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Histological observation on acellular nerve grafts co-cultured with Schwann cells for repairing defects of the sciatic nerve

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Neural Regeneration Research 2006年第1期1卷 44-46页

作者： xiaohong Sun Jiangyi Tian Xiaojie tong Xu Zhang Zheng He Department of Neurology Fourth Affiliated Hospital China Medical University Shenyang 110032 Liaoning Province China Department of Orthopaedics Fourth Affiliated Hospital China Medical University Shenyang 110032 Liaoning Province China Department of Human Anatomy School of Basic Medicel Sciences China Medical University Shenyang 110001 Liaoning Province China

BACKGROUND： Animal experiments and clinical studies about tissue engineering method applied to repair nerve injury mainly focus on seeking ideal artificial nerve grafts, nerve conduit and seed cells. Autologous nerve, allogeneic nerve and xenogeneic nerve are used to bridge nerve defects, it is one of the methods to promote the repair of nerve injury by culturing and growing Schwann cells, which can secrete various neurotrophic factor activities, in the grafts. OBJECTIVE ： To observe the effect of acellular nerve grafts co-cultured with Schwann cells in repairing defects of sciatic nerve. DESIGN： An observational comparative study.SETTING： Tissue Engineering Laboratory of China Medical University.MATERIALS： The experiment was carried out in the Tissue Engineering Laboratory of China Medical University between April 2004 and April 2005. Forty neonatal Sprague-Dawley rats of 5-8 days （either males or females） and 24 male Wistar rats of 180-220 g were provided by the experimental animal center of China Medical University. METHODS： ① Culture of Schwann cells： The bilateral sciatic nerves and branchial plexus were isolated from the 40 neonatal SD rats. The sciatic nerves were enzymatically digested with collagenase and dispase, isolatd, purified and cultured with the method of speed-difference adhersion, and identified with the SABC immunohistochemical method. ② Model establishment： In vitro Schwann cells were microinjected into 10-mm long acellular nerve grafts repairing a surgically created gap in the rat sciatic nerve. According to the different grafted methods, the animals were randomly divided into three groups： autografts （n=8）, acellular nerve grafts （n=8）, or acellular nerve grafts with Schwann cells （n=8）. ③ The regenerated nerve fiber number and average diameter of myeline sheath after culture were statistically anlayzed. MAIN OUTCOME MEASURES： ① The regenerated nerve ultrastructure, total number and density of myelinated nerve fibers, and the thickne

关键词： Histological observation on acellular nerve grafts co-cultured with Schwann cells for repairing defects of the sciatic nerve

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Prevalent intrinsic emission from nonaromatic amino acids and poly(amino acids)

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Science China Chemistry 2018年第3期61卷 351-359页

作者： xiaohong Chen Weijian Luo Huili Ma Qian Peng Wang Zhang Yuan Yongming Zhang School of Chemistry and Chemical Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Electrochemical Energy Devices Research Center Shanghai Jiao Tong University Department of Chemistry Tsinghua University Institute of Chemistry Chinese Academy of Sciences

Nonaromatic amino acids are generally believed to be nonemissive, owing to their lack of apparently remarkable conjugation within individual molecules. Here we report the intrinsic visible emission of nonaromatic amino acids and poly(amino acids) in concentrated solutions and solid powders. This unique and widespread luminescent characteristic can be well rationalized by the clustering-triggered emission(CTE) mechanism, namely the clustering of nonconventional chromophores(i.e. amino, carbonyl,and hydroxyl) and subsequent electron cloud overlap with simultaneous conformation rigidification. Such CTE mechanism is further supported by the single crystal structure analysis, from which 3 D through space electronic communications are *** prompt fluorescence, room temperature phosphorescence(RTP) is also detected from the solids. Moreover, persistent RTP is observed in the powders of exampled poly(amino acids) of ε-poly-L-lysine(.-PLL) after ceasing UV irradiation. These results not only illustrate the feasibility of employing the building blocks of nonaromatic amino acids in the exploration of new luminescent biomolecules, but also provide significant implications for the emissions of peptides and proteins at aggregated or crystalline states. Meanwhile, they may also shed lights on further understanding of autofluorescence from biological systems.

关键词： nonaromatic amino acids aggregation-induced emission clustering-triggered emission through space electronic communications room temperature phosphorescence

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False data injection attacks against smart grid state estimation:Construction, detection and defense

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Science China(Technological Sciences) 2019年第12期62卷 2077-2087页

作者： ZHANG Meng SHEN Chao HE Ning HAN SiCong LI Qi WANG Qian GUAN xiaohong Ministry of Education Key Laboratory for Intelligent Networks and Network Security Xi'an Jiao tong UniversityXi'an 710049China Faculty of Electronic and Information Engineering Xi'an Jiaotong UniversityXi'an 710049China School of Mechanical and Electrical Engineering Xi'an University of Architecture and TechnologyXi'an 710049China Institute for Network Sciences and Cyberspace Tsinghua UniversityBeijing 100084China School of Cyber Science and Engineering Wuhan UniversityWuhan 430072China

As a typical representative of the so-called cyber-physical system,smart grid reveals its high efficiency,robustness and reliability compared with conventional power ***,due to the deep integration of electrical components and computinginformation in cyber space,smart grid is vulnerable to malicious attacks,especially for a type of attacks named false data injection attacks(FDIAs).FDIAs are capable of tampering meter measurements and affecting the results of state estimation stealthily,which severely threat the security of smart *** to the significantinfluence of FDIAs on smart grid,the research related to FDIAs has received considerable attention over the past *** paper aims to summarize recent advances in FDIAs against smart grid state estimation,especially from the aspects of background materials,construction methods,detection and defense ***,future research directions are discussed and outlined by analyzing existing *** is expected that through the review of FDIAs,the vulnerabilities of smart grid to malicious attacks can be further revealed and more attention can be devoted to the detection and defense of cyber-physical attacks against smart grid.

关键词： false data injection attacks(FDIAs) state estimation smart grid cyber security

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数据跨境流动安全管理协同研究

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现代情报 2024年第8期44卷 39-50页

作者：牛晓宏夏童黑龙江大学信息管理学院黑龙江哈尔滨150080

[目的/意义]数据跨境流动推动了数字经济发展和国际交流合作,探索数据跨境流动安全管理协同问题,有利于维护数据安全和国家安全,促进数据利用体系与能力建设。[方法/过程]运用Nvivo软件,分析我国数据跨境流动安全管理协同存在的问题与... 详细信息

[目的/意义]数据跨境流动推动了数字经济发展和国际交流合作,探索数据跨境流动安全管理协同问题,有利于维护数据安全和国家安全,促进数据利用体系与能力建设。[方法/过程]运用Nvivo软件,分析我国数据跨境流动安全管理协同存在的问题与产生的原因,基于协同理论和霍尔三维模型,构建数据跨境流动安全管理协同三维模型。[结果/结论]构建以组织协同机制、法制协同机制和资源协同机制3个子机制构成的数据跨境流动安全管理协同机制,并从知识共享、技术实力、文化环境3方面提出数据跨境流动安全管理协同机制运行保障措施,实现数据跨境流动安全管理协同效果。

关键词：数据跨境流动数据安全安全管理协同理论协同机制霍尔三维模型

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A human-sensitive frequency band vibration isolator for heavy-duty truck seats

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1733-1748页

作者： Qingqing LIU Shenlong WANG Ge YAN Hu DING Haihua WANG Qiang SHI xiaohong DING Huijie YU School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechnoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Yanfeng Adient Seating Co. Ltd.Shanghai 201315China College of Mechanical and Electrical Engineering Jiaxing Nanhu UniversityJiaxing 314001Zhejiang ProvinceChina

In this study,a human-sensitive frequency band vibration isolator(HFBVI)with quasi-zero stiffness(QZS)characteristics for heavy-duty truck seats is designed to improve the comfort of heavy-duty truck drivers on uneven ***,the analytical expressions for the force and displacement of the HFBVI are derived with the Lagrange equation and d'Alembert's principle,and are validated through the prototype restoring force ***,the harmonic balance method(HBM)is used to obtain the dynamic responses under harmonic excitation,and further the influence of pre-stretching on the dynamic characteristics and transmissibility is ***,the experimental prototype of the HFBVI is fabricated,and vibration experiments are conducted under harmonic excitation to verify the vibration isolation performance(VIP)of the proposed vibration *** experimental results indicate that the HFBVI can effectively suppress the frequency band(4-8 Hz)to which the human body is sensitive to vertical *** addition,under real random road spectrum excitation,the HFBVI can achieve low-frequency vibration isolation close to 2 Hz,providing new prospects for ensuring the health of heavy-duty truck drivers.

关键词： human-sensitive frequency band quasi-zero stiffness(QZS) heavy-duty truck seat real random road spectrum low-frequency vibration isolation

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Neural Firing Mechanism Underlying Two-Electrode Discrimination by 3D Transcutaneous Electrical Nerve Stimulation Computational Model

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Journal of Shanghai Jiaotong university(Science) 2019年第6期24卷 716-722页

作者： YE Shuan ZHU Kaihua LI Peng SUI xiaohong School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Transcutaneous electrical nerve stimulation(TENS) has been widely used for sensory feedback which is a key consideration of improving the performance of prosthetic hands. Two-electrode discriminability is the key to realize high-spatial-resolution TENS, but the neural firing mechanism is not clear yet. The goal of this research is to investigate the neural firing patterns under two-electrode stimulation and to reveal the potential mechanisms. A three-dimensional(3 D) model is established by incorporating Aβ fiber neuron clusters into a layered forearm structure. The diameters of the stimulating electrodes are selected as 5, 7, 9 and 12 mm, and the two-electrode discrimination distance(TEDD) is quantified. It is found that a distant TEDD is obtained for a relatively large electrode size, and 7 mm is suggested to be the optimal diameter of stimulating electrodes. The present study reveals the neural firing patterns under two-electrode stimulation by the 3 D TENS model. In order to discriminate individual electrodes under simultaneous stimulation, no crosstalk of activated Aβ fibers exists between two electrodes. This research can further guide the optimization of the electrode-array floorplan.

关键词： transcutaneous electrical nerve stimulation(TENS) computational model artificial tactile sensation two-electrode discrimination distance(TEDD)

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Features of A New 500 kVAR Static VAR Generator

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Electricity 1998年第4期 42-45页

作者： Chen Xianming Xu Heping Tian Jie Wang xiaohong Wang tong (Nanjing Automation Research Institute)

The paper briefly describes the main features of a new 500 kVAR static VAR generator designed and manufactured by NAm for industrial test and trial

关键词： Features of A New 500 kVAR Static VAR Generator TLI VAR

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Rare variants play critical roles in the maize ear genetic architecture

Rare variants play critical roles in the maize ear genetic a...

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第一届全国玉米生物学学术研讨会

作者：肖英杰 Hao tong xiaohong Yang Shizhong Xu Jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University National Maize Improvement Center of China Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural University Department of Botany and Plant Sciences University of California

Improving grain yield is an essential long-term goal of maize breeding to meet continual and increasing food demands *** dissected the genetic architecture of maize ear traits using a set of 10 independent recombinati...

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东胜地区直罗组砂岩型铀矿包裹体特征与铀矿成因研究

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石油学报 2007年第5期28卷 72-78,84页

作者：林潼罗静兰刘小洪张三西北大学大陆动力学国家重点实验室

鄂尔多斯盆地东胜地区直罗组含铀矿层位中流体包裹体均一温度和成分的测定及荧光分析表明,东胜地区至少存在三期有机流体充注与运移,流体特征总体反映出烃类从早期到晚期由低成熟到高成熟的演化过程。包裹体成分中含有大量CO2、烃类物质... 详细信息

鄂尔多斯盆地东胜地区直罗组含铀矿层位中流体包裹体均一温度和成分的测定及荧光分析表明,东胜地区至少存在三期有机流体充注与运移,流体特征总体反映出烃类从早期到晚期由低成熟到高成熟的演化过程。包裹体成分中含有大量CO2、烃类物质(CH4与C2+)和还原性气体(H2S与H2),含矿砂岩中有丰富的碳酸盐胶结物。这说明还原环境为铀的沉淀、富集提供了有利的成矿介质环境条件,CO2与碳酸盐对东胜地区铀的迁移与沉淀起了重要作用,烃类与铀成矿具有密切的联系。包裹体均一温度及其他证据显示,本区曾经历过明显的热事件。该热事件的发生与早期铀矿形成的时间相近,对铀矿的形成有重要贡献。

关键词：流体包裹体烃类充注热事件铀矿成因东胜地区

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Asymmetric synthesis of bedaquiline based on bimetallic activation and non-covalent interaction promotion strategies

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Science China Chemistry 2022年第10期65卷 1968-1977页

作者： Feng Gao Jing Li Tanveer Ahmad Yicong Luo Zhenfeng Zhang Qianjia Yuan xiaohong Huo Tao Song Wanbin Zhang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China

Bedaquiline(BDQ),approved by Food and Drug Administration(FDA)in 2012 as the first anti-tuberculosis-specific drug in the last 40 years,is viewed as one of the world’s most promising treatments for tuberculosis(TB).Due to the stereoselective construction of the Csp^(3)–Csp^(3)bond with vicinal stereocenters of BDQ and its analogues being an unsolved challenge,there have not been any reports concerning its asymmetric synthesis for the current industrial production process until ***,we have successfully developed a cooperative bimetallic system for the asymmetric synthesis of BDQ under the guidance of density functional theory(DFT)*** on the optimized conditions,BDQ could be synthesized with excellent enantioselectivity(>99%ee)and diastereoselectivity(16:1 dr).A 5-g scale reaction was also conducted with comparably excellent results,showing its potential for industrial application.

关键词： asymmetric synthesis bedaquiline bimetallic system industrial synthetic process DFT computation

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