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Recent advances in endoscopic retrograde cholangiopancreatography in Billroth II gastrectomy patients: A systematic review

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World Journal of Gastroenterology 2019年第24期25卷 3091-3107页

作者： tae young park tae Jun Song Department of Internal Medicine Inje University Seoul Paik HospitalSeoul 04551South Korea Division of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 138-736South Korea

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)in patients with Billroth Ⅱ gastrectomy has been considered a challenging procedure due to the surgically altered gastrointestinal ***,there has been a paucity of comparative studies regarding ERCP in Billroth Ⅱ gastrectomy cases because of procedure-related morbidity and mortality and practical and ethical *** systematic and comprehensive review was performed to obtain a recent perspective on ERCP in Billroth Ⅱ gastrectomy *** To systematically review the literature regarding ERCP in Billroth Ⅱ gastrectomy *** A systematic review was performed on the literature published between May 1975 and January *** following electronic databases were searched:PubMed,EMBASE,and Cochrane *** outcomes of successful afferent loop intubation and successful selective cannulation and occurrence of adverse events were *** A total of 43 studies involving 2669 patients were *** study designs were 36(83.7%)retrospective cohort studies,4(9.3%)retrospective comparative studies,2(4.7%)prospective comparative studies,and 1(2.3%)prospective cohort *** a total of 2669 patients,there were 1432 cases(55.6%)of sideviewing endoscopy,664(25.8%)cases of forward-viewing endoscopy,171(6.6%)cases of balloon-assisted enteroscopy,169(6.6%)cases of anterior obliqueviewing endoscopy,64(2.5%)cases of dual-lumen endoscopy,31(1.2%)cases of colonoscopy,and 14(0.5%)cases of multiple bending *** overall success rate of afferent loop intubation was 91.3%(2437/2669),and the overall success rate of selective cannulation was 87.9%(2346/2437).A total of 195 cases(7.3%)of adverse events *** success rates of afferent loop intubation and the selective cannulation rate for each type of endoscopy were as follows:side-viewing endoscopy 98.2%and 95.3%;forward-viewing endoscopy 97.4%and 95.2%;balloon-assisted enteroscopy 95.4%and 97.5%;oblique-viewing endosco

关键词： Endoscopic retrograde Cholangiopancreatography Therapeutic Endoscope Billroth Ⅱ operation Adverse event Systematic review

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Clinical characteristics of peptic ulcer perforation in Korea

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World Journal of Gastroenterology 2017年第14期23卷 2566-2574页

作者： young Joo Yang Chang Seok Bang Suk Pyo Shin tae young park Ki tae Suk Gwang Ho Baik Dong Joon Kim Department of Internal Medicine Hallym University College of Medicine Chuncheon Sacred Heart Hospital

AIM To elucidate the epidemiological characteristics and associated risk factors of perforated peptic ulcer(PPU).METHODS We retrospectively reviewed medical records of patients who were diagnosed with benign PPU from 2010 through 2015 at 6 Hallym university-affiliated *** A total of 396 patients were identified with postoperative complication rate of 9.1% and mortality rate of 0.8%. Among 174(43.9%) patients who were examined for Helicobacter pylori(H. pylori) infection, 78(44.8%) patients were positive for H. pylori infection, 21(12.1%) were on non-steroidal anti-inflammatory drugs(NSAIDs) therapy, and 80(46%) patients were neither infected of H. pylori nor treated by any kinds of NSAIDs. Multivariate analysis indicated that older age(OR = 1.09, 95%CI: 1.04-1.16) and comorbidity(OR = 4.11, 95%CI: 1.03-16.48) were risk factors for NSAID-associated PPU compared with non-H. pylori, non-NSAID associated PPU and older age(OR = 1.04, 95%CI: 1.02-1.07) and alcohol consumption(OR = 2.08, 95%CI: 1.05-4.13) were risk factors for non-H. pylori, non-NSAID associated PPU compared with solely H. pylori positive *** Elderly patients with comorbidities are associated with NSAIDs-associated PPU. Non-H. pylori, non-NSAID peptic ulcer is important etiology of PPU and alcohol consumption is associated risk factor.

关键词： Helicobacter pylori Non-steroidal anti-inflammatory drugs Peptic ulcer perforation Stomach ulcer Duodenal ulcer

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Expression of protein S100A4 is a predictor of recurrence in colorectal cancer

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World Journal of Gastroenterology 2010年第31期16卷 3897-3904页

作者： Jung Myun Kwak Hyun Joo Lee Seon Hahn Kim Han Kyeom Kim young Jae Mok young tae park Jong Sang Choi Hong young Moon Department of Surgery Korea University Anam Hospital Department of Pathology Korea University Guro Hospital Department of Surgery Korea University Guro Hospital Department of Gastroenterology Korea Uni-versity Guro Hospital

AIM: To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS: A cohort of archival formalin-fixed paraff inembedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between April 2000 and March 2004 at the Department of Surgery, Korea University Guro Hospital. The expression of protein S100A4 was evaluated according to the proportion of positively stained cancer cells. In each case, three core biopsies with a diameter of 2 mm were punched out and positioned in a recipient paraff in array block. Four-μm sections of these tissue array blocks were used for immunohistochemical analysis of protein S100A4, E-cadherin, and p53. Clinicopathological data were based on the original histopathologic reports and clinical records of patients. RESULTS: In normal colorectal mucosa, protein S100A4 immunoreactivity was clearly absent in both cytoplasm and nucleus. However, positive immunoreactivity of protein S100A4 was detected in 45 (35.4%) of the tumor cases. There was no significant association between positive immunoreactivity of protein S100A4 and clinicopathological parameters such as tumor differentiation or TNM stage, and also no correlation between the reactivity and E-cadherin or p53 expression. However, positive immunoreactivity of protein S100A4 was found to be associated with tumor recurrence (P = 0.004), and was also associated with significantly worse overall survival in the Kaplan-Meyer survival analysis (P = 0.044). After adjustment for tumor differentiation, tumor depth and nodal status, however, it failed to achieve statistical significance (P = 0.067). CONCLUSION: The expression of protein S100A4 is associated with tumor recurrence and poor overall survival in patients with colorectal cancer.

关键词： S100A4 E-cadherin p53 Prognostic factor Colorectal cancer

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Extracellular vesicles for neural regeneration after spinal cord injury

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Neural Regeneration Research 2024年第3期19卷 491-492页

作者： young-Ju Lim Wook-tae park Gun Woo Lee Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaeguKorea

What is spinal cord injury:Spinal cord injury(SCI)is the damage to the structure of the bundles of cells and nerves that communicate signals from the brain to the body and *** pathology of SCI includes both primary and secondary injuries(Morales et al.,2016).Physical forces such as compression,shearing,contusion,and tearing are major causes of primary injury in *** are two main processes in primary injury:acute and *** acute phase includes traumatic disruption of axons and hemorrhage of the blood vessels around the spinal *** injury to the vessels can lead to increased edema within the neural and cord tissues,susceptibility to infiltration by microglia and astrocytes,excitotoxicity,and ***,disruption of the blood-spinal cord barrier results in the release of inflammatory cytokines from specific cells and vessels.

关键词： acute injuries nerves

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Tidal effects based on a GUP-induced effective metric

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Communications in Theoretical Physics 2024年第9期76卷 63-72页

作者： Soon-tae Hong Yong-Wan Kim young-Jai park Center for Quantum Spacetime and Department of Physics Sogang UniversitySeoul 04107Republic of Korea Department of Physics and Research Institute of Physics and Chemistry Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Physics Sogang UniversitySeoul 04107Republic of Korea

In this paper,we study tidal forces in the Schwarzschild black hole,whose metric explicitly includes a generalized uncertainty principle(GUP)*** also investigate interesting features of the geodesic equations and tidal effects that are dependent on the GUP parameterαrelated to a minimum ***,by solving the geodesic deviation equations explicitly with appropriate boundary conditions,we show thatαin the effective metric affects both the radial and angular components of the geodesic equation,particularly near the singularities.

关键词： generalized uncertainty principle geodesic deviation equation effective metric

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A case of hypereosinophilic syndrome presenting with intractable gastric ulcers

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World Journal of Gastroenterology 2009年第48期15卷 6129-6133页

作者： tae young park Chang Hwan Choi Suh Yoon Yang InSoo Oh In-Do Song Hyun Woong Lee Hyung Joon Kim Jae Hyuk Do Sae Kyung Chang Ah Ra Cho young Joo Cha Department of Internal Medicine Chung-Ang University College of Medicine Department of Laboratory Medicine Chung-Ang University College of Medicine

We report a rare case of hypereosinophilic syndrome （HES） presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacterpylori （Hpylon） eradication therapy followed by proton pump inhibitor （PPI） therapy. However, follow- up endoscopy at 4, 6, 10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement. The proportion of his eosinophil count increased to 43% （total count： 7903/mm3）. Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs. The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration, and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid. A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%. The patient was finally diagnosed with HES involving the stomach, liver, lung, and bone marrow. When gastric ulcers do not improve despite H pylon eradication and prolonged PPI therapy, infiltrative gastric disorders such as HES should be considered.

关键词： Gastric ulcer Hypereosinophilic syndrome

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Wearable Triboelectric Nanogenerators Based on Printed Polyvinylidene Fluoride Films Incorporated with Cobalt-Based Metal-Organic Framework for Self-Powered Mobile Electronics

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Energy & Environmental Materials 2024年第4期7卷 396-403页

作者： Myeong-Hyeon Kim Sang-Joon park tae-Jun Ha Department of Electronic Materials Engineering Kwangwoon University

In this study,wearable triboelectric nanogenerators comprising bar-printed polyvinylidene fluoride (PVDF) films incorporated with cobalt-based metalorganic framework (Co-MOF) were *** enhanced output performance of the TENCs was attributed to the phase transition of PVDF from α-crystals to β-crystals,as facilitated by the incorporation of the MOF.

关键词： bar printing phase transition polyvinylidene fluoride incorporated with cobalt-based metal–organic framework self-powered mobile electronics wearable triboelectric nanogenerators

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Recent progress and future research directions for electrochromic zinc-ion batteries

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Journal of Energy Chemistry 2024年第3期90卷 220-232,I0007页

作者： tae Gwang Yun Byungil Hwang Jun young Cheong Department of Molecular Science and Technology Ajou UniversitySuwon 16499Republic of Korea School of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Bavarian Center for Battery Technology(Bay Batt)and Department of Chemistry University of Bayreuth95447 BayreuthGermany

In recent times,future energy storage systems demand a multitude of functionalities beyond their traditional energy storage *** line with this technological shift,there is active research and development of electrochromic-energy storage systems designed to visualize electrochemical charging and discharging *** conventional electrochromic-energy storage devices primarily integrated supercapacitors,known for their high power density,to enable rapid color ***,the low energy density of supercapacitors restricts overall energy storage capacity,acting as a significant barrier to expanding the application range of such *** this review,we introduce electrochromic zinc(Zn)-ion battery systems,which effectively overcome the limitation of low energy density,and provide illustrative examples of their applicability across diverse *** many recent research works are present for electrochromic Zn-ion batteries,little review has so far taken *** objective is to discuss on the current progress and future directions for electrochromic Zn-ion batteries,which are applicable for wearable electronics applications and energy storage *** review provides an initial milestone for future researchers in electrochromic energy storage and zinc-ion batteries,which will lead to a stream of future works related to them.

关键词： Electrochromic Zn-ion battery Flexible Transition metal oxide Conductive polymer

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Environmentally adaptive reshaping of plant photomorphogenesis by karrikin and strigolactone signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 865-882页

作者： young-Joon park Bo Eun Nam Chung-Mo park Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea Departmentof Biological Sciences Seoul National UniversitySeoul 08826Korea Department of Chemistry Seoul National UniversitySeoul 08826Korea

Coordinated morphogenic adaptation of growing plants is critical for their survival and propagation under fluctuating *** morphogenic responses to light and warm temperatures,termed photomorphogenesis and thermomorphogenesis,respectively,have been extensively studied in recent *** photomorphogenesis,plants actively reshape their growth and developmental patterns to cope with changes in light ***,photomorphogenesis is closely associated with diverse growth hormonal ***,accumulating evidence indicates that light-directed morphogenesis is profoundly affected by two recently identified phytochemicals,karrikins(KARs)and strigolactones(SLs).KARs and SLs are structurally related butenolides acting as signaling molecules during a variety of developmental steps,including seed *** receptors and signaling mediators have been identified,and associated working mechanisms have been explored using gene-deficient mutants in various plant *** particular interest is that the KAR and SL signaling pathways play important roles in environmental responses,among which their linkages with photomorphogenesis are most comprehensively studied during seedling *** this review,we focus on how the phytochemical and light signals converge on the optimization of morphogenic *** also discuss molecular mechanisms underlying the signaling crosstalks with an aim of developing potential ways to improve crop productivity under climate changes.

关键词： karrikins morphogenic adaptation photomorphogenesis seedling establishment strigolactones

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Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma

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Cancer Communications 2024年第6期44卷 705-709页

作者： Jinkwon Lee Gyeonghwa Kim tae-Su Han Eunsun Jung taesang Son Kwangho Kim Kiyoon Kwon Yuna Roh tae young Ryu In Hwan tae Yunsang Kang Byungheon Lee Yu Rim Lee Soo young park Won young Tak Dae-Soo Kim Mi-young Son Keun Hur Hyun-Soo Cho Stem Cell Convergence Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea Department of Bioscience Korea University of Science and TechnologyDaejeonRepublic of Korea Department of Biochemistry and Cell Biology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biological Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Internal Medicine School of MedicineKyungpook National University HospitalDaeguRepublic of Korea Department of Biomedical Convergence Science and Technology School of ConvergenceKyungpook National UniversityDaeguRepublic of Korea

Hepatocellular carcinoma(HCC)is the second most common cancer and the third leading cause of cancer-related death worldwide[1].Recently,HCC incidence and mortality rates have further increased due to changes in the global social environment and dietary habits[2].HCC is treated by surgical resection or combination chemotherapy,but the overall survival rate of HCC patients has not improved,and the recurrence rate is still high due to strong invasiveness and resistance to chemotherapy[3].

关键词： chemotherapy mortality cancer

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