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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

Journal of Integrative medicine 2024年第2期22卷 137-162页

作者： Bizhar a.med tayeb Ikhwan Yuda Kusuma Alaa A.m.Osman Renáta minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

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Transanal total mesorectal excision:Towards standardization of technique

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World Journal of Gastroenterology 2015年第44期21卷 12686-12695页

作者： Albert m Wolthuis Gabriele Bislenghi Anthony de Buck van Overstraeten André D'Hoore Department of Abdominal Surgery University Hospital Leuven

AIm: To describe the role of Transanal total mesorectal excision(ta TmE) in minimally invasive rectal cancer surgery, to examine the differences in patient selection and in reported surgical techniques and their impactson postoperative outcomes and to discuss the future of ta TmE. mETHODS: medLINE(Pub med), EmBASE, and The Cochrane Library were systematically searched through the 1st of march 2015 using a predefined search strategy. RESULTS: A total of 20 studies with 323 patients were included. most studies were single-arm prospective studies with fewer than 100 patients. multiple transanal access platforms were used, and the laparoscopic approach was either multi- or single port. The procedure was initiated transanally or transabdominally. If a simultaneous approach with 2 operating surgeons was chosen, the operative time was significantly reduced. CONCLUSION: ta TmE was also associated with better TmE specimens and a longer distal resection margin. ta TmE is thus feasible in expert hands, but the learning curve and safety profile are not well defined. Longterm follow-up regarding anal function and oncological outcomes should be performed in the future.

关键词： Laparoscopy Colorectal surgery Rectal cancer Total

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