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RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model

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Journal of Genetics and Genomics 2024年第12期51卷 1389-1403页

作者： Ji-Won Park tae-Ik Choi tae-Yoon kim Yu-Ri Lee Dilan Wellalage Don Jaya K.George-Abraham Laurie A.Robak Cristina C.Trandafir Pengfei Liu Jill A.Rosenfeld tae hyeong kim Florence Petit Yoo-Mi kim Chong Kun Cheon Yoonsung Lee Cheol-Hee kim Department of Biology Chungnam National University Department of Pediatrics The University of Texas at Austin Dell Medical School Department of Molecular and Human Genetics Baylor College of Medicine Baylor Genetics Laboratories Department of Pediatrics Kyung Hee University Hospital at Gangdong Univ.Lille CHU LilleClinique de g en etique Guy Fontaine Department of Pediatrics Chungnam National University Sejong Hospital Department of Pediatrics Pusan National University Children’s Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Clinical Research Institute Kyung Hee University Hospital at GangdongSchool of MedicineKyung Hee University

Williams syndrome (WS) is a rare multisystemic disorder caused by recurrent microdeletions on 7q11.23,characterized by intellectual disability,distinctive craniofacial and dental features,and cardiovascular *** studies have explored the roles of individual genes within these microdeletions in contributing to WS ***,we report five patients with WS with 1.4 Mb-1.5 Mb microdeletions that include RFC2,as well as one patient with a 167-kb microdeletion involving RFC2 and six patients with intragenic variants within *** investigate the potential involvement of RFC2 in WS pathogenicity,we generate a rfc2 knockout (KO) zebrafish using CRISPR-Cas9 ***,we generate a KO zebrafish of its paralog gene,rfc5,to better understand the functions of these RFC genes in development and *** rfc2 and rfc5 KO zebrafish exhibit similar phenotypes reminiscent of WS,including small head and brain,jaw and dental defects,and vascular ***-seq analysis reveals that genes associated with neural cell survival and differentiation are specifically affected in rfc2 KO *** addition,heterozygous rfc2 KO adult zebrafish demonstrate an anxiety-like behavior with increased social *** results suggest that RFC2 may contribute to the pathogenicity of WS,as evidenced by the zebrafish model.

关键词： Williams syndrome RFC2 RFC5 Zebrafish Knockout CRISPR-Cas9

Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

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Nano Research 2015年第7期8卷 2340-2350页

作者： Doo-Won Lee Jinhwan Lee II Yung Sohn Bo-Yeong kim Young Min Son Hunyoung Bark JaehyuckJung Minseok Choi tae hyeong kim Changgu Lee Nae-Eung Lee Department of Advanced Materials Science & Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Department of Mechanical Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Samsung Advanced Institute for Health Sciences & Technology (SAIHST) Sungkyunkwan University Suwon Gyeonggi-do 440-746 Republic of Korea New Materials Team Future Device R&D Department LG Electronics Advanced Research Institute Seou1137-724 Republic of Korea These authors contributed equally to this work.

A field-effect transistor （FET） with two-dimensional （2D） few-layer MoS2 as a sensing-channel material was investigated for label-free electrical detection of the hybridization of deoxyribonucleic acid （DNA） molecules. The high-quality MoS2-channel pattern was selectively formedthrough the chemical reaction of the Mo layer with H2S gas. The MoS2 FET was very stable in an electrolyte and inert to pH changes due to the lack of oxygen-containing functionalities on the MoS2 surface. Hybridization of single-stranded target DNA molecules with single-stranded probe DNA molecules physically adsorbed on the MoS2 channel resulted in a shift of the threshold voltage （Vt,） in the negative direction and an increase in the drain current. The negative shift in Vth is attributed to electrostatic gating effects induced by the detachment of negatively charged probe DNA molecules from the channel surface after hybridization. A detection limit of 10 fM, high sensitivity of 17 mWdec, and high dynamic range of 106 were achieved. The results showed that a bio-FET with an ultrathin 2D MoS2 channel can be used to detect very small concentrations of target DNA molecules specifically hybridized with the probe DNA molecules.

关键词： two-dimensional(2D)materials, MoS2,field-effect transistor, biosensor,deoxyribonucleic acid (DNA) hybridization

Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo Park Jong-Seong Bae taehyun Park Il tae kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Artificial layer Dielectric constant Zn metal anode Zinc aqueous battery

ACS Nano：科学家利用来自尿液的生物标志物进行早期癌症筛查

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现代生物医学进展 2017年第11期17卷 I0003-I0003页

作者： Hyun-Kyung Woo[†]‡ Vijaya Sunkara[†]‡ Juhee Park[⊥] tae-hyeong kim[⊥] Ja-Ryoung Han[†] Chi-Ju kim[†][⊥] Hyun-Il Choi[§] Yoon-Keun kim[§][∥] Yoon-Kyoung Cho[*][†][⊥] [†] Department of Biomedical Engineering School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea[§] Department of Life Sciences Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea[∥] Institute of MD Healthcare Seoul 03923 Republic of Korea[⊥] Center for Soft and Living Matter Institute for Basic Science (IBS) Ulsan 44919 Republic of Korea

日前。来自韩国蔚山国家科学技术研究所的研究人员通过研究开发出了一种新技术，该技术能够有效在尿液或血液中有效鉴别出促进癌症发生的物质，相关研究刊登于国际杂志ACS Nano上。

关键词： Nano ACS 生物标志物癌症尿液科学家筛查早期

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul C.Khot Chenjie Yao Nahyun kim tae Geun kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Ag-GST/HfO_(x)-based unidirectional threshold switching selector with low leakage current and threshold voltage distribution for high-density cross-point arrays

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Rare Metals 2024年第1期43卷 280-288页

作者： Kyoung-Joung Yoo Dae-Yun Kang Nahyun kim Ho-Jin Lee Ta-hyeong kim taeho kim tae Geun kim School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea

The use of electrochemical-metallization-based volatile threshold switching selectors in cross-point arrays has been widely explored owing to their high on-off ratios and simple ***,these devices are unsuitable for cross-point architectures because of the difficulty in controlling the random filament formation that results in large fluctuations in the threshold voltage during *** this study,we investigated the unidirectional threshold transition characteristics associated with an Ag/GST/HfO_(x)/Pt-based bilayer selector and demonstrated the occurrence of a low leakage current(<1×10^(-11) A) and low distribution of the threshold voltage(Δ0.11 V).The bilayer structure could control the filament formation in the intermediate state through the insertion of an HfO_(x) tunneling *** stacking a bilayer selector with NiO_(x)based resistive random-access memory,the leakage and programming currents of the device could be significantly *** the crossbar array configuration,we performed equivalent circuit analysis of a one-selector oneresistor(1S1R) devices and estimated the optimal array size to demonstrate the applicability of the proposed *** maximum acceptable crossbar array size of the 1S1R device with the Ag/GST/HfO_(x)/Pt/Ti/NiO_(x)/Pt structure was 5.29×10^(14)(N^(2),N=2.3×10^(7)).

关键词： Selector device Tunneling barrier Threshold switching Sputtering 1S1R Cross-point array

Prediction of Monthly Mean Surface Air Temperature in a Region of China

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Advances in Atmospheric Sciences 2007年第3期24卷 503-508页

作者： Jeong-hyeong LEE Keon-tae SOHN Division of Management Information Science Dong-A University Busan 604-714Korea Department of Statistics Pusan National University Busan 609-735Korea

In conventional time series analysis, a process is often modeled as three additive components： linear trend, seasonal effect, and random noise. In this paper, we perform an analysis of surface air temperature in a region of China using a decomposition method in time series analysis. Applications to the National Centers for Environmental Prediction/the National Center for Atmospheric Research （NCEP/NCAR） Collaborative Reanalysis data in this region of China are discussed. The main finding was that the surface air temperature trend estimated for January 1948 to February 2006 was not statistically significant at 0.5904℃ （100 yr）^-1. Forecasting aspects are also considered.

关键词： Chinese region surface air temperature time series decomposition method regression

k-Nearest Neighbor Query Processing Algorithms for a Query Region in Road Networks

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Journal of Computer Science & Technology 2013年第4期28卷 585-596页

作者： hyeong-Il kim Jae-Woo Chang Department of Computer Engineering Chonbuk National University Cloud Open R&D Center Chonbuk National University

Recent development of wireless communication technologies and the popularity of smart phones .are making location-based services （LBS） popular. However, requesting queries to LBS servers with users＇ exact locations may threat the privacy of users. Therefore, there have been many researches on generating a cloaked query region for user privacy protection. Consequently, an efficient query processing algorithm for a query region is required. So, in this paper, we propose k-nearest neighbor query （k-NN） processing algorithms for a query region in road networks. To efficiently retrieve k-NN points of interest （POIs）, we make use of the Island index. We also propose a method that generates an adaptive Island index to improve the query processing performance and storage usage. Finally, we show by our performance analysis that our k-NN query processing algorithms outperform the existing k-Range Nearest Neighbor （kRNN） algorithm in terms of network expansion cost and query processing time.

关键词： island index k-nearest neighbor query processing scheme locatiombased service road network

Use of various MgO resources for high-purity Mg metal production through molten salt electrolysis and vacuum distillation

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Journal of Magnesium and Alloys 2023年第2期11卷 562-579页

作者： hyeong-Jun Jeoung tae-Hyuk Lee Youngjae kim Jin-Young Lee Young Min kim Toru HOkabe Kyung-Woo Yi Jungshin Kang Korea Institute of Geoscience and Mineral Resources 124 Gwahak-ro Yuseong-guDaejeon 34132South Korea Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826South Korea Department of Resources Engineering University of Science and Technology217 Gajeong-ro Yuseong-guDaejeon 34113South Korea Korea Institute of Materials Science 797 Changwondae-roSeongsan-guChangwonGyeongnam 51508South Korea Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan School of Materials Science and Engineering Pusan National University2 Busandaehak-roGeumjeong-guBusan 44241South Korea

A green and effective electrolytic process was developed to produce high-purity Mg metal using primary and secondary resources containing Mg O as a feedstock. The electrolysis of various Mg O resources was conducted using a Cu cathode in MgF2– LiF – KCl molten salt at 1043 K by applying an average current of 1.44 A for 12.5 h. The electrolysis of calcined North Korean magnesite and seawater Mg O clinker yielded Mg alloys of MgCu2and(Cu) phases with current efficiencies of 89.6–92.4%. The electrolysis of oxidized Mg O-C refractory brick, aged ferronickel slag, and ferronickel slag yielded Mg alloys of MgCu2and(Cu) phases with current efficiencies of 59.3–92.3%. The vacuum distillation of Mg alloys obtained was conducted at 1300 K for 10 h to produce high-purity Mg metal. After vacuum distillation, Mg metal with a purity of above 99.994% was obtained. Therefore, this study demonstrates the feasibility of the production of high-purity Mg metal from various Mg O resources using a novel electrolytic process with a Cu cathode, followed by vacuum distillation.

关键词： High-purity magnesium Magnesium oxide resources Electrolytic process Metal cathode Vacuum distillation