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The Loss of Heterozygosity of FHIT Gene in sporadic Breast Cancer

Journal of Oncology Research 2021年第2期3卷 33-39页

作者： Lisiane silveira Zavalhia Andrea Pires souto Damin Grasiela Agnes Aline Weber taís frederes kramer alcalde Laura Marinho Dorneles Guilherme Watte Adriana Vial Roehe Research Laboratory in Pathology Graduate Program in PathologyFederal University of Health Sciences of Porto Alegre(UFCSPA)Brazil Department of Gynecology and Obstetrics of Federal University Rio Grande do Sul(UFRGS)Porto AlegreBrazil Research Laboratory in Molecular Biology Federal University of Health Sciences of Porto Alegre(UFCSPA)Rio Grande do SulBrazil Department of Respiratory Medicine and Thoracic surgery Irmandade da Santa Casa de Misericordia de Porto AlegreRio Grande do SulBrazil Department of Pathology Graduate Programa in PathologyFederal University of Health Sciences of Porto Alegre(UFCSPA)Porto AlegreBrazil

*** is a potential tumor suppressor *** the precise FHIT molecular mechanism of action is not well understood,evidences suggest that Fhit protein reduced levels are involved in mammary *** aim of this study was to investigate if FHIT LOH could influence on sporadic breast cancer(BC)biological behavior,through its association with prognostic factors for sporadic *** tissue and peripheral blood samples were analyzed using the microsatellite marker *** findings were associated with clinicopathological parameters including overall *** was detected in 31.1%(52/167)of the informative BC’*** clinical and pathological characteristics we have found no significant association with FHIT LOH *** mean follow-up time was 80 *** the Cox regression analysis two parameters remained associated with BC’s risk of death:TNM stage III and IV-HR=3.74(95%CI,1.16-12.1)P=0.027 and disease relapse HR=3.14(CI 95%1.26-7.80)P=*** study shows that FHIT LOH by itself is not a prognostic factor for sporadic *** researches are required to elucidate the functional role of FHIT LOH concerning to BC.

关键词： Breast cancer D3s1300 LOH survival Loss of heterozygosity

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