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Safety in Surgery:Evaluation of Safety and Efficiency in Use of Aminoglycosides in Acute Appendicitis

Surgical Science 2020年第5期11卷 99-110页

作者： tadeja pintar Bojana Beovic Abdominal Surgery Department Medical FacultyUniversity Medical Center LjubljanaLjubljanaSlovenia Clinic for Infectious Diseases and Therapeutics Medical FacultyUniversity Medical Center LjubljanaLjubljanaSlovenia

Background: Aminoglycosides are used as empirical antibiotic treatment of intraabdominal infections which are caused by Gram negative bacteria and for which the treatment of choice is surgery. Aminoglycosides maintain good efficacy against these bacteria and reduce the need for prescribing fluoroquinolone, cephalosporin and carbapenem antibiotics which contribute to the development of resistant bacterial strains. In recent years, several clinical trials and international guidelines have advised against the use of aminoglycosides owing largely to doubts about their effectiveness and to the concern for their known nephrotoxicity and ototoxicity. Aim: In our study, we aimed to prove whether aminoglycosides are appropriate agents in the treatment of acute appendicitis. Methods: Retrospectively, patients with acute appendicitis we included in the trial. Demographic characteristics, comorbidities, clinical signs and symptoms, the type of antibiotic and surgical treatment were analyzed. The effect of independent variables on the occurrence of complications was calculated using Student’s T-test and Fisher’s precise test. The effect of aminoglycosides on the loss of kidney function was determined by means of a linear regression method. Results: 300 patients proved acute appendicitis were included in the study. Univariate statistical analysis showed that the risk factors for postoperative complications in treating acute appendicitis were: age over 76 years (p Conclusion: Aminoglycoside antibiotics are a safe and effective treatment of acute appendicitis;our not published data are positive of AGs use in acute cholecystitis and left colon diverticulitis which requires surgery. If used for a limited time period, they do not increase the risk for kidney injury and remain a stable low level of all over complications.

关键词： IAI(Intraabdominal Infections) Aminoglycosides Acute Appendicitis Safety Use and Efficiency

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Effective Laparoscopic Catheter Insertion Technique for Peritoneal Dialysis Using Specially Designed Trocar:22 Years Multi-Center Retrospective Study of 804 Patients

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Surgical Science 2018年第4期9卷 135-147页

作者： Zoran Cala Ivo Soldo Zdravko Perko Nikola Knezevic Ivica Kocman Vinko Alfier Miodrag Gudelj Andelko Koprek Mario Kordic Edo Matosevic Irena Senecic-Cala Jasenka Kraljevic tadeja pintar Department of Surgery General Hospital OgulinOgulinCroatia Department of Surgery University Hospital Sveti DuhZagrebCroatia Department of Surgery University Hospital SplitSplitCroatia Department of Urology University Hospital Center ZagrebZagrebCroatia University Hospital Merkur ZagrebCroatia Department of Surgery General Hospital SibenikSibenikCroatia Department of Surgery University Hospital RijekaRijekaCroatia Department of Surgery General Hospital VarazdinVarazdinCroatia Department of Urology University Hospital MostarMostarBosnia and Herzegovina Department of Surgery General Hospital PulaPulaCroatia Department of Pediatrics University Hospital Center ZagrebZagrebCroatia University Medical Center Ljubljana LjubljanaSlovenia

Introduction: Literature reveals several peritoneal dialysis laparoscopic catheter insertion techniques developed to improve long-term results for treatment chronic kidney failure with the technic of peritoneal dialysis. The purpose of the study is evaluation of developed and recommended minimally invasive laparoscopic technic for chronic peritoneal dialysis catheter placement using specially constructed trocar. Materials and Methods: Retrospective study included 804 patients in 10 departments of surgery. Surgical and non surgical complications related to PD catheter placement were analysed: bleeding, dialysate leak, early SSI, peritonitis, catheter tip migration, catheter obstruction, omental wrapping and visceral perforations. Available software (Microsoft? Excel for Windows 10, MedCalc, Mariakerke, Belgium) was used for statistical analysis (presented as percentages, mean ± SD or median). Conclusions: The presented technique with specially constructed trocar is a simple and effective procedure with fewer complications comparing to literature. The advantages of this method include long rectus sheath tunnel with the deep cuff placed pre-peritoneally, the small size of the entrance into the peritoneum and accurate position and control of catheter tip in the pelvis.

关键词： Minimally Invasive Surgical Technic Laparoscopic Catheter Insertion Peritoneal Dialysis Peritoneal Catheter Trocar For Laparoscopic Catheter Insertion

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Teaching Systems Theory/Thinking/Behavior: Systemic Behavior Instead of One-Sidedness: Making Bridges Among Specialists

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Journal of Systems Science and Information 2019年第4期10卷 390-398页

作者： Matjaz MULEJ Zdenka zENKO tadeja Jere JAKULIN University of Maribor Slovenia Faculty of Economics and Business University of MariborMariborSlovenia Faculty of Tourism University of PrimorskaPiranSlovenia

In the current real life, systems theory is an abstract background of systems thinking,which is a part of systemic behavior. The systemic behavior is the alternative to the currently prevailing one-sidedness that puts all of humankind in danger of self-destruction due to the crucial over-sights(all the way to world wars) that unavoidably result from the current over-specialization(along with crucial, but partial insights), if the specialists fail to practice creative interdisciplinary *** contribution is a next phase of research after the contributions by Matja? Mulej, Zdenka ?enko and Viktor ?akelj(2017) and by Matja? Mulej, et al.(2013). Although the abstract background and thinking that the systemic behavior applies, are very necessary, theory and thinking are no longer enough for systems science to be a relevant science and practice helping humankind find the way out from the current blind alley and survive as a healthy civilization with a healthy social and natural environment. The suggestion in this contribution therefore reads: Let us systems and cybernetics scientists make/enable the transition to systemic behavior, which applies all the many theories, which are components in the background of systemic behavior in practice, next to each other and/or in synergy. Analysis, i.e., studying per isolated parts is too overlooking and one-sided to be enough. So is teaching on a single one out of several systems theories. Reality is too complex. Teaching is a part of this necessary effort, which must lead to a global peace and survival of humankind of today instead of the current hating the human descendants.

关键词： systems theory systemic thinking systemic behavior systems science humankind survival of human civilization social environment natural environment

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Electric Energy Saving

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Journal of Life Sciences 2014年第12期8卷 972-976页

作者： Gordana pintar Marijana Magdic Sesvetska Sela Elementary School Zagreb 10360 Croatia

Over all fuel condition and the money we spend on the said fuel leads us to think about savings. What can we do？ As individuals, we can educate our students and their family members. The easiest way to do that is to monitor their weekly spending for them. Together with their family members, the students have to monitor the consumption of electrical energy through three weeks. In the first week, they should spend electricity as they do everyday. During the second week they have the increase of spending of electrical energy. The third week is the saving energy week. They have to make a plan with their family members on how to save energy, for example, turning offthe lights in the empty rooms, turning offthe TV when there is no one watching it, etc.. Every week they have to note the data in kilowatts. When they acquire all the information and transform it into money they can see if it＇s worth saving electrical energy or not. They will see they don＇t have to give up the comforts of the modern life. The value of the project is in the fact that many households continue with the electrical energy saving. In fact, the number of the households is increasing.

关键词： Electrical energy saving education

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孤啡肽基因敲除小鼠电针镇痛作用增强(英文)

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北京大学学报（医学版） 2009年第3期41卷 376-379页

作者：万有韩济生 John E.pintar 北京大学神经科学研究所北京100191 Department of Neuroscience and Cell Biology Robert Wood JohnsonMedical SchoolUniversity of Medicine and Dentistry of New JerseyUSA

目的:采用痛敏肽/孤啡肽FQ(OFQ)基因敲除的小鼠,进一步明确OFQ在电针镇痛中的作用。方法:选用足三里和三阴交两个穴位,电针参数如下:恒流输出方波,电针强度为0.5、0.7、0.9 mA递增,每一强度持续10min,电针频率分别为2 Hz或100 Hz。采用... 详细信息

目的:采用痛敏肽/孤啡肽FQ(OFQ)基因敲除的小鼠,进一步明确OFQ在电针镇痛中的作用。方法:选用足三里和三阴交两个穴位,电针参数如下:恒流输出方波,电针强度为0.5、0.7、0.9 mA递增,每一强度持续10min,电针频率分别为2 Hz或100 Hz。采用热辐射甩尾方法测定痛阈,在电针前、电针中和电针后评价痛阈的变化。结果:OFQ基因敲除小鼠的基础热痛阈比野生型小鼠明显延长。无论是2 Hz还是100 Hz电针,对OFQ基因敲除小鼠和野生型小鼠都有镇痛作用,对OFQ基因敲除小鼠的镇痛作用更强。结论:在体情况下,OFQ致痛敏,但拮抗电针镇痛。

关键词：肽类电针针刺镇痛痛阈小鼠,基因敲除

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Using Host-Specificity of Cryptosporidium to Understand Contaminant Sources, Seasonality, and Human Health Risk in Three Watersheds of Differing Land-Use

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Journal of Environmental Protection 2016年第3期7卷 372-381页

作者： Janis L. Thomas Katarina D. M. pintar Peter M. Wallis Norman F. Neumann Environmental Monitoring and Reporting Branch Ontario Ministry of the Environment and Climate Change Toronto Canada Centre for Food-Borne Environmental and Zoonotic Infectious Diseases (CFEZID) Public Health Agency of Canada Ottawa Canada Hyperion Research Ltd. Medicine Hat Canada School of Public Health University of Alberta Edmonton Canada

Three tributaries of the Grand River watershed (Ontario, Canada), each representing different watershed types (urban, agricultural/rural, and mixed land-use) were examined to understand the spatial, temporal, and host-source distribution of the waterborne pathogen, Cryptosporidium. Cryptosporidium was frequently found throughout the study (73%, 65/89) with occurrence and concentrations observed to be similar among the varying watershed types. However, applying advanced genotyping techniques, marked differences in dominant host sources could be observed in each watershed. The agricultural/rural and mixed land-use watersheds were dominated by genotypes typically associated with cattle (i.e., C. andersoni), while the urban watershed had the highest diversity of Cryptosporidium genotypes with a variety of wildlife as the common source of contamination (e.g., muskrat and cervine genotypes). A similar seasonal trend observed in the urban, agricultural, and mixed land-use watershed suggests that factors beyond specific land use activities (e.g. autumn manure spreading) may influence the timing and concentration of Cryptosporidium in these streams. Corresponding genotyping results provided additional insight into source inputs during these seasonal peaks, indicating that wildlife may be important seasonal contributors to Cryptosporidium contamination in these streams. Despite the abundance of Cryptosporidium in these watersheds, most of the genotypes observed were of limited human health importance. This study provides evidence regarding the significance of including genotyping results into studies examining waterborne Cryptosporidium. Using this technique can provide a greater understanding of the risk to the population using water sources, as well as provide insight into the probable sources and timing of contamination. This ancillary information can contribute to implementation of targeted management strategies to further protect sources of drinking water and recreation

关键词： Cryptosporidium Genotyping Source Tracking Health Risk Water Contamination

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未退变颈椎在侧屈状态下与节段相关的在冠状面和轴向上的旋转运动轨迹

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脊柱外科杂志 2007年第3期5卷 189-190页

作者： Yoganandan N pintar FA Stemper BD 王乃国（译）

作者提到年龄、创伤或退变能改变椎体间的运动模式。虽然体内研究能确定运动的存在，但是却不易对运动进行量化。以前体内研究的对象大多数是老年患者，伴有不同节段的退变，在侧屈状态下旋转运动方式在不同的脊柱节段没有明显的变化。... 详细信息

作者提到年龄、创伤或退变能改变椎体间的运动模式。虽然体内研究能确定运动的存在，但是却不易对运动进行量化。以前体内研究的对象大多数是老年患者，伴有不同节段的退变，在侧屈状态下旋转运动方式在不同的脊柱节段没有明显的变化。因此，本次体内生物力学研究的目的是确定在侧屈状态下未退变的、正常的、完整的人类尸体颈胸段脊柱在冠状面和轴向上的旋转运动模式。

关键词：运动轨迹脊柱节段冠状面退变状态轴向颈椎体内研究

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What is the role of adolescent body mass index and physical activity on adult health risk behaviors?

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Open Journal of Preventive Medicine 2012年第1期2卷 72-78页

作者： Jennifer A. pintar Kristi L. Storti Vincent C. Arena Robert J. Robertson Elizabeth F. Nagle Andrea M. Kriska Department of Human Performance and Exercise Science Youngstown State University Youngstown USA

Introduction: A high prevalence of modifiable risk factors exists among adolescents that may lead to increased levels of morbidity and mortality in adulthood. This study sought to determine whether higher levels of physical activity (PA) and/or having a healthy body weight in adolescence influences future health risk behaviors (HRB) in young adulthood. Methods: Complete data were gathered for 536 participants from a prospective study and a follow-up survey conducted 10 years apart. At both time points, the questionnaires included information about HRB, PA, and health status. Results: Males who engaged in HRB during adolescence were more likely to continue these same risk behaviors during adulthood. Using multivariate models, only HRB in adolescence predicted HRB in adulthood for drinking, binge drinking and smoking among males, and for binge drinking and smoking among females. Conclusions: It appears that for males, once a health-risk behavior is initiated, it will likely continue into young adulthood, regardless of the presence of other healthy behaviors such as the proper maintenance of body weight and higher levels of PA. Similarly for females, binge drinking and smoking in adolescence is predictive of the same behavior in adulthood.

关键词： Smoking Drinking Binge Drinking

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玉米中水的性质的核磁共振研究

玉米中水的性质的核磁共振研究

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第四届全国波谱学学术会议

作者：靳健何毅 M·M·pintar 南开大学物理系加拿大滑铁卢大学物理系

＜正＞利用二维时间演化相关NMR谱方法,测量了玉米中水的性质,分别研究了玉米的外层（ENDOSPERM）和胚胎（GERM）.假定油和水之间交换作用很小,因此将胚胎中的玉米油用化学方法萃取掉,对一系列不同含水百分比的无油胚胎样品进行测量.玉...

＜正＞利用二维时间演化相关NMR谱方法,测量了玉米中水的性质,分别研究了玉米的外层（ENDOSPERM）和胚胎（GERM）.假定油和水之间交换作用很小,因此将胚胎中的玉米油用化学方法萃取掉,对一系列不同含水百分比的无油胚胎样品进行测量.玉米的外层含油可忽略,

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孤啡肽基因敲除小鼠电针镇痛作用增强

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中国疼痛医学杂志 2001年第3期7卷 161-164页

作者：万有 Bonnie Peng John E.pintar 韩济生北京大学神经科学研究所神经生物学系北京100083 Dept.of Neuro science and Cell Biology RWJ Medical School Univ.of Med.and Dentistry of New JerseyPiscataway

目的 :孤啡肽是阿片受体样受体 (ORL1)的内源性配基 ,它能调节疼痛与镇痛反应以及针刺镇痛反应 ,但各个实验室所得结果各不相同。本文利用OFQ基因敲除的小鼠为工具 ,观察内源性OFQ在针刺镇痛中的作用。方法 :采用本实验室建立的小鼠电... 详细信息

目的 :孤啡肽是阿片受体样受体 (ORL1)的内源性配基 ,它能调节疼痛与镇痛反应以及针刺镇痛反应 ,但各个实验室所得结果各不相同。本文利用OFQ基因敲除的小鼠为工具 ,观察内源性OFQ在针刺镇痛中的作用。方法 :采用本实验室建立的小鼠电针方法 ,选用穴位足三里 (SP 36)与三阴交 (SP 6) ,电针参数采用韩氏仪恒流方波输出 ,强度 1.0 1.2 1.4mA ,每 10min递增一级。痛阈的改变以热辐射甩尾来评价。结果 :与野生型小鼠相比 ,OFQ基因敲除小鼠基础痛阈明显延长 ,对 10 0Hz电针镇痛反应显著增强 ,但不影响 2Hz电针镇痛。结论 :在整体情况下 ,内源性OFQ有紧张性的致痛敏作用 ,并对 10 0Hz针刺镇痛有拮抗作用。

关键词：孤啡肽电针治疗镇痛基因敲除小鼠

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