The aerodynamic roughness z0m, the thermodynamic roughness Z0h and the excess resistance to heat transfer kB-1 are analyzed with the data obtained from Global Energy and Water Cycle Experiment (GEWEX) Asian Monsoon Ex...
详细信息
The aerodynamic roughness z0m, the thermodynamic roughness Z0h and the excess resistance to heat transfer kB-1 are analyzed with the data obtained from Global Energy and Water Cycle Experiment (GEWEX) Asian Monsoon Experiment on Tibetan Plateau (GAME/Tibet) in the Intensive Observation Period (IOP), 1998. Some new concepts on the aerodynamic and thermodynamic parameters over the grassy marshland surface of the Tibetan Plateau are proposed.
AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treat...
详细信息
AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression ***: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, "NAT2*4", was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity.
暂无评论