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Cost analysis of childhood glaucoma surgeries using the US medicaire allowable costs

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International Journal of Ophthalmology(English edition) 2023年第5期16卷 700-704页

作者： Abdelrahman m.Elhusseiny mohamed m.Khodeiry Nicolas A.Yannuzzi ta C.Chang Richard K.Lee William E.Smiddy Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFlorida 33136USA Department of Ophthalmology Harvey and Bernice Jones Eye InstituteUniversity of Arkansas for Medical SciencesLittle RockArkansas 72205USA

AIm: To analyze and calculate the relative cost of various childhood glaucoma surgical interventions per mm Hg intraocular pressure(IOP) reduction($/mm Hg).mETHODS: Representative index studies were reviewed to quantitate the reduction of mean IOP and glaucoma medications for each surgical intervention in childhood glaucoma. A US perspective was adopted, using medicare allowable costs to calculate cost/mm Hg IOP reduction($/mm Hg) at 1y ***: At 1y postoperatively, the cost/mm Hg IOP reduction was $226/mm Hg for microcatheter-assisted circumferential trabeculotomy, $284/mm Hg for cyclophotocoagulation, $288/mm Hg for conventional ab-externo trabeculotomy, $338/mm Hg for Ahmed glaucoma valve, $350/mm Hg for Baerveldt glaucoma implant, $351/mm Hg for goniotomy, and $400/mm Hg for ***: microcatheter-assisted circumferential trabeculotomy is the most cost-efficient surgical method to lower IOP in childhood glaucoma, while trabeculectomy is the least cost-efficient surgical method.

关键词： glaucoma cost analysis trabeculotomy trabeculectomy intraocular pressure childhood glaucoma

High-performance transparent conducting films of long single-walled carbon nanotubes synthesized from toluene alone

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Nano Research 2020年第1期13卷 112-120页

作者： er-Xiong Ding Aqeel Hussain Saeed Ahmad Qiang Zhang Yongping Liao Hua Jiang Esko I.Kauppinen Department of Applied Physics School of ScienceAalto UniversityPuumiehenkuja 200076AaltoEspooFinland

Single-walled carbon nanotube(SWCNT)transparent conducting films(TCFs)are attracting increasing attention due to their exceptional optoelectronic *** is a proposed carbon source for SWCNT synthesis,but the growth parameters of SWCNTs and their TCF optoelectronic performance(i.e.,sheet resistance versus transmittance)have been insufficiently ***,we have for the first time reported a systematic study of the fabrication of high-performance SWCNT TCFs using toluene alone as the carbon *** mechanisms behind each observed phenomenon were elucidated using optical and microscopy *** optimizing the growth parameters,high yields of SWCNT TCFs exhibiting a considerably low sheet resistance of 57Ω/sq at 90%transmittance were *** competitive optoelectronic performance is mainly attributable to long SWCNT bundles(mean length is 41.4μm)in the ***,a chirality map determined by electron diffraction displays a bimodal distribution of chiral angles divided at 15°,which is close to both armchair and zigzag *** study paved the way towards scaled-up production of SWCNTs for the fabrication of high-performance TCFs for industrial applications.

关键词： single-walled carbon nanotubes transparent conducting films toluene floating catalyst chemical vapor deposition

Candidate Eclipsing Binary Systems with aδScuti Star in Northern TESS Field

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Research in Astronomy and Astrophysics 2022年第8期22卷 34-48页

作者： F.Kahraman Aliçavuş D.Gümüş Ö.Kırmızıtaş Ö.Ekinci S.Çavuş Y.T.Kaya F.Aliçavuş Çanakkale Onsekiz mart University Faculty of Sciences and ArtsPhysics Department17100ÇanakkaleTurkey Çanakkale Onsekiz mart University Astrophysics Research Center and Ulupnar ObservatoryTR-17100ÇanakkaleTurkey Istanbul University Institute of Graduate Studies in ScienceProgramme of Astronomy and Space Sciences34116BeyazıtIstanbulTurkey Çanakkale Onsekiz mart University School of Graduate StudiesDepartment of PhysicsTR-17100ÇanakkaleTurkey Çanakkale Onsekiz mart University School of Graduate StudiesDepartment of Space Sciences and TechnologiesTR-17100ÇanakkaleTurkey Çanakkale Onsekiz mart University Faculty of Engineering Computer EngineeringTR-17100ÇanakkaleTurkey

The existence of pulsating stars in eclipsing binaries has been known for *** types of objects are extremely valuable systems for astronomical studies as they exhibit both eclipse and pulsation *** eclipsing binaries are the only way to directly measure the mass and radius of stars with a good accuracy(≤1%),while the pulsations are a unique way to probe the stellar interior via oscillation *** are different types of pulsating stars existing in eclipsing *** of them is theδScuti ***,the known number ofδScuti stars in eclipsing binaries is around 90 according to the latest catalog of these *** increasing number of these kinds of variables is important to understand the stellar structure,evolution and the effect of binarity on the ***,in this study,we focus on discovering new eclipsing binaries withδScuti component(s).We searched within the northern Transiting Exoplanet Survey Satellite(TESS)field with a visual inspection by following some criteria such as light curve shape,the existence of pulsation like variations in the out-of-eclipse light curve and the T_(eff) values of the *** a result of these criteria,we discovered some *** orbital variations were first removed from the TESS light curves and frequency analysis was performed on the *** luminosity,and absolute and bolometric magnitudes of the targets were calculated as *** find how much of these parameters represent the primary(more luminous)binary component,we also computed the flux density ratio of the systems by utilizing the area of the *** addition,the positions of the systems in the H-R diagram were examined considering the flux density *** a consequence of the investigation,we defined 38 candidateδScuti stars and also one maia variable in eclipsing binary systems.

关键词： (stars:)binaries:eclipsing stars:variables:delta Scuti techniques:photometric

Estimates of Autumntime Benthic Secondary Production in Laizhou Bay and Adjacent Bohai Sea Waters

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Journal of Ocean University of China 2010年第3期9卷 279-285页

作者： HUA er ZHOU Hong ZHANG Zhinan YU Zishan ~ College of marine Life Science Ocean University of China Qingdao 266003 P. R. China

The whole metazoan community inhabiting Laizhou Bay and adjacent Bohai Sea waters were sampled in late autumn, 2006. Secondary production estimates for macrofauna and meiofauna were made separately. Total benthic secondary production was as high as 8.38 ±4.08 g ash-free dry weight （AFDW） m^-2 a^-1, which represented the autumn production level. In general, macrofaunal secondary production in Laizhou Bay was much lower than that in adjacent Bohai Sea areas. In contrast, meiofaunal secondary production in Laizhou Bay was higher than that in adjacent Bohai Sea areas. macrofatma contributed 61% to benthic secondary production （5.09 ±3.26 g AFDW m^-2 a^-1）, lower than the value in previous studies in Bohai Sea. Sediment granulometric characteristics and bottom-water salinity could explain the substantial variability in the macrofauna biomass and production. meiofaunal production was an important component of benthic production and exceeded macrofauna production under exceptional conditions, e.g. in Laizhou Bay, where macrofauna was restricted. Chlorophyll pigments （Chl-a） concentrations in sediment explained the general meiofaunal biomass and production distribution here.

关键词： benthic secondary production meiofauna macrofauna Laizhou Bay the Bohai Sea

Highly dispersed Nimo@rGO nanocomposite catalysts fabricated by a two-step hydrothermal method for hydrogen evolution

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International Journal of minerals,metallurgy and materials 2023年第12期30卷 2432-2440页

作者： Duanhao Cao Xiaofeng ma Yipeng Zhang La ta Yakun Yang Chao Xu Feng Ye Jianguo Liu School of Energy Power and mechanical Engineering North China Electric Power UniversityBeijing 102206China

Exploring and designing a high-performance non-noble metal catalyst for hydrogen evolution reaction(Her)are crucial for the large-scale application of H2 by water ***,novel catalysts with Nimo nanoparticles decorated on reduced graphene oxide(Nimo@r GO)synthesized by a two-step hydrothermal method were *** characterization results showed that the prepared Nimo@r GO-1 had an irregular lamellar structure,and the Nimo nanoparticles were uniformly dispersed on the ***@rGO-1 exhibited outstanding Her performance in an alkaline environment and required only 93 and 180 mV overpotential for Her in 1.0 m KOH solution to obtain current densities of-10 and-50 mA·cm^(-2),*** tests showed that Nimo@rGO-1 had a certain operating stability for32 *** the same condition,the performance of Nimo@rGO-1 can be comparable with that of commercial Pt/C catalysts at high current *** synergistic effect between Nimo particles and lamellate graphene can remarkably promote charge transfer in electrocatalytic *** a result,Nimo@rGO-1 presented the advantages of high intrinsic activity,large specific surface area,and small electrical *** lamellar graphene played a role in dispersion to prevent the aggregation of *** prepared Nimo@rGO-1 can be used in anion exchange membrane water electrolysis to produce *** study provides a simple preparation method for efficient and low-cost water electrolysis to produce hydrogen in the future.

关键词： hydrogen evolution reaction Nimo nanocomposite reduced graphene oxide synergistic effect

Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第9期7卷 749-756页

作者： SONG Ying LI meng LI Ji-cheng WEI er-qing Department of Cellular Biology School of Medicine Zhejiang University Hangzhou 310031 China Department of Pharmacology School of Medicine Zhejiang University Hangzhou 310031 China

Background： Edaravone had been validated to effectively protect against ischemic injuries. In this study, we investigated the protective effect of edaravone by observing the effects on anti-apoptosis, regulation of Bcl-2/Bax protein expression and recovering from damage to mitochondria after OGD （oxygen-glucose deprivation）-reperfusion. methods： Viability of PC 12 cells which were injured at different time of OGD injury, was quantified by measuring mTT （2-（4,5-dimethylthia-zol-2-yl）-2,5-diphenyltetrazolium bromide） staining. In addition, PC 12 cells＇ viability was also quantified after their preincubation in different concentration of edaravone for 30 min followed by （OGD）. Furthermore, apoptotic population of PC 12 cells that reinsulted from OGD-reperfusion with or without preincubation with edaravone was determined by flow cytometer analysis, electron microscope and Hoechst/Pl staining. Finally, change of Bcl-2/Bax protein expression was detected by Western blot. Results：（1） The viability of PC12 cells decreased with time （1-12 h） after OGD. We regarded the model of OGD 2 h, then replacing DmEm （Dulbecco＇s modified Eagle＇s medium） for another 24 h as an OGD-reperfusion in this research. Furthermore, most PC 12 cells were in the state of apoptosis after OGD-reperfusion. （2） The viability of PC 12 cells preincubated with edaravone at high concentrations （1, 0.1, 0.01 μmol/L） increased significantly with edaravone protecting PC 12 cells from apoptosis after OGD-reperfusion injury. （3） Furthermore, edaravone attenuates the damage of OGD-reperfusion on mitochondria and regulated Bcl-2/Bax protein imbalance expression after OGD-reperfusion. Conclusion： Neuroprotective effects of edaravone on ischemic or other brain injuries may be partly mediated through inhibition of Bcl-2/Bax apoptotic pathways by recovering from the damage of mitochondria.

关键词： Edaravone lschemia Apoptosis Rat pheochromocytoma (PC 12) cells mitochondria Bax Bcl-2 Oxygen-glucose deprivation (OGD)

Analysis of crowdfunding platforms for microgrid project investors via a q-rung orthopair fuzzy hybrid decision-making approach

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Financial Innovation 2022年第1期8卷 1338-1359页

作者： Xiaohang Wu Hasan Dinçer Serhat Yüksel School of Economics and management Chongqing Normal UniversityChongqing 401331China The School of Business İstanbul Medipol University34817 BeykozİstanbulTurkey

Effective crowdfunding platforms positively contribute toward improving micro-grid energy management ***,a comprehensive analysis is required to understand the key factors responsible for success in crowdfunding systems by considering various *** study evaluates crowdfunding platforms for microgrid project *** this context,a novel fuzzy decision-making model that includes two different stages is ***,the selected criteria for the crowdfunding platforms for microgrid project investments are ***,alternatives,regarding the microgrid project investments,are *** this process,a multi-stepwise weight assessment ratio analysis(m-SWARA)approach based on q-rung orthopair fuzzy sets(q-ROFSs)is *** and Pythagorean fuzzy sets are also used in the calculation process to make a comparative ***,a sensitivity analysis of the ranking alternatives is also conducted with 12 different q *** the results are rather similar;thus,the findings are *** model is also created for this purpose with the help of the decision-making trial and evaluation laboratory(DEmA-TEL)and the technique for order preference by similarity to ideal solution methodologies to check the performance of the proposed *** is defined that by considering the q-ROF DEmATEL weights,the ranking results vary for different *** proposed model with a m-SWARA is more reliable than the model created via the DEmATEL *** situation provides information regarding the superiority of the model proposed in this *** is concluded that security is the most important factor in crowdfunding platforms for smart-grid project ***,solar panels and energy storage systems/batteries are the most significant alternatives for microgrid project *** measures should be taken to forestall the risk of fraud that may occur on this ***,the website to be established

关键词： Financial innovation Crowdfunding microgrid projects Energy investments q-rung fuzzy sets

Analysis of financial development and open innovation oriented fintech potential for emerging economies using an integrated decision‑making approach of mF‑X‑DmA and golden cut bipolar q‑ROFSs

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Financial Innovation 2023年第1期9卷 170-203页

作者： Alexey mikhaylov Hasan Dinçer Serhat Yüksel Financial University under the Government of the Russian Federation MoscowRussia The School of Business İstanbul Medipol UniversityIstanbulTurkey

The purpose of the paper is to identify the factors of financial development that have the greatest impact on open innovation in 7 emerging *** analysis was performed featuring the mF-X-DmA method,as well as its further verification for auto-correlation and *** time period covers years from 2002 to *** article states that the main indicators to improve financial development should enhance the process of bank lending and equity market *** important area is the development of competition by providing equal access to information to all market participants in a continuously refining technical *** analysis with the mF-X-DmA method confirms the statistical significance of this *** article fills the knowledge gap into the link between open innovations and the relatively low capitalization of the modern emerging countries’financial market,low liquidity in small cap stocks at the financial market and concentration of the banking sector,as well as risks arising in the process of *** analysis has also been conducted by generating a novel fuzzy decision-making *** the first stage,the determinants of open innovation-based fintech potential are weighted for the emerging *** this purpose,m-SWARA methodology is taken into consideration based on bipolar q-ROFSs and golden *** second stage of the analysis includes evaluating the emerging economies with the determinants of open innovation-based fintech *** this context,emerging seven countries are examined with ELECTRE *** found the most significant factor is the open innovation-based fintech potential.

关键词： Financial depth Economic monetization macroeconomic impact Banking sector Concentration

Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis

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World Journal of Gastroenterology 2006年第1期12卷 110-113页

作者： Judit Bene Katalin Komlósi Viktória Havasi Gábor talián Beáta Gasztonyi Krisztina Horváth Gyula mózsik Béla Hunyady Béla melegh mária Figler mta PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs PécsHungary Department of Medical Genetics and Child DevelopmentUniversity of PécsPécsHungary Department of medical Genetics and Child Development University of PécsPécsHungary Department of medicine School of MedicineUniversity of PécsPécsHungary

AIm： To determine the plasma carnitine ester profile in adult patients with ulcerative culitis （UC） and compared with healthy control subjects. mETHOD： Using ESI triple quadrupole tandem mass spectrometry, the carnitine ester profile was measured in 44 patients with UC and 44 age- and sex-matched healthy controls. RESULTS： There was no significant difference in the fasting free carnitine level between the patients with UC and the healthy controls. The fasting propionyl- （0.331 ± 0.019 vs 0.392 ± 0.017 μmol/L）, butyryl- （0.219 ± 0.014 vs 0.265 ± 0.012）, and isovalerylcarniUne （0.111 ± 0.008 vs 0.134 ± 0.008） levels were decreased in the UC patients. By contrast, the level of octanoyl- （0.147 ± 0.009 vs 0.114 ± 0.008）, decanoyl- （0.180 ± 0.012 vs 0.137 ± 0.008）, myristoyl- （0.048 ± 0.003 vs 0.039 ± 0.003）, palmitoyl- （0.128 ± 0.006 vs 0.109 ± 0.004）, palmitoleyl- （0.042±0.003 vs 0.031 ± 0.002） and oleylcarnitine （0.183 ± 0.007 vs 0.163 ± 0.007; P 〈 0.05 in all comparisons） were increased in the patients with UC. CONCLUSION： Our data suggest selective involvement of the carnitine esters in UC patients, probably due to their altered metabolism.

关键词： Carnitine Carnitine ester profile Ulcerativecolitis