检索结果-南通市图书馆

Does intraoperative frozen section really predict significant positive surgical margins after robot-assisted laparoscopic prostatectomy?A retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2021年第1期23卷 74-79页

作者： Se Young Choi Byung Hoon Chi tae-Hyoung Kim Bumjin Lim Wonchul Lee Dalsan You Choung-soo Kim Department of Urology Chung-Ang University HospitalChung-Ang University College of MedicineDongjak-guSeoul 06973Korea Department of Urology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Korea

We investigated the relationship between positive surgical margin(PSM)-related factors and biochemical recurrence(BCR)and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate *** study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral *** frozen sections of the periurethra,dorsal vein,and bladder neck were *** ability of PSM-related factors to predict BCR and significant PSM was assessed by logistic *** 271 patients,108(39.9%)had PSM and 163(60.1%)had negative *** Gleason score^8(18.9%vs 7.5%,P=0.015)and T stage≥T3a(51.9%vs 24.6%,P<0.001)were significantly more frequent in the PSM *** analysis showed that Gleason pattern≥4(vs<4;hazard ratio:4.386;P=0.0004)was the only significant predictor of BCR in the PSM *** frozen sections had a sensitivity of 83.3%and a specificity of 84.2%in detecting PSM with Gleason pattern≥*** analysis showed that membranous urethra length(odds ratio[OR]:0.79,P=0.0376)and extracapsular extension of the apex(OR:4.58,P=0.0226)on magnetic resonance imaging(MRI)and positive periurethral tissue(OR:17.85,P<0.0001)were associated with PSM of the *** with Gleason pattern≥4 is significantly predictive of *** frozen sections of periurethral tissue can independently predict PSM,whereas sections of the bladder neck and dorsal vein could *** examination of these samples may help predict significant PSM in patients undergoing robot-assisted laparoscopic prostatectomy with preservation of functional outcomes.

关键词： biochemical recurrence frozen section positive surgical margin robotic-assisted prostatectomy

Cytotoxicity and anti-inflammatory effects of root bark extracts of Acanthopanax henryi

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2014年第2期12卷 121-125页

作者： KIM Jong-Hwan LIU Xiang-Qian DAI Ling YOOK Chang-soo LEE Kyung-tae Herbal Medicine Research Division Korea Food & Drug Administration Hunan Key Laboratory of Traditional Chinese Medicine modernization School of Pharmacy Hunan University of Chinese Medicine College of Pharmacy Kyung-Hee University

AIM: To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi. METHOD: The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-inflammatory effects of the MeOH fractions were evaluated on the inhibition on lipopolysaccharide(LPS)-induced nitric oxide, prostaglandin E2, interleukin-1β, and interleukin-6 production in RAW 264.7 macrophages. RESULTS: The 80% MeOH fraction was a better inhibitor of LPS-induced NO, PGE2, IL-1β, and IL-6 production, and expression of inducible nitric oxide synthase(iNOS) at the protein levels in a concentration-dependent manner. CONCLUSION: The 80% MeOH fraction of A. henryi root bark has significant anti-inflammatory activity. This provides a pharmacological basis for clinical application for the treatment of inflammation.

关键词： Acanthopanax henryi(Oliv.) Harms Root bark extract Cytotoxic activity Anti-inflammatory activity

Expert Opinions on the Concept of Blood Stasis in China: An Interview Study

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2016年第11期22卷 823-831页

作者： tae-Young Choi Ji Hee Jun Ju Ah Lee Bongki Park sooseong You Jeeyoun Jung Myeong soo Lee Medical Research Division Korea Institute of Oriental Medicine

Objective: To study various experts’ opinions on the definition and diagnosis of blood stasis in China. Methods: We e-mailed the selected experts to explain the purpose of the study and to invite them to participate and asked them to name a time for the investigator to call them. Eight experts and five organizations were interviewed in the research community investigating blood stasis in China. Results: Six main categories emerged from the interviews:(1) blood stasis concepts;(2) blood stasis-related biomarkers;(3) methods of diagnosing blood stasis;(4) drugs for promoting blood circulation and dissipating stasis;(5) blood stasis-related diseases; and(6) blood stasis-related societies. The consensus among the interviewed experts was that the definition of blood stasis is rather complicated and that there is no gold standard marker for detecting blood stasis. Conclusion: This paper acquired experts’ opinions on the definition and diagnosis of blood stasis in order to establish a modern concept of blood stasis. This paper also developed a diagnostic tool and diagnostic indices for blood stasis and identified biological indices and pathologic mechanisms related to blood stasis, which might be of great reference value in future blood stasis standardization research.

关键词： blood stasis concept interview experts Chinese medicine

Chemoresistive materials for electronic nose:Progress,perspectives,and challenges

在线全文

学校读者我要写书评

暂无评论

InfoMat 2019年第3期1卷 289-316页

作者： Seo Yun Park Yeonhoo Kim taehoon Kim tae Hoon Eom soo Young Kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Center for Integrated Nanotechnologies Los Alamos National LaboratoryLos AlamosNew Mexico School of Chemical Engineering and Materials Science Chung-Ang UniversitySeoulRepublic of Korea

An electronic nose(e-nose)is a device that can detect and recognize odors and flavors using a sensor *** has received considerable interest in the past decade because it is required in several areas such as health care,environmental monitoring,industrial applications,automobile,food storage,and ***,there are still obstacles in developing a portable e-nose that can be used for a wide variety of *** practical applications of an e-nose,it is necessary to collect a massive amount of data from various sensing materials that can transduce interactions with molecules reliably and analyze them via pattern *** addition,the possibility of miniaturizing the e-nose and operating it with low power consumption should be ***,it should work efficiently over a long period of *** satisfy these requirements,several different chemoresistive material platforms including metal oxides,organics such as polymers and carbonbased materials,and two-dimensional materials were investigated as sensor elements for an *** an individual material has limited selectivity,there is a continuing effort to improve the selectivity and gas sensing properties through surface decoration and compositional and structural *** produce a reliable e-nose,which can be used for practical applications,researches in various fields have to be *** paper reviews the progress of research on e-noses based on a chemoresistive gas sensor array and discusses the inherent challenges and potential solutions.

关键词： chemoresistive materials electronic nose metal oxides polymers two-dimensional materials

Critical cooling rate on carbide precipitation during quenching of austenitic manganese steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Foundry 2010年第2期7卷 178-182页

作者： Youn-soo Ham Jeong-tae Kim Si-Young Kwak Jeong-Kil Choi Woo-Young Yoon Daeyang R-Tech.Co. Ltd290-28Daehwa-DongDaeduk-GuDaejeonKorea e-Design Center KITECH7-47Songdo-DongYeonsu-GuIncheon 406-800Korea Department of Materials Science and Engineering Korea UniversityAnam-DongSeongbuk-GuSeoul 136-701Korea

Critical cooling rate to avoid carbide precipitation during quenching of austenitic manganese steel was investigated by means of optical microscopy,image analyzer and numerical *** efficient heat treatment analysis program including temperature-dependent material properties was developed for the prediction of cooling rate and probability of carbide precipitation during quenching by finite difference ***-dependent heat transfer coefficient was adopted to achieve more precise *** ratio of carbide precipitation was measured by image analyzer to determine the critical point of carbide ***-dependent critical cooling rate at that point was calculated by the developed numerical ***,the probability of carbide precipitation on the whole area of specimen can be predicted by the proposed numerical program and the numerical result of a specimen was compared with the experimental result.

关键词： austenitic manganese steel carbide precipitation quenching critical cooling rate

Extracts from Paeonia lactiflora Pallas, Rehmannia Glutinosa var. Purpurea Makino, Perilla Frutescens var. Acuta Kudo may increase the endometrial receptivity through expression of leukemia inhibitory factor and adhesion molecules

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2019年第1期39卷 15-25页

作者： Eun-Yeong Kim tae-Wook Chung Hee-Jung Choi Yeon-Seop Jung Syng-Ook Lee Jun-Yong Choi Hyung Sik Kim sooseong You Myeong soo Lee Ki-tae Ha School of Korean Medicine and Korean Medical Research Center for Healthy Aging Pusan National UniversityYangsan 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-aging Pusan National UniversityYangsan 50612Republic of Korea Department of Food Science and Technology Keimyung UniversityDaegu 42601Republic of Korea National Clinical Research Center for Korean Medicine Korean Medicine Hospital of Pusan National UniversityYangsan 50612Republic of Korea Laboratory of Molecular Toxicology School of PharmacySungKyunKwan UniversitySuwon 16419Republic of Korea Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea

OBJECTIVE: To find out the combination of the extracts from Paeonia lactiflora Pallas(PL), Rehmannia Glutinosa var. Purpurea Makino(RG), Perilla Frutescens var. Acuta Kudo(PF) to increase endometrial ***: Herbal medicines were extracted with boiling water and polysaccharides were *** examined the effect of PL, RG, and PF(PRP), a most effective herbal formula deduced from constitutive ingredient herbs of Antai Yin which is composed of PRP, on the leukemia inhibitory factor(LIF) expression and endometrial ***: The combination of the extracts from PRP induced the LIF expression in Ishikawa cells and increased the adhesion between Ishikawa and JAr cells. In addition, PRP-induced attachment of JAr cells onto Ishikawa cells and expression of adhesion molecules, ITGAV, ITGB5, CD44 s, and Lselectin, are significantly reduced by knock-down of LIF ***: Induced by the combination of the PRP extracts, the adhesion between trophoblast and endometrial cells are mediated by expression of LIF and adhesion molecules. Thus, we suggest the combination of the PRP extracts may be a novel therapy for enhancing embryo implantation rate.

关键词： Paeonia Rehmannia Perilla Embryo implantation Endometrium Leukemia inhibitory factor Cell adhesion molecules

Influence of tool plunge depth and welding distance on friction stir lap welding of AA5454-O aluminum alloy plates with different thicknesses

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2012年第S3期22卷 624-628页

作者： Jun-Won KWON Myoung-soo KANG Sung-Ook YOON Yong-Jai KWON Sung-tae HONG Dae-Il KIM Kwang-Hak LEE Jong-Dock SEO Jin-soo MOON Kyung-Sik HAN School of Materials Science and Engineering University of Ulsan School of Mechanical Engineering University of Ulsan Technical Research Laboratories Shin Young Co.Ltd. Automotive Parts Innovation Center Ulsan Technopark

AA5454-O aluminum alloy plates with thicknesses of 1.4 and 1.0 mm were friction-stir-lap-welded (FSLWed).The influences of the tool plunge depth and welding distance on surface appearance,macrostructure and mechanical properties of the FSLWed plates were experimentally *** tensile shear load of the FSLWed plates was compared with that of the adhesive-bonded ***-free FSLWed zones were successfully obtained in all the tool plunge depths and the welding *** FSLWed zones exhibited the relatively smooth surface *** all the FSLWed conditions,the FSLWed zone exhibited higher average hardness than the base *** addition,the upper plate exhibited a higher average hardness than the lower plate,although there was no special tendency in spite of the change in the tool plunge depth and the welding *** maximum tensile shear load of the FSLWed plates was much higher than that of the adhesive-bonded aluminum alloy ***,under the FSLW condition of the plunge depth of 1.8 mm and the welding distance of 40 mm,the tensile shear load of the FSLWed plate reached a level about 41% greater than that of the adhesive-bonded aluminum alloy *** addition,the maximum tensile shear load of the FSLWed plate was increased with the increase of the welding distance.

关键词： friction stir lap welding AA5450-O aluminum alloy tool plunge depth welding distance mechanical properties

Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 1536-1547页

作者： Jungeun Kim Sang-Ho Kang Sin-Gi Park tae-Jin Yang Yi Lee Ok tae Kim Oksung Chung Jungho Lee Jae-Pil Choi soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee Seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-soog Kim Chang pyo Hong Jong Bhak Chang-Kug Kim Personal Genomics Institute Genome Research FoundationOsong 28160Korea Genomics Division National Institute of Agricultural Sciences(NAS)Jeonju 54874Korea Theragen Etex Bio Institute Suwon 16229Korea Department of Plant Science Plant Genomics and Breeding Instituteand Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea Department of Industrial Plant Science&Technology Chungbuk National UniversityCheongju 28644Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal ScienceRural Development Administration(RDA)Eumseong 27709Korea Clinomics Inc Ulsan 44919Korea Green Plant Institute Yongin 16954Korea Korean Genomics Center(KOGIC) Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Biomedical Engineering School of Life SciencesUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea

Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical *** grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East *** oleanane-type TSs,platycosides,are a major component of the *** root *** studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy ***,the evolutionary history of platycoside biosynthesis genes remains *** this study,we sequenced the genome of *** and investigated the genes involved in platycoside *** draft genome of *** is 680.1 Mb long and contains 40,017 protein-coding *** analysis revealed that the CYP716 family genes play a major role in platycoside *** CYP716 gene family of *** was much larger than that of other Asterid *** gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in ***,which was confirmed by tissue-specific gene *** these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside *** addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in ***,suggesting that epigenetic modification of these two gene families affects platycoside *** whole-genome,transcriptome,and methylome data of *** provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families.

关键词： properties insight roots

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

韩国高速列车防撞设计与评估

中国铁道科学 2004年第1期25卷 1-7页

作者： Jeong-Seo Koo tae-soo Kwon Hyun-Jik Cho KoreanRailroadResearshInstitute KoreanRailroadResearshInstituteKoreanRailroadResearshInstitute UiwangcityKyonggiDo437050KoreaUiwangcityKyonggiDo437050KoreaUiwangcityKyonggiDo437050Korea

针对韩国高速列车(KHST)的防撞性能进行深入地研究。选定行驶速度为110km·h-1的列车与一个15t重的刚性障碍物的撞击、两列行驶速度为30km·h-1的列车相撞作为严重撞击的事故场景,两列行驶速度为8km·h-1的列车相撞作为轻度撞击的事故... 详细信息

针对韩国高速列车(KHST)的防撞性能进行深入地研究。选定行驶速度为110km·h-1的列车与一个15t重的刚性障碍物的撞击、两列行驶速度为30km·h-1的列车相撞作为严重撞击的事故场景,两列行驶速度为8km·h-1的列车相撞作为轻度撞击的事故场景。用有限元方法对KHST的防撞性进行了数学评估。一维和二维的仿真分析表明该车整体上具有良好的耐撞性。同时,对动车的前端部分做了三维壳体单元的仿真分析。使用安全带的旅客伤亡试验的结果说明KHST的良好性能足以在设置的事故场景中保护旅客的安全。最后,用实比例的撞击试验对仿真方法进行了验证。

关键词：高速列车防撞性能有限元法铁路安全试验评估