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A Family of GCK-MODY, About 02 Cases and Review of the Literature

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Understanding the Recovery of the Intervertebral Disc:A Comprehensive Review of In Vivo and In Vitro Studies

Open Journal of Endocrine and Metabolic Diseases（内分泌与新陈代谢疾病期刊） 2024年第7期 135页

作者： Malad Mohamed tadlaoui abderrahman Riznat Malak Guerboub Ahmed Anas

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Journal of Bionic Engineering 2024年第4期21卷 1919-1948页

作者： Faten Feki Fahmi Zaïri abderrahman Tamoud Melissa Moulart Rym Taktak Nader Haddar Fahed Zaïri Sfax University ENISMaterials Engineering and Environment Laboratory3038SfaxTunisia University of Lille IMT Nord EuropeJUNIAUniversity of ArtoisULR 4515-LGCgELaboratoire de Génie Civil et geo-Environnement59000LilleFrance PrediTwins Lab 59000LilleFrance Japet Medical Device 59000LilleFrance Sfax University ENISLaboratory of Advanced Materials3038SfaxTunisia Ramsay Générale de Santé Hôpital PrivéLe Bois59000LilleFrance

Within the consistent daily rhythm of human life,intervertebral discs endure a variety of complex loads beyond the influences of gravity and muscle forces,leading to significant morphological changes(in terms of volume,area,and height)as well as biomechanical alterations,including an increase in disc stiffness and a decrease in intradiscal ***,the discs demonstrate an ability to regain their original morphological and biomechanical characteristics after a period of nocturnal *** preservation of normal disc function is critically dependent on this recovery phase,which serves to forestall premature disc *** phenomenon of disc recovery has been extensively documented through numerous in vivo studies employing advanced clinical techniques such as Magnetic Resonance Imaging(MRI),stadiometry,and intradiscal pressure ***,the findings from in vitro studies present a more complex picture,with reports varying between full recovery and only partial recuperation of the disc ***,research focusing on degenerated discs in vitro has shed light on the quantifiable impact of degeneration on the disc ability to *** dynamics within the disc are considered a primary factor in recovery,yet the disc intricate multiscale structure and its viscoelastic properties also play key *** elements interact in complex ways to influence the recovery mechanism,particularly in relation to the overall health of the *** objective of this review is to collate,analyze,and critically evaluate the existing body of in vivo and in vitro research on this topic,providing a comprehensive understanding of disc recovery *** understanding offers a blueprint for future advancements in medical treatments and bionic engineering solutions designed to mimic,support,and enhance the natural recovery processes of intervertebral discs.

关键词： Intervertebral disc Recovery In vivo vs.in vitro studies Degeneration Viscoelastic effects Fluid dynamics

CFD investigation of the agitation in the desupersaturation during the wet-process phosphoric acid(WPPA)process

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Chinese Journal of Chemical Engineering 2020年第8期28卷 2064-2074页

作者： Asmaa Hadane Lhachmi Khamar Saad Benjelloun abderrahman Nounah Mohammed Khamar LGCE Higher School of Technology in SaléMohammed V University in RabatMorocco MSDA Mohammed 6th Polytechnic UniversityBenguerir 43150Morocco LIPIM National School of Applied sciences in KhouribgaSultan Moulay Sliman University in Beni MellalMorocco

Desupersaturation is a complex cooling operation that involves hydrodynamic,thermal and mechanical *** process requires continuous agitation to avoid fouling problems and sludge *** current work aims to investigate the well mixedness in the desupersaturation tank for optimal *** this purpose,a multi-fluid CFD study was conducted based on the Euler–Euler modeling approach,considering a multiphase flow involving a liquid phase(phosphoric acid)and a poly-dispersed solid phase,i.e.a sludge with three different sizes where each size is considered as a separate ***,the hydrodynamic behavior of the flow within the agitated desupersaturator is analyzed through the investigation of the velocity fields as well as the power and pumping numbers,to determine both the agitator capacity to pump the flow and its power consumption during the ***,in order to assess the mixture homogeneity,we evaluated the solid suspension in the desupersaturation reactor following conventional methods and two new proposed methodologies:the first approach is to evaluate the suspension quality in the mixing system by compartment and the second consists on the assessment of the uniform convergence of the solid ***,we calculated the time required to achieve a full suspension at different solid *** other hand,we conducted a detailed analysis of the solid distribution dependency on the impeller rotational speed at different solid volume fraction,which allows a good understanding of the parameters controlling the homogenization in the desupersaturator.

关键词： CFD Multiphase flow Mass transfer Phosphoric acid Agitation

Strong and weak output stabilisation for distributed bilinear systems

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Journal of Control and Decision 2021年第3期8卷 314-321页

作者： abderrahman Ait Aadi El Hassan Zerrik MACS Laboratory Department of MathematicsUniversity of Moulay IsmailMeknesMorocco

This paper is concerned with the output stabilisation for a class of distributed bilinear system evolving in a spatial domain.We give sufficient conditions for strong and weak output ***,the output stabilisation is d... 详细信息

关键词： Bilinear systems output stabilisation feedback controls decay estimate minimisation problem

On the gradient tracking problem for a bilinear reaction–diffusion equation excited by distributed bounded controls

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Journal of Control and Decision 2023年第3期10卷 365-373页

作者： El Hassan Zerrik abderrahman Ait Aadi Mohamed Ouhafsaa MACS Laboratory Faculty of SciencesMoulay Ismail UniversityMeknesMorocco Department of Sciences Ecole Normale SupérieureMoulay Ismail UniversityMeknesMorocco

This paper addresses a gradient tracking problem of a bilinear reaction–diffusion equation evolvingin a spatial domainΩ ⊂ Rn, n ≤ 3. Such an equation is excited with distributed and boundedcontrols. The problem is formulated by the minimisation of a functional constituted of the deviationbetween the desired gradient and the current one all over a time interval and the energyterm. Then we prove the existence of an optimal control that we characterise by an optimalitysystem. Moreover, we discuss two sets of particular controls: the set of time dependent controlsand the space dependent ones. A computational approach and illustrative simulations are alsogiven.

关键词： Infinite dimensional systems bilinear systems reaction–diffusion equation controllability optimal control

Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 598-603页

作者： Monia Deghrigue Carmen Festa Lotfi Ghribi Maria Valeria D’Auria Simona De Marino Hichem Ben Jannet abderrahman Bouraoui Laboratoire de développement chimique galénique et pharmacologique des médicaments (LR12ES09).Equipe de Pharmacologie marineFaculté de pharmacie de MonastirUniversité de Monastir Department of Pharmacy University of Naples "Federico II" Laboratoire de chimie hétérocyclique produits naturels et réactivité. Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir Laboratoire de chimie hétérocyclique produits naturels et réactivité.Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir

Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases.

关键词： Eunicella singularis Anti-inflammatory activity Analgesic activity Gastroprotective effect Diterpenoid Sterols

Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes:A systematic review

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Journal of Sport and Health Science 2023年第3期12卷 359-368页

作者： Hassane Zouhal Juan Del Coso Ayyappan Jayavel Claire Toumy Guillaume Ravé Nidhal Jebabli Cain C.T.Clark Benjamin Barthélémy Anthony C.Hackney Abderraouf Ben abderrahman M2S(Laboratoire Mouvement SportSanté)-EA 1274Department of Sport SciencesUniversity of RennesRennes F-35000France Rey Juan Carlos University Centre for Sport StudiesMadrid 28032Spain SRM College of Physiotherapy SRM Institute of Science and TechnologySRM NagarKattankulathur 603203India Department of Sport Sciences University of RouenMont Saint AignanCETAPS EA 3832F-76821France Toulouse Football Club Toulouse 31000France Higher Institute of Sport and Physical Education Ksar-SaidUniversity of ManoubaTunis 2010Tunisia Centre for Intelligent Healthcare Coventry UniversityCoventry CV15FBUK Department of Exercise&Sport Science Department of NutritionUniversity of North CarolinaChapel HillNC 27514USA

Purpose:The aim of this study was to review,systematically,evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training ***:A computerized literature search was performed in the electronic databases PubMed,Web of Science,and SPORTDiscus,from inception until November *** included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the ACTN3 R577X ***:Our search identified 492 *** the screening of titles,abstracts,and full texts,13 studies examining the association between the ACTN3 genotypes and the rate and severity of non-contact injury were included in the *** studies were performed in 6 different countries(Spain,Japan,Brazil,China,the Republic of Korea,and Italy)and involved a total participant pool of 1093 *** the studies,2 studies involved only women,5 studies involved only men,and 6 studies involved both men and *** the studies included were classified as highquality studies(≥6 points in the Physiotherapy Evidence Database(PEDro)scale score).Overall,evidence suggests there is an association between the ACTN3 R577X genotype and non-contact injury in 12 *** studies observed a significant association between A CTN3 R577X polymorphism and exercise induced muscle damage:2 with non-contact ankle injury,3 with non-contact muscle injury,and 1 with overall non-contact ***:The present findings support the premise that possessing the ACTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries,such as muscle injury,ankle sprains,and higher levels of exercise-induced muscle damage.

关键词： α-actinin-3 deficiency Athletic performance Exercise-related injury Muscle injury Single nucleotide polymorphism

The Impact of Pollution on the Bouregreg Estuary （Morocco, Atlantic Ocean）： The Molluscs as an Indicator of Metal Contamination

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Journal of Environmental Science and Engineering(B) 2013年第7期2卷 432-435页

作者： Essediya Cherkaoui abderrahman Nounah Mohamed Khamar The Laboratory of Energy Materials and Environment Higher School of Technology University Mohammed V Agdal-Rabat SaidMedina 11060 Morocco

On the Morrocan Atlantic coast, the estuary of the Bouregreg was submitted to many anthropic effects. After the dam Sidi Mohammed ben Abdellah was built in 1974, the flow became almost null. The waters of the estuary are meant for recreational activities, fishing, but at the same time they receive water collecting domestic and industrial wastewater. The waste in old landfills was not treated and leaked into the river water. The matter gets worse with the action of tides which make it difficult to escape the pollution load （physicochemical, bacteriological, heavy metals, etc.）. The concentrations of heavy metals （Pb, Fe, Cu and Cr） recorded in the sediments are higher than those found in the two molluscs. However, we have found out that Mytilus has accumulated more heavy metals （Cr, Pb and Zn） than Solen marginatus. The Zn makes an exception： It presents a greater concentration in the molluscs （63.015 mg/kg dry weight for Mytilus and 232.736 mg/kg dry weigh for Solen） than in the sediments （57.639 mg/kg）. The amount of these metals exceeds the standard values. The impact of the marine pollution on human health derives from the consumption by humans of heavy-metal polluted molluscs. The detected concentrations of these pollutants are superior to the permissible maximum amounts.

关键词： Bouregreg estuary heavy metals molluscs indicators.

Effect of Carbon Graphite on the Crystallization of Andalusite: Application to the Synthesis of Mullite and the Improvement of Refractory Quality

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Materials Sciences and Applications 2013年第6期4卷 337-346页

作者： Chaouki Sadik Iz-Eddine El Amrani abderrahman Albizane Department of Chemistry Faculty of Science and Technology University Hassan II Mohammedia-Casablanca Morocco Department of Earth Sciences Scientific Institute University Mohammed V Agdal Rabat Morocco

Different mixtures of Moroccan silica-alumina geomaterials were used for the preparation of refractory ceramics. A formula of composition (M2) has allowed obtaining a good quality of refractory. Addition of a small quantity of carbon (1%) to the M2 formula has substantially improved the quality of the refractory. The morphological, textural and mineralogical evolution, through SEM and XRD shows that the addition of carbon, which plays a catalytic role, favors the crystallization of andalusite. Then, from 1200°C, the andalusite starts to transform to primary mullite needles. At 1400°C, the mullite becomes the major mineral phase beside cristobalite and vitreous phase.

关键词： Refractory Alumina-Silica Andalusite Mullite Morocco