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A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo

Nano Research 2019年第12期12卷 3024-3030页

作者： Jin Sil Lee Youngmin Hwang Hyeryeon Oh Sunghyun Kim Jin-Hwa Kim Jeung-hoon Lee Yong Chui Shin Giyoong tae Won II Choi Center for Convergence Bioceramic Materials Convergence R&D DivisionKorea Institute of Ceramic Engineering and Technology202Osongsaengmyeong l-rof Osong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology123 Cheomdan-gwagiroBuk-guGwangju 61005Republic of Korea SKINMED Co. Ltd.Daejeon 34028Republic of Korea Amicogen Inc.64 Dongburo 1259JinsungJinju 52621Republic of Korea

Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in *** n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair ***,the effect of topical application of CsA is limited by its poor water *** deliverysystems developed to enhance its solubility still showed poor skin *** overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of *** chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kDa enhanced the skin permeation of CsA through humancadaver skin in *** administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in *** results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs.

关键词： chitosan nanocapsule cyclosporin A transdermal delivery hair growth

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An investigation of the microstructural effects on the mechanical and electrochemical properties of a friction stir processed equiatomic CrMnFeCoNi high entropy alloy

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Journal of Materials Science & Technology 2021年第28期87卷 60-73页

作者： Sam Yaw Anaman Solomon Ansah hoon-Hwe Cho Min-Gu Jo Jin-Yoo Suh Minjung Kang Jong-Sook Lee Sung-tae Hong Heung Nam Han Department of Materials Science and Engineering Hanbat National University125 Dongseodae-roYuseong-GuDaejeonRepublic of Korea Center for Energy Materials Research Clean Energy InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Materials Science and Engineering&Research Institute of Advanced Materials Seoul National University1Gwanak-roGwanak-guSeoul08826Republic of Korea Advanced Functional Technology R&D Department Korea Institute of Industrial TechnologyIncheon21999Republic of Korea School of Materials Science and Engineering Chonnam National UniversityGwangju61186Republic of Korea School of Mechanical Engineering University of UlsanUlsan680-749Republic of Korea

The electrochemical properties of a friction stir processed(FSPed)equiatomic CrMnFeCoNi high-entropy alloy(HEA)was investigated in an aerated 0.5 M Na_(2)SO_(4) electrolyte solution at room *** microstructural analysis reveals a highly refined stir zone(SZ)with an average grain size that decreases from the top region of the SZ to the bottom region of the SZ(also known as shear-processed zone;SPZ).However,the region below the SPZ,(*** the plunge depth)experienced an increase in average grain size and dislocation densities compared to the other *** is no secondary phase observed in the FSPed region,however,the microstructural evolution in the FSPed region affects the electrochemical behavior of the ***_(2)O_(3) passive layer was observed to form on the FSPed HEA,leading to excellent corrosion properties from the polarization corrosion *** refinement in the SZ enhances the rapid formation of the passive layer,thus,leading to better corrosion properties in the front surface of the FSPed *** localized corrosion behavior of the FSPed HEA was predicted to be caused by the micro-galvanic nature of the HEA,which leads to an increase in polarization at the anodic sites(pits).A numerical model was established using the corrosion parameters from the experiment to simulate the localized corrosion behavior on the surface of the FSPed HEA in a neutral *** predicted initial pitting potential and corresponding current density agree well with the experimental *** model is also capable of tracking the dissolution of the pits over longer periods.

关键词： High entropy alloys Friction stir processing Grain refinement Passive film Pitting Simulation

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Acute myeloid leukemia with t(11;19)(q23;p13.1) in a patient with a gastrointestinal stromal tumor undergoing imatinib therapy:A case report

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World Journal of Clinical Cases 2020年第7期8卷 1251-1256页

作者： Hong Jun Kim Sun Kyung Baek Chi hoon Maeng Si-Young Kim tae Sung Park Jae Joon Han Department of Hematology and Medical Oncology Kyung Hee UniversitySeoul 02447South Korea Department of Laboratory Medicine Kyung Hee UniversitySeoul 02447South Korea

BACKGROUND Acute myeloid leukemia(AML)harboring 11q23 translocations is classified as therapy-related AML in patients who have undergone prior treatment with cytotoxic *** have been only a few reports of AML that subsequently developed during imatinib mesylate(IM)treatment for gastrointestinal stromal tumors(GISTs).CASE SUMMARY A 63-year-old woman was diagnosed with a hepatic GIST recurrence in April 2012;she was administered IM 400 mg/*** November 2015,she developed dyspnea with pancytopenia while IM treatment was continued for 42 mo.A chromosome study using a bone marrow sample showed a 46,XX karyotype with t(11;19)(q23;p13.1)in 22 of 26 analyzed metaphase *** in situ hybridization using the locus-specific indicator(11q23)gene break-apart probe showed positive rearrangement in 82%of interphase ***-transcription polymerase chain reactions subsequently confirmed the KMT2A/ELL *** achieved complete response with incomplete neutrophil recovery with two decitabine treatment *** the third cycle of decitabine,the disease relapsed,and she refused further *** died of hemorrhagic stroke 5 mo after *** the best of our knowledge,this is the first report of AML with KMT2A gene rearrangements in a patient with a GIST receiving IM *** Physicians should consider the potential risks of developing hematologic malignancies,including therapy-related AML,in patients with GISTs receiving IM treatment.

关键词： Acute myeloid leukemia Gastrointestinal stromal tumor Imatinib KMT2A Myelodysplastic syndrome Case report

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Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway

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World Journal of Gastroenterology 2015年第33期21卷 9749-9757页

作者： Jeong Mo Bae Jung Ho Kim Ye-Young Rhee Nam-Yun Cho tae-You Kim Gyeong hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Internal Medicine Seoul National University College of Medicine

AIM: To validate the utility of Annexin A10 as a surrogate marker of the serrated neoplasia pathway in invasive colorectal cancers(CRCs).METHODS: A total of 1133 primary CRC patients who underwent surgical resection at Seoul National University Hospital between January 2004 and December 2007 were *** of Annexin A10 was evaluated by immunohistochemistry using tissue microarray and paired to our findings on clinicopathologic and molecular characteristics of each *** G island methylator phenotype was determined by Methy Light assay and microsatellite instability was determined by high performance liquid *** and BRAF mutation status was evaluated by direct sequencing and allele-specific *** and stage-specific survival analyses were performed to reveal the prognostic value of Annexin A10 ***: Annexin A10 expression was observed in 66(5.8%) of the 1133 *** A10 expression was more commonly found in females and was associated with proximal location,ulcerative gross type,advanced T category,N category and TNM *** with Annexin A10 expression showed an absence of luminal necrosis,luminal serration and mucin *** with Annexin A10 expression were associated with Cp G island methylator phenotype,microsatellite instability and BRAF *** survival analysis,Annexin A10 expression was associated with poor overall survival and progression-free survival,especially in stage Ⅳ ***: Annexin A10 expression is associated with poor clinical behavior and can be used a supportive surrogate marker of the serrated neoplasia pathway in invasive CRCs.

关键词： Annexin A10 Serrated neoplasia pathway CpG island

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Delayed pseudoaneurysm formation of the carotid artery following the oral cavity injury in a child:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4104-4109页

作者： Byeoung hoon Chung Mi Rin Lee Jae Do Yang Hee Chul Yu Yong tae Hong Hong Pil Hwang Byeoung hoon Chung Mi Rin LeeJae Do YangHee Chul YuYong Tae HongHong Pil Hwang Research Institute of Clinical Medicine Jeonbuk National UniversityJeonju 54907South Korea Biomedical Research Institute Jeonbuk University HospitalJeonju 54907South Korea Department ofOtolaryngology-Head-Neck-Surgery Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND An impalement injury of the oral cavity is a common traumatic injury in *** most cases,it is not accompanied by sequelae,but if foreign body residues are not found due to a minor injury,they may result in inflammatory responses and delayed vascular injuries in the surrounding *** early diagnosis and appropriate initial management,residual foreign bodies can cause serious complications and even mortality in some *** SUMMARY A 9-year-old boy suffered an intra-oral injury by a wooden chopstick,and the patient was discharged from the hospital after receiving conservative treatment for the ***,the patient was readmitted to the hospital due to intraoral bleeding,and since neck hematoma and right internal carotid artery pseudoaneurysm formation were detected on computed tomography,emergency surgery was performed.A remnant fragment of a wooden chopstick was found during the operation,and a delayed rupture of the internal carotid artery caused by the foreign body was also *** The failure of early detection and diagnosis of a residual foreign body may result in delayed vascular rupture.

关键词： Pseudoaneurysm Carotid artery injury Oral cavity Wooden chopsticks Case report

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Effects of edible insect extracts on the antioxidant, physiochemical, and microbial properties of Tteokgalbi during refrigerated storage

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Food Bioscience 2023年第2期52卷 326-333页

作者： Hae In Yong tae-Kyung Kim Ji Yoon Cha Jae hoon Lee Min-Cheol Kang Samooel Jung Yun-Sang Choi Research Group of Food Processing Korea Food Research InstituteWanju55365Republic of Korea Division of Animal and Dairy Science Chungnam National UniversityDaejeon34134Republic of Korea

In this study,Tteokgalbi,a meat product,was prepared with edible insect larvae extracts and its antioxidant,physiochemical,and microbial properties were evaluated during refrigerated *** prepared with 2%*** and 2%*** showed the highest radical-scavenging activity and metal-chelating activity,but the lowest thiobarbituric acid reactive substance(TBARS)value,among the treatments(P<0.05).In addition,those antioxidant activities were the lowest and the TBARS value was the highest in control Tteokgalbi(P<0.05)during all storage *** prepared with 2%*** showed the highest brownness index,pH,and cooking yield,but the lowest shear force value(P<0.05).During all storage days,the total aerobic bacteria level did not differ significantly among the *** conclusion,*** extracts(2%)were effective as antioxidants,inhibiting lipid oxidation,and improving the quality properties of Tteokgalbi,without negatively affecting microbial *** results confirmed that the edible insect extracts have industrial value as a food additive.

关键词： Edible insect Lipid oxidation Natural antioxidant Refrigerated storage Tteokgalbi

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PDL Reduction in Arrayed-Waveguide Gratings by Control of Stress in the Waveguide

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光学学报 2003年第S1期23卷 287-288页

作者： Se Yoon Kim Joo-hoon Lee Jaegeol Cho Dong-Su Kim Sun tae Jung Telecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 KoreaTelecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 KoreaTelecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 KoreaTelecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 KoreaTelecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 Korea

We have demonstrated polarization insensitive AWGs by controlling the doping concentration of Boron in overcladding and the etching depth of waveguide. The proposed method uses the conventional fabrication process and... 详细信息

关键词： PDL Reduction in Arrayed-Waveguide Gratings by Control of Stress in the Waveguide on of in by

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Network-based identification of feedback modules that control RhoA activity and cell migration

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Journal of Molecular Cell Biology 2015年第3期7卷 242-252页

作者： tae-Hwan Kim Naser Monsefi Je-hoon Song Alex von Kriegsheim Drieke Vandamme Olivier Pertz Boris NKholodenko Walter Kolch Kwang-Hyun Cho Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 305-701Republic of Korea Systems Biology Ireland University College DublinBelfieldDublin 4Ireland Department of Biomedicine University of BaselBaselSwitzerland School of Medicine and Medical Science University College DublinBelfieldDublin 4Ireland Conway Institute of Biomolecular&Biomedical Research University College DublinBelfieldDublin 4Ireland

Cancer cell migration enables metastatic spread causing most cancer ***-family GTPases control cell migration,but being embedded in a highly interconnected feedback network,the control of their dynamical behavior during cell migration remains *** address this question,wereconstructed the Rho-family GTPases signaling network involved in cell migration,and developed a Boolean network model to analyze the different states and emergent rewiring of the Rho-family GTPases signaling network at protrusions and during extracellular matrix-dependent cell *** simulations and experimental validations revealed that the bursts of RhoA activity induced at protrusions by EGFare regulated by a negative-feedback module composed of Src,FAK,and ***,perturbing this module interfered with cyclic Rho activation and extracellular matrix-dependent migration,suggesting that CSK inhibition can be a novel and effective intervention strategy for blocking extracellular matrix-dependent cancer cell migration,while Src inhibition might fail,depending on the genetic background of ***,this study provides new insights into the mechanisms that regulate the intricate activation states of Rho-family GTPases during extracellular matrix-dependent migration,revealing potential new targets for interfering with extracellular matrix-dependent cancer cell migration.

关键词： cell migration Rho-family GTPases signaling network Boolean network model cyclical RhoA bursts

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Cambrian Stem-group Cnidarians with a New Species from the Cambrian Series 3 of the taebaeksan Basin, Korea

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Acta Geologica Sinica(English Edition) 2016年第3期90卷 827-837页

作者： tae-Yoon S.PARK Ji-hoon KIHM Jusun WOO Yong-Yi ZHEN Michael ENGELBRETSEN Jongsun HONG Suk-Joo CHOH Dong-Jin LEE Division of Polar-Earth System Sciences Korea Polar Research Institute Geological Survey of New South Wales W.B.Clarke Geoscience Centre Research Affiliate Biological Sciences Macquarie University Department of Earth and Environmental Sciences Korea University Department of Earth and Environmental Sciences Andong National University

Five species, Lipopora lissa Jell and Jell, 1976, Lipopora daseia Jell and Jell, 1976, Tretocylichne perplexa Engeibretsen, 1993 from Australia, Cambroctoconus orientalis Park, Woo, Lee, Lee, Lee, Han and Chough, 2011 from China, and Cambroctoconus kyrgyzstanicus Peel, 2014 from Kyrgyzstan, belonging to the Cambrian stem-group cnidarians have been documented in the fossil record. Cambroctoconus coreaensis sp. nov., interpreted here as a stem-group cnidarian, from the Seokgaejae section in the Daegi Formation, taebaek Group （Cambrian Series 3）, taebaeksan Basin, central-eastern Korean Peninsula, has a slender cup-shaped skeleton. A cladistic analysis produced 21 most parsimonious trees, which invariably placed the six stem-group cnidarians below the crown-group, but their relationships within the stem-group are unresolved. Nine out of the 21 trees suggest a monophyletic relationship for the Cambrian stem-group cnidarians, whereas in six other trees a monophyly of Cambroctoconus and Tretocylichne appeared as the sister-group to the crown-group cnidarians with Lipopora at the most basal branch. This result may reflect the fact that crown-group cnidarians evolved in the Precambrian, and suggests that the diversity of stem-group cnidarians was a result of an independent radiation in the Cambrian.

关键词： Phylogeny Cnidaria Cambrian Drumian taebaeksan Basin Korea

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Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis

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Molecular Plant 2021年第11期14卷 1951-1960页

作者： Arabidopsis Sera Choi Maxim Prokchorchik Hyeonjung Lee Ravi Gupta Yoonyoung Lee Eui-Hwan Chung Buhyeon Cho Min-Sung Kim Sun tae Kim Kee hoon Sohn Department of Life Sciences Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Plant Bioscience Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Department of Botany School of Chemical and Life SciencesJamia HamdardHamdard NagarNew Delhi 110062India Division of Biotechnology Korea UniversitySeoul 02841Republic of Korea The Institute of Crop Science and Resource Conservation(INRES) University of BonnNussallee 953115 BonnGermany

Plant pathogenic bacteria deliver effectors into plant cells to suppress immunity and promote pathogen survival;however, these effectors can be recognised by plant disease resistance (R) proteins to activate innate immunity. The bacterial acetyltransferase effectors HopZ5 and AvrBsT trigger immunity in Arabidopsis thaliana genotypes lacking SUPPRESSOR OF AVRBST-ELICITED RESISTANCE 1 (SOBER1). Using an Arabidopsis accession, Tscha-1, that naturally lacks functional SOBER1 but is unable to recognise HopZ5, we demonstrate that RESISTANCE TO P. SYRINGAE PV MACULICOLA 1 (RPM1) and RPM1-INTERACTING PROTEIN 4 (RIN4) are indispensable for HopZ5- or AvrBsT-triggered immunity. Remarkably, T166 of RIN4, the phosphorylation of which is induced by AvrB and AvrRpm1, was directly acetylated by HopZ5 and AvrBsT. Furthermore, we demonstrate that the acetylation of RIN4 T166 is required and sufficient for HopZ5- or AvrBsT-triggered RPM1-dependent defence activation. Finally, we show that SOBER1 interferes with HopZ5- or AvrBsT-triggered immunity by deacetylating RIN4 T166. We have thus elucidated detailed molecular mechanisms underlying the activation and suppression of plant innate immunity triggered by two bacterial acetyltransferases, HopZ5 and AvrBsT from different bacterial pathogens.

关键词： Acetyltransferase effectors Effector-triggered immunity Immunity suppressors NLR Plant deacetylase Plant immunity

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