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A combination strategy of functionalized polymer coating with ta ion implantation for multifunctional and biodegradable vascular stents

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Journal of Magnesium and Alloys 2021年第6期9卷 2195-2207页

作者： Kwang-Hee Cheon Cheonil Park Min-ho kang Suhyung Park Jinyoung Kim Seol-Ha Jeong Hyoun-Ee Kim Hyun-Do Jung tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon-si 03083Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon-si 14662Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Biodegradable stents made of magnesium(Mg)and its alloys have been developed to minimize persistent inflammation or in-stent restenosis,which are the main problems for permanent ***,their rapid corrosion behavior under physiological conditions leads to poor vascular compatibility and premature structural failure,which remains an important unsolved clinical ***,we demonstrate a new strategy for solving this problem by combining poly(ether imide)(PEI)coating and subsequent tantalum(ta)ion *** PEI coating covers the whole surface of the Mg stent uniformly via a spray coating technique and provides Mg with superior corrosion resistance and stable sirolimus-carrying *** ion implantation is conducted by a sputtering-based plasma immersion ion implantation technique only onto the luminal surface of the PEI-coated Mg *** extremely short processing time(ta-implanted skin layer that forms on the topmost surface of the PEI coating plays an effective role in not only preventing a rapid release of sirolimus from the surface but also improving the PEI coating’s surface *** on in vitro cellular response and blood compatibility tests,ta ion implantation leads to the improvement of endothelial cell adhesion/proliferation and suppression of platelet adhesion/activation regardless of sirolimus *** results indicate that the combination of PEI coating and ta ion implantation has significant innovative potential to provide excellent vascular compatibility and prevent in-stent restenosis and thrombosis.

关键词： Magnesium stent Biodegradability tantalum Plasma immersion ion implantation Multifunctionality

Construction of tantalum/poly(ether imide)coatings on magnesium implants with both corrosion protection and osseointegration properties

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Bioactive Materials 2021年第4期6卷 1189-1200页

作者： Kwang-Hee Cheon Cheonil Park Min-ho kang In-Gu kang Min-Kyu Lee Hyun Lee Hyoun-Ee Kim Hyun-Do Jung tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheonGyeonggi-doRepublic of Korea Institute of Health Science Research Korea UniversitySeoul02841Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangjuRepublic of Korea

Poly(ether imide)(PEI)has shown satisfactory corrosion protection capability with good adhesion strength as a coating for magnesium(Mg),a potential candidate of biodegradable orthopedic implant ***,its innate hydrophobic property causes insufficient osteoblast affinity and a lack of ***,we modify the physical and chemical properties of a PEI-coated Mg implant.A plasma immersion ion implantation technique is combined with direct current(DC)magnetron sputtering to introduce biologically compatible tantalum(ta)onto the surface of the PEI *** PEI-coating layer is not damaged during this process owing to the extremely short processing time(30 s),retaining its high corrosion protection property and adhesion *** ta-implanted layer(roughly 10-nm-thick)on the topmost PEI surface generates long-term surface hydrophilicity and favorable surface conditions for pre-osteoblasts to adhere,proliferate,and ***,in a rabbit femur study,the ta/PEI-coated Mg implant demonstrates significantly enhanced bone tissue affinity and osseointegration *** results indicate that ta/PEI-coated Mg is promising for achieving early mechanical fixation and long-term success in biodegradable orthopedic implant applications.

关键词： Magnesium tantalum Poly(ether imide) Bio-functionalized coating Biodegradable orthopedic implants

Functionalized Hydrogels for Articular Cartilage Tissue Engineering

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Engineering 2022年第6期8卷 71-90页

作者： Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.V.M.van Osch Kevin Ki-Wai ho Zhen Li Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China AO Research Institute Davos DavosCH 7270Switzerland Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518000China Department of Orthopaedics and Sports Medicine&Department of Otorhinolaryngology Erasmus MCUniversity Medical CenterRotterdam 3000 CAthe Netherlands f Department of Biomechanical EngineeringDelft University of TechnologyDelft 2600 AAthe Netherlands Centre for Translational Medicine Research and Development Shenzhen Institute of Advanced TechnologyThe Chinese Academy of SciencesShenzhen 518000China

Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial *** defects are common in the knees of young and physically active *** of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage *** rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating *** can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of *** article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC ***,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation.

关键词： Articular cartilage Functionalized hydrogels Cartilage repair Cartilage tissue engineering Clinical translation

基于高通量测序的厚唇裸重唇鱼微卫星分子标记筛选

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动物学杂志 2023年第6期58卷 817-826页

作者：刘峰林王泽松王太邓嘉俊王小东金燕君宋昭彬四川大学生命科学学院生物资源与生态环境教育部重点实验室成都610065 甘肃省水产科学研究所甘肃省冷水性鱼类种质资源与遗传育种重点实验室兰州730030 四川大学自然博物馆成都610065 四川大学生命科学学院长江上游鱼类资源与环境四川省野外科学观测研究站成都610065

本研究对厚唇裸重唇鱼(Gymnodiptychus pachycheilus)基因组进行Illumina hi Seq高通量测序,共获得85905条序列,包含567200个微卫星位点,从中筛选出15个微卫星位点,采用雅砻江新龙种群和黄河渭河种群对其多态性进行了验证。新龙种群中,1... 详细信息

本研究对厚唇裸重唇鱼(Gymnodiptychus pachycheilus)基因组进行Illumina hi Seq高通量测序,共获得85905条序列,包含567200个微卫星位点,从中筛选出15个微卫星位点,采用雅砻江新龙种群和黄河渭河种群对其多态性进行了验证。新龙种群中,15个位点的平均等位基因数为6.9(3~13),观测杂合度(ho)为0.7124,多态信息含量(PIC)为0.6303,有8个位点显著偏离哈迪-温伯格平衡,1对位点表现出连锁。渭河种群中,15个位点的平均等位基因数为8.4(4~16),观测杂合度(ho)为0.7195,多态信息含量(PIC)为0.6807,有7个位点显著偏离了哈迪-温伯格平衡,4对位点表现出连锁。筛选获得的15个微卫星位点多态性较高,适合用于厚唇裸重唇鱼种群遗传学研究。

关键词：厚唇裸重唇鱼高通量测序微卫星分子标记