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Gallbladder Metastasis of Non-small Cell Lung Cancer Presenting as Acute Cholecystitis

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Chinese Journal of Cancer Research 2012年第3期24卷 249-252页

作者： Yu-Sook Jeong Hye-Suk Han Sung-Nam Lim Mi-Jin kim Joung-Ho Han Min-Ho Kang Dong-Hee Ryu Ok-Jun Lee Ki-Hyeong Lee Seung-Taik kim Department of Internal Medicine College of MedicineChungbuk National University Department of Radiology College of MedicineChungbuk National University Department of Surgery College of MedicineChungbuk National University Department of Pathology College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University

Although non-small cell lung cancer （NSCLC） can metastasize to almost any organ, metastasis to the gallbladder with significant clinical manifestation is relatively rare. Here, we report a case of gallbladder metastasis of NSCLC presenting as acute cholecystitis. A 79-year-old man presented with pain in the right upper quadrant and fever. A computed tomography （CT） scan of the chest and abdomen showed a cavitary mass in the right lower lobe of the lung and irregular wall thickening of the gallbladder. Open cholecystectomy and needle biopsy of the lung mass were performed. Histological examination of the gallbladder revealed a moderately-differentiated squamous cell carcinoma displaying the same morphology as the lung mass assessed by needle biopsy. Subsequent immunohistochemical examination of the gallbladder and lung tissue showed that the tumor cells were positive for P63 but negative for cytokeratin 7, cytokeratin 20 and thyroid transcription factor-1. A second primary tumor of the gallbladder was excluded by immunohistochemical methods, and the final pathological diagnosis was gallbladder metastasis of NSCLC. Although the incidence is extremely rare, acute cholecystitis can occur in association with lung cancer metastasis to the gallbladder.

关键词： Cholecystitis Gallbladder Non-small cell lung cancer Metastasis

Clinical application of repetitive transcranial magnetic stimulation in stroke rehabilitation

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Neural Regeneration Research 2012年第8期7卷 627-634页

作者： Joonho Shin EunJoo Yang KyeHee Cho Carmelo L Barcenas Woo Jin kim Nam-Jong Paik Department of Rehabilitation Medicine Bundang Hospital College of Medicine Seoul National University

Proper stimulation to affected cerebral hemisphere would promote the functional recovery of patients with stroke. Effects of repetitive transcranial magnetic stimulation on cortical excitability can be can be altered by the stimulation frequency, intensity and duration. There has been no consistent recognition regarding the best stimulation frequency and intensity. This study reviews the intervention effects of repetitive transcranial stimulation on motor impairment, dysphagia, visuospatial neglect and aphasia, and summarizes the stimulation frequency, intensity and area for repetitive transcranial magnetic stimulation to yield the best therapeutic effects.

关键词： stroke repetitive transcranial magnetic stimulation rehabilitation review

Development of Cd-doped Co Nanoparticles Encapsulated in Graphite Shell as Novel Electrode Material for the Capacitive Deionization Technology

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Nano-Micro Letters 2013年第4期5卷 303-313页

作者： Nasser A.M.Barakat Khalil Abdelrazek Khalil Ahmad G.El-Deen Hak yong kim Organic Materials and Fiber Engineering Department Chonbuk National University Chemical Engineering Department Minia University Mechanical Engineering Department (NPST) King Saud University Dept of Bionano System Engineering College of Engineering Chonbuk National University

Because of the low energy requirement and the environmentally safe byproducts, the capacitive deionization water desalination technology has attracted the attention of many researchers. The important requirements for electrode materials are good electrical conductivity, high surface area, good chemical stability and high specific capacitance. In this study, metallic nanoparticles that are encapsulated in a graphite shell(Cd doped Co/C NPs) are introduced as the new electrode material for the capacitive deionization process because they have higher specific capacitance than the pristine carbonaceous materials. Cd doped Co/C NPs perform better than graphene and the activated carbon. The introduced nanoparticles were synthesized using a simple sol gel technique. A typical sol gel composed of cadmium acetate, cobalt acetate and poly(vinyl alcohol)was prepared based on the polycondensation property of the acetates. The physiochemical characterizations that were used confirmed that the drying, grinding and calcination in an Ar atmosphere of the prepared gel produced the Cd doped Co nanoparticles, which were encapsulated in a thin graphite layer. Overall, the present study suggests a new method to effectively use the encapsulated bimetallic nanostructures in the capacitive deionization technology.

关键词： Capacitive deionization Water desalination Bimetallic nanoparticles Specific capacitance

Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7,Species Differences, and Regulation by Paclitaxel

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Neuroscience Bulletin 2018年第1期34卷 4-12页

作者： Wonseok Chang Temugin Berta Yong Ho kim Sanghoon Lee Seok-Yong Lee Ru-Rong Ji Department of Anesthesiology Duke University Medical Center Durham NC 27710 USA Department of Physiology and Biophysics College of Medicine Eulji University Daejeon Korea Pain Research Center Department of Anesthesiology University of Cincinnati Medical Center Cincinnati OH 45267 USA D epartment of Physiology College of Medicine Gachon University Incheon Korea Department of Biochemistry Duke University Medical Center Durham NC 27710 USA Department of Neurobiology Duke University Medical Center Durham NC 27710 USA

Voltage-gated sodium channels （Navs） play an important role in human pain sensation. However, the expression and role of Nav subtypes in native human sensory neurons are unclear. To address this issue, we obtained human dorsal root ganglion （hDRG） tissues from healthy donors. PCR analysis of seven DRG-expressed Nav subtypes revealed that the hDRG has higher expression of Navl.7 （,-~ 50% of total Nav expression） and lower expres- sion of Navl.8 （~ 12%）, whereas the mouse DRG has higher expression of Nav 1.8 （- 45%） and lower expression of Navl.7 （- 18%）. To mimic Nav regulation in chronic pain, we treated hDRG neurons in primary cultures with paclitaxel （0.1-1 μmol/L） for 24 h. Paclitaxel increased the Navl.7 but not Navl.8 expression and also increased the transient Na＋ currents and action potential firing frequency in small-diameter （〈50 ~tm） hDRG neurons. Thus, the hDRG provides a translational model in which to study ＂human pain in a dish＂ and test new pain therapeutics.

关键词： Dorsal root ganglion Neuropathic pain Paclitaxel Voltage-gated sodium channels

Tonsil-derived stem cells as a new source of adult stem cells

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World Journal of Stem Cells 2019年第8期11卷 506-518页

作者： Kyung-Ah Cho Hyun Jung Lee Hansaem Jeong Miri kim Soo Yeon Jung Hae Sang Park Kyung-Ha Ryu Seung Jin Lee Byeongmoon Jeong Hyukjin Lee Han Su kim Department of Microbiology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 South Korea College of Pharmacy Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul 03760 South Korea Department of Otorhinolaryngology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Otorhinolaryngology College of Medicine Hallym University Chuncheon 24252 South Korea Department of Pediatrics College of Medicine Ewha Womans University Seoul 07985 South Korea

Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, TSCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.

关键词： Stem cell Tonsil-derived stem cell Differentiation Endoderm Mesoderm Ectoderm Cell therapy

Synthesis of Single-Walled Carbon Nanotubes by Induction Thermal Plasma

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Nano Research 2009年第10期2卷 800-817页

作者： Keun Su kim Ala Moradian Javad Mostaghimi Yasaman Alinejad Ali Shahverdi Benoit Simard Gervais Soucy Department of Chemical Engineering Universitéde SherbrookeJ1K 2R1Canada Department of Mechanical and Industrial Engineering University of TorontoM5S 3G8Canada Steacie Institute for Molecular Sciences National Research CouncilK1A 0R6Canada

The production of high quality single-walled carbon nanotubes(SWCNTs)on a bulk scale has been an issue of considerable ***,it has been demonstrated that high quality SWCNTs can be continuously synthesized on large scale by using induction thermal plasma *** this process,the high energy density of the thermal plasma is employed to generate dense vapor-phase precursors for the synthesis of *** the current reactor system,a carbon soot product which contains approximately 40 wt%of SWCNTs can be continuously synthesized at the high production rate of~100 g/*** this article,our recent research efforts to achieve major advances in this technology are ***,the processing parameters involved are examined systematically in order to evaluate their individual inuences on the SWCNT synthesis.Based on these results,the appropriate operating conditions of the induction thermal plasma process for an effective synthesis of SWCNTs are discussed.A characterization study has also been performed on the SWCNTs produced under the optimum processing ***,a mathematical model of the process currently under development is *** model will help us to better understand the synthesis of SWCNTs in the induction plasma process.

关键词： Single-walled carbon nanotubes(SWCNTs) large-scale continuous synthesis radio frequency(RF)induction thermal plasma optimization numerical modeling

Temporal and Spatial Requirement of EMF1 Activity for Arabidopsis Vegetative and Reproductive Development

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Molecular Plant 2009年第4期2卷 643-653页

作者： Rosario Sanchez Minjung Y. kim Myriam Calonje Yong-Hwan Moon Z. Renee Sung Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA Present address: Heidelberg Institute for Plant Science Biodiversity and Plant Systematics Heidelberg University 69120 Heidelberg Germany Present address: Department of Molecular Biology Pusan National University 30 Jangjeon-dong Geumjeong-gu Busan 609-735 Korea

EMBRYONIC FLOWER （EMF） genes are required to maintain vegetative development via repression of flower homeotic genes in Arabidopsis. Removal of EMF gene function caused plants to flower upon germination, producing abnormal and sterile flowers. The pleiotropic effect of ernfl mutation suggests its requirement for gene programs involved in diverse developmental processes. Transgenic plants harboring EMF1 promoter：：glucuronidase （GUS） reporter gene were generated to investigate the temporal and spatial expression pattern of EMF1. These plants displayed differential GUS activity in vegetative and flower tissues, consistent with the role of EMF1 in regulating multiple gene programs. EMFI：：GUS expression pattern in emf mutants suggests organ-specific auto-regulation. Sense- and antisense （as） EMF1 cDNA were expressed under the control of stage- and tissue-specific promoters in transgenic plants. Characterization of these transgenic plants showed that EMF1 activity is required in meristematic as well as differentiating tissues to rescue emf mutant phenotype. Temporal removal or reduction of EMF1 activity in the embryo or shoot apex of wild-type seedlings was sufficient to cause early flowering and terminal flower formation in adult plants. Such reproductive cell memory is reflected in the flower MADS-box gene activity expressed prior to flowering in these early flowering plants. However, temporal removal of EMF1 activity in flower meristem did not affect flower development. Our results are consistent with EMF1＇s primary role in repressing flowering in order to allow for vegetative growth.

关键词： EMF1 stage-specific promoter early flowering reproductive cell memory vegetative/reproductive development repression of flower MADS-box genes.

Dehydro-Diels-Alder reaction and diamondization of bowl-shaped clusters C_(18)Te_(3)Br_(4)(Bu-O)_(6)

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Nano Research 2022年第5期15卷 4606-4612页

作者： Jinbo Zhang Manli Ma Rong Zhou Hongqiang Chu Xue Wang Shaojie Wang Huhu Tian Zhipeng Yan Mingtao Li Zhongyan Wu Bin Li Jiafeng Yan Lan Anh Thi Nguyen Rongxing Cao Guoqing Wu Xianghua Zeng Hao-Li Zhang Jaeyong kim Lin Wang Yongjun Tian College of Physical Science and Technology Yangzhou UniversityYangzhou 225002China Center for High Pressure Science(CHiPS) State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000China Baotou Research Institute of Rare Earths Baotou 014000China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China Department of Physics and High Pressure Research CenterHanyang UniversitySeoul 04763Republic of Korea

Dehydro-Diels-Alder(DDA)reaction is a textbook reaction for preparing six-membered rings in solution but is scarcely seen in solid-state *** this work,using multiple characterization techniques,we demonstrate that the bowl-shaped clusters C_(18)Te_(3)Br_(4)(Bu-O)_(6) might experience a DDA reaction at room temperature and high pressure between 5.5 and 7.4 *** 17.0 GPa,it is found that the bonding conversion from the intramolecular sp^(2) to the intermolecular spa occurred,in the form of pressure-induced *** recovered samples from 20.0 and 36.1 GPa showed incomplete reversibility,while the decompression-induced graphitization of glassy carbon was observed during decompression from 46.5 *** electrochemical impedance spectroscopy results indicated that the transport properties changed from grain boundary dominant to grain dominant due to the DDA reaction and the grain boundary effect disappeared as the intermolecular sp3 bonding building-up and carrier transmission channel formation above 17.0 *** results in this study open a new route to construct the crystalline carbon materials with different transport properties.

关键词： polycyclic aromatic hydrocarbons dehydro-Diels-Alder reaction diamondization high-pressure

The effect of fire disturbance on short-term soil respiration in typical forest of Greater Xing'an Range, China

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Journal of Forestry Research 2014年第3期25卷 613-620页

作者： Long Sun Tongxin Hu Ji Hong kim Futao Guo Hong Song Xinshuang Lv Haiqing Hu College of Forestry Northeast Forestry University Department of Forest Management Kangwon National University College of Forestry Fujian Agriculture and Forestry University

We investigated the effect of fire disturbance on short-term soil respiration in birch （Betula platyphylla Suk.） and larch （Larix gmelinii Rupr.） forests in Greater Xing’an range, northeastern China for further understanding of its effect on the carbon cycle in ecosystems. Our study show that post-fire soil respiration rates in B. platyphylla and L. gmelinii forests were reduced by 14%and 10%, respectively. In contrast, the soil heterotrophic respiration rates in the two types of forest were similar in post-fire and control plots. After fire, the contribution of root respiration to total soil respiration was dramatically reduced. Variation in soil respiration rates was explained by soil moisture （W） and soil tem-perature （T） at a depth of 5 cm. Exponential regression fitted T and W models explained Rs rates in B. platyphylla control and post-fire plots （83.1% and 86.2%） and L. gmelinii control and post-fire plots （83.7%and 88.7%）. In addition, the short-term temperature coefficients in B.

关键词： fire disturbance short-term soil respiration environmentfactors Q10