources Community KongJu National University340-702Republic of Korea

The potential benefits of generating and using transgenic cattle range from improvements in agriculture to the production of large quantities of pharmaceutically relevant proteins. Previous studies have attempted to produce transgenic cattle and other livestock by pronuclear injection and somatic cell nuclear transfer, but these approaches have been largely ineffective; however, a third approach, lentivirus-mediated transgenesis, has successfully produced transgenic livestock. In this study, we generated transgenic （TG） Korean native cattle using perivitelline space injection of viral vectors, which expressed enhanced green fluorescent protein （EGFP） systemically. Two different types of lentiviral vectors derived from feline immunodeficiency virus （FIV） and human immunodeficiency virus （HIV） carrying EGFP were injected into the perivitelline space of MII oocytes. EGFP expression at 8-cell stage was significantly higher in the FIV group compared to the HIV group （47.5% ± 2.2% v.s. 22.9% 4± 2.9%）. Eight-cell embryos that expressed EGFP were cultured into blastocysts and then transferred into 40 heifers. Ten heifers were successfully impregnated and delivered 10 healthy calves. All of these calves expressed EGFP as detected by in vivo imaging, PCR and Southern blotting. In addition, we established an EGFP-expressing cell line from TG calves, which was followed by nuclear transfer （NT）. Recloned 8-cell embryos also expressed EGFP, and there were no differences in the rates of fusion, cleavage and development between cells derived from TG and non-TG calves, which were subsequently used for NT. These results illustrate that FIV-based lentiviruses are useful for the production of TG cattle. Moreover, our established EGFP cell line can be used for additional studies that involve induced pluripotent stem cells.

关键词： Transgenic cattle Lentiviral vector Perivitelline space injection Enhanced green fluorescent protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of honing treatment on AIP-TiN and TiAlN coated end-mill for high speed machining

引用

Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 83-87页

作者： Jae-young heo Sung-Hak CHO tae-Jin JE Kwang-Ho KIM Hyung-Woo LEE Myung-Chang KANG National Core Research Center for Hybrid Materials Solution Pusan National University Nano Machining Laboratory Korea Institute of Machinery and Material (KIMM) 171 Jang-dong Yuseong-Gu Daejeon 305-343 Korea

The objective of this work is to compare the tool performance of TiN and TiA1N coated carbides end-mills deposited by an arc ion plating （ALP） method, using honing treatment to polish the cutting edge surface sleekly. The curve of surface roughness versus honing time showed a rapid improvement initially and thereafter became steady, manifesting a saturation effect. The optimal honing time related to surface roughness was determined to be approximately 20 s. As the surface roughness increased, the critical loads reduced. At an average surface roughness （Ra） of 0.028 p.m, the highest critical loads of TiN and TiAlN coating layers were 98 and 114 N, respectively. Tool performances of uncoated and coated tools were conducted under high speed machining （HSM） of AISI D2 cold-worked die steel （62 HRC）. Consequently, the TiAlN coated end-mill using honing treatment showed excellent tool life under HSM conditions.

关键词： TiA1N arc ion plating honing treatment high speed machining tool life

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model

引用

Journal of Traditional Chinese Medicine 2019年第6期39卷 833-841页

作者： young-Wook Park Gi Yoon heo Min Jae Kim Seo-Yeon Lee Byung tae Choi Hwa Kyoung Shin Division of Meridian and Structural Medicine School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea Korean Medical Science Research Center for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea

OBJECTIVE:To investigate the optimal timing and underlying mechanism of electroacupuncture(EA)at Baihui(GV 20)and Dazhui(GV 14)for improved long-term functional recovery after focal cerebral ischemia in a photothrombotic stroke mouse ***:Totally 50 adult male C57 BL/6 J mice were assigned into 5 groups:(a)the control group,sham-operated mice(n=10);(b)the vehicle group,focal cerebral ischemia induction without EA(n=10);(c)the acute EA group,mice received EA immediately post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(d)the subacute EA group,mice received EA 4 days post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(e)the delayed EA *** stimulation(2 Hz,2 V for 20 min)was applied to acupuncture points(acupoints),Baihui(GV 20)and Dazhui(GV 14),once a day for 7 consecutive days beginning immediately(acute treatment),4 d(subacute treatment)and 10 d(delayed treatment)after focal cerebral ischemia in C57 BL/6 J *** assessments were conducted 21 and 28 d post-ischemia and histopathological analyses were performed 28 days ***:The subacute EA treatment at Baihui(GV20)and Dazhui(GV 14)significantly improved functional recovery compared to the vehicle group 28 d after ischemic brain injury,although brain atrophy was not *** number of Neu N+and Neu N+/Brd U+cells as well as GFAP intensity in the ipsilateral cortex were significantly increased in the subacute group compared to the vehicle group 28 d *** concluded that EA stimulation 4 d post-ischemia(subacute treatment)enhanced neurogenesis and astrogliosis,likely contributing to long-term functional recovery following focal cerebral ***:Our findings suggest that the timing of the EA therapy at Baihui(GV 20)and Dazhui(GV 14)determines the therapeutic effects in mice with focal cerebral ischemia induced by photothrombotic occlusion.

关键词： Electroacupuncture Stroke Astrocytes Neurogenesis Post-stroke remodeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cutting force signal pattern recognition using hybrid neural network in end milling

引用

中国有色金属学会会刊：英文版 2009年第B9期19卷 209-214页

作者： Song-tae SEONG Ko-tae JO young-Moon LEE Research and Development Department Gyeongbuk Hybrid Technology Institute School of Mechanical Engineering Yeongnam University School of Mechanical Engineering Kyungpo ok National University

Under certain cutting conditions in end milling, the signs of cutting forces change from positive to negative during a revolution of the tool. The change of force direction causes the cutting dynamics to be unstable which results in chatter vibration. Therefore, cutting force signal monitoring and classification are needed to determine the optimal cutting conditions and to improve the efficiency of cut. Artificial neural networks are powerful tools for solving highly complex and nonlinear problems. It can be divided into supervised and unsupervised learning machines based on the availability of a teacher. Hybrid neural network was introduced with both of functions of multilayer perceptron (MLP) trained with the back-propagation algorithm for monitoring and detecting abnormal state, and self organizing feature map (SOFM) for treating huge datum such as image processing and pattern recognition, for predicting and classifying cutting force signal patterns simultaneously. The validity of the results is verified with cutting experiments and simulation tests.

关键词：切削力信号混合神经网络模式识别铣床人工神经网络切削条件信号监测监督学习

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of foundation damage and water-level change on vibration modal parameters of gravity-type caisson structure

引用

Science China(Technological Sciences) 2015年第2期58卷 316-329页

作者： LEE So-young KIM Jeong-tae Department of Ocean Engineering Pukyong National University

In this paper,the effects of foundation damage and water-level change on vibration characteristics of gravity-type caisson structure are examined by analyzing modal parameters extracted from output-only *** achieve the objective,the following approaches are ***,vibration response analysis methods are selected to estimate power spectral density and modal parameters such as natural frequency,damping ratio and mode shape of a lab-scale caisson structural ***,vibration tests on the lab-scale caisson system are performed under a series of test scenarios which include three water-level changes and three damage ***,experimental modal parameters corresponding to the damaging cases as well as the water level cases are extracted by frequency domain decomposition method and stochastic subspace identification ***,the effects of the water-level variation and foundation damage on the extracted modal parameters are examined to assess the feasibility of the vibration-based damage detection in gravity-type caisson structures under water-level uncertainty.

关键词： caisson structure gravity-type structure modal parameter effect of water-level foundation damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances in endoscopic retrograde cholangiopancreatography in Billroth II gastrectomy patients: A systematic review

引用

World Journal of Gastroenterology 2019年第24期25卷 3091-3107页

作者： tae young Park tae Jun Song Department of Internal Medicine Inje University Seoul Paik HospitalSeoul 04551South Korea Division of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 138-736South Korea

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)in patients with Billroth Ⅱ gastrectomy has been considered a challenging procedure due to the surgically altered gastrointestinal ***,there has been a paucity of comparative studies regarding ERCP in Billroth Ⅱ gastrectomy cases because of procedure-related morbidity and mortality and practical and ethical *** systematic and comprehensive review was performed to obtain a recent perspective on ERCP in Billroth Ⅱ gastrectomy *** To systematically review the literature regarding ERCP in Billroth Ⅱ gastrectomy *** A systematic review was performed on the literature published between May 1975 and January *** following electronic databases were searched:PubMed,EMBASE,and Cochrane *** outcomes of successful afferent loop intubation and successful selective cannulation and occurrence of adverse events were *** A total of 43 studies involving 2669 patients were *** study designs were 36(83.7%)retrospective cohort studies,4(9.3%)retrospective comparative studies,2(4.7%)prospective comparative studies,and 1(2.3%)prospective cohort *** a total of 2669 patients,there were 1432 cases(55.6%)of sideviewing endoscopy,664(25.8%)cases of forward-viewing endoscopy,171(6.6%)cases of balloon-assisted enteroscopy,169(6.6%)cases of anterior obliqueviewing endoscopy,64(2.5%)cases of dual-lumen endoscopy,31(1.2%)cases of colonoscopy,and 14(0.5%)cases of multiple bending *** overall success rate of afferent loop intubation was 91.3%(2437/2669),and the overall success rate of selective cannulation was 87.9%(2346/2437).A total of 195 cases(7.3%)of adverse events *** success rates of afferent loop intubation and the selective cannulation rate for each type of endoscopy were as follows:side-viewing endoscopy 98.2%and 95.3%;forward-viewing endoscopy 97.4%and 95.2%;balloon-assisted enteroscopy 95.4%and 97.5%;oblique-viewing endosco

关键词： Endoscopic retrograde Cholangiopancreatography Therapeutic Endoscope Billroth Ⅱ operation Adverse event Systematic review

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pancreatic abscess following scrub typhus associated with multiorgan failure

引用

World Journal of Gastroenterology 2007年第25期13卷 3523-3525页

作者： Sun young Yi Jung Hyun tae Department of Internal Medicine School of Medicine Ewha Womans University Seoul South Korea

Clinical severity of scrub typhus ranges from mild to fatal. Acute pancreatitis with abscess formation is a rare complication among patients with scrub typhus. This paper reports a case of scrub typhus in a 75 years old man with acute pancreatitis with abscess formation and multiorgan failure. Abdominal computed tomography showed multiple infected pancreatic pseudocysts with periopancreatic infiltration. Multiorgan failure was successfully treated with doxycycline, ceftriaxone, and supportive management. The pancreatic abscess was successfully drained percutaneously and the sizes of pseudocysts decreased remarkably.

关键词： Scrub typhus Pancreatitis Pancreaticabscess Multiorgan failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The 3-Hour-Interval Prediction of Ground-Level Temperature in South Korea Using Dynamic Linear Models

引用

Advances in Atmospheric Sciences 2003年第4期20卷 575-582页

作者： Keon-tae SOHN Deuk-KyunRHA young-KyungSEO Dept.of Statistics Pusan National University30 Jangjeon-dongGeumjung-guPusan609-735KoreaKorea Meteorological Administration460-18 Shindaebang-dongTongjak-guSeoul156-720KoreaKorea Meteorological Administration460-18 Shindaebang-dongTongjak-guSeoul156-720Korea

The 3-hour-interval prediction of ground-level temperature from +00 h out to +45 h in South Korea (38 stations) is performed using the DLM (dynamic linear model) in order to eliminate the systematic error of numerical model forecasts. Numerical model forecasts and observations are used as input values of the DLM. According to the comparison of the DLM forecasts to the KFM (Kalman filter model) forecasts with RMSE and bias, the DLM is useful to improve the accuracy of prediction.

关键词： temperature forecasting systematic error dynamic linear model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：