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Geochemical and Isotopic Techniques Constraints on the Origin,Evolution,and Residence Time of Low-enthalpy Geothermal Water in Western Wugongshan,SE China

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 801-818页

作者： WANG Luyao LIU Kai MA Yan ZHANG Yaoyao tong jue JIA Wuhui ZHANG Shouchuan SUN Junliang Chinese Academy of Geological Sciences Beijing 100037China School of Water Resources and Environment China University of Geoscience(Beijing)Beijing 100083China The Fourth Geological Brigade of Jiangxi Geological Bureau PingxiangJiangxi 337000China

Geothermal resources are increasingly gaining attention as a competitive,clean energy source to address the energy crisis and mitigate climate *** Wugongshan area,situated in the southeast coast geothermal belt of China,is a typical geothermal anomaly and contains abundant medium-and low-temperature geothermal *** study employed hydrogeochemical and isotopic techniques to explore the cyclic evolution of geothermal water in the western Wugongshan region,encompassing the recharge origin,water-rock interaction mechanisms,and residence *** results show that the geothermal water in the western region of Wugongshan is weakly alkaline,with low enthalpy and mineralization *** hydrochemistry of geothermal waters is dominated by Na-HCO_(3)and Na-SO_(4),while the hydrochemistry types of cold springs are all Na-HCO_(3).The hydrochemistry types of surface waters and rain waters are NaHCO_(3)or Ca-HCO_(3).The δD and δ^(18)O values reveal that the geothermal waters are recharged by atmospheric precipitation at an altitude between 550.0 and 1218.6 *** ratios of maj or solutes and isotopic compositions of^(87)Sr/^(86)Sr underscore the significant role of silicate weathering,dissolution,and cation exchange in controlling geothermal water ***,geothermal waters experienced varying degrees of mixing with cold water during their ***δ^(13)C values suggest that the primary sources of carbon in the geothermal waters were biogenic and ***δ^(34)S value suggests that the sulfates in geothermal water originate from sulfide minerals in the surrounding *** dating using 3H and^(14)C isotopes suggests that geothermal waters have a residence time exceeding 1 kaBP and undergo a long-distance cycling process.

关键词： geothermal water hydrochemistry isotope residence time Wugongshan area

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江西吉安钱山地区地热资源特征及热源机制

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地球学报 2024年第1期45卷 39-52页

作者：张垚垚刘凯童珏何庆成贺晓龙贾伍慧张浩然王书训中国地质科学院北京100037 中国地质大学(北京)地球科学与资源学院北京100083 江西省地质局第四地质大队江西萍乡337000 湘潭大学环境与资源学院湖南湘潭411105 中国矿业大学(北京)地球科学与测绘工程学院北京100083

位于罗霄山脉北支武功山西南地区的钱山地热田是研究武功山地热资源的关键地区。本文综合区域地质、研究区地质特征、热物性参数、水化学特征、锆石同位素等方法,重点分析了钱山地区的地热系统特征,深入研究了钱山地热的构造背景和热源... 详细信息

位于罗霄山脉北支武功山西南地区的钱山地热田是研究武功山地热资源的关键地区。本文综合区域地质、研究区地质特征、热物性参数、水化学特征、锆石同位素等方法,重点分析了钱山地区的地热系统特征,深入研究了钱山地热的构造背景和热源机制。研究表明:(1)NE–SW向的和平—三江断裂是钱山地热重要的导热和控热构造;(2)水化学及同位素特征指示钱山地区的地热水和冷水均为大气降水补给;(3)早志留世黑云二长花岗岩热导率特征表明花岗岩具有很好的导热效果和聚热能力;(4)黑云二长花岗岩放射性生热率较低且时代久远,揭示放射性元素生热和岩浆岩余热对热源做出的贡献非常小,钱山地热的热源主要来自壳源深部地热。本研究可为武功山地区地热资源成因及合理开发利用等提供重要的启示。

关键词：钱山地热热物性参数水化学特征热源机制武功山

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Cerebral pseudoinfarction due to venoarterial extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3130-3137页

作者： Mi Xu jue-Yue Yan Jia-Jia Jin tong Li Department of Critical Care Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Neurological complications are common in the management of venoarterial extracorporeal membrane oxygenation(VA-ECMO),with most patients requiring sedation and intubation,limiting the assessment of neurological ***,we must rely on advanced neuroimaging techniques,such as computed tomography angiography(CTA)and computed tomography perfusion(CTP).Because ECMO changes the normal blood flow pattern,it may interfere with the contrast medium in some special cases,leading to artifacts and ultimately misleading clinical *** SUMMARY A 61-year-old man presented to a local hospital with chest tightness and pain 1 d prior to *** patient was treated with VA-ECMO after sudden cardiac and respiratory arrest at a local *** further treatment,the patient was transferred to our *** initial consciousness assessment was not clear,and routine CTP was performed to understand the intracranial changes,which suggested a large area of cerebral infarction on the right side;however,the cerebral oxygen was not consistent with the CTP results,and the reexamination of CTA still suggested a right cerebral *** identify this difference,bedside transcranial Doppler was performed,and the blood flow on both sides was *** reducing the ECMO flow,CTP reexamination showed that the results were normal and consistent with the clinical *** day 3,the patient was alert and showed good limb *** In patients with peripheral VA-ECMO,cerebral perfusion confirmed by CTP and CTA may lead to false cerebral infarction.

关键词： Extracorporeal membrane oxygenation Computed tomography perfusion Computed tomography angiography Cerebral perfusion Contrast medium artifacts Case report

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Inferring the Effects of Protein Variants on Protein-Protein Interactions with Interpretable Transformer Representations

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Research 2024年第2期2023卷 473-489页

作者： Zhe Liu Wei Qian Wenxiang Cai Weichen Song Weidi Wang Dhruba Tara Maharjan Wenhong Cheng jue Chen Han Wang Dong Xu Guan Ning Lin Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina School of Information Science and Technology Institute of Computational BiologyNortheast Normal UniversityChangchunChina Department of Electrical Engineering and Computer Science University of MissouriColumbiaMO 65211USA Christopher S.Bond Life Sciences Center University of MissouriColumbiaMO 65211USA

Identifying pathogenetic variants and inferring their impact on protein-protein interactions sheds light on their functional consequences on *** by the availability of experimental data on the consequences of protein interaction,most existing methods focus on building models to predict changes in protein binding ***,we introduced MIPPI,an end-to-end,interpretable transformer-based deep learning model that learns features directly from sequences by leveraging the interaction data from *** was specifically trained to determine the types of variant impact(increasing,decreasing,disrupting,and no effect)on protein-protein *** demonstrate the accuracy of MIPPI and provide interpretation through the analysis of learned attention weights,which exhibit correlations with the amino acids interacting with the ***,we showed the practicality of MIPPI in prioritizing de novo mutations associated with complex neurodevelopmental disorders and the potential to determine the pathogenic and driving ***,we experimentally validated the functional impact of several variants identified in patients with such ***,MIPPI emerges as a versatile,robust,and interpretable model,capable of effectively predicting mutation impacts on protein-protein interactions and facilitating the discovery of clinically actionable variants.

关键词： consequences weights versatile

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江西省地热资源赋存特征及潜力评价

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中国地质 2023年第6期50卷 1646-1654页

作者：王安东孙占学蔺文静杨旎叶海龙童珏王运东华理工大学核资源与环境国家重点实验室江西南昌330013 东华理工大学地球科学学院江西南昌330013 东华理工大学水资源与环境工程学院江西南昌330013 中国地质科学院水文地质环境地质研究所河北石家庄050061 江西省勘察设计研究院江西南昌330095 江西省地质局九〇一地质大队江西萍乡337000

【研究目的】江西省地热资源丰富,具有较好的地热资源开发利用潜力。【研究方法】本文介绍了江西省地热资源分布特征、地热成因类型、地热水化学特征,并评估了各设区市的地热资源潜力。【研究结果】江西省地热资源主要可分为隆起山地循... 详细信息

【研究目的】江西省地热资源丰富,具有较好的地热资源开发利用潜力。【研究方法】本文介绍了江西省地热资源分布特征、地热成因类型、地热水化学特征,并评估了各设区市的地热资源潜力。【研究结果】江西省地热资源主要可分为隆起山地循环对流型和沉积盆地型两种类型,其中隆起山地循环对流型占95%以上。隆起山地循环对流型地热系统主要分布在九连山、武功山、九岭山和罗霄山脉一带,主要受控于周围的断裂构造尤其是深大断裂构造,通常出露在两大断裂交汇的位置。【结论】江西省地热资源分布基本与地温梯度、大地热流和深部温度格局特征相吻合,地热流体水化学类型以HCO_(3)-Na型为主,矿物度较低,以淡水为主,地热流体主要来源于大气降水。地热资源潜力评价结果显示赣州和宜春地热资源最为丰富,地热资源量均超过45000×10^(10)kJ。

关键词：地热资源赋存特征潜力评价隆起山地循环对流型地热地热地质调查工程江西省

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scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt/β-catenin signaling

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Asian Journal of Andrology 2024年第1期26卷 46-56页

作者： Shi-Wei Liu Jia-Qiang Luo Liang-Yu Zhao Ning-Jing Ou Chao-Yang Yu-Xiang Zhang Hao-Wei Bai Hong-Fang Sun Jian-Xiong Zhang Chen-Cheng Yao Peng Li Ru-Hui Tian Zheng Li Zi-jue Zhu Department of Andrology Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Lab of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Shanghai Key Lab of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200080China Department of Urology Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining *** single-cell RNA sequencing(scRNA-seq)analysis of the testis was performed to identify genes upregulated in *** scRNAseq analysis,we identified the spermatogonia upregulated gene origin recognition complex subunit 6(Orc6),which is involved in DNA replication and cell cycle regulation;its protein expression in the human and mouse testis was detected by western blot and *** explore the potential function of Orc6 in spermatogonia,the C18-4 cell line was transfected with control or Orc6 ***,5-ethynyl-2-deoxyuridine(EdU)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,flow cytometry,and western blot were used to evaluate its effects on proliferation and *** was revealed that ORC6 could promote proliferation and inhibit apoptosis of C18-4 *** RNA sequencing and bioinformatics analysis indicated that Orc6 was involved in the activation of wingless/integrated(Wnt)/β-catenin *** blot revealed that the expression ofβ-catenin protein and its phosphorylation(Ser675)were significantly decreased when silencing the expression of *** findings indicated that Orc6 was upregulated in spermatogonia,whereby it regulated proliferation and apoptosis by activating Wnt/β-catenin signaling.

关键词： cell proliferation ORCG scRNA-seq analysis spermatogonia Wnt/β-catenin signaling

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考虑人因-环境因素的山区公路警觉水平量化模型

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重庆交通大学学报（自然科学版） 2024年第7期43卷 44-51,69页

作者：刘通胡红单珏刘唐志刘星良重庆交通大学交通运输学院重庆400064 浙江交工集团股份有限公司设计院分公司浙江杭州310051

为描述山区公路驾驶者的警觉状态及水平,综合考虑人因-环境因素,提出了一种山区公路警觉水平量化方法。通过分析驾驶者的眼动及行为数据来确定初始观测指标,基于核主成分分析法对多源数据进行降维,对降维后的主成分使用K-means聚类方法... 详细信息

为描述山区公路驾驶者的警觉状态及水平,综合考虑人因-环境因素,提出了一种山区公路警觉水平量化方法。通过分析驾驶者的眼动及行为数据来确定初始观测指标,基于核主成分分析法对多源数据进行降维,对降维后的主成分使用K-means聚类方法划分高低警觉水平;以低警觉水平样本概率为目标变量,通过筛选人因-环境因素得到了警觉水平量化因子;基于评分卡方法建立了山区公路警觉水平量化模型,并对模型进行了实例验证。研究结果表明:基于人因-环境因素的山区公路警觉水平量化模型的AUC值为0.907,KS值为71.86%,模型效果较好,能为山区公路驾驶者警觉水平动态评价及安全配套设施建设提供参考依据。

关键词：交通工程警觉水平山区公路评分卡模型实车试验核主成分分析

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双安息香缩三乙四胺双核过渡金属配合物的合成、表征与载氧性质

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高等学校化学学报 1998年第2期19卷 174-178页

作者：钟超凡邓建成童珏姚笑红朱文松湘潭大学化学化工学院

合成了双安息香缩三乙四胺及其与草酸共同配位的Ｃｏ（Ⅱ）、Ｎｉ（Ⅱ）、Ｃｕ（Ⅱ）、Ｚｎ（Ⅱ）、Ｃｄ（Ⅱ）的三元双核金属配合物．经质谱、红外光谱、元素分析、摩尔电导与磁矩测定及热分析等方法表征．用气体吸收装置探讨了配合物... 详细信息

合成了双安息香缩三乙四胺及其与草酸共同配位的Ｃｏ（Ⅱ）、Ｎｉ（Ⅱ）、Ｃｕ（Ⅱ）、Ｚｎ（Ⅱ）、Ｃｄ（Ⅱ）的三元双核金属配合物．经质谱、红外光谱、元素分析、摩尔电导与磁矩测定及热分析等方法表征．用气体吸收装置探讨了配合物在ＤＭＦ溶剂中的载氧性质和载氧动力学．

关键词：双安息香缩三乙四胺双核配合物载氧性质

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地热水氢氧同位素控制因素识别与定量计算:以青海贵德盆地为例

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地学前缘 2021年第1期28卷 420-427页

作者：戴蔓蒋小伟罗银飞张鸿雷玉德童珏中国地质大学(北京)水资源与环境学院北京100083 青海九○六工程勘察设计院青海西宁810008 青海省环境地质勘查局青海西宁810008 青海省环境地质重点实验室青海西宁810008

氢氧同位素在地热水研究中得到了广泛应用,但由于影响因素较多,对地热水氢氧同位素组成的控制过程通常缺少全面认识。本文以贵德盆地周边两条断裂带上五处温泉为例,通过对比不同地热水之间的水化学差异和热储温度差异,建立了不同地热水... 详细信息

氢氧同位素在地热水研究中得到了广泛应用,但由于影响因素较多,对地热水氢氧同位素组成的控制过程通常缺少全面认识。本文以贵德盆地周边两条断裂带上五处温泉为例,通过对比不同地热水之间的水化学差异和热储温度差异,建立了不同地热水的水岩反应程度与氢氧同位素是否偏离大气降水线的关系。在前人识别并定量出扎仓寺地热水存在冷水混合作用的基础上,借助冷水混合比例估算了冷水混合和水汽分离引起的氢氧同位素的变化幅度,在此基础上通过“氧漂移”规律恢复了扎仓寺地热水在发生水岩反应前的氢氧同位素组成。本文关于三个过程对氢氧同位素影响程度的计算方法可以用于分析其他地区地热水的氢氧同位素成因,从而加深对地热水循环过程的认识。

关键词：水化学特征氢氧同位素水岩反应水汽分离扎仓寺

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Infection with SARS-CoV-2 can cause pancreatic impairment

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2143-2160页

作者： Wei Deng Linlin Bao Zhiqi Song Ling Zhang Pin Yu Yanfeng Xu jue Wang Wenjie Zhao Xiuqin Zhang Yunlin Han Yanhong Li Jiangning Liu Qi Lv Xujian Liang Fengdi Li Feifei Qi Ran Deng Siyuan Wang Yibai Xiong Ruiping Xiao Hongyang Wang Chuan Qin NHC Key Laboratory of Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking UniversityBeijing 100871China State Key Laboratory of Biomembrane and Membrane Biotechnology Peking-Tsinghua Center for Life SciencesBeijing 100871China Chinese Academy of Engineering Eastern Hepatobiliary Surgery Hospital225 Changhai RoadYangpu DistrictShanghai 200438China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438PR China National Laboratory for Oncogenes and Related Genes Cancer Institute of Shanghai Jiao Tong UniversityShanghai 200441PR China Changping National laboratory(CPNL) Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity National Health Commission of the People’s Republic of ChinaBeijingPR China

Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of ***,we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates(NHPs)models and 121 vaccinated and infected NHPs from 2020 to 2023 and COVID-19 ***-label immunofluorescence revealed direct infection of both exocrine and endocrine pancreatic cells by the virus in NHPs and *** and limited phenotypic and histopathological changes were observed in adult *** proteomics and metabolomics results indicated metabolic disorders,mainly enriched in insulin resistance pathways,in infected adult NHPs,along with elevated fasting C-peptide and C-peptide/glucose ratio ***,in elder COVID-19 NHPs,SARS-CoV-2 infection causes loss of beta(β)cells and lower expressed-insulin in situ characterized by islet amyloidosis and necrosis,activation ofα-SMA and aggravated fibrosis consisting of lower collagen in serum,an increase of pancreatic inflammation and stress markers,ICAM-1 and G3BP1,along with more severe glycometabolic *** contrast,vaccination maintained glucose homeostasis by activating insulin receptorαand insulin receptorβ.Overall,the cumulative risk of diabetes post-COVID-19 is closely tied to age,suggesting more attention should be paid to blood sugar management in elderly COVID-19 patients.

关键词： infected elevated homeostasis

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