检索结果-南通市图书馆

Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第5期12卷 931-941页

作者： Hongsik Kim song-Yi Choi tae-Young Heo Kyeong-Rok Kim Jisun Lee Min Young Yoo taek-Gu Lee Joung-Ho Han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Pathology Chungnam National University College of MedicineDaejeon 35015South Korea Information and Statistics Chungbuk National UniversityCheongju 28644South Korea Department of Radiology College of MedicineChungbuk National UniversityChungbuk National University HospitalCheongju-si 28644South Korea Department of Nuclear Medicine School of MedicineInha UniversityIncheon 22332South Korea Department of Surgery Chungbuk National UniversityCollege of MedicineCheongju-si 28644South Korea Department of Internal Medicen Chungbuk National UniversityCollege of medicineCheongju-si 28644South Korea

BACKGROUND There are limited data on the use of glucose transport protein 1(GLUT-1)expre-ssion as a biomarker for predicting lymph node metastasis in patients with colorectal ***-1 and GLUT-3,hexokinase(HK)-II,and hypoxia-induced factor(HIF)-1 expressions may be useful biomarkers for detecting primary tumors and lymph node metastasis when combined with fluorodeoxyglucose(FDG)uptake on positron emission tomography/computed tomography(PET/CT).AIM To evaluate GLUT-1,GLUT-3,HK-II,and HIF-1 expressions as biomarkers for detecting primary tumors and lymph node metastasis with 18F-FDG-PET/*** This retrospective study included 169 patients with colorectal cancer who underwent colectomy and preoperative 18F-FDG-PET/CT at Chungbuk National University Hospital between January 2009 and May *** tissue cores from the central and peripheral areas of the tumors were obtained and were examined by a dedicated pathologist,and the expressions of GLUT-1,GLUT-3,HK-II,and HIF-1 were determined using immunohisto-chemical *** analyzed the correlations among their expressions,various clinicopathological factors,and the maximum standardized uptake value(SUVmax)of PET/*** GLUT-1 was found at the center or periphery of the tumors in 109(64.5%)of the 169 ***-1 positivity was significantly correlated with the SUVmax of the primary tumor and lymph nodes,regardless of the biopsy site(tumor center,P<0.001 and P=0.012;tumor periphery,P=0.030 and P=0.010,respectively).GLUT-1 positivity and negativity were associated with higher and lower sensitivities of PET/CT,respectively,for the detection of lymph node metastasis,regardless of the biopsy ***3,HK-II,and HIF-1 expressions were not significantly correlated with the SUVmax of the primary tumor and lymph *** GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT for primary tumors and lymph *** should consider GLUT-1 expression in preoperative endoscop

关键词： 18F-FDG-PET-CT Biomarker Colorectal neoplasms Glucose transporter type 1 Lymph node

Mirizzi syndrome in an anomalous cystic duct:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第41期13卷 5527-5529页

作者： Cheol Woong Jung Byung Wook Min tae jin song Gil Soo Son Hong Sik Lee Seung Joo Kim Jun Won Um Department of Surgery Korea University College of Medicine126-15-Ga Anam-DongSungbuk-GuSeoul 136-705Korea Department of Internal Medicine Korea University College of Medicine126-15-Ga Anam-DongSungbuk-GuSeoul 136-705Korea

Mirizzi syndrome is a rare complication of gallstone disease,and results in partial obstruction of the common bile duct or a cholecystobiliary fistula. Moreover,congenital anatomical variants of the cystic duct are common,occurring in 18%-23% of cases,but Mirizzi syndrome underlying an anomalous cystic duct is an important clinical consideration. Here,we present an unusual case of typeⅠMirizzi syndrome with an uncommon anomalous cystic duct,namely,a low lateral insertion of the cystic duct with a common sheath of cystic duct and common bile duct.

关键词：胆管疾病胆管手术胆石症胆囊管

Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman:A rare cause of hemoperitoneum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第1期14卷 136-139页

作者： Seong-Heum Park Jong-Han Kim Byung Wook Min tae jin song Gil Soo Son Seung Joo Kim Sang Woo Lee Hwan-Hoon Chung Ju Han Lee Jun Won Um Department of Surgery Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Internal Medicine Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Radiology Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Pathology Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea

Inflammatory myofibroblastic tumor (IMT) of the stomach in adults is extremely rare, with unpredictable prognosis. We present a 55-year-old woman with a gastric IMT. She experienced sudden abdominal pain 4 d previously. Physical examination showed mild abdominal tenderness in the hypogastrium, but no palpable abnormal abdominal mass. Abdominal CT showed a mass of approximately 8 cm in the gastrocolic ligament. On laparoscopic exploration, unexpected hemoperitoneum of approximately 1.5 L of blood was found, and an exophytic gastric mass of approximately 10 cm, appeared from the anterior wall of the gastric body along the greater curvature. Laparoscopy further showed that non-clotting blood in the abdominal cavity seemed to be from the gastric tumor. After conversion to open surgery for more precise evaluation of the cause of hemoperitoneum and the large friable tumor, gastric wedge resection, including the tumor, was conducted. The final diagnosis was consistent with IMT that originated from the gastric wall.

关键词：胃病胃肿瘤肌纤维瘤腹腔积血胃外科学

Antioxidant effects of the aqueous extract of turmeric against hydrogen peroxide-induced oxidative stress in spotted seabass(Lateolabrax maculatus)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2024年第1期9卷 71-77页

作者： Zhe Wang Xiuqin Wang Xueshan Li Kangle Lu Ling Wang Xuekun Ma Kai song Chunxiao Zhang Xiamen Key Laboratory for Feed Quality Testing and Safety Evaluation Fisheries College of Jimei UniversityXiamen361021China Guangdong Yuehai Feed Group Co. Ltd.GuangdongZhanjiang524000China

Intensive aquaculture-induced oxidative stress is detrimental to fish health and *** plants show promise as natural health boosters and antioxidants in the aquaculture ***,this work investigated the effects of turmeric aqueous extract(tae)on the growth performance,antioxidant status,and hydrogen peroxide(H2O2)-induced oxidative stress in spotted seabass(Lateolabrax maculatus).Fish were fed diets supplemented with 0(Con),2(tae2),or 4(tae4)g/kg tae for eight weeks,then were injected with *** results showed that dietary supplementation of tae did not affect fish growth,feed utilization,or body *** treatment increased liver antioxidant enzyme activities and decreased liver malondialdehyde content and serum levels of glutamate oxalate transaminase,glutamate pyruvate transaminase,and lactate ***,the increases in mortality,liver malondialdehyde content,and serum biomarkers of liver injury in the H2O2-treated fish were inhibited as a consequence of the tae *** addition,tae treatment activated the Nrf2/Keap1 pathway in the liver,supported by the up-regulated expression of nrf2,ho-1,and gclc,and down-regulated keap1 ***,dietary incorporation of tae protected against H2O2-induced oxidative stress in spotted seabass probably by enhancing antioxidant capacity through the Nrf2/Keap1 pathway.

关键词： Turmeric Medicinal plant Hydrogen peroxide Oxidative stress Lateolabrax maculatus

Comparative detection of syndecan-2 methylation in preoperative and postoperative stool DNA in patients with colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 2032-2041页

作者： Ji Hyeong song tae Jeong Oh Sungwhan An Kyung Ha Lee Ji Yeon Kim jin Soo Kim Department of Surgery Chungnam National University Sejong HospitalSejong 30099South Korea Genomictree Inc.Daejeon 34027South Korea Department of Surgery College of MedicineChungnam National UniversityDaejeon 35015South Korea

BACKGROUND Early detection of colorectal cancer(CRC)is essential to reduce cancer-related morbidity and *** DNA(sDNA)testing is an emerging method for early CRC ***-2(SDC2)methylation is a potential biomarker for the sDNA *** DNA methylation is an early epigenetic event during tumorigenesis and can occur in the normal colonic mucosa during aging,which can compromise the sDNA test *** In this prospective study,we enrolled 151 patients with CRC who underwent curative surgical resection between September 2016 and May *** stool samples were collected from 123 patients and postoperative samples were collected from 122 patients.A total of 104 samples were collected from both preoperative and postoperative *** promoter methylation of SDC2 in sDNA was assessed using linear target enrichment quantitative methylation-specific real-time polymerase chain *** parameters were analyzed using the results of SDC2 *** Detection rates of SDC2 methylation in the preoperative and postoperative stool samples were 88.6%and 19.7%,*** tumor size(3 cm,P=0.019)and advanced T stage(T3–T4,P=0.033)were positively associated with the detection rate of SDC2 methylation before *** sex was associated with false positives after surgery(P=0.030).Cycle threshold(CT)values were significantly decreased postoperatively compared with preoperative values(P<0.001).The postoperative negative conversion rate for preoperatively methylated SDC2 was 79.3%(73/92).CONCLUSION Our results suggested that the SDC2 methylation test for sDNA has acceptable sensitivity and ***,small size and early T stage tumors are associated with a low detection rate of SDC2 *** the cycle threshold values significantly decreased after surgery,SDC2 methylation test for sDNA might have a diagnostic value for CRC.

关键词： Biomarkers DNA methylation Syndecan-2 Colorectal cancer

Minimum dose path planning for facility inspection based on the discrete Rao-combined ABC algorithm in radioactive environments with obstacles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第4期34卷 26-40页

作者： Kwon Ryong Hong Su Il O Ryon Hui Kim tae song Kim Jang Su Kim Faculty of Energy Science Kim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea High-Tech Research&Development Centre Institute of Information TechnologyKim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea

Workers who conduct regular facility inspections in radioactive environments will inevitably be affected by ***,it is important to optimize the inspection path to ensure that workers are exposed to the least amount of *** study proposes a discrete Rao-combined artificial bee colony(ABC)algorithm for planning inspection paths with minimum exposure doses in radioactive environments with *** this algorithm,retaining the framework of the traditional ABC algorithm,we applied the directional solution update rules of Rao algorithms at the employed bee stage and onlooker bee stage to increase the exploitation ability of the algorithm and implement discretion using the swap operator and swap *** increase the randomness of solution generation,the chaos algorithm was used at the initialization *** K-opt operation technique was introduced at the scout bee stage to increase the exploration ability of the *** path planning in an environment with complex structural obstacles,an obstacle detour technique using a recursive algorithm was *** evaluate the performance of the proposed algorithm,we performed experimental simulations in three hypothetical environments and compared the results with those of improved particle swarm optimization,chaos particle swarm optimization,improved ant colony optimization,and discrete Rao’s *** experimental results show the high performance of the proposed discrete Rao-combined ABC algorithm and its obstacle detour capability.

关键词： Minimum dose Path planning Nuclear facility inspection ABC algorithm Rao algorithms Swap sequence K-opt operation

Cardiac rehabilitation in a heart failure patient after left ventricular assist device insertion and subsequent heart transplantation:A case report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第8期10卷 2577-2583页

作者： tae Woong Yang Seunghwan song Hye Won Lee Byeong-Ju Lee Department of Rehabilitation Medicine Biomedical Research InstitutePusan National University HospitalPusan 602-739South Korea Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicinePusan National University HospitalPusan 602-739South Korea Division of Cardiology Department of Internal MedicinePusan National University School of MedicinePusan National University HospitalPusan 602-739South Korea

BACKGROUND Insertion of a left ventricular assist device(LVAD)and heart transplantation(HT)improve the survival of patients with heart *** addition,cardiac rehabilitation(CR)further increases the functional *** case report describes a successful case of CR after LVAD insertion and subsequent *** SUMMARY In the present case,during the LVAD insertion period,peak oxygen consumption(VO2)increased by 12.16%after *** was performed 7 mo after the LVAD insertion,and the patient participated in phases I and II *** peak VO2 increased from 17.24 to 22.29 m L/kg/*** improvement was more significant than that reported in previous studies on CR after LVAD insertion or *** patient’s quality of life also *** total average score of the short form-36 questionnaire increased from 29.5 points at admission to 53.3 points 9 mo after *** A tailored CR program after LVAD insertion or HT may improve the patients’quality of life and increase survival.

关键词： Left ventricular assist device Heart transplantation Cardiac rehabilitation Case report

Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 262-269页

作者： Su-Hyeon Cho tae-Hyung Kwon Hoibin Jeong jin Sook Kim song-Rae Kim Myeong Seon Jeong SeonJu Park Miri Choi Jung-Hee Woo Juhee Ahn Kil-Nam Kim Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Department of Medical Biomaterials Engineering College of Biomedical SciencesKangwon National UniversityChuncheon 24341Republic of Korea Department of Research and Development Chuncheon Bio-industry FoundationChuncheonRepublic of Korea Marine Industry Research Institute for East se rim Uljin-gunGyeongsangbuk-doRepublic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To demonstrate the effect of dieckol from Eisenia bicyclis on osteoclastogenesis using RAW 264.7 ***:Murine macrophage RAW 264.7 cells were subjected to dieckol treatment,followed by treatment with receptor activator of nuclear factor kappa-B ligand(RANKL)to induce ***-resistant acid phosphatase(TRAP)activity was examined using a TRAP activity *** blotting analysis was conducted to examine the level of osteoclast-related factors,including TRAP and calcitonin receptor(CTR),transcriptional factors,including c-Fos,c-Jun,and nuclear factor of activated T cells cytoplasmic 1(NFATc1),nuclear factor kappa-B(NF-κB),extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase(JNK).Immunofluorescence staining was conducted to examine the expression of c-Fos,c-Jun,and ***:Among the four phlorotannin compounds present in Eisenia bicyclis,dieckol significantly hindered osteoclast differentiation and expression of RANKL-induced TRAP and *** addition,dieckol downregulated the expression levels of c-Fos,c-Jun,NFATc1,ERK,and JNK,and suppressed NF-κB ***:Dieckol can suppress RANKL-induced ***,it has therapeutic potential in treating osteoclastogenesis-associated diseases.

关键词： Eisenia bicyclis Dieckol Osteoclasts ERK JNK NF-κB RANKL TRAP Calcitonin receptor NFATc1 RAW 264.7 cell

Tyrosine-mediated analog resistive switching for artificial neural networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu song Seok Daniel Namgung Hojung Lee Jeong Hyun Yoon Young-Woong song Kang Hee Cho Yoon-Sik Lee Jong-Seok Lee Ki tae Nam Jang-Yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network