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Indocyanine green fluorescence and three-dimensional imaging of right gastroepiploic artery in gastric tube cancer

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World Journal of Gastroenterology 2015年第1期21卷 369-372页

作者： Toru Nakano tadashi sakurai Shota Maruyama Yohei Ozawa Takashi Kamei Go Miyata Noriaki Ohuchi Division of Advanced Surgical Science and Technology Tohoku University Graduate School of MedicineSendaiMiyagi 980-8574Japan

A 79-year-old male was admitted to our hospital for the treatment of cancer of the gastric *** examination revealed a T1 b Union for International Cancer Control(UICC) tumor at the pyloric region of the gastric *** did not reveal infiltration intothe serosa,peritoneal dissemination,regional lymph node swelling,or distant *** performed a distal gastrectomy preserving the right gastroepiploic artery by referencing the preoperative three-dimensional computed *** also evaluated the blood flow of the right gastroepiploic artery and in the proximal gastric tube by using indocyanine green fluorescence imaging intra-operatively and then followed with a gastrojejunal anastomosis with Roux-en-Y *** definitive diagnosis was moderately differentiated adenocarcinoma of the gastric tube,pT 1bN 0M0,pS tage IA(UICC).His postoperative course was ***-dimensional computed tomographic imaging is effective for assessing the course of blood vessels and the relationship with the surrounding *** evaluation of blood flow of the right gastroepiploic artery and of the gastric tube in the anastomotic portion is very valuable information and could contribute to a safe gastrointestinal reconstruction.

关键词： Gastrectomy Indocyanine green Computed tomography

Use of water jet instruments in gastrointestinal endoscopy

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World Journal of Gastrointestinal Endoscopy 2016年第3期8卷 122-127页

作者： Toru Nakano Chiaki Sato tadashi sakurai Takashi Kamei Atsuhiro Nakagawa Noriaki Ohuchi Division of Advanced Surgical Science and Technology Tohoku University Graduate School of MedicineSendai 980-8574Japan Department of Neurosurgery Tohoku University Graduate School of MedicineSendai 980-8574Japan

In recent years, water jet instruments have been used in the field of gastrointestinal endoscopy, mainly in two clinical situations: Investigation and treatment under endoscopic view. Injecting water jet into the gastrointestinal lumen is helpful for maintaining a clear endoscopic view, washing away blood or mucous in the lumen or on the surface of the tip of the endoscope. This contributes to reducing time and discomfort of examination. Water jet technology is an alternative method for dissecting soft tissue; this method does not harm the small vessels or cause mechanical or thermal damage. However, its use in clinical settings has been limited to the transmucosal injection of water into the submucosal layer that elevates the mucosa to prepare for endoscopic mucosal resection or endoscopic submucosal dissection, instead of tissue dissection, which may occur because of the continuous water jet. A preclinical study has been conducted using a pulsed water jet system as an alternative method for submucosal dissection by reducing intraoperative water consumption and maintenance of dissection capability. This review introduces recent studies pertaining to using a water jet in gastrointestinal endoscopy and discusses future prospects.

关键词： Endoscopy Water jet Endoscopic submucosaldissection Endoscopic mucosal resection Pulse

Case series of three patients with hereditary diffuse gastric cancer in a single family:Three case reports and review of literature

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World Journal of Gastroenterology 2020年第42期26卷 6689-6697页

作者： Masahiro Hirakawa Kohichi Takada Masanori Sato Chisa Fujita Naotaka Hayasaka Takayuki Nobuoka Shintaro Sugita Aki Ishikawa Miyako Mizukami Hiroyuki Ohnuma Kazuyuki Murase Koji Miyanishi Masayoshi Kobune Ichiro Takemasa tadashi Hasegawa Akihiro sakurai Junji Kato Department of Medical Oncology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Gastroenterology National Hospital Organization Hokkaido Cancer CenterSapporo 003-0804HokkaidoJapan Department of Surgery Surgical Oncology and ScienceSapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Surgical Pathology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Medical Genetics Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Hematology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan

BACKGROUND Hereditary diffuse gastric cancer(HDGC)is a familial cancer syndrome often associated with germline mutations in the CDH1 ***,the frequency of CDH1 mutations is low in patients with HDGC in East Asian ***,we report three cases of HDGC harboring a missense CDH1 variant,c.1679C>G,from a single Japanese *** SUMMARY A 26-year-old female(Case 1)and a 51-year-old male(father of Case 1),who had a strong family history of gastric cancer,were diagnosed with advanced diffuse gastric *** genetic counselling,a 25-year-old younger brother of Case 1 underwent surveillance esophagogastroduodenoscopy that detected small signet ring cell carcinoma foci as multiple pale lesions in the gastric *** analysis revealed a CDH1 c.1679C>G variant in all three *** It is important for individuals suspected of having HDGC to be actively offered genetics *** report will contribute to an increased awareness of HDGC.

关键词： Hereditary diffuse gastric cancer Signet ring cell carcinoma CDH1 Ecadherin Endoscopic findings Case report

Generation of pig primary fibroblast cells harboring defective MC4R genes by N-ethyl-N-nitrosourea mutagenesis: A gene-driven, nontransgenic approach to pig improvement

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American Journal of Molecular Biology 2013年第3期3卷 139-147页

作者： Michiharu sakurai Shun-ichi Suzuki tadashi Furusawa Satoshi Mikawa Tomoyuki Tokunaga Akira Onishi Takashi Awata National Institute of Agrobiological Sciences Tsukuba Japan

Transgenic pigs have been produced with the aim of further improving pigs in terms of economic and environmental traits, but these animals have not been allowed to enter the food chain. As an alternative approach to generating pigs with novel traits of economic importance that cannot be introduced by conventional breeding, we propose a strategy for combining in vitro mutagenesis of pig primary cells with N-ethyl-N-nitrosourea (ENU) and somatic-cell nuclear transfer (SCNT) technology. To explore the feasibility of this strategy, we treated pig primary fibroblast cells with ENU, estimated the per-base mutation frequency induced by the mutagen, clonally cultured about 4000 of the mutagenized cells, and screened them for mutation within the coding region of the melanocortin-4 receptor (MC4R) gene, a key gene in energy homeostasis. Through this screening, we obtained 14 cell clones, each harboring a heterozygous base change within the coding region for MC4R. Of the mutant cell clones, each of two contained a mutant allele encoding MC4R with greatly reduced receptor activity. By SCNT using these cell clones as donors, pigs harboring mutated MC4R alleles with reduced receptor activity can be produced. Our strategy for generating pigs with novel genetic traits likely will be more acceptable to the public than is the use of transgenic technology.

关键词： Pig Fibroblasts N-Ethyl-N-Nitorosourea Mutagenesis

Laparoscopic splenectomy for histiocytic sarcoma of the spleen

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World Journal of Gastrointestinal Surgery 2013年第4期5卷 129-134页

作者： Satoshi Yamamoto tadashi Tsukamoto Akishige Kanazawa Sadatoshi Shimizu Keiichiro Morimura Takahiro Toyokawa Zhang Xiang Katsunobu sakurai Tatsunari Fukuoka Kayo Yoshida Mamiko Takii Ken Inoue Department of Hepato-Biliary-Pancreatic Surgery Osaka City General Hospital Division of Surgery Department of Hepatobiliary Pancreatic Surgery and Artificial Organ and Transplantation Graduate School of Medicine the University of Tokyo Department of Pathology Osaka City General Medical Hospital

Primary histiocytic sarcoma of the spleen is a rare but potentially lethal condition. It can remain asymptomatic or only mildly symptomatic for a long time. An 81-year-old woman presented with an extremely enlarged spleen. She suffered from progressive anemia and required a red blood cell transfusion once a month. Although computed tomography, ultrasonography, and magnetic resonance imaging were performed for diagnosis, a confirmed diagnosis was not obtained. Her enlarged spleen compressed her stomach, and she suffered from gastritis and a sense of gastric fullness just after meals. She underwent laparoscopic splenectomy for therapeutic and diagnostic purposes. Her postoperative course was uneventful. After surgery, her red blood cell and platelet counts increased markedly. The tumor was diagnosed as splenic histiocytic sarcoma. Post-surgical chemotherapy was not performed, and the patient died of liver failure due to liver metastasis 5 mo after surgery. Laparoscopic splenectomy is minimally invasive and useful for the relief of symptoms related to hematological disorders. However, in cases of an enlarged spleen, optimal views and working space are limited. In such cases, splenic artery ligation can markedly reduce the size of the spleen, thus facilitating the procedure. The case reported herein suggests that laparoscopic splenectomy may be useful for the treatment of splenic malignancy.

关键词： Histiocytic sarcoma Laparoscopic splenectomy Malignancy Splenomegaly Chemotherapy