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The importance of Righi-Leduc heat flux to the ablative Rayleigh-Taylor instability during a laser irradiating targets

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High Power Laser Science and Engineering 2024年第3期 14-24页

作者： Ye Cui xiao-Hu yang yan-Yun Ma Guo-Bo Zhang Bi-Hao Xu Ze-Hao Chen Ze li Fu-Qiu Shao Jie Zhang Department of Nuclear Science and Technology National University of Defense Technology Collaborative Innovation Centre of IFSA Shanghai Jiao Tong University College of Advanced Interdisciplinary Studies National University of Defense Technology Department of Physics National University of Defense Technology Key Laboratory for Laser Plasmas (Ministry of Education) School of Physics and Astronomy Shanghai Jiao Tong University

The Righi±Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh±Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic simulations. The perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of teslas. The Righi±Leduc effect plays an essential impact both in the linear and nonlinear stages, and it deflects the total heat flux towards the spike base. Compared to the case without the self-generated magnetic field included, less heat flux is concentrated at the spike tip, finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike tip. It is shown that the linear growth rate is increased by about 10%and the amplitude during the nonlinear stage is increased by even more than 10%due to the feedback of the magnetic field,respectively. Our results reveal the importance of Righi±Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field, especially during the acceleration stage in inertial confinement fusion.

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Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

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Science China Chemistry 2024年第8期67卷 2497-2523页

作者： Yuan Zeng shuhan Zhang Yuecong Guo Yalin Cong Xu Ding Peihua li Yunxiang lin Wenzhi Ren Hui Su Weigang Sun liuxin Xu Guikai Zhang Shihua Chen Yu Chen Weiren Cheng Shengqi Chu Yong Guan Jinru Han Jie lin Hengjie liu Zheyi liu Pan Luo Fanchun Meng Sicong Qiao Zongyin Song Ying Wang Zhao Wu Chenyu yang Meng yang Shirui yang Zi Yin Zhibin Yin Pengjun Zhang Hongyu Zhang Pingping Zheng Jia Zhou Wanlin Zhou Pengfei An He Cheng Chunhai Fan Xingjiu Huang Yong Lei lina li Mu li Qinghua liu shuming Peng li Song Zhihu Sun yangchao tian Fangjun Wang lihua Wang liming Wang Shiqiang Wei Aiguo Wu Chunlei xiao Xueming yang Panchao Yin Jing Zhang Mingxin Zhang Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science LaboratoryNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410081China State Key Laboratory of Luminescent Materials and Devices South China Advanced Institute for Soft Matter Science and TechnologySouth China University of TechnologyGuangzhou 510640China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Advanced Science Facilities Shenzhen 518107China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Acade

With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron *** further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.

关键词： large scientific facilities synchrotron radiation FEL light sources neutron sources spectroscopic analysis methods X-ray imaging techniques structural information chemical dynamics

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： yan Sun Xiu-Na yang shuang-shuang yang Yi-Zhu Lyu Bing Zhang Kai-Wen liu Na li Jia-Chen Cui Guang-Xiang Huang Cheng-lin liu Jie Xu Jian-Qing Mi Zhu Chen xiao-Hu Fan Sai-Juan Chen shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes

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Nuclear Science and Techniques 2024年第4期35卷 208-220页

作者： Ao-yan Cheng Hao Cai Shi Chen tian-Lu Chen Xiang Dong You-liang Feng Qi Gao Quan-Bu Gou Yi-Qing Guo Hong-Bo Hu Ming-Ming Kang Hai-Jin li Chen liu Mao-Yuan liu Wei liu Fang-Sheng Min Chu-Cheng Pan Bing-Qiang Qiao Xiang-li Qian Hui-Ying Sun Yu-Chang Sun Ao-Bo Wang Xu Wang Zhen Wang Guang-Guang Xin Yu-Hua Yao Qiang Yuan Yi Zhang School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650091China Ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China College of Physics Sichuan UniversityChengdu 610064China School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Aerospace Information Research Institute Suzhou 215123China College of Physics Chongqing UniversityNo.55 Daxuecheng South RoadHigh‑tech DistrictChongqing 401331China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China

The High Altitude Detection of Astronomical Radiation(HADAR)experiment,which was constructed in Tibet,China,combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity advantages of focused Cherenkov *** objective is to observe transient sources such as gamma-ray bursts and the counterparts of gravitational *** study aims to utilize the latest AI technology to enhance the sensitivity of HADAR *** datasets and models with distinctive creativity were constructed by incorporating the relevant physical theories for various *** models can determine the type,energy,and direction of the incident particles after careful *** obtained a background identification accuracy of 98.6%,a relative energy reconstruction error of 10.0%,and an angular resolution of 0.22°in a test dataset at 10 *** findings demonstrate the significant potential for enhancing the precision and dependability of detector data analysis in astrophysical *** using deep learning techniques,the HADAR experiment’s observational sensitivity to the Crab Nebula has surpassed that of MAGIC and *** energies below 0.5 TeV and remains competitive with conventional narrow-field Cherenkov telescopes at higher *** addition,our experiment offers a new approach for dealing with strongly connected,scattered data.

关键词： VHE gamma-ray astronomy HADAR Deep learning Convolutional neural networks

sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1177-1188页

作者： Song-Man Yu Hai li Guo-Hong Deng Xian-Bo Wang Xin Zheng Jin-Jun Chen Zhong-Ji Meng Yu-Bao Zheng yan-Hang Gao Zhi-Ping Qian Feng liu xiao-Bo Lu Yu Shi Jia Shang Ruo-Chan Chen yan Huang Department of Infectious Diseases Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 442009Hubei ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvineChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 463599Henan ProvineChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvineChina

BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and *** triggering receptor expressed on myeloid cells-1(sTREM-1)is released from activated innate immune cells and correlated with various inflammatory *** To explore the prognostic value of sTREM-1 in patients with AD of *** A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=133).Demographic and clinical data were collected,and serum sTREM-1 was measured at *** enrolled patients were followed-up for at least 1 *** In patients with AD and cirrhosis,serum sTREM-1 was an independent prognosis predictor for 1-year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1,blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CliF-C)ACLF and CliF-C AD ***,sTREM-1 was increased in ACLF and predicted the development of ACLF during first 28-d *** ACLF risk score incorporating serum sTREM-1,BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CliF-C ACLF,CliF-C AD and P-AD in predicting risk of ACLF *** Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.

关键词： Soluble triggering receptor expressed on myeloid cell-1 Acute decompensation Cirrhosis Acute-on-chronic liver failure Prognostic biomarker

黄河三角洲不同植物群落土壤有机碳特征及其影响因子

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环境科学 2024年第7期45卷 4177-4186页

作者：李丛笑张彦覃茜瑾贾琪周爽李天乐刘福德天津理工大学环境科学与安全工程学院天津300384 天津市生态环境科学研究院天津300191

土壤有机碳的变化对于土壤质量演变有着十分重要的意义.以黄河三角洲潮上带芦苇(Phragmites australis)、盐地碱蓬(Suaeda salsa)和柽柳(Tamarix chinensis)群落为研究对象,分析0~50 cm土层范围内土壤有机碳(SOC)、易氧化有机碳(EOC)、... 详细信息

土壤有机碳的变化对于土壤质量演变有着十分重要的意义.以黄河三角洲潮上带芦苇(Phragmites australis)、盐地碱蓬(Suaeda salsa)和柽柳(Tamarix chinensis)群落为研究对象,分析0~50 cm土层范围内土壤有机碳(SOC)、易氧化有机碳(EOC)、溶解性有机碳(DOC)和颗粒有机碳(POC)的分布特征,并基于紫外-可见光谱、三维荧光光谱和平行因子分析(PARAFAC)技术,对土壤溶解性有机物(DOM)的组成和来源进行解析,最终结合土壤理化性质揭示影响不同植物群落土壤有机碳和DOM组分特征的关键因子.结果表明:(1)不同群落比较,盐地碱蓬群落ω(SOC)最高,为7.53 g·kg^(-1),柽柳群落ω(DOC)最高,为0.98 g·kg^(-1),芦苇群落ω(EOC)和ω(POC)显著高于盐地碱蓬和柽柳群落,分别为1.47 g·kg^(-1)和0.65 g·kg^(-1);垂直分布上,除POC含量外,均呈现出随着土层加深而降低的趋势.(2)芦苇、盐地碱蓬和柽柳群落土壤DOM的主要成分均为腐殖质、类蛋白物质、类富里酸物质,其中外源组分在以上群落中占比分别为55.80%、56.41%和52.81%;(3)不同群落比较,芦苇群落的腐殖化程度显著高于盐地碱蓬和柽柳群落,但其芳香化程度和自生源占比显著低于柽柳群落;垂直分布上,DOM芳香化和腐殖化程度随土层的加深逐渐增加,且深层土主要以疏水组分占比低的相对分子质量小的DOM为主.(4)冗余分析可知,N(P<0.01)、NO_(2)^(-)-N(P<0.01)和NH_(4)^(+)-N(P<0.05)是影响土壤有机碳和DOM组分变化的关键因子.

关键词：黄河三角洲土壤有机碳(SOC) 溶解性有机质(DOM) 潮上带湿地植物群落

Localization effect in single crystal of RuAs2

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Chinese Physics B 2024年第4期33卷 620-625页

作者：易哲铠刘琪光双魁徐升岳小宇梁慧李娜周颖吴丹丹孙燕李秋菊程鹏夏天龙孙学峰王义炎 Anhui Key Laboratory of Magnetic Functional Materials and Devices Institute of Physical Science and Information TechnologyAnhui University Department of Physics and Key Laboratory of Strongly-Coupled Quantum Matter Physics (CAS) University of Science and Technology of China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials & Micro-nano Devices Renmin University of China School of Optical and Electronic Information Suzhou City University School of Physics and Optoelectronic Engineering Anhui University Collaborative Innovation Center of Advanced Microstructures Nanjing University

We report the magnetotransport and thermal properties of RuAs2single crystal. RuAs2exhibits semiconductor behavior and localization effect. The crossover from normal state to diffusive transport in the weak localization（WL） state and then to variable range hopping（VRH） transport in the strong localization state has been observed. The transitions can be reflected in the measurement of resistivity and Seebeck coefficient. Negative magnetoresistance（NMR） emerges with the appearance of localization effect and is gradually suppressed in high magnetic field. The temperature dependent phase coherence length extracted from the fittings of NMR also indicates the transition from WL to VRH. The measurement of Hall effect reveals an anomaly of temperature dependent carrier concentration caused by localization effect. Our findings show that RuAs2is a suitable platform to study the localized state.

关键词： weak localization variable range hopping RuAs_2 single crystal

我国食品防腐剂联合使用情况及理论累积风险评估

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中国食品卫生杂志 2024年第6期36卷 714-721页

作者：欧曈常炯炯李强雍凌肖潇李善雅文宋雁国家食品安全风险评估中心北京100022 烟台市疾病预防控制中心山东烟台264003 振安区疾病预防控制中心辽宁丹东118003

目的了解我国食品中防腐剂的联合使用情况并评估常见防腐剂组合的摄入水平及其累积暴露风险。方法根据全球新产品数据库(GNPD)中我国食品中防腐剂的联合使用情况、防腐剂的健康指导值、GB 2760—2014《食品安全国家标准食品添加剂使用... 详细信息

目的了解我国食品中防腐剂的联合使用情况并评估常见防腐剂组合的摄入水平及其累积暴露风险。方法根据全球新产品数据库(GNPD)中我国食品中防腐剂的联合使用情况、防腐剂的健康指导值、GB 2760—2014《食品安全国家标准食品添加剂使用标准》中防腐剂最大允许使用量,结合第5次中国总膳食研究消费量数据,采用简单分布法计算我国一般人群常见防腐剂组合暴露量,并采用危害指数法(HI)进行累积暴露风险评估。结果我国使用防腐剂的食品中有43.36%使用两种及以上的防腐剂,使用率最高的是二元组合(31.78%),最多存在6种防腐剂的组合使用。仅单独考虑一种防腐剂的人群暴露风险,我国一般人群最常见防腐剂组合中苯甲酸钠、山梨酸钾和双乙酸钠每日平均暴露量以及每日P95暴露量均未超过其每日允许摄入量(ADI),乳酸链球菌素、亚硝酸钠和脱氢乙酸及钠盐每日平均暴露未超过其ADI,但其P95暴露量均已超过其相应ADI。累积评估表明一般人群最常见的二元、三元防腐剂组合HI的均值小于1,但最常见的四元、五元防腐剂组合HI的均值以及二元、三元、四元、五元防腐剂组合HI的P95均大于1。累积风险评估显示常见防腐剂组合中防腐剂单独使用,有一部分个体存在摄入超量的问题,但若组合使用则可能有1.47~1.75倍的个体存在健康风险。结论我国食品防腐剂常以多元形式使用,最常见的二元、三元、四元、五元防腐剂组合的累积暴露风险逐渐增加,累积风险评估显示最常见的四元和五元防腐剂组合的使用已经对部分人群形成健康风险,应对这些防腐剂的实际使用量进行监测并进行更精确的评估。同一防腐功能的食品添加剂混合使用时,各自用量占其最大使用量的比例之和不应超过1。

关键词：防腐剂联合使用暴露评估累积风险评估食品安全

Research progress of traditional Chinese medicine in the treatment of endocrine metabolic diseases in 2023

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Traditional Medicine Research 2024年第12期9卷 51-65页

作者： Ming-Yao Fan Jing Ru Si Wang yan Chen xiao-Xia Zhang Guo-Long li Qing-Shan Hai Wei-Bo Wen Huan-tian Cui College of Basic Medical of Yunnan University of Chinese Medicine Kunming 650000China Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment Kunming 650000China The First Clinical Medical College of Yunnan University of Chinese Medicine Kunming 650000China Department of Endocrinology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000China Yunnan Engineering Research Centre of Preventive Treatment of Chinese Medicine First Affiliated HospitalYunnan University of Chinese MedicineKunming 650000China

This study aimed to provide a comprehensive review of the research progress in Chinese medicine in the treatment of endocrine metabolic diseases in 2023,covering traditional Chinese medicine(TCM)monomers,TCM extracts,and TCM combinations,including non-alcoholic fatty liver disease,type 2 diabetes mellitus and its complications,obesity,hyperuricaemia,and thyroid *** systematic sorting and summary,we found that in 2023,the research focusing on the application of TCM for endocrine metabolic diseases was still on the mechanism of action at the cellular and molecular levels,which not only influenced the classical pathways of lipid metabolism,but also delved into the key mechanisms of anti-inflammation,anti-oxidation,anti-insulin resistance,and so ***,TCM has shown remarkable results in the treatment of endocrine metabolic diseases by improving intestinal flora disorders and abnormal cellular iron *** research results provide valuable ideas,methods,and tools for TCM in the prevention and treatment of endocrine metabolic diseases,and provide important references and guidance for future research and practice.

关键词： endocrine metabolic diseases traditional Chinese medicine Chinese medicine extracts Chinese medicine compound therapeutic mechanism