检索结果-南通市图书馆

RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第12期51卷 1389-1403页

作者： Ji-Won Park tae-ik choi tae-Yoon Kim Yu-Ri Lee Dilan Wellalage Don Jaya K.George-Abraham Laurie A.Robak Cristina C.Trandafir Pengfei Liu Jill A.Rosenfeld tae Hyeong Kim Florence Petit Yoo-Mi Kim Chong Kun Cheon Yoonsung Lee Cheol-Hee Kim Department of Biology Chungnam National UniversityDaejeon 34134Republic of Korea Department of Pediatrics The University of Texas at Austin Dell Medical SchoolAustinTX 78723USA Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Baylor Genetics Laboratories HoustonTX 77021USA Department of Pediatrics Kyung Hee University Hospital at GangdongSeoul 05278Republic of Korea Univ.Lille CHU LilleClinique de g en etique Guy FontaineF-59000 LilleFrance Department of Pediatrics Chungnam National University Sejong HospitalSejong 30099Republic of Korea Department of Pediatrics Pusan National University Children’s HospitalYangsan 50612Republic of Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsan 50612Republic of Korea Clinical Research Institute Kyung Hee University Hospital at GangdongSchool of MedicineKyung Hee UniversitySeoul 05278Republic of Korea

Williams syndrome(WS)is a rare multisystemic disorder caused by recurrent microdeletions on 7q11.23,characterized by intellectual disability,distinctive craniofacial and dental features,and cardiovascular *** studies have explored the roles of individual genes within these microdeletions in contributing to WS ***,we report five patients with WS with 1.4 Mb-1.5 Mb microdeletions that include RFC2,as well as one patient with a 167-kb microdeletion involving RFC2 and six patients with intragenic variants within *** investigate the potential involvement of RFC2 in WS pathogenicity,we generate a rfc2 knockout(KO)zebrafish using CRISPR-Cas9 ***,we generate a KO zebrafish of its paralog gene,rfc5,to better understand the functions of these RFC genes in development and *** rfc2 and rfc5 KO zebrafish exhibit similar phenotypes reminiscent of WS,including small head and brain,jaw and dental defects,and vascular ***-seq analysis reveals that genes associated with neural cell survival and differentiation are specifically affected in rfc2 KO *** addition,heterozygous rfc2 KO adult zebrafish demonstrate an anxiety-like behavior with increased social *** results suggest that RFC2 may contribute to the pathogenicity of WS,as evidenced by the zebrafish model.

关键词： Williams syndrome RFC2 RFC5 Zebrafish Knockout CRISPR-Cas9

Machine Learning for QoS Optimization and Energy-Efficient in Routing Clustering Wireless Sensors

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 327-343页

作者： Rahma Gantassi Zaki Masood Yonghoon choi Department of Electrical Engineering Chonnam National University Gwangju61186Republic of Korea

Wireless sensor network(WSN)technologies have advanced significantly in recent *** in WSNs,machine learning algorithms are crucial in selecting cluster heads(CHs)based on various quality of service(QoS)*** paper proposes a new clustering routing protocol employing the Traveling Salesman Problem(TSP)to locate the optimal path traversed by the Mobile Data Collector(MDC),in terms of energy and QoS *** bemore specific,to minimize energy consumption in the CH election stage,we have developed the M-T protocol using the K-Means and the grid clustering *** addition,to improve the transmission phase of the Low Energy Adaptive Clustering-Grid-KMeans(LEACH-G-K)protocol,the MDC is employed as an intermediary between the CH and the sink to improve the wireless sensor network(WSN)*** results of the experiment demonstrate that the M-T protocol enhances various Low Energy Adaptive Clustering protocol(LEACH)improvements such as the LEACH-G-K,LEACH-C,Threshold sensitive Energy Efficient Sensor Networks(TEEN),MDC maximum residual energy leach protocol.

关键词： LEACH-G-K MDC TSP QoS K-Means

Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2025年第1期17卷 40-52页

作者： Seoung-Woo Lee Young-Ju Lim Hee-Yeon Kim Wansoo Kim Wook-tae Park Min-Jung Ma Junho Lee Min-Soo Seo Young In Kim Sangbum Park Seong-Kyoon choi Gun Woo Lee Core Protein Resources Center Daegu-Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaegu 42415South Korea Department of Veterinary Pathology College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea School of Life Science BK21 FOUR KNU Creative BioResearch GroupKyungpook National UniversityDaegu 41566South Korea Laboratory of Veterinary Tissue Engineering College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea College of Veterinary Medicine Kyungpook National UniversityDaegu 41566South Korea Department of Veterinary Tissue Engineering Kyungpook National UniversityDaegu 41566South Korea Cellexobio. Ltd.Daegu 42415South Korea Michigan State University Institute for Quantitative Health Science&EngineeringEast LansingMI 48824United States Department of Orthopedic Surgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Mesenchymal stem cells(MSCs)are promising candidates for regenerative therapy due to their self-renewal capability,multilineage differentiation potential,and immunomodulatory *** molecular characteristics of MSCs are influenced by their ***,epidural fat(EF)and EF-derived MSCs(EF-MSCs)have garnered attention due to their potential benefits to the spinal microenvironment and their high expression of neural SC ***,their clinical applications are limited due to cell senescence and limited accessibility of *** many studies have attempted to establish an immortalized,stable SC line,the characteristics of immortalized EF-MSCs remain to be *** To establish and analyze stable immortalized *** The phenotypes of EF-MSCs were analyzed using optical *** immortalization was performed using lentiviral *** biomolecular characteristics of the cells were analyzed by immunoblotting,quantitative PCR,and *** The immortalized EF-MSCs demonstrated a significantly extended lifespan compared to the control group,with well-preserved adipogenic potential and SC surface marker *** of human telomerase reverse transcriptase genes markedly increased the lifespan of *** analysis revealed substantial increase in the expression of DNA replication pathway components in immortalized *** Immortalized EF-MSCs exhibited significantly enhanced proliferative capacity,retained adipogenic potential,and upregulated the expression of DNA replication pathway components.

关键词： Immortalization Transfection Stem cell Epidural fat Proteomics

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

A taxonomic review of the genus Miaenia Pascoe, 1864(Coleoptera: Cerambycidae) from South Korea with a new record of M. tonsa(Bates)

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2018年第3期29卷 822-829页

作者： ik Je choi tae Sung Kwon Jongok Lim Silkworm and Insect Management Center Gyeongsangbuk-do Agricultural Resource Management Institute Forest Insect Pests and Disease Division Korea Forest Research Institute Division of Forest Biodiversity Korea National Arboretum

The cerambycid genus Miaenia Pascoe(Coleoptera: Cerambycoidea) of South Korea is taxonomically reviewed. Two species, Miaenia fasciata fasciata(Matsushita) and Miaenia maritima Tsherepanov have been recorded. In this paper, M. tonsa(Bates) is added to the Korean cerambycid fauna for the first time. A key to Korean Miaenia species, re-description and diagnostic illustrations, including male genitalia for each species, are provided.

关键词： Acanthocinini Cerambycidae Miaenia New species South Korea Taxonomy

Examples and effects of avalanches on the surface of mountain lakes:Morskie Oko,a case study from Poland(Tatra Mountains)

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2025年第2期22卷 375-390页

作者： Adam choiŃSKI Wojciech DENEGA Andrzej MACIAS Witold PINIARSKI Department of Hydrology and Water Management Faculty of Geographical and Geological SciencesAdam Mickiewicz UniversityPoznań61680Poland Independent Researcher Poland Landscape Ecology Research Unit Faculty of Geographical and Geological SciencesAdam Mickiewicz UniversityPoznań61680Poland

This study represents a pioneering effort to analyze the impact of avalanches descending into Morskie Oko from Marchwiczny Gully,the most active avalanche path around the *** focuses on catastrophic avalanches that descended from the analyzed gully,as reported in the literature from the 1900s until ***,only the data collected in recent years,our field studies,combined with modern LIDAR data and GIS-based modeling,allowed us to perform a detailed *** GIS-based approach effectively uses spatial data to address snow avalanche modeling *** the study area lies within Tatra National Park,no official services carry out systematic avalanche monitoring or *** impact of hazardous events,such as snow avalanches,on the most famous Polish mountain lake,Morskie Oko,has been poorly described in the literature and has yet to be ***,to analyze the selected avalanche parameters,we mainly used our ground and additional aerial photographs taken by local mountain services and related field *** analysis resulted in figurative estimates of the extent and volume of avalanche snow and its weight,both on the surface of the ice sheet and the part of the avalanche that did not reach the lake's shore and remained on the slope of Marchwiczny *** example,the values for the mighty avalanche on February 3,2023,are 23,500 m~3 and 4,700 tons on the ice surface and 20,000 m~3 and 4,000 tons on the *** was determined that avalanches that descend onto the studied lake's surface result in its *** process occurs because of sedimentation of slope material carried by avalanches,especially during the final phase of ice cover *** openings appear in the solid ice cover in spring,floating ice can migrate,driven by wind pressure,and deposit avalanche material in various parts of the lake ***,avalanches contributed to the gradual disappearance of the lake.

关键词： Snow avalanches Mountain lakes Sedimentation Morskie Oko Tatra Mountains Avalanche modeling

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration