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Journal of Mountain Science 2016年第5期13卷 882-890页

作者： SHEN xiao-ming li De-wen tian Yun-tao LV yan-wu li Da-wei li yan-feng Key Laboratory of Crustal Dynamics Institute of Crustal DynamicsCEA Department of Earth Sciences University College London National Earthquake Response Support Service CEA

Offset geomorphic features and deformed late Quaternary strata indicate active deformation along the Langshan-Seertengshan piedmont fault （LSPF）, one of the most active faults in the Hetao fault zone in Inner Mongolia, North China. The widespread occurrence of bedrock fault scarps along the LSPF offers excellent opportunity to examine the faulting history. Using cosmogenic ^10Be exposure dating, we measured the exposure ages of the western Langshankou scarp, located in the middle segment of the LSPF. Our data revealed at least two earthquakes that occurred at 22.2±3.3 Ira and 7.2±2.4 ka, respectively. These events are consistent with previous paleoseismic trench studies. The regression of the relationship between the age and sampling height along the scarp yield a fault slip rate of 0.10 ±0.05/-0.06 mm/yr, which is significantly lower than the average post-late Pleistocene fault slip rate of ~1 mm/yr, as estimated from the offset of the T2 terraces by previous studies. This indicates that the slip of the LSPF may have been accommodated by other fault branches.

关键词： Lanshan-Seertengshan piedmont fault(LSPF) Fault scarp Cosmogenic nuclide Exposureage Fault slip rate

Delayed-onset adenosine deaminase deficiency with a novel synonymous mutation and a case series from China

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World Journal of Pediatrics 2023年第7期19卷 687-700页

作者： Yue Zhang Wei liu Zhou shu yan li Fei Sun Zhi-Gang li tong-Xin Han Hua-Wei Mao tian-You Wang Department of Immunology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthNo.56 Nan Lishi RoadXicheng DistrictBeijing 100045China Hematology Oncology Center Henan Children's HospitalChildren's Hospital Affiliated of Zhengzhou UniversityZhengzhou Children's HospitalZhengzhouChina Hematologic Disease Laboratory Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Hematology Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthNo.56 Nan Lishi RoadXicheng DistrictBeijing 100045China Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of PediatricsCapital Medical UniversityBeijingChina Key Laboratory of Major Diseases in Children Ministry of EducationBeijingChina

Background Adenosine deaminase(ADA)is a key enzyme in the purine salvage *** defects of the ADA gene can cause a subtype of severe combined *** date,few Chinese cases have been *** We retrospectively reviewed the medical records of patients diagnosed with ADA deficiency in Beijing Children's Hospital and summarized the previously published ADA deficiency cases from China in the *** Nine patients were identified with two novel mutations(W272X and Q202=).Early-onset infection,thymic abnor-malities and failure to thrive were the most common manifestations of Chinese ADA-deficient *** ADA genotype has a major effect on the clinical ***,a novel synonymous mutation(c.606G>A,p.Q202=)was identified in a delayed-onset patient,which affected pre-mRNA splicing leading to a frameshift and premature truncation of the ***,the patient showed γδT cells expansion with an increased effect or phenotype,which may be associated with the delayed onset of *** addition,we reported cerebral aneurysm and intracranial artery stenosis for the first time in ADA *** patients died with a median age of four months,while two patients received stem cell transplantation and are *** This study described the first case series of Chinese ADA-deficient ***-onset infection,thymic abnormalities and failure to thrive were the most common manifestations in our *** identified a synonymous muta-tion that affected pre-mRNA splicing in the ADA gene,which had never been reported in ADA ***,we reported cerebral aneurysm in a delayed-onset patient for the first *** study is warranted to investigate the underlying mechanisms.

关键词： Adenosine deaminase deficiency Cerebral aneurysm Gamma delta Severe combined immunodeficiency Synonymous mutation

Accumulation of Carbohydrate and Regulation of 14-3-3 Protein on Sucrose Phosphate Synthase(SPS) Activity in Two Tomato Species

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Journal of Integrative Agriculture 2014年第2期13卷 358-364页

作者： WANG li CUI Na ZHAO xiao-cui FAN Hai-yan li tian-lai Biological Science and Technology College Shenyang Agricultural University Key Laboratory of Protected Horticulture Ministry of Education/College of HorticultureShenyang Agricultural University

To explore the differences of carbohydrate metabolism in two tomato species and discuss the possible regulation of 14-3-3 proteins on the sucrose phosphate synthase （SPS） activity, we determined the contents of soluble sugar and starch through high performance liquid chromatography （HPLC）. The activities of sugar-metabolizing enzymes were assayed in desalted extract, and the relative expression levels of related genes in sugar metabolism were determined though real-time RT-PCR. The results indicated that glucose and fructose were mainly accumulated during the maturation of the fruit because of the high acid invertase （AI） and neutral invertase （NI） in Micro-Tom （Solanum lycopersicum） fruit, while in Solanum chmielewskii fruit, SPS which went along with the change of sucrose content led to the rapid sucrose increase during the fruit ripening. TFT1 and TFT10, belonging to 14-3-3 protein in tomato, were likely to down-regulated SPS activity during young and intumescence period.

关键词： Micro-Tom Solanum chmielewskii carbohydrate accumulation 14-3-3 proteins fruit development

A three-year clinical investigation of a Chinese child with craniometaphyseal dysplasia caused by a mutated ANKH gene

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World Journal of Clinical Cases 2021年第8期9卷 1853-1862页

作者： Jia-li Wu xiao-li li shu-Mei Chen xiao-Ping Lan Jin-Jin Chen xiao-yan li Wei Wang Department of Otolaryngology and Head and Neck Surgery Shanghai Children’s HospitalShanghai Jiaotong University School of MedicineShanghai 200062China Department of Radiation Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Molecular Diagnostic Laboratory Shanghai Children’s HospitalShanghai Jiaotong University School of MedicineShanghai 200062China Department of Child Healthcare Shanghai Children’s HospitalShanghai Jiaotong University School of MedicineShanghai 200062China Shanghai AhCare Consulting Shanghai 20120China

BACKGROUND Craniometaphyseal dysplasia(CMD)is a rare genetic *** dominant CMD(AD-CMD)is caused by mutations in the ANKH *** individuals typically have distinctive facial features including progressive thickening of the craniofacial *** for AD-CMD primarily consists of surgical intervention to release compression of the cranial nerves and the brain stem/spinal *** alleviate progression of the clinical course and improve the quality of life in children waiting to undergo the necessary surgery,we investigated clinical changes in a diagnosed patient with AD-CMD over three *** SUMMARY A 17-mo-old boy presented with progressive nasal obstruction,snoring and hearing loss *** examination showed enlargement of the head circumference and clinical features such as wide nasal bridge,paranasal bossing,widely spaced eyes with an increased bizygomatic width,and a prominent *** patient underwent otolaryngological examination,endoscopy,hearing test,laboratory examination of phosphorus and bone metabolism,cranial and femoral computed tomography,X-ray and next-generation *** patient was diagnosed with AD-CMD due to ***377 deletion(c.1129_1131del)on exon 9 of the ANKH *** adherence to a prescribed low-calcium diet,the boy’s alkaline phosphatase(ALP)levels continuously decreased to within the normal ***,after 14 mo of dietary intervention,his parents altered his diet to an intermittent low-calcium diet to include milk and *** patient’s ALP was slightly higher than normal after the dietary change but remained close to the normal *** serum osteocalcin changed to within normal levels after dietary regulation for 33 *** serum combined beta C-terminal telopeptide of type I collagen also continuously decreased after the nutritional intervention,although still slightly higher than normal *** fluctuating blood test results,the boy’s nasal symptoms were markedly relieved

关键词： ANKH gene mutation Clinical investigation Craniometaphyseal dysplasia Case report Child

Aquaporin 1 Facilitated Hepatocellular Carcinoma SMMC7221 Cell Migration Associated with Water Permeability

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Chemical Research in Chinese Universities 2011年第1期27卷 99-103页

作者： ZHANG Ai-li li Jiang WANG yan-qing ZAKNROU Zohra MA tong-hui li xiao-meng School of life Sciences Northeast Normal University Changchun 130024 P. R. China Dental Hospital Jilin University Changchun 130021 P. R. China Bo ＇an Brothers Holding Pharmaceutical Co. Ltd. （China） Changchun 130012 P. R. China Central Research Laboratory The Second Hospital of Jilin University Changchun 130041 P R. China

The authors investigated the regulation of human aquaporin I（hAQP1） and the involvement of aquaporin 1 （AQP 1） in the migration of human hepatocellular carcinoma SMMC-7221 cells using RNA intereference technology Firstly, two short hairpin RNA（shRNA） constructs in PBSU6 vector were reconstructed and their knockdown effects were identified in SMMC-7221 cells. Next, the involvement of endogenous hAQP1 in regulating the migration of SMMC-7221 cells was investigated via siRNA technology. HAQPI-shRNA can specifically inhibit AQP1 dependent osmotic water permeability. Meanwhile the migration of SMMC-7221 cells was inhibited remarkably after silencing AQP1 by performing transwell cell migration assay and in vitro wound healing assay. Furthermore, in the presence of an inhibitor HgCl2, the water permeability of the cell membrane was remarkably decreased, the expression of AQP1 was upregulated after HgCla treatment and the cell movement was decreased at the moment. Increased AQP1 cannot attenuate cell migration ability when cell membrane loses its water permeability function. This demonstrates that the cell migration was remarkably related to the transporting water function of cell membrane.

关键词： Aquaporin 1 shRNA HgCl2 Cell migration

Bacterial and archaeal community structures in the Arctic deepsea sediment

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Acta Oceanologica Sinica 2015年第2期34卷 93-113页

作者： li yan liU Qun li Chaolun DONG Yi ZHANG Wenyan ZHANG Wuchang xiao tian Key Laboratory of Marine Ecology and Environmental Sciences Institute of Oceanology Chinese Academy of Sciences Center for Transport Phenomena Energy Research Institute Shandong Academy of Sciences State Field Research Station of Jiaozhou Bay Marine Ecology Institute of Oceanology Chinese Academy of Sciences

Microbial community structures in the Arctic deep-sea sedimentary ecosystem are determined by organic matter input, energy availability, and other environmental factors. However, global warming and earlier ice-cover melting are affecting the microbial diversity. To characterize the Arctic deep-sea sediment microbial diversity and its relationship with environmental factors, we applied Roche 454 sequencing of 16 S r DNA amplicons from Arctic deep-sea sediment sample. Both bacterial and archaeal communities＇ richness, compositions and structures as well as taxonomic and phylogenetic affiliations of identified clades were characterized. Phylotypes relating to sulfur reduction and chemoorganotrophic lifestyle are major groups in the bacterial groups; while the archaeal community is dominated by phylotypes most closely related to the ammonia-oxidizing Thaumarchaeota（96.66%） and methanogenic Euryarchaeota（3.21%）. This study describes the microbial diversity in the Arctic deep marine sediment（〉3 500 m） near the North Pole and would lay foundation for future functional analysis on microbial metabolic processes and pathways predictions in similar environments.

关键词： Arctic deep-sea sediment microbial community structure pyrosequencing

Direct-Current Magnetization of Y-Type Zeolites Containing Fe Ions

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Chinese Physics Letters 1996年第3期13卷 223-226页

作者： tong li-tai WU Feng li Guo-hong yan Shou-sheng JI tian-hao liN Bing-xiong Department of Physics Peking UniversityBeijing 100871 Department of Chemistry Peking UniversityBeijing 100871

The de magnetization of Y-type zeolite containing Fe ions and that after reduction treatment were measured in the temperature range of *** samples show paramagnetic behavior・The obtained value for the magnetic moment of the paramagnetic units strongly implies the existence of ferromagnetic coupling between the Fe ion at site I in hexagonal prism and the one at the nearest site I' in β cage.

关键词： zeolite hexagonal ferromagnetic

Correlation between ductus venosus spectrum and right ventricular diastolic function in isolated single-umbilical-artery foetus and normal foetus in third trimester

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World Journal of Clinical Cases 2020年第23期8卷 5866-5875页

作者： tian-Gang li Fang Nie xiao-yan Xu Department of Ultrasound Diagnosis Gansu Provincial Maternity and Child-Care HospitalLanzhou 730050Gansu ProvinceChina Department of Ultrasound Diagnosis Lanzhou University Second HospitalLanzhou 733000Gansu ProvinceChina

BACKGROUND Single umbilical artery(SUA)is the most common umbilical cord malformation in prenatal *** presence of an SUA can cause blood circulation disorder in the foetus and functional changes of the foetal heart,affecting foetal *** right ventricular diastolic functions in foetuses with isolated SUA and in normal foetuses in the third trimester were evaluated using the spectral Doppler of blood flow in the foetal ductus venosus(DV).AIM To evaluate the right ventricular diastolic functions in foetuses with isolated SUA and in normal foetuses in the third *** Colour Doppler was used to measure the spectrum of foetal DV and tricuspid orifice in 34 foetuses with isolated SUA aged 28-39 wk and in age-matched healthy *** DV flow velocities and velocity ratios were *** early passive/late active(E/A)ratio at the tricuspid orifice and tissue Doppler Tei index of the foetal right ventricular in the two groups were also *** During the third trimester,the isolated SUA group showed a lower‘a’-wave peak velocity in the DV than the control group(Plic velocity/ventricular diastolic peak flow velocity and E/A ratios was the best(R^2of the isolated SUA group:0.520;R2 of the control group:0.358).The correlations between the velocity ratios and tissue Doppler Tei index of foetal right ventricular in the two groups were analysed,and the correlation between the pulsatility index for veins(PIV)and tissue Doppler Tei index ratios was the best(R2 of the isolated SUA group:0.865;R2 of the control group:0.627).CONCLUSION In the isolated SUA group,the atrial systolic peak velocity‘a’decreased,and this finding might be related to the changes in foetal cardiac *** ratio of ventricular late diastolic velocity to ventricular diastolic peak flow

关键词： Isolated single umbilical artery Ductus venosus Velocity Right ventricular diastolic function Foetus

Geochemistry and detrital zircon records of the Ruyang-Luoyu groups,southern North China Craton:Provenance,crustal evolution and Paleo-Mesoproterozoic tectonic implications

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Geoscience Frontiers 2020年第2期11卷 679-696页

作者： Xi-Yao li Sanzhong li tong-Shan Wang Yunpeng Dong xiao-Guang liu shu-Juan Zhao Kun Wang Jiao-Peng Sun li-Ming Dai yan-Hui Suo Key Lab of Submarine Geosciences and Prospecting Techniques MOEand Institute for Advanced Ocean StudyCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China State Key Laboratory of Continental Dynamics Northwest UniversityXi’an 710069China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China

Paleo-to Mesoproterozoic sedimentary rocks in the southern margin of the North China Craton(NCC)are represented by the Ruyang and Luoyu *** studied the sedimentary rocks from the Yunmengshan and Beidajian formations of the Ruyang Group and the Cuizhuang and Sanjiaotang formations of the Luoyu *** zircon grains from these formations have U–Pb age populations of 3.64–3.31 Ga,2.96–2.86 Ga,2.72–2.59 Ga,2.56–2.47 Ga,2.45–2.0 Ga,1.99–1.85 Ga and 1.84–1.65 *** geochemical features of the sedimentary rocks suggest that some of the sediments were sourced from intermediate to felsic magmatic *** age groups of the detrital zircon are roughly consistent with the tectono-thermal events in the southern margin of the *** Hf isotopic compositions of detrital zircon from the sedimentary rocks in Ruyang and Luoyu groups suggest that significant crustal growth and reworking of the NCC took place during the Neoarchean and early-to mid-Paleoproterozoic,while crustal reworking at the Paleoarchean and late-Paleoproterozoic,and crustal growth at the *** suggest the depositional times of the Ruyang Group and Luoyu Group are constrained to no older than 1.75–1.7 Ga and 1.7–1.65 Ga,*** of late-Paleoproterozoic basins related to the strike slip and extrusion tectonics that cross-cut the NCC during the late Paleoproterozoic(linked the yanshan–liaoxi regions of the northern NCC.

关键词： Detrital zircon North China craton Proterozoic Tectonics U–Pb ages Hf isotope

Variations, effectiveness and its associated factors of a nationwide web-based hypertension management training project in China: insights from a government-led campaign for 1.2 million lay health workers

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Journal of Geriatric Cardiology 2024年第7期21卷 733-750页

作者： Wei WANG Hai-Bo ZHANG Jia-Min liU yan li Na tian Lei yan Jin-xiao SONG Mei-li li Yue PENG Jing li National Primary Health Care Hypertension Management Office National Clinical Research Center for Cardiovascular DiseasesNHC Key Laboratory of Clinical Research for Cardiovascular MedicationsFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To evaluate the effectiveness of a large-scale,web-based,in-service hypertension management training project among lay health workers(LHWs) at primary care health(PHC) settings in China,and to examine the factors contributing to the variations of *** We used data from a web-based national hypertension management training project implemented in 2018,it was designed to facilitate LHWs to learn,understand,and apply the relevant knowledge and skills in hypertension management through providing training courses by use of the web-based platform with unified *** LHWs were required to participate in the exams before and after training to acquire scores for the use of evaluating their performance of hypertension management *** first used descriptive analysis to present the variations of effectiveness in hypertension management knowledge among LHWs by important ***,we used multilevel logistic regression to examine the individual and regional factors contributing to the variations and quantify the magnitude of how these factors affected training *** There were 1,208,610 LHWs who completed training and were ***,the scores of LHWs increased significantly from 62.87 ± 21.14 out of 100 in the pre-test to 88.30 ± 11.31 in the post-test by 25.43(95% confidence interval[CI]:25.40-25.47).Training contents involved in antihypertensive medication showed the lowest score(54.36) in the pre-test and soared the most after training,up to 84.22 by 54.94%.Individual factors associated with disparities in the knowledge of hypertension management decreased substantially after training,which included sex,age,education,practice type,professional level,and hierarchy of working *** variations were shown at the provincial level,with the majority of them being explained by factors at the regional *** Accessible web-based training modality,government efforts,accompa

关键词： hypertension workers nationwide