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Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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world Journal of Clinical Cases 2024年第15期12卷 2506-2521页

作者： i-Chien Chen Lin-Ju Chou Shih-Chen Huang ta-w.i chu Shang-Sen Lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive Officer's Office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND The prevalence of non-alcoholic fatty liver(NAFLD)has increased *** with NAFLD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MLR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medical research is increasingly relying on emerging machine learning(Mach-L)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFLD(NAFLD+,NAFLD-)and to rank their *** To uses three different Mach-L methods to identify key impact factors for eGFR in healthy women with and without *** A total of 65535 healthy female study participants were enrolled from the taiwan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),w.ile eGFR was used as the dependent *** from MLR,three Mach-L methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indicated better model *** income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFLD+group,w.ile other factors were all significantly higher except for smoking ***-L had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma calcium level(Ca),plasma albumin level(Alb)and T-bilirubin were the most important factors in the NAFLD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(LDH)and Ca for the *** the importance percentage was much higher than the 2nd important factor,we built Model 2 by removing *** The eGFR were lower in the NAFLD+group compared to the NAFLD-group,with age being was the most important impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women

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Atomic-level insights into the initial oxidation mechanism of high-entropy diborides by first-principles calculations

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Journal of Materiomics 2024年第2期10卷 423-430页

作者： Yiwen Liu Hulei Yu Hong Meng Yanhui chu School of Materials Science and Engineering South China University of TechnologyGuangzhou510641China

Understanding the initial oxidation mechanism is critical for studying the oxidation resistance of high-entropy ***,related studies are ***,the initial oxidation mechanism of(Zr_(0.25)Ti_(0.25)Nb_(0.25)ta_(0.25))B_(2)high-entropy diborides(HEB_(2)-1)is investigated by first-principles calculations at the atomic *** employing the two-region model method,the most stable surface of HEB_(2)-1 is determined to be(1120)*** dissociative adsorption process of the oxygen molecule on the HEB_(2)-1-(1120)surface is predicted to proceed spontaneously,where OeO bond breaks and each oxygen atom is chemisorbed on the most preferable hollow *** adsorption energy and the diffusion barrier of the oxygen atom on the(1120)surface of HEB_(2)-1 are in the vicinity of the average level of the cor-responding four individual *** addition,ab initio molecular dynamics simulations indicate a high initial oxidation resistance of HEB_(2)-1 at 1000 *** results are beneficial to further designing the high-entropy diborides with excellent oxidation resistance.

关键词： High-entropy diborides Oxidation First-principles calculations

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Petrogenesis and Tectonic implications of the Early Triassic Nianzi Adakitic Granite Unit in the Yanshan Fold and Thrust Belt:New Constraints from U-Pb Geochronology and Sr-Nd-Hf isotopes

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 50-66页

作者： ZHANG Huijun wU chu HE Fubing wANG Biren CUi Yubin LiU Zhenghua YOU Shina DONG Jing Development and Research Center of the China Geological Survey Beijing 100037China Beijing institute of the Geological Survey Beijing 100095China institute of Disaster Prevention LangfangHebei 065201China

The Nianzi granite unit,w.ich includes the Nianzi,Xiaolianghou and Xiawopu granitic intrusions,is a significant component of the northern part of the North China Craton(NCC)and is situated in the Yanshan fold and thrust belt(YFTB).However,there is still debate regarding the tectonic evolutionary history of the YFTB during the late Permian to Triassic period,specifically regarding the timing of subduction and collision between the NCC and the Paleo-Asian *** Nianzi granite unit exhibits unique petrological,geochronological and geochemical signatures that shed light on the tectonic evolutionary history of the *** study presents detailed petrology,whole-rock geochemistry,together with Sr-Nd isotopic,zircon U-Pb dating and Lu-Hf isotopic data of the granites within the Nianzi granite *** findings demonstrate that the granites primarily consist of subhedral K-feldspar,plagioclase,quartz,minor biotite and hornblende,with accessory titanite,apatite,magnetite and *** U-Pb dating indicates that the Xiaolianghou granite was emplaced at 247.5±0.62 ***,the adakitic characteristics of the Nianzi,Xiawopu and Xiaolianghou granitic intrusions,such as high Sr and Ba contents and high ratios of Sr/Y and(La/Yb)N,combined with negative Sr-Nd and Lu-Hf isotopes(87Sr/86Sr)i=0.705681–0.7057433,εNd(t)=−21.98 to−20.97,zirconεHf(t)=−20.26 to−9.92,as well as the i-type granite features of high SiO_(2),Na_(2)O and K_(2)O/Na_(2)O ratios,enriched Rb,K,Sr and Ba,along with depleted Th,U,Nb,ta,P and Ti,suggest that the Nianzi granitic unit was mainly derived from the partial melting of a thickened lower crust containing hydrous,calc-alkaline to high-K calc-alkaline,mafic to intermediate metamorphic *** light of these parameters,we further integrate our data with previous studies and conclude that the Nianzi granitic unit was generated in a post-collisional extensional environment during the Early Triassic.

关键词： tectonic evolution zircon geochronology Sr-Nd-Hf isotopes Nianzi granite unit Yanshan fold and thrust belt

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Bi^(3+)-activated dual-wavelength emitting phosphors toward effective optical thermometry

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Chinese Chemical Letters 2024年第3期35卷 486-492页

作者： Yu Xue Yuqi Chen Guixian Li w.ixi Xia Qinan Mao Lang Pei Meijiao Liu Liang chu Jiasong Zhong Center of Advanced Optoelectronic Materials College of Materials and Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China College of Electronics and information Hangzhou Dianzi UniversityHangzhou 310018China Department of Chemistry Zhejiang Sci-Tech UniversityHangzhou 310018China

Optical thermometry as an important local temperature-sensing technique,has received increasing attention in scientific and industrial ***,it is still a big challenge to develop luminescent materials with self-activated dual-wavelength emissions toward high-sensitivity optical ***,a novel ratiometric thermometric strategy of Bi^(3+)-activated dual-wavelength emission band was realized in the same lattice position with two local electronic states of La_(3)Sb_(1-x)ta_xO_(7):Bi^(3+)(0≤x≤1.0)materials based on the different temperature-dependent emission behaviors,benefiting from the highlysensitive and regulable emission to the coordination environment of Bi^(3+).The structural and spectral results demonstrate that the emission tremendously shifted from green to blue with 68 nm and the intensity was enhanced 2.6 ***,the visual dual-wavelength emitting from two emission centers was presented by increasing the ta^(5+)substitution concentration to 20%or 25%,mainly originating from the two local electronic states around the Bi^(3+)emission ***,the dual-wavelength with different thermal-quenching performance provided high-temperature sensitivity and good discrimination signals for optical thermometry in the range between 303 and 493 *** maximum relative sensitivity reached 2.64%/K(La_(3)Sb_(0.8)ta_(0.2)O_(7):0.04Bi^(3+)@383 K)and 1.91%/K(La_(3)Sb_(0.75)ta_(0.25)O_(7):0.04Bi^(3+)@388 K).This work reveals a rational design strategy of different local electronic states around the singledoping multiple emission centers towards practical applications,such as luminescence thermometry and w.ite LED lighting.

关键词： Dual-wavelength emitting Cationic substitution Two local electronic states Optical thermometry Bi^(3+)-doped phosphor

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Discussion of the Composition of Jaboticaba in Different Processes

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Food and Nutrition Sciences 2024年第1期15卷 101-112页

作者： Ching-Hu Tsai Yi-chun Lin Chih-ta Liu Yo-Ju Chen Department of Long-Term Care Kang Ning University Taipei Department of Respiratory Therapy En Chu Kong Hospital New Taipei City Department of Thoracic Surgery Division En Chu Kong Hospital New Taipei City

This study discusses the composition analysis and comparison of Jaboticaba under different processing conditions for fermented liquid, jam, fruit powder, and fruit vinegar. The differences and comparison of the contents of total polyphenols, anthocyanins, resveratrol, superoxide dismutase, small molecular peptides and ellagic acid in their products were analyzed. After analysis and comparison of results, the content of total polyphenols was found to be the highest 44.82 ± 0.89 (mg/g) after being fermented directly from fresh fruit. The fresh fruit was dried at low temperature and ground into powder, with a maximum ellagic acid content of 12.799 ± 0.12 (mg/g). Fresh fruit was then made into jam, with the highest anthocyanin content of 57.39 ± 1.20 (mg/g). The fruit vinegar was produced by fermentation. Except for the content of small molecule peptides, w.ich was similar to the content of fermentation broth and fruit powder, they were 20.63 ± 1.61, 23.84 ± 2.51 and 20.52 ± 1.21 (mg/g), and the rest of the composition was not as good as other samples. in the fresh fruit fermentation broth samples, resveratrol was produced and detected, and its content was 2.14 (mg/L), w.ile it was not detected in other samples, and a superoxide dismutase (SOD)-like enzyme was detected in the fresh fruit fermentation broth. The highest activity was 49002.5 units/mL. Jaboticaba is prepared using a fermentation broth processing method with fresh fruit, and its total polyphenol content is higher than that of fruit powder, jam, and fruit vinegar. The commercial value of Jaboticaba and the establishment of composition content data are relatively improved, w.ich is more promising for the future.

关键词： Jaboticaba Total Polyphenols Anthocyanins Resveratrol Small Molecule Peptides

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Enhanced oxidation resistance of high-entropy diborides by multicomponent synergistic effects

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Science China Materials 2024年第10期67卷 3392-3400页

作者： Zhongyu tang Zihao wen Lei Zhuang Hulei Yu Yanhui chu School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China

Oxidation resistance is critical for high-entropy diborides(HEBs)to be used as thermal structural components under oxygen-containing high-temperature ***,we successfully realize the exploitation of(Zr,ta,Cr,w)B2 HEBs with superior oxidation resistance by comprehensively screening their *** be specific,21 kinds of HEB-xTM(x=0–25 mol%,TM=Zr,ta,Cr,and w)samples are fabricated via an ultrafast high-temperature sintering *** as-fabricated HEB-5Cr samples show the best oxidation resistance at 1673 K among all the *** oxidation investigations further confirm the as-fabricated HEB-5Cr samples possess superior oxidation resistance with the parabolic oxidation behavior across 1473–1773 *** superior oxidation resistance is believed to result from the multi-component synergistic ***,the ta^(5+)and w^(4+)cations with high ionic field strengths can promote the formation of 4B–O–4B linkages between[BO4]tetrahedrons by charge balance,w.ich can stabilize the threedimensional skeletal structure of B_(2)O_(3)glass and consequently result in an improved viscosity of the B_(2)O_(3)glassy *** addition,the ZrO_(2)and Cr_(2)O_(3)with high melting points can dissolve into the B_(2)O_(3)glass to increase its glass transition temperature,leading to an enhanced viscosity of the B_(2)O_(3)glassy layer.

关键词： high-entropy diborides composition screening oxidation resistance synergistic effects

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identifying indicator Species in Habitats Created by Coastal Structures

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China Ocean Engineering 2010年第1期24卷 117-134页

作者： Yi-Yu KUO chun-Han SHiH Ying-Chou LEE w.i-Tse CHANG ta-Jen chu Department of Civil Engineering National Chiao Tung University Hsinchu 30010 China institute of Fisheries Science National Taiwan University Taipei 10617 China Department of Leisure and Recreation Management Chung Hua Univershy Hsinchu 30012 China

in this paper, three approachs were developed to find indicator species from the habitat created by coastal structures. These approachs consist of a model of species co-occurrence probability, a model of k-environmental factor probability and a composite model. Simultaneously, a case study was conducted in Hsinchu Fishing Port of north-western taiwan. Based on the aforementioned models, three primary producer species, Ahnfeltiopsis flabelliformis, Chondrus ocellatus and Sarcodia montagneana, were chosen as the indicator species w.ich had the highest co-occurrence probabilities and showed greater tolerance to more critical environment. it is imperative to understand how the three species under particular co-occurring conditions and environmental factors influence the composition of sessile assemblages in coastal water. The results indicate that for the purpose of increasing biodiversity, these models are feasible to find indicator species of artificial structures, and to help make it possible to design coastal structures based on biological considerations. This study provides an innovative approach for further advanced application in the artificial habitat of coast management.

关键词： coastal structures indicator species sessile organisms ecological restoration

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Eco-Environmental impact Assessment of Pre-Leisure Beach Nourishment on the Benthic invertebrate Community at Anping Coast

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China Ocean Engineering 2011年第2期25卷 215-236页

作者： chun-Han SHiH Yi-Yu KUO ta-Jen chu wen-Chieh CHOU w.i-Tse CHANG Ying-Chou LEE institute of Fisheries Science National Taiwan University Taipei 10617 China Department of Civil Engineering National Chiao Tung University Hsinchu 30010 China Department of Leisure and Recreation Management Chung Hua University Hsinchu 30012 China Department of Civil Engineering Chung Hua University Hsinchu 30012 China

in recent years, owing to global warming and the rising sea levels, beach nourishment and groin building have been increasingly employed to protect coastal land from shoreline erosion. These actions may degrade beach habitats and reduce biomass and invertebrate density at sites where they were employed. we conducted an eco-environmental evaluation at the Anping artificial beach-nourishment project area. At this site, sand piles within a semi-enclosed spur groin have been enforced by use of eco-engineering concepts since 2003. Four sampling sites were monitored during the study period from July 2002 to September 2008. The environmental impact assessment and biological investigations that we conducted are presented here. The results from this study indicate that both biotic （number of species, number of individual organisms, and Shannon-wiener diversity） and abiotic parameters （suspended solids, biological oxygen demand, chemical oxygen demand, dissolved inorganic nitrogen, dissolved inorganic phosphorus, total phosphorus, total organic carbon, median diameter, and water content） showed significant differences before and after beach engineering construction. Biological conditions became worse in the beginning stages of the engineering but improved after the restoration work completion. This study reveals that the composition of benthic invertebrates changed over the study period, and two groups of organisms, Bivalvia and Gastropoda, seemed to be particularly suitable to this habitat after the semi-enclosed artificial structures completion.

关键词： beach nourishment benthic invertebrate eco-engineering ecological restoration spur groin

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Roles of biochemistry data, lifestyle, and inflammation in identifying abnormal renal function in old Chinese

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world Journal of Clinical Cases 2023年第29期11卷 7004-7016页

作者： Chao-Hung Chen chun-Kai wang Chen-Yu wang chun-Feng Chang ta-w.i chu Division of Urology Department of SurgeryKaohsiung Armed Forces General HospitalKaohsiung 802TaiwanChina Division of Urology Department of SurgeryChang Gung Memorial HospitalKeelung 204TaiwanChina Department of Obstetrics and Gynecology Zuoying Branch of Kaohsiung Armed Forces General HospitalKaohsiung 813TaiwanChina Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Division of Urology Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Chief Executive Officer's Office MJ Health Research FoundationTaipei 114TaiwanChina

BACKGROUND The incidence of chronic kidney disease(CKD)has dramatically increased in recent years,with significant impacts on patient mortality *** studies have identified multiple risk factors for CKD,but they mostly relied on the use of traditional statistical methods such as logistic regression and only focused on a few risk *** To determine factors that can be used to identify subjects with a low estimated glomerular filtration rate(L-eGFRin per 1.73 m^(2))in a cohort of 1236 Chinese people aged over *** Twenty risk factors were divided into three *** 1 consisted of demographic and biochemistry *** 2 added lifestyle data to Model 1,and Model 3 added inflammatory markers to Model *** machine learning methods were used:Multivariate adaptive regression splines,eXtreme Gradient Boosting,stochastic gradient boosting,Light Gradient Boosting Machine,and Categorical Features+Gradient *** criteria included accuracy,sensitivity,specificity,area under the receiver operating characteristic curve(AUC),F-1 score,and balanced *** A trend of increasing AUC of each was observed from Model 1 to Model 3 and reached statistical *** 3 selected uric acid as the most important risk factor,followed by age,hemoglobin(Hb),body mass index(BMi),sport hours,and systolic blood pressure(SBP).CONCLUSiON Among all the risk factors including demographic,biochemistry,and lifestyle risk factors,along with inflammation markers,UA is the most important risk factor to identify L-eGFR,followed by age,Hb,BMi,sport hours,and SBP in a cohort of elderly Chinese people.

关键词： Biochemistry data Lifestyle Machine learning Renal function

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Epidemiology, Clinical Features and Antifungal Resistance Profile of Candida auris in Africa: Systematic Review

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Journal of Biosciences and Medicines 2024年第1期12卷 126-149页

作者： isidore wendkièta Yerbanga Seydou Nakanabo Diallo Toussaint Rouamba Delwendé Florence Ouedraogo Katrien Lagrou Rita Oladele Jean-Pierre Gangneux Olivier Denis Hector Rodriguez-Villalobos isabel Montesinos Sanata Bamba Centre Hospitalier Universitaire Régional de Ouahigouya Ouahigouya Burkina Faso Ecole Doctorale des Sciences De la Santé Université Nazi Boni Bobo-Dioulasso Burkina Faso Centre Muraz/institut National de Santé Publique Bobo-Dioulasso Burkina Faso Clinical Research Unit of Nanoro Institute for Research in Health Sciences National Center for Scientific and Technological Research Ouagadougou Burkina Faso Department of Microbiology Immunology and Transplantation KU Leuven Leuven Belgium and Department of Laboratory Medicine and National Reference Center for Mycosis Excellence Center for Medical Mycology (ECMM) University Hospitals Leuven Leuven Belgium College of Medicine University of Lagos Lagos Nigeria Univ Rennes CHU Rennes Inserm Irset (Institut de recherche en santé environnement et travail) European ECMM Excellence Center in Medical Mycology Université de Rennes Rennes France Department of Microbiology CHU Namur site-Godinne Université Catholique de Louvain Yvoir Belgium Ecole de Santé Publique Université Libre de Bruxelles Brussels Belgium Department of Microbiology Cliniques Universitaires Saint-Luc—Université Catholique de Louvain Bruxelles Belgium Centre Hospitalier Universitaire Sour? Sanou Bobo-Dioulasso Burkina Faso

Candida auris since it discovery in 2009 is becoming a severe threat to human health due to its very quickly spread, its worldwide high resistance to systemic antifungal drugs. in resource-constrained settings where several conditions are met for its emergence and spread, this worrisome fungus could cause large hospital and/or community-based outbreaks. This review aimed to summarize the available data on C. auris in Africa focusing on its epidemiology and antifungal resistance profile. Major databases were searched for articles on the epidemiology and antifungal resistance profile of C. auris in Africa. Out of 2,521 articles identified 22 met the inclusion criteria. in Africa, nearly 89% of African countries have no published data on C. auris. The prevalence of C. auris in Africa was 8.74%. The case fatality rate of C. auris infection in Africa was 39.46%. The main C. auris risk factors reported in Africa were cardiovascular disease, renal failure, diabetes, HiV, recent intake of antimicrobial drugs, iCU admissions, surgery, hemodialysis, parenteral nutrition and indwelling devices. Four phylogenetic clades were reported in Africa, namely clades i, ii, iii and iV. Candida auris showed a pan-African very high resistance rate to fluconazole, moderate resistance to amphotericin B, and high susceptibility to echinocandins. Finally, C. auris clade-specific mutations were observed within the ERG2, ERG3, ERG9, ERG11, FKS1, taC1b and MRR1 genes in Africa. This systematic review showed the presence of C. auris in the African continent and a worrying unavailability of data on this resilient fungus in most African countries.

关键词： Africa Antifungal Resistance Candida auris Clinical Features Phylogenetic Clades

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