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BEACH-Domain Proteins Act Together in a Cascade to Mediate Vacuolar Protein Trafficking and Disease Resistance in Arabidopsis

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Molecular Plant 2015年第3期8卷 389-398页

作者： Ooi-kock Teh Noriyuki Hatsugai Kentaro Tamura Kentaro Fuji Ryo tabata Katsushi Yamaguch Shuji Shingenobu Masashi Yamada Mitsuyasu Hasebe Shinichiro Sawa Tomoo Shimada Ikuko Hara-Nishimura Graduate School of Science Kyoto University Sakyo-ku Kyoto 606-8502 Japan Research Centre for Cooperative Projects Hokkaido University Kita-ku Sapporo 060-8638 Japan Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan Functional Genomics Facility National Institute for Basic Biology Okazaki 444-8585 Japan Department of Biology and IGSP Center for Systems Biology Duke University Durham NC 27708 USA Division of Evolutionary Biology National Institute for Basic Biology Okazaki 444-8585 Japan School of Life Science The Graduate University for Advanced Studies Okazaki 444-8585 Japan Present address: Department of Plant Biology and Forest Genetics Uppsala BioCenter Swedish University of Agricultural Sciences (SLU) and Linnean Centre ofPlant Biology Uppsala SE-75007 Sweden present address: Microbial and Plant Genomics Institute University of Minnesota St Paul MN 55108 USA Present address: RIKEN Innovation Center RIKEN 2-1 Hirosawa Wako Saitama 351-0198 Japan

Membrane trafficking to the protein storage vacuole （PSV） is a specialized process in seed plants. However, this trafficking mechanism to PSV is poorly understood. Here, we show that three types of Beige and Chediak-Higashi （BEACH）-domain proteins contribute to both vacuolar protein transport and effector- triggered immunity （ETI）. We screened a green fluorescent seed （GFS） library of Arabidopsis mutants with defects in vesicle trafficking and isolated two allelic mutants gfs3 and gfs12 with a defect in seed pro- tein transport to PSV. The gene responsible for the mutant phenotype was found to encode a putative pro- tein belonging to group D of BEACH-domain proteins, which possess kinase domains. Disruption of other BEACH-encoding loci in the gfs12 mutant showed that BEACH homologs acted in a cascading manner for PSV trafficking. The epistatic genetic interactions observed among BEACH homologs were also found in the ETI responses of the gfs12 and gfs12 bchb-1 mutants, which showed elevated avirulent bacterial growth. The GFS12 kinase domain interacted specifically with the pleckstrin homology domain of BchCl. These results suggest that a cascade of multiple BEACH-domain proteins contributes to vacuolar protein transport and plant defense.

关键词： BEACH-domain protein Arabidopsis thaliana vacuolar protein transport protein storage vacuoles,plant immunity

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Techniques for Avoiding Saccular Extended Obstruction at the Anastomotic Site of Functional End-to-End Anastomosis

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Surgical Science 2017年第7期8卷 305-311页

作者： Koichi Yoshida Kenichi Ietsugu Jyunpei Okamoto Saki Hayashi Yoshihide Asaumi Naohiro Ota Hiroyuki Sugawara Satoshi tabata Masahiro Kaneki Mitsuaki Sakatoku Kaoru Kiyohara Department of Surgery Tonami General Hospital Toyama Japan

Saccular extended obstruction is generated when the anastomotic site of functional end-to-end anastomosis is extended saccularly and blocked by intestinal contents. This is a specific complication of functional end-to-end anastomosis. Saccular extended obstruction of the anastomotic site of func-tional end-to-end anastomosis causes postoperative intestinal obstruction. Saccular extended obstruction places a heavy burden on patients because surgery is necessary for treatment of intestinal obstruction due to saccular extended obstruction. However, saccular extended obstruction is not a commonly recognized complication. The greatest factor contributing to the development of saccular extended obstruction is an acute angle between the portions of the intestinal tract oral and aboral to the anastomotic site. When this angle approaches obtuse angle, preferably close to a straight line, stagnation of the intestinal contents does not occur at the anastomotic site of functional end-to-end anastomosis and saccular extended obstruction is avoided. For making the angle of anastomotic intestinal tracts obtuse or straight, it may be effective that the entry hole of stapling suture instrument creating the anastomotic stoma is closed perpendicular to the intestinal axis.

关键词： Functional End-to-End Anastomosis Stapling Anastomosis Anastomosis Postoperative Complication Intestinal Obstruction

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重症监护患者副交感神经系统活性评价的初步研究

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中华临床医师杂志（电子版） 2012年第3期6卷 137-138页

作者：董伟达殷敏程雷 Ryoko tabata Soichiro Miyazaki 南京医科大学第一附属医院江苏省人民医院耳鼻咽喉科 210029 日本滋贺医科大学睡眠医学教研室

目的初步探讨检测分析副交感神经系统(PNS)活性在评价重症监护患者整体功能状况中的应用。方法将23例重症监护患者(男15例、女8例,年龄21～83岁)分为手术组(12例)和非手术组(11例)。使用Holter心电图仪进行连续心电监测,将所获R-R间隔... 详细信息

目的初步探讨检测分析副交感神经系统(PNS)活性在评价重症监护患者整体功能状况中的应用。方法将23例重症监护患者(男15例、女8例,年龄21～83岁)分为手术组(12例)和非手术组(11例)。使用Holter心电图仪进行连续心电监测,将所获R-R间隔的时间序列资料以10min为一个单位进行分隔,采用粗视化频谱分析连续对所有分隔序列进行PNS活性分析。结果手术组患者PNS活性较强而非手术组患者PNS活性较弱。非手术组患者PNS活性在病情好转后回升。手术组患者在手术当日PNS活性较强,但术后1～2dPNS活性降至较低水平。所有患者随着病情稳定和恢复,PNS活性逐渐回升。结论 PNS活性分析可用于评价重症患者整体功能状态及其预后。

关键词：重症监护副交感神经系统心电描记术粗视化频谱分析

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Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy

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World Journal of Radiology 2015年第12期7卷 494-500页

作者： Hideyasu Tsumura Takefumi Satoh Hiromichi Ishiyama Shuhei Hirano Kenichi tabata Shinji Kurosaka Kazumasa Matsumoto Tetsuo Fujita Masashi Kitano Shiro Baba Kazushige Hayakawa Masatsugu Iwamura Department of Urology Kitasato University School of Medicine Department of Radiation Oncology Kitasato University School of Medicine

AIM: To investigate the time course of testosterone(T) recovery after cessation of androgen deprivation therapy(ADT) in patients treated with brachytherapy. METHODS: One-hundred and seventy-four patients treated between June 1999 and February 2009 were studied. Patients were divided into a short-term usage group(≤ 12 mo, n = 91) and a long-term usage group(≥ 36 mo, n = 83) according to the duration of gonadotropin-releasing hormone agonist therapy. Median follow-up was 29 mo in the short-term group and was 60 mo in the long-term ***: Cumulative incidence rates of T recovery to normal and supracastrate levels at 24 mo after cessationwere 28.8% and 74.6%, respectively, in the long-term usage group, whereas these values were 96.4% and 98.8% in the short-term usage group. T recovery to normal and supracastrate levels occurred significantly more rapidly in the short-term than in the long-term usage group(P < 0.001 and P < 0.001, respectively). Five years after cessation, 22.6% of patients maintained a castrate T level in the long-term usage group. On multivariate analysis, lower T levels(< 10 ng/d L) at cessation of ADT was significantly associated with prolonged T recovery to supracastrate levels in the longterm usage group(P = 0.002). CONCLUSION: Lower T levels at cessation of ADT were associated with prolonged T recovery in the longterm usage group. Five years after cessation of longterm ADT, approximately one-fifth of patients still had castrate T levels. When determining the therapeutic effect, especially biochemical control, we should consider this delay in T recovery.

关键词： Androgen deprivation Gonadotropinreleasing hormone agonist Prostate brachytherapy Prostate cancer Testosterone

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Clear cell carcinoma of salivary gland type presenting as an endotracheal polypoid tumor

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Case Reports in Clinical Medicine 2013年第2期2卷 159-162页

作者： Kazuhiro tabata Michiyo Higashi Shinichi Kitajima Ikumi Kitazono Tsubasa Hiraki Tsunayuki Otsuka Masaya Aoki Kazuhiro Wakita Hirofumi Nakayama Suguru Yonezawa Junya Fukuoka Department of General Thoracic Surgery Kagoshima University Graduate School of Medical and Dental Science Kagoshima Japan Department of Human Pathology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Department of Pathology Kagoshima University Hospital Kagoshima Japan Department of Pathology Nagasaki University Graduate School of Biomedical Science Nagasaki Japan Department of Radiology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Laboratory of Pathology Nagasaki University Hospital Nagasaki Japan

A 66-year-old woman presented with a 2-year history of asthma has progression of dyspnea within a week, and a computed tomography (CT) revealed an endotracheal tumor at level of aortic arch. The resected tumor, measured by 18 × 12 × 10 mm, has histologically malignant features including frank invasion with desmoplastic stroma and foci of necrosis. Presence of glycogen and mucin was confirmed by periodic acid-Schiff (PAS) and diastase PAS staining. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin (CK) 7 and AE1/3, focally positive for CK5/6 and CK14, but negative for CK20. Thyroid transcription factor-1 (TTF-1), Napsin A, and SP-A, indicating lung parenchymal origin were all negative. Other muscular markers, neuroendocrine markers, renal cell carcinoma markers, and markers related to perivascular epithelioid cell tumors were all negative. Postoperative systemic examination suggests no primary tumor outside the lung. The follow up was excellent being recurrence free for 14 months in spite of the positive surgical margin by the tumor cells. This is a first report ?of rare neoplasm, clear cell carcinoma of salivary gland type, presenting as an endotracheal mass.

关键词： Clear Cell Carcinoma Salivary Gland Lung Primary Histological Feature

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A standardized technique for safe pancreaticojejunostomy:Pair-Watch suturing technique

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World Journal of Gastrointestinal Surgery 2010年第8期2卷 260-264页

作者： Yoshinori Azumi Shuji Isaji Hiroyuki Kato Yuu Nobuoka Naohisa Kuriyama Masashi Kishiwada Takashi Hamada Shugo Mizuno Masanobu Usui Hiroyuki Sakurai Masami tabata Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine

AIM:To prevent pancreatic leakage after pancreaticoje-junostomy,we designed a new standardized technique that we term the "Pair-Watch suturing technique".METHODS:Before anastomosis,we imagine the faces of a pair of watches on the jejunal hole and pancreatic *** first stitch was put between 9 o'clock of the pancreatic side and 3 o'clock of the jejunal side,and a total of 7 stitches were put on the posterior wall,followed by the 5 stitches on the anterior *** this technique,twelve stitches can be sutured on the first layer anastomosis regardless of the caliber of the pancreatic *** all cases the amylase activity of the drain were measured.A postoperative pancreatic fistula was diagnosed using postoperative pancreatic fistula ***:From March 2007 to July 2008,29 consecutive cases underwent pancreaticojejunostomy using this *** examination results showed pancreatic carcinoma(n=14),intraductal papillary-mucinous neoplasm(n=10),intraductal papillary-mucinous carcinoma(n=1),carcinoma of ampulla of Vater(n=1),carcinoma of extrahepatic bile duct(n=1),metastasis of renal cell carcinoma(n=1),and duodenal carcinoma(n=1).Pancreaticojejunal anastomoses using this technique were all watertight during the surgical *** mean diameter of main pancreatic duct was 3.4 mm(range 2-7 mm).Three patients were recognized as having an amylase level greater than 3 times the serum amylase level,but all of them were diagnosed as grade A postoperative pancreatic fistula grading and required no *** of the cases developed complications such as hemorrhage,abdominal abscess,and pulmonary *** was no postoperative ***:Our technique is less complicated than other methods and very secure,providing reliable anastomosis for any size of pancreatic duct.

关键词： Pancreaticoduodenectomy Pancreaticoje-junostomy Suturing technique

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睡眠过程中交感和副交感拮抗活动的初步分析

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中国中西医结合耳鼻咽喉科杂志 2015年第5期23卷 368-371页

作者：叶红飞李静殷敏程雷 tabata Ryoko Soichiro Miyazaki 南京高淳区人民医院耳鼻咽喉科 210000 日本国立滋贺医科大学睡眠医学教研室

目的探讨睡眠过程中交感和副交感神经功能的拮抗关系。方法对10名健康年轻大学生(男性7名,女性3名,年龄19-23岁)使用Holter,L,电图仪进行连续心电监测,将所获R-R间隔的时间序列资料以10分钟为一个单位进行分隔,利用粗视化频谱分析技术(C... 详细信息

目的探讨睡眠过程中交感和副交感神经功能的拮抗关系。方法对10名健康年轻大学生(男性7名,女性3名,年龄19-23岁)使用Holter,L,电图仪进行连续心电监测,将所获R-R间隔的时间序列资料以10分钟为一个单位进行分隔,利用粗视化频谱分析技术(Coarse Graining Spectral Analysis,CGSA)分析SNS和PNS拮抗活动的趋势。结果进入睡眠期后SNS活动明显下降,而PNS活动明显增强,觉醒后交替。且每个单位的PNS和SNS值呈反比例函数关系。结论睡眠过程中交感和副交感神经功能存在相互拮抗的关系,此消彼长。

关键词：阻塞性睡眠呼吸暂停综合征交感/副交感神经粗视化频谱分析拮抗

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KEEL LOSS1(KEL1)/RED BULL(REB), Encodeing an AP2-like Transcription Factor, Participates in Zygomorphic Flower Development in Legumes

KEEL LOSS1(KEL1)/RED BULL(REB), Encodeing an AP2-like Transc...

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2010全国植物生物学研讨会

作者： Jun Yang Lin Weng Chengwu Liu Shusei Sato Satoshi tabata Mike Ambrose Jim Weller Xiaohe Hu Zhongchi Liu Da Luo National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and EcologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences Kazusa DNA Research Institute 2-6-7 Kazusakamatari Department of Cell Biology and Molecular Genetics University of Maryland College Park School of Plant Sciences University of Tasmania Department of Crop genetics John Innes Centre

Paplionoideae plants have the typical bilateral symmetry flowers and manifest two types of asymmetries:dorsoventral(DV)asymmetry in floral plane and organ internal(IN)asymmetries in floral organ *** previous research ...

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用于通用变频器的DIP-CIB

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电力电子技术 2007年第2期41卷 75-77,80页

作者：長原輝明田畑光晴三菱电机功率器件福岡制作所

针对小功率通用变频器对低成本和小型化的需求,三菱电机开发了集整流、逆变和制动功能于一体的双列直插式封装-整流逆变制动(Dual In Line Package-Converter Inverter Brake,简称DIP-CIB)模块。在此详细介绍了DIP-CIB模块的内部电路、... 详细信息

针对小功率通用变频器对低成本和小型化的需求,三菱电机开发了集整流、逆变和制动功能于一体的双列直插式封装-整流逆变制动(Dual In Line Package-Converter Inverter Brake,简称DIP-CIB)模块。在此详细介绍了DIP-CIB模块的内部电路、半导体硅片技术、封装技术,以及如何配合专用的HVIC来实现通用变频器的小型化设计。

关键词：变频器模块/双列直插式封装-整流逆变制动模块

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Trans-acting siRNA Controls the Lateral Organs Development in Lotus japonicas

Trans-acting siRNA Controls the Lateral Organs Development i...

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2010全国植物生物学研讨会

作者： Xuefei Cai Jun Yan Jun Yang Shusei Sato Qunyi Jiang Xiangling Cao Xiaohe Hu Satoshi tabata Peter M.Gresshoff Da Luo National Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Australian Research Council Centre of Excellence for Integrative Legume Research University of Queensland Kazusa DNA Research Institute Kisarazu

Endogenous trans-acting small interfering RNA(ta-si RNA)pathway has been shown to play critical roles in lateral organ development,while little is known about its functions in legume ***,we identified and characterize...

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