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Survival benefit of adjuvant treatment for ampullary cancer with lymph nodal involvement:A systematic review and meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 559-565页

作者： Min Kyu Kim Jin Ho Choi In Rae Cho Sang Hyub Lee Ji Kon ryu Yong-tae Kim Woo hyun Paik Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Internal Medicine Liver Research InstituteSeoul National University HospitalSeoul National University College of MedicineSeoulKorea

Background:The efficacy of adjuvant treatment(AT)in ampullary cancer(AmC)remains *** systematic review and meta-analysis aimed to evaluate the role of AT for *** sources:A comprehensive systematic search was performed in PubMed,EMBASE,Cochrane Library,and Web of Science *** comparing overall survival(OS)and recurrence-free survival(RFS)of patients who underwent AT or not following AmC resection were ***:A total of 3971 patients in 21 studies were *** pooled data showed no significant difference in effect on the OS by AT[hazard ratio(HR)=0.998,95%confidence interval(CI):0.768–1.297].No significant difference in recurrence between the AT and non-AT(nAT)groups was noted(HR=1.158,95%CI:0.764–1.755).In subgroup analysis,patients who received AT showed favorable outcomes in the OS compared with those who received nAT in nodal-positive AmC(HR=0.627,95%CI:0.451–0.870).Neither AT consisted of adjuvant chemotherapy with radiotherapy(HR=0.804,95%CI:0.563–1.149)nor AT with adjuvant chemotherapy(HR=0.883,95%CI:0.642–1.214)showed any significant effect on the ***:The effect of AT in AmC on survival and recurrence did not show a significant ***,effectiveness according to AT strategies did not show enhancement in *** had an advantage in survival compared with nAT strategy in nodal-positive *** cases of AmC with positive lymph nodal involvement,AT may be warranted regardless of detailed strategies.

关键词： Ampulla of Vater Adjuvant chemotherapy Adjuvant chemoradiotherapy Meta-analysis

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Comparison of cytological and histological preparations in the diagnosis of pancreatic malignancies using endoscopic ultrasoundguided fine needle aspiration

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 418-423页

作者： Dong Kee Jang Sang Hyub Lee Jun Kyu Lee Woo hyun Paik Kwang hyun Chung Ban Seok Lee Jun Hyuk Son Jae Woo Lee Ji Kon ryu Yong-tae Kim Kyoung-Bun Lee Department of Internal Medicine Dongguk University Ilsan Medical CenterGoyang-siGyeonggi-doKorea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Inje University Ilsan Paik HospitalGoyang-siGyeonggi-doKorea Department of Pathology Seoul National University College of MedicineSeoulKorea

BACKGROUND:Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) has become a crucial diagnostic technique for pancreatic *** specimen obtained by EUS-FNA can be prepared for either cytological or histological *** study was to compare diagnostic performance of cytological and histological preparations using EUSFNA in the same lesions when pancreatic malignancies were ***:One hundred and eighteen patients who underwent EUS-FNA for suspected pancreatic malignancies were consecutively *** procedures were conducted by a single echoendoscopist under the same *** adequate preparations were obtained by 22-gauge needles with 20 to-and-fro movements for each *** 4 preparations included 2 cytological and 2 histological *** pathologic reviews of all specimens were conducted independently by a single experienced ***,specificity,and accuracy of the 2 preparations were ***:The enrolled patients consisted of 62 males(52.5%),with the mean age of 64.6±10.5 *** was performed in 23(19.5%) *** hundred and sixteen(98.3%) lesions were classified as malignant,while 2(1.7%) were *** of cytology and histology were 87.9% and 81.9%,respectively,with no significant difference(P=0.190).Accuracy was also not significantly *** preparation was more sensitive when the size of lesion was <3 cm(86.7% vs 68.9%,P=0.033).CONCLUSIONS:Our results suggested that the diagnostic performances of cytological and histological preparations are not significantly different for the diagnosis of pancreatic ***,cytological preparation might be more sensitive for pancreatic lesions <3 cm.

关键词： endoscopic ultrasound-guided fine needle aspiration pancreatic neoplasms cytology pathology histology

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Real-time detection of mercury ions based on vertically grown ReS_(2) film

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Journal of Materials Science & Technology 2023年第33期164卷 52-58页

作者： Anupom Devnath Yongsu Choi Hyeyoon ryu Annadurai Venkatesan Gihwan hyun Sanghoek Kim Seunghyun Lee Department of Electronic Engineering Kyung Hee UniversityYongin-SiGyeonggi-do 17104Republic of Korea Department of Electronics and Information Convergence Engineering Kyung Hee UniversityYongin-SiGyeonggi-do 17104Republic of Korea

Mercury(Hg^(2+)),one of the most dangerous toxins in water,is a heavy metal that causes organ damage from both short-term and chronic *** methods for detecting mercury such as atomic absorption spectrometry or Raman spectroscopy require bulky equipment with complicated *** this work,we fabricated a highly sensitive,real-time thin-film sensor based on vertically aligned rhenium disulfide(ReS_(2)).Its outstanding large surface area and the unique electronic appearance of its layered architecture make a ReS_(2) nanosheet a strong contender for such an *** sensor exhibited a fast response speed(<2 s)to Hg^(2+)and an ultralow detection limit of 4 nM,which is significantly less than that of the *** Protection Agency's(***)allowed utmost contamination limit for Hg^(2+)in drinking water(10 nM).It also exhibited strong selectivity for Hg^(2+)against other metal ions such as Na^(+),Zn^(2+),Fe^(3+),Cu^(2+),Ca^(2+),Ni^(2+),Ag+,Cd^(2+),Fe^(2+),and Pb^(2+).Because this nanosheet can be replaced with any secondary substrate and possibly patterned into a microscale size,the sensor can be integrated into multiple platforms such as portable devices or sensor nodes in a grid network.

关键词： ReS_(2) Field-effect transistor Hg^(2+)ions Real-time sensor Selectivity

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Complications and management of forgotten long-term biliary stents

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World Journal of Gastroenterology 2017年第4期23卷 622-628页

作者： Se Hoon Sohn Jae hyun Park Kook hyun Kim tae Nyeun Kim Division of Gastroenterology and Hepatology Department of Internal MedicineYeungnam University College of MedicineDaegu 42415South Korea

AIMTo evaluate complications and management outcomes of retained long-term plastic biliary *** plastic biliary stent placement was performed in 802 patients at Yeungnam University Hospital between January 2000 and December 2014. Follow-up loss with a subsequently forgotten stent for more than 12 mo occurred in 38 patients. We retrospectively examined the cause of biliary stent insertion, status of stents, complications associated with biliary stents and management outcomes of long-term plastic biliary stents. Continuous variables were analyzed using the t test. Observed frequencies in subsets of the study population were compared using Fisher’s exact test and χ2 tests. Statistical significance was defined as P < 0.05 (two-tailed).RESULTSMean age of patients was 73.7 ± 12 years and male-to-female ratio was 2.2:1. Indications of plastic biliary stent insertion were bile duct stones (63.2%, 24/38) and benign bile duct stricture (52.6%, 20/38). Mean duration of retained plastic stent was 22.6 ± 12.2 mo, and in 10 cases (26.3%), stents were retained for more than 24 mo. Common bile duct (CBD) stones or sludge were found in most cases (92.1%, 35/38). The most common complication was acute cholangitis (94.7%, 36/38). Stent removal by endoscopic approach was successfully performed in 92.1% (35/38) of the cases. In 3 cases, an additional plastic stent was inserted alongside the previous stent due to failure of the stent removal. Endoscopic removal of bile duct stones was successful in 73.7% (28/38) of the cases. When patients were divided into two groups by duration of stent placement (12 to 24 mo vs over 24 mo), there were no differences in the development of cholangitis, presence of biliary stones, and success rate of endoscopic removal of stones and biliary *** most common complication of retained long-term plastic biliary stents was acute cholangitis associated with CBD stones. Endos

关键词： Biliary stent Long-term complications Forgotten stents Acute cholangitis Biliary stone

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Memory-centric neuromorphic computing for unstructured data processing

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Nano Research 2021年第9期14卷 3126-3142页

作者： Sang hyun Sung tae Jin Kim Hera Shin Hoon Namkung tae Hong Im Hee Seung Wang Keon Jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea

The unstructured data such as visual information,natural language,and human behaviors opens up a wide array of opportunities in the field of artificial intelligence(Al).The memory-centric neuromorphic computing(MNC)has been proposed for the efficient processing of unstructured data,bypassing the von Neumann bottleneck of current computing *** development of MNC would provide massively parallel processing of unstructured data,realizing the cognitive Al in edge and wearable *** this review,recent advances in memory-centric neuromorphic devices are discussed in terms of emerging nonvolatile memories,volatile switches,synaptic plasticity,neuronal models,and memristive neural network.

关键词： neuromorphic computing memory-centric memristor artificial synapses artificial neurons memristive neural network

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Process analysis of direct laser melting to fabricate layered hybrid beads

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中国有色金属学会会刊：英文版 2012年第S3期22卷 813-819页

作者： Jeong-hwan JANG Sung-min MUN tae-hyun KIM Young-hoon MOON School of Mechanical Engineering Engineering Research Center for Net Shape and Die ManufacturingPusan National University

The successful fabrication of layered hybrid beads by DLM process is limited by dissimilar melting ranges of different *** the application of DLM process into manufacturing industries,target mechanical properties of final product must be *** analysis was performed for the DLM fabrication of layered hybrid beads by using stainless steel (SS 316L) and titanium *** the analysis of fabrication characteristics,single hybrid bead was formed using SS316L powder onto the base plate and then Ti powder was melted onto the previous melted *** addition,multi-layer hybrid beads were fabricated for the analysis of the layering effects between *** these studies,the effects of the processing parameters,such as laser power,scan rate and scan line spacing on surface morphology were characterized and optimum processing conditions for the DLM fabrication of layered hybrid beads were developed.

关键词： stainless steel 316L Ti powder energy density surface roughness direct laser melting process layered hybrid beads

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Velocity Profiles between Two Baffles in a Shell and Tube Heat Exchanger

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Journal of Thermal Science 2015年第4期24卷 356-363页

作者： tae-hyun Chang Chang-Hoan Lee Hae-Soo Lee Kwon-Soo Lee Senior Research Fellow of RESEAT Korea Institute of Science and Technology Information Korea Institute of Science and Technology Information Postdoctoral Research Fellow School of Mechanical Engineering of Kyungnam University International University of Korea

Heat exchangers are extensively utilized for waste heat recovery,oil refining,chemical processing,and steam *** this study,velocity profiles are measured using a 3D particle image velocimetry(PIV)system between two baffles in a shell and tube heat exchanger for parallel and counter *** PIV and computational fluid dynamics results show the occurrence of some strong vectors near the *** vectors are assumed due to the clearance between the inner tubes and the front ***,the major parts of the vectors are moved out through the bottom opening of the rear baffle,and other vectors produce a large circle between the two *** simulations are conducted to investigate the effects of the baffle on the heat exchanger using the Fluent *** k-εturbulence model is employed to calculate the flows along the heat exchanger.

关键词： Baffle P1V Shell and tube heat exchanger Cut off ratio CFD

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A new dimmer for alternating-current directly driven light-emitting-diode lamp

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Journal of Central South University 2012年第2期19卷 374-379页

作者： KIM Jong-hyun ryu Myung-hyo YOON Hyok-min SONG Eui-ho School of Mechatronics Changwon National University

A new dimmer using a mental-oxide-semiconductor field-effect transistor (MOSFET) for alternating-current (AC) directly driven light-emitting-diode (LED) lamp was presented. The control method of proposed dimmer is pulse width control (PWM) method. Compared with the conventional phase-controlled dimmer, the proposed PWM dimmer can produce sine wave and did not cause harmonics problem. Furthermore, the proposed control method did not amplify the light flicker due to the independence of input voltage. Therefore, the PWM dimmer can be used as the dimmer of the AC LED lamp instead of the conventional phase-controlled dimmer. The experimental result shows that the proposed PWM dimmer has good performances.

关键词： alternating-current directly driven light-emitting-diode pulse width control total harmonic distortion flicker triac

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Successful endoscopic treatment of biliary stricture following mesenteric tear caused by blunt abdominal trauma

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World Journal of Gastroenterology 2008年第14期14卷 2277-2279页

作者： Dong O Kang tae Hyo Kim Seung Suk You hyun Ju Min hyun Jin Kim Woon tae Jung Ok Jae Lee Department of Internal Medicine Institute of Health Science Gyeongsang National University School of Medicine Jinju 660-702 Korea

Biliary duct injuries are frequently iatrogenic, being associated with surgery for gallbladder stones. However, blunt abdominal trauma such as a motor vehicle crash is a rare cause of extrahepatic biliary stricture. A few reports have been published on biliary strictures treated with endoscopic therapy. In the present study, we describe a suprapancreatic biliary stricture associated with mesenteric tear following road traffic accident. We performed endoscopic stent placement, which was successful in relieving the biliary stricture.

关键词： Biliary stricture Blunt abdominal trauma Mesenteric tear Endoscopic stent treatment

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Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer

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World Journal of Gastroenterology 2014年第26期20卷 8545-8557页

作者： Woo hyun Paik Ji Kon ryu Kyoung-Sin Jeong Jin Myung Park Byeong Jun Song Sang Hyub Lee Yong-tae Kim Yong Bum Yoon Department of Internal Medicine Inje University Ilsan Paik Hospital Division of Gastroenterology Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine

AIM: To evaluate the anti-tumor effect of clobenpropit, which is a specific H3 antagonist and H4 agonist, in combination with gemcitabine in a pancreatic cancer cell line.

关键词： Clobenpropit Epithelial-mesenchymal transition Histamine Histamine receptors Pancreatic neoplasm

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