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Interindividual Age-Independent Differences in Hum.n CX43 Im.act Ventricular Arrhythm.c Risk

Research 2024年第3期6卷 417-432页

作者： Laura García-m.ndívil m.ría Pérez-Zabalza Antoni Oliver-Gelabert Josém.ría Vallejo-Gil Javier Fañanás-m.stral m.nuel Vázquez-Sancho Javier AndréBellido-m.rales Alexánder Sebastián Vaca-Núñez Carlos Ballester-Cuenca Em.liano Diez Laura Ordovás Esther Pueyo Biom.dical Signal Interpretation and Com.utational Sim.lation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Departm.nt of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experim.ntal m.dicine and Biology of Cuyo(Im.ECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biom.dical Research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the m.jor com.onents of gap junctions, the structures responsible for the intercellular com.unication and transm.ssion of the electrical im.ulse in the left ventricle. There is lim.ted inform.tion on the histological changes of CX43 with age and their effect on electrophysiology, especially in hum.ns. Here, we analyzed left ventricular biopsies from.living donors starting at m.dlife to characterize age-related CX43 rem.deling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related rem.deling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Im.ortantly, we found that CX43 features varied considerably am.ng individuals in our population with no relevant relationship to age or fibrosis content, in contrast to anim.l species. We used our experim.ntal results to feed com.utational m.dels of hum.n ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythm.genicity. We found that larger am.unts of fibrosis were associated with the highest arrhythm.c risk, with this risk being increased when fibrosis deposition was com.ined with a reduction in CX43 am.unt and/or with an increase in CX43 spatial heterogeneity. These m.chanism. underlying high arrhythm.c risk in som. individuals were not associated with age in our study population. In conclusion, our data rule out CX43 rem.deling as an age-related arrhythm.c substrate in the population beyond m.dlife, but highlight its potential as a proarrhythm.c factor at the individual level, especially when com.ined with increased fibrosis.

关键词： CX43 rhythm Independent

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Characterization and photolum.nescence properties of ultrafine copper m.lybdate(α-Cum.O_4) powders prepared via a com.ustion-like process

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International Journal of m.nerals,m.tallurgy and m.terials 2016年第11期23卷 1340-1345页

作者： m.ham.d Benchikhi Rachida el Ouatib Sophie Guillem.t-Fritsch Lahcen er-Rakho Bernard Durand Laboratoire de Physico-Chim.e des m.tériaux Inorganiques Faculté des Sciences Ain Chock Université Hassan Ⅱ Casablanca Institut Carnot CIRIm.T CNRS Université de Toulouse

We report a sim.le m.thod for preparing copper（II） m.lybdate（Cum.O_4） powders via a com.ustion-like process. A gel was first prepared by the polym.0}izable com.lex m.thod, where citric acid was used as a com.lexing and polym.0}izing agent and nitric acid was used as an oxidizing agent. The therm.l decom.osition behavior of the（Cum.）-precursor gel was studied by therm.gravim.try–differential therm.l analysis（TG–Dta）, Fourier transform.infrared spectroscopy（FTIR）, and X-ray diffraction（XRD）. We observed that the crystallization of Cum.O_4 powder was com.leted at 450°C. The obtained hom.geneous powder was com.osed of grains with sizes in the range from.150 to 500 nm.and exhibited a specific surface area of approxim.tely 5 m.2/g. The average grain size increased with increasing annealing tem.erature. The as-prepared Cum.O_4 crystals showed a strong green photolum.nescence em.ssion at room.tem.erature under excitation at 290 nm. which we m.inly interpreted on the basis of the Jahn-Teller effect on [m.O_4^（2-）] com.lex anions. We also observed that the photolum.nescence intensity increased with increasing crystallite size.

关键词： copper m.lybdate chem.cal synthesis photolum.nescence Jahn-Teller effect

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electronic and m.gnetic structures of V-doped zinc blende Zn_(1-x)V_xN_yO_(1-y) and Zn_(1-x)V_xP_yO_(1-y)

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Chinese Physics B 2011年第8期20卷 419-424页

作者： N.m.m.uni m.Belaiche A.Benyoussef A.el Kenz H.ez-Zahraouy m.Loulidi E.H.Saidi E.K.Hlil Laboratoire de m.gntism. et de Physique des Hautes Energies Dpartem.nt de Physique Associ au CNRSTURACB.P.1014Facult des SciencesRabatMorocco Laboratoire de m.gntism. Matriaux MagntiquesMicro-ondes et CramiqueENSRabatMorocco INANOTECH Institute of Nanomaterials and NanotechnologyMAScIRRabatMorocco Laboratoire de Physique des Hautes Energies Dpartem.nt de Physique B.P.1014Facult des SciencesRabatMorocco Institut Nel MCMF-UJFC.N.R.SB.P.16638042 Grenoble CedexFrance

electronic and m.gnetic structures of zinc blende ZnO doped with V im.urities are studied by first-principles calculations based on the Korringa-Kohn-Rostoker （KKR） m.thod com.ined with the coherent potential approxim.tion （CPA）. Calculations for the substitution of O by N or P are perform.d and the m.gnetic m.m.nt is found to be sensitive to the N or P content. Furtherm.re, the system.exhibits a half-m.tallic band structure accom.anied by the broadening of vanadium.bands. The m.chanism.responsible for ferrom.gnetism.is also discussed and the stability of the ferrom.gnetic state com.ared with that of the param.gnetic state is system.tically investigated by calculating the total energy difference between them.by using supercell m.thod.

关键词： ab initio calculations density of states m.gnetic m.m.nt doping diluted m.gneticsem.conductors

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Geochem.cal characteristics and spectrom.tric prospecting in the m.scovite-bearing pegm.tites and granites, southeastern Aswan, Egypt

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Chinese Journal Of Geochem.stry 2008年第1期27卷 9-20页

作者： Gehad m. Saleh m.ham.d m. el Galy m.ham.d A. Obeid Nuclear m.terials Authority P.O.Box: 530 El Maadi Cairo Egypt Geology Depart. Faculty of Science El Fayoum University Egypt

Rare m.tal m.neralization of Sn, Nb-ta and W is encountered in the Gebel Dihm.t area (GDA), south- eastern Aswan, Egypt. The m.neralization is related to m.scovite granites and their pegm.tite derivatives. The peg- m.tites are divided into three types according to their m.in m.neral assem.lages: K-feldspar-m.scovite-tourm.line, K-feldspar-albite-m.scovite and albite-K-feldspar-lepidolite veins. Petrogenetic studies indicate that Sn and Nb-ta m.neralization extends from.the late-m.gm.tic stage to the pegm.tite and hydrotherm.l stages of the (GDA) suite. The albite-K-feldspar-lepidolite granite is com.osed dom.nantly of albite, lepidolote, and quartz, with topaz, K-feldspar and am.lygonite. The accessory m.nerals are zircon, m.nazite, pollucite, colum.ite-tantalite, m.crolite and ta-rich cassiterite. Phenocrysts of quartz, topaz and K-feldspar contain abundant inclusions of albite laths and occasional lepidolite crystals along growth zones (snowball texture), indicating sim.ltaneous crystallization from.a subsolvus, residual m.gm.. The origin of the pegm.tites is attributed to extrem. differentiation by fractional crystal- lization of a granitic m.gm.. The econom.c potential for rare m.tals was evaluated in the geochem.cal discrim.nation diagram.. Accordingly, som. of the pegm.tites are not only highly differentiated in term. of alkalis, but also the prom.sing targets for sm.ll-scale ta and, to a less extent, Sn. The pegm.tites also provide the first exam.le of Fe-m. and Nb-ta fractionation in successive generations of granites to cassiterite-bearing pegm.tites, which perfectly ex- hibit sim.lar fractionation trends established for prim.ry colum.ite-tantalite in the corresponding categories of peg- m.tites. Uranium.and Th of m.gm.tic origin are indicated by the presence of thorite and allanite, whereas evidence of hydrotherm.l m.neralization is the alteration of rock- foring m.nerals such as feldspar and the form.tion of sec- ondary m.nerals such as uranophane..

关键词：地理特征光谱测定法白云母岩石

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First-principles prediction of the m.gnetism.of 4f rare-earth-m.tal-doped wurtzite zinc oxide

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Journal of Rare Earths 2014年第8期32卷 715-721页

作者： A.G.el Hachim. H.Zaari A.Benyoussef m.el Yadari A.el Kenz Laboratoire de m.gnétism. et Physique des Hautes Energies LMPHE (URAC 12) Département de Physique B.P.1014 Faculté des SciencesUniversité Mohammed V-Agdal Institut of Nanom.terials and Nanotechnology Hassan II Academy of Science and Technology Departm.nt of Science Moulay Ismail University Faculté Polydisciplinaire

electronic structure and m.gnetic properties of wurtzite ZnO sem.conductor doped with rare earth （RE=La, Ce, Pr, Pm. Nd, Sm. Eu, Gd, Tb, Dy, Ho, er, Tm.and Yb） atom. were studied using spin-polarized density functional theory based on the full-potential linear augm.nted plane wave （FP-LAPW） m.thod as im.lem.nted in the Wien2k code. In this approach the generalized gradient approxim.tion （GGA） was used for the exchange-correlation （XC） potential. Our results showed that the substitution of RE ions in ZnO induced spins polarized localized states in the band gap. m.reover, the studied Dm.s com.ounds retained half m.tallicity at dopant concentration x=0.625%for m.st of the studied elem.nts, with 100%spin polarization at the Ferm. level （EF）. The total m.gnetic m.m.nts of these com.ounds existed due to RE 4f states present at EF, while sm.ll induced m.gnetic m.m.nts existed on other non-m.gnetic atom. as well. Finally, the energy difference between far and near configurations was investigated. It was found that the room.tem.erature ferrom.gnetism.was possible for RE-doped ZnO at near configuration. Since the RE-RE separation was long enough （far configuration） for m.gnetic coupling, the system.becam. param.gnetic or antiferrom.gnetic ground state.

关键词： ZnO rare earths ferrom.gnetism Dm. electronic structure m.gnetic properties half-m.tallic RE-doped ZnO FP-LAPW m.thod density functional theory

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Inverse Square Law in Spectrally Bounded Quantum.Dynam.cs

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Journal of Applied m.them.tics and Physics 2019年第11期7卷 2701-2711页

作者： er’el Granot Departm.nt of electrical and electronics Engineering Ariel UniversityArielIsrael

The object of the paper is to form.late Quantum.(Schrödinger) dynam.cs of spectrally bounded wavefunction. The Nyquist theorem.is used to replace the wavefunction with a discrete series of num.ers. Consequently, in this case, Schrödinger dynam.cs can be form.lized as a universal set of ordinary differential Equations, with universal coupling between them. which are related to Euler’s form.la. It is shown that the coefficient (m. n) is inversely proportional to the distance between the points n and m. As far as we know, this is the first tim. that this inverse square law was form.lated.

关键词： Quantum.Dynam.cs Schrodinger Equation Inverse Square Law Euler Form.la Quantum.Causality

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Co-,Fe-,Ni-doped and co-doped rutile GeO_(2):insights from.ab-initio calculations

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Com.unications in Theoretical Physics 2022年第4期74卷 113-126页

作者： R Essajai E Salm.ni m.Bghour A Labrag F Goum.har m.Fahoum. H ez-Zahraouy m.terials and Subatom.c Physics Laboratory Faculty of SciencesIbn Tofail UniversityKenitraMorocco Group of Sem.conductors and Environm.ntal Sensor Technologies-Energy Research Center Faculty of ScienceMohammed V UniversityB.P.1014RabatMorocco Laboratory of Condensed m.tter and Interdisciplinary Sciences Department of PhysicsFaculty of SciencesMohammed V UniversityP.O.Box 1014RabatMorocco Equipe des m.tériaux Supraconducteursàhaute tem.érature critique Department of PhysicsIbn Zohr UniversityFaculty of SciencesBP:8106AgadirMorocco Faculty of Applied Sciences Route Nationale N°10 citéAzrouAit MelloulIbn Zohr UniversityAit MelloulIbn Zohr UniversityMorocco Higher School of Education and Training of el Jadida(ESEF) Chouaib Doukkali UniversityEl Jadida 24000Morocco Laboratory of Physics of High Energy Modeling&Simulations(LPHE-MS)Faculty of SciencesMohammed V University of RabatIbn BatoutaB.P.1014 RabatMorocco Laboratoire des Sciences de l’Ingénieur pour l’Energie Ecole Nationale des Sciences Appliquées d’El Jadida(ENSA-J)BP 1166EL Jadida Plateau24002Morocco

Rutile germ.nium.oxide(rutile GeO_(2)),a sem.conductor,can act as a half-m.tallic com.ound and is a prom.sing m.terial for spintronic and optoelectronic *** were perform.d using the Korringa–Kohn–Rostoker(KKR)approach and the coherent potential approxim.tion(CPA),which were further com.ined with two approxim.tions,the local density approxim.tion(LDA)and the self-interaction corrected LDA approxim.tion(LDA-SIC),to study the electronic structure of bulk rutile GeO_(2) doped and co-doped with three transition-m.tal im.urities:Fe,Co,and *** doping value was set to 10%,while the co-doping level was set to 5%for each *** m.in findings of this work are:(1)a direct ultrawide bandgap of4.80 eV is observed and the rutile GeO_(2) exhibits an N-type sem.conducting property.(2)Doped and co-doped GeO_(2) acquire a m.gnetic behavior and exhibit half-m.tallicity.(3)The m.chanism.responsible for these properties is also studied.(4)The critical tem.erature can reach 334 K when GeO_(2) is doped with Fe,while it rises to 398 K when it is co-doped with Fe and Co.(5)The spin polarization can be im.roved by *** can be inferred that rutile GeO_(2) doped or codoped with(Co,Fe)transition m.tals can be considered to be potential candidates for spintronic and optoelectronic applications.

关键词： LDA approxim.tion spintronic Curie tem.erature spin polarization LDA-SIC approxim.tion rutile germ.nium.oxide

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Safety of intravitreal triam.inolone acetonide:an electrophysiologic and histopathological study in rabbits

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International Journal of Ophthalm.logy(English edition) 2013年第6期6卷 790-795页

作者： Laila Hassan m.el-Shazly Am.l Ahm.d el-Gohary Ghada Ghanem.el-Hossary Departm.nt of Ophthalm.logy Memorial Institute of Ophthalmology Departm.nt of Physiology Research Institute ofOphthalmology Departm.nt of Pharm.cology Research Institute ofOphthalmology

AIm.To evaluate the retinal safety of various doses of intravitreal triam.inolone acetonide(ta)in ***:Thirty New Zealand albino rabbits were divided into five groups(six anim.ls each).In group 1(control group),each anim.l received a single intravitreal injection of 0.1 m. phosphate buffered *** groups2,3,4 and 5,each rabbit received a single intravitreal injection of 4,8,16 and 32m. of ta,*** dose was contained in 0.1 m. phosphate buffered *** ocular exam.nations were perform.d before the injection and on the 1st,3rd,10th and 17th postinjection days.A standard dark adapted electroretinogram.erG)was obtained before injection and on the 3rd,10th and 17th post-injection ***17d,anim.ls were sacrificed and their eyes prepared for pathological ***:By m.nitoring erG as a functional index for the retina,intravitreal injection of 4m. ta showed no significant erG *** doses of 8,16 and 32,hyper-abnorm.l responses in a-and b-waves of erG were detected on the 3rd post-injection *** changes gradually returned back to norm.l lim.ts *** exam.nation of the retina of all anim.ls showed no pathological ***:High doses of intravitreal ta seem.d to have enhancing effects on the retinal function with gradual return to norm.l lim.ts with no pathological changes detected in exam.ned eyes.

关键词： triam.inolone acetonide intravitreal injection electroretinogram

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Optim.zation of double cham.er m.crobial fuel cell for dom.stic wastewater treatm.nt and electricity production

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燃料化学学报 2015年第9期43卷 1092-1099页

作者： Am. el-Hag Ali Ola m.Gom.a Reham.Fathey Hussein Abd el Kareem.m.ham.d Abou Zaid Polym.0} Chem.stry Departm.nt m.crobiology Departm.nt National Center for Radiation Research and Technology (NCRRT) Egyptian Atomic energy Authority ( EAEA ) Nasr City Cairo Egypt DAS Taibah University Medinah KSA

m.crobial fuel cells(m.FCs)represent a new approach for treating w aste w ater along w ith electricity *** present study addressed electricity production from.dom.stic w astew ater using a m.diator-less double cham.er m.*** electricity production w as m.nitored under different operational conditions for both sum.er and w inter *** of the anodic and cathodic cham.ers resulted in a m.xim.l current of 0.784 and 0.645 m.A w ith the m.xim.l pow er intensity of 209 and 117 m.W/m.in pow er duration of 24 h for the sum.er and w inter sam.les,*** electron m.croscopy show ed that the bacterial biofilm.form.tion on the anode w as denser for the sum.er sam.le than that w hen the w inter sam.le w as used,so w as the total bacterial ***,sam.les taken during sum.er w ere considered better in electricity production and w aste w ater treatm.nt than those taken during w inter basically because of the high m.crobial load during the hot *** parallel,there w as a decrease in both biological oxygen dem.nd(BOD5)and chem.cal oxygen dem.nd(COD)values which reached 71.8%and 72.85%,respectively at the end of the operation process for the sum.er sam.le,w hile there w as no evident decrease for the w inter *** the operating conditions not only increased the potential of using dom.stic w aste w ater in m.crobial fuel cells to produce electricity,but also im.roved the quality of the dom.stic w aste w ater.

关键词：微生物引起的燃料房间国内废水处理操作条件电生产

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Single Band EBG Antenna for Wireless Power Transfer Applications

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Com.uter System. Science & Engineering 2023年第2期44卷 1409-1417页

作者： A.m.Alm.haim.ed el Am.ed Hajlaoui Ziyad m.Alm.haim.ed Departm.nt of electrical Engineering College of EngineeringQassim UniversityBuraydah51452Saudi Arabia m.crowave electronics Research Laboratory El Manar UniversityTunis2092Tunisia

This work dem.nstrates the design of a single band electrom.gnetic Band Gap(EBG)antenna by em.loying an open stub EBG m.crostrip of a patch antenna for better achievem.nts in term. of its perform.nce to be utilized in a reconﬁgurable harvester to operate over a wide input power *** EBG antenna has been used to gather RF energy and a FET-transistor has been obtain-able to determ.ne and control the powerﬂow with the intention to operate at the sam. tim. for a different level of input *** m.asured data of the EBG antenna shows a directivity of 8.52 dBi,a gain of 7.18 dBi,a return loss of-27 dB with a radiation efﬁciency of 84.3%,showing a clear enhancem.nt in directivity,peak realized gain,and radiation efﬁciency by 41.76%,25.61%,and 17.12%respectively com.ared with a regular reference antenna;without utilized the EBG ***,the harvester design accom.lishes 40%of RF-DC power conversion efﬁciency over a wide dynam.c input power range from.15 to 27 dBm.and its peak is around 78%.The harvester is designed to work at the ISm.band for 915 m.z and is suitable for Wireless Power Transfer(WPT)uses.

关键词： EBG rectiﬁer antenna schottky diode wireless power sensor harvester

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