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Journal of Chemistry and Chemical Engineering 2016年第2期10卷 53-59页

作者： Eirika tsuda Yuya Mitsumoto Kazuya Takakura Nobumitsu Sunaga Takashiro Akitsu Taro Konomi Masahiro Katoh Department of Chemistry Faculty of Science Tokyo University of Science 1-3 Kagurazaka Shinjuku-ku Tokyo 162-8601 Japan UVSOR Institute for Molecular Science 38 Nishigonaka Myodaiji OkazakL Aichi 444-8585 Japan

The authors have prepared supramolecular systems as artificial metalloproteins composed of several chiral salen-type Mn（II） and Co（II） complexes in a HSA （human serum albumin） matrix. The docking was discussed by UV-vis spectral changes and a ligand-protein docking simulation program. After linearly polarized UV light irradiation, that anisotropy of molecular orientation of the complexes increased was confirmed by polarized IR spectra. The authors have observed that the electrochemical behavior of the aligned complexes incorporating diphenyl groups in HSA can be tuned without UV radiation damage of HSA higher structures.

关键词： Redox potential Schiff base Mn(II) complex Co(II) complex albumin.

Usefulness of Immuno-Magnetic Beads Conjugated with Anti-EpCAM Antibody for Detecting Endometrial Cancer Cells

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Journal of Cancer Therapy 2013年第8期4卷 1273-1282页

作者： Yoshikatsu Koga Satoshi Katayose Nobuko Onoda Takahiro Kasamatsu Tomoyasu Kato Shunichi Ikeda mitsuya Ishikawa Ken Ishitani Yasuo Hirai Hideo Matsui Yasuhiro Matsumura Department of Gynecology National Cancer Center Hospital Tokyo Japan Department of Obstetrics and Gynecology Tokyo Women’s Medical University Tokyo Japan Department of Obstetrics and Gynecology Tokyo Women’s Medical University Tokyo Japan. Division of Developmental Therapeutics Research Center for Innovative Oncology National Cancer Center Hospital East Kashiwa Japan R & D Department Unit 1 JSR Life Sciences Corporation Tsukuba Japan

A simple and non-invasive method for detecting endometrial cancer in women with abnormal uterine bleeding is required. For this purpose, we prepared immuno-magnetic beads conjugated with anti-human EpCAM rat monoclonal antibody (mAb) for isolating exfoliated endometrial cells including endometrial cancer cells in vaginal discharge. The affinities of the anti-human EpCAM rat mAbs were analyzed by flow cytometry and immunocytochemistry and then magnetic beads were conjugated with the mAbs. The rate of retrieval of endometrial cells using the immuno-magnetic beads was calculated. Endometrial cells were isolated using the immuno-magnetic beads from the vaginal discharges of 22 patients with endometrial cancer and 16 non-malignant controls. The isolated cells were stained using endometrial cancer specific-mAbs and analyzed by flow cytometry and imaging cytometry. The immuno-magnetic beads conjugated with high-affinity mAb (clone 1456) appeared to have very low auto-fluorescence. Sufficient enrichment of Ep-CAMpositive cells using immuno-magnetic beads was observed in both simulation and clinical samples. The overall sensitivities of flow cytometry and imaging cytometry to detect endometrial cancer cells were 72.7% and 45.5%, respectively. Meanwhile, the overall specificities of flow cytometry and imaging cytometry for healthy controls were 75.0% and 81.3%, respectively. Our immuno-magnetic beads have very low auto-fluorescence, so they could be useful for fluorescent analysis, such as fluorescent immunochemical staining. In the future, these novel immuno-magnetic beads could be used for cytological study.

关键词： Immuno-Magnetic Beads Auto-Fluorescence Endometrial Cancer Cancer Screening

Analysis of Degenerative Discs in Lumbar Spondylolisthesis Using MRI T2 Mapping

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Open Journal of Radiology 2012年第3期2卷 77-80页

作者： Tsuneo Takebayashi Hiroyuki Takashima Mitsunori Yoshimoto Yoshinori Terashima Hajime tsuda Kazunori Ida Toshihiko Yamashita Department of Orthopedic Surgery School of Medicine Sapporo Medical University Sapporo Japan

Background: Spinal instability, including lumbar degenerative spondylolisthesis (DS), mainly results from degeneration of intervertebral discs (IVD) and the facet joints (FJ). Characterization of the relationship between IVD degeneration in cases of lumbar degenerative spondylolisthesis (DS), and T2 values may be useful for accurate noninvasive evaluation and subsequent treatment. Thus, the goal of this study was to measure T2 values of IVDs in cases with (DS) and without (NS) spondylolisthesis, and to characterize changes of IVDs in DS. Methods: A total of 40 subjects who presented with L4 spondylolisthesis comprised the DS group. Another 40 subjects who did not have lumbar spondylolisthesis, constituted the NS group. T2 values of IVDs were measured and compared in these groups. Results: T2 values for IVDs tended to be lower in the DS group than in the NS group, and these values were significantly different (p < 0.01) within the anterior annulus fibrosus (AF). No significant differences in T2 values between Meyerding grades I and II were observed in any areas of IVDs. Conclusions: It is speculated that in the early stages, the degeneration of the anterior AF develops and is related to the onset of lumbar spondylolisthesis, while in later stages, degeneration of facet joints influences the progression of spondylolisthesis.

关键词： Degenerative Spondylolisthesis Intervertebral Disc T2 Mapping

Gastrointestinal stromal tumor presenting with prominent calcification

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World Journal of Gastroenterology 2012年第39期18卷 5645-5648页

作者： Naoki Izawa Takeshi Sawada Ryuichi Abiko Daisuke Kumon Mami Hirakawa Mika Kobayashi Nobuyuki Obinata Masahito Nomoto Tadateru Maehata Shun-ichi Yamauchi Takefumi Kouro Takashi tsuda Satoshi Kitajima Hiroshi Yasuda Keiichi Tanaka Ichiro Tanaka Masahiro Hoshikawa Masayuki Takagi Fumio Itoh Division of Gastroenterology and Hepatology St.Marianna University School of MedicineKawasaki 216-8511Japan Division of Gastroenterological and General Surgery St.Marianna University School of MedicineKawasaki 216-8511Japan Department of Pathology St.Marianna University School of MedicineKawasak 216-8511Japan

We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism.

关键词： Gastrointestinal stromal tumor Calcifica-tion Stomach Computed tomography Imatinib me-sylate

ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status

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World Journal of Gastroenterology 2015年第7期21卷 2159-2168页

作者： Ryo Inada Shigeki Sekine Hirokazu Taniguchi Hitoshi tsuda Hitoshi Katai Toshiyoshi Fujiwara Ryoji Kushima Pathology and Clinical Laboratory Division National Cancer Center Hospital Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Molecular Pathology Division National Cancer Center Research Institute Gastric Surgery Division National Cancer Center Hospital

AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric ***:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric *** results were further correlated with clinicopathological ***:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,P<0.001),a female sex(55.3%vs 31.3%,P=0.004),an antral location(44.7%vs 25.7%,P=0.021),and a differentiated histology(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,P<0.001).A multivariate analysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas.

关键词： Adenocarcinoma ARID1A Mismatch Repair Stomach Immu

Factor Structure of the Center for Epidemiologic Studies Depression Scale in South Korea

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Open Journal of Medical Psychology 2014年第4期3卷 301-305页

作者： Shuntaro Aoki Akira tsuda Satoshi Horiuchi Euiyeon Kim Mayu Naruse Aki Tsuchiyagaito Kwangshik Hong Department of Education Inha University Incheon Korea Department of Elementary Education Jeonju National University of Education Jeonju Korea Department of Psychology Kurume University Kurume Japan Graduate School of Psychological Science Health Sciences University of Hokkaido Sapporo Japan School of Psychological Science Health Sciences University of Hokkaido Sapporo Japan

Results of previous studies from North America reported that only 14 out of the 20 items from the Center for Epidemiologic Studies Depression Scale (CES-D) were required to assess negative affect, somatic symptoms, and anhedonia. However, it remains unclear whether this three-factor structure of the CES-D would be valid in South Korea. The purpose of this study is to examine the validity of the three-factor structure with a Korean version of the CES-D. The participants were Korean college students (N = 215), elementary school teachers (N = 234), and parents of elementary school students (N = 230). Confirmatory factor analysis was performed to examine the scale’s validity. Results indicated that the three-factor structure showed acceptable fit to data (comparative fit index = 0.95;root mean square error of approximation = 0.06). The findings indicated that the three-factor structure of the CES-D was valid in South Korea.

关键词： Depressive Symptoms CES-D Factor Structure South Korea

Genetic polymorphism of CYP2A6 is one of the potential factors determining tobacco-related cancer risk

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中国药理学与毒理学杂志 2006年第3期20卷 163-163页

作者： S tsuda I SATO N SAITO K OAMI JIN YH Laboratory of Veterinary Public Health Department of Veterinary Medicine Faculty of Agriculture lwate University Japan Research Institute for Environmental Science and Public Health of Iwate Prefecture Japan Graduate School of Life and Environmental Sciences University of Tsukuba Japan Department of Hygienic Toxicology College of Public Health China Medical University China

While we studied pharmacokinetics of SM-12502 which was under development as an anti-PAF agent, we found three subjects showing a slow metabolic phenotype in its pharmacokinetics. Analyzing the genes for CYP2A6 from the three subjects, we discovered that the three subjects possessed the whole CYP2A6 gene deletion (CYP2A6*4C), a novel genetic polymorphism of the CYP2A6 gene. Genetically engineered Salmonella YG7108 cells expressing human CYP2A6 or CYP2E1 together with the NADPH-CYP reductase were established in our laboratory to compare the mutagen-producing capacity of these enzymes for various N-nitrosamines. We found that CYP2E1 was responsible for the metabolic activation of N-nitrosamines with relatively short alkyl chains, whereas CYP2A6 was involved in the metabolic activation of N-nitrosamines possessing relatively bulky alkyl chains such as a tobacco-specific nitrosamine, NNK, which has been known to cause lung tumor in rodents. Thus, to examine a hypothesis that individuals possessing the CYP2A6*4C have the reduced risk of lung cancer due to the lack of the capacity of the metabolic activation of certain carcinogens in tobacco smoke, a case-control study was performed.

关键词： CYP Genetic polymorphism of CYP2A6 is one of the potential factors determining tobacco-related cancer risk

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喷油嘴的改进对直喷式柴油机的影响

汽车与新动力 1999年第2期 50-54+62页

作者： Toshiyuki Yoda Tomoyuki tsuda 顾聪

燃油喷束的雾化对于改进柴油机性能,例如降低NOX排放、颗粒物（PM）和提高输出功率等有很重要的作用。为了在不提高喷油压力条件下获得更好的燃油雾化,提高喷孔处的流速被认为是一种有效的方法。通过试验,证实扩大喷孔进口的圆角半径是... 详细信息

燃油喷束的雾化对于改进柴油机性能,例如降低NOX排放、颗粒物（PM）和提高输出功率等有很重要的作用。为了在不提高喷油压力条件下获得更好的燃油雾化,提高喷孔处的流速被认为是一种有效的方法。通过试验,证实扩大喷孔进口的圆角半径是获得高流速喷油嘴最有效而适用的方法。作者将高流速喷油嘴的喷油特性和油束特性与传统喷油嘴作了对比,前者的雾化得到了改善。最后将高流速喷油嘴装到中等功率自然吸气直喷式柴油机上进行了试验,高流速喷油嘴显示了NOX排放和PM排放同时获得改善,因而是改进发动机的有效方法。

关键词：喷油嘴圆角半径高流速喷油器喷孔进口喷油特性直喷式柴油机

Hayabusa2’s superior solar conjunction mission operations: Planning and post-operation results

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Astrodynamics 2020年第4期4卷 265-288页

作者： Stefania Soldini Hiroshi Takeuchi Sho Taniguchi Shota Kikuchi Yuto Takei Go Ono Masaya Nakano Takafumi Ohnishi Takanao Saiki Yuichi tsuda Fuyuto Terui Naoko OgawaYuya MimasuTadateru Takahashi Atsushi Fujii Satoru NakazawaKent Yoshikawa Yusuke Oki Chikako Hirose Hirotaka Sawada Tomohiro Yamaguchi Makoto Yoshikawa Department of Mechanical Materials and Aerospace EngineeringUniversity of LiverpoolLiverpool L693BXUK Institute of Space and Astronautical Science Japan Aerospace Exploration AgencySagamihara 252-5210Japan Fujitsu Limited Tokyo 105-7123Japan Mitsubishi Electric Corporation Tokyo 100-8310Japan

In late 2018,the asteroid Ryugu was in the Sun's shadow during the superior solar conjunction *** the Sun-Earth-Ryugu angle decreased to below 3°,the Hayabusa2 spacecraft experienced 21 days of planned blackout in the Earth-probe communication *** was the first time a spacecraft had experienced solar conjunction while hovering around a minor *** the safety of the spacecraft,a low energy transfer trajectory named Ayu was designed in the Hill reference frame to increase its altitude from 20 to 110 *** trajectory was planned with the newly developed optNEAR tool and validated with real time *** article shows the results of the conjunction operation,from planning to fight data.

关键词： superior solar conjunction Hayabusa2 Ryugu hovering satellite mission operations

Wind Power Forecasting using an Artificial Neural Network for ASPCS

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Energy and Power Engineering 2013年第4期5卷 414-417页

作者： Kazuma Hanada Takataro Hamajima Makoto tsuda Daisuke Miyagi Takakazu Shintomi Tomoaki Takao Yasuhiro Makida Masataka Kajiwara Advanced Research Institute for the Sciences and Humanities Nihon University Tokyo Japan Department of Electrical and Electronics Systems Hachinohe Institute of Technology Aomori Japan Department of Electrical Engineering Tohoku University Miyagi Japan Department of Engineering and Applied Sciences Sophia University Tokyo Japan High Energy Accelerator Research Organization Ibaraki Japan Iwatani Corporation Tokyo Japan

In order to use effectively renewable energy sources, we propose a new system, called Advanced Superconducting Power Conditioning System (ASPCS) that is composed of Superconducting Magnetic Energy Storage (SMES), Fuel Cell-Electrolyzer (FC-EL), hydrogen storage and DC/DC and DC/AC converters in connection with a liquid hydrogen station for fuel cell vehicles. The ASPCS compensates the fluctuating electric power of renewable energy sources such as wind and photovoltaic power generations by means of the SMES having characteristics of quick response and large Input-Output power, and hydrogen energy with FC-EL having characteristics of moderate response and large storage capacity. The moderate fluctuated power of the renewable energy is compensated by a trend forecasting method with the Artificial Neural Network. In case of excess of the power generation by the renewable energy to demand it is converted to hydrogen with EL. In contrast, shortage of the electric power is made up with FC. The faster fluctuation power that cannot be compensated by the forecasting method is effectively compensated by SMES. In the ASPCS, the SMES coil with an MgB2 conductor is operated at 20 K by using liquid hydrogen supplied from a liquid hydrogen tank of the fuel cell vehicle station. The necessary storage capacity of SMES is estimated as 50 MJ to 100 MJ depending on the forecasting time for compensating fluctuation power of the rated wind power generation of 5.0 MW. As a safety case, a thermosiphon cooling system is used to cool indirectly the MgB2 SMES coil by thermal conduction. In this paper, a trend forecasting result of output power of a wind power generation and the estimated storage capacity of SMES are reported.

关键词： Renewable Energy Artificial Neural Network Forecasting SMES Liquid Hydrogen Fuel Cell and Electrolyzer